breath analysis research paper

For the analysis of exhaled VOCs and disease diagnosis, two different methods can be used; analytical techniques and sensors. Gas chromatography combined with mass spectrometry (GC-MS) comprises the gold-standard method for the analysis of VOCs patterns in exhaled breath [1,17,33].Both quantitative analysis (characterized by high sensitivity in the ppb to ppt range []) and qualitative analysis ...

Journal of Breath Research. ISSN: 1752-7163. SUPPORTS OPEN ACCESS. This journal is dedicated to all aspects of breath science, with the major focus on analysis of exhaled breath in physiology and medicine, and the diagnosis and treatment of breath odours. Official Journal of the International Association for Breath Research ( IABR ).

Additional articles were included following forward and reverse searching resulting in the final inclusion of 110 papers. From the final 110 articles the following parameters were assessed: ... Beauchamp J. Current sampling and analysis techniques in breath research-results of a task force poll. Journal of Breath Research. 2015; 9:047107. ...

The most recent comprehensive meta-analysis regarding VOC-based breath analysis to detect COVID-19 infection consisted of only six research papers; the present study serves to expand on their work and provide further insight with expanding research in the field since their publication. [65]

1. Introduction. Breath diagnostics can be traced back to ancient Chinese and Greek literature that recorded breath aroma could provide clues to human health [1, 2].The analysis of exhaled breath is an attractive field of research owing to its great potential for diagnosing disease non-invasively [3, 4].Most recently, volatiles in exhaled breath have been investigated in terms of diagnosing ...

Breath analysis is a relatively recent field of research with much promise in scientific and clinical studies. Breath contains endogenously produced volatile organic components (VOCs) resulting from metabolites of ingested precursors, gut and air-passage bacteria, environmental contacts, etc. Numerous recent studies have suggested changes in breath composition during the course of many ...

The respective breath biomarkers targeted in each test are discussed in relation to their physiological production in the human body and the development and implementation of the associated tests. The paper concludes with a brief insight into prospective tests and an outlook of the future direction of breath research.

Maier, D. et al. Toward continuous monitoring of breath biochemistry: a paper-based wearable sensor for real-time hydrogen peroxide measurement in simulated breath. ACS Sens. 4 , 2945-2951 (2019).

Recently, research interest focused on the diagnosis of SARS-CoV-2 viral infection via breath analysis with remarkable results [24,25,26], employing a diagnostic test, i.e., "BreFence Go COVID-19 Breath Test System" developed by Breathonix and "TracieX Breathalyser" developed by Silver Factory Technology, which have been already ...

COVID-19 is a highly contagious respiratory disease that can be infected through human exhaled breath. Human breath analysis is an attractive strategy for rapid diagnosis of COVID-19 in a non-invasive way by monitoring breath biomarkers. Mass spectrometry (MS)-based approaches offer a promising analytical platform for human breath analysis due to their high speed, specificity, sensitivity ...

Exhaled breath analysis in academic research entails the utilization of several prevalent techniques. ... An EC gas biosensor based on an enzyme immobilized on chromatographic paper is shown in ...

Breath analysis by laser spectroscopy can differentiate between SARS-CoV-2 infection positives and negatives. Using the two spectral pre-processing techniques for machine learning analysis, we found the pattern-based approach yielded an AUC of 0.849 (standard deviation [SD], 0.004) (figure 3 (b)) and the molecule-based approach yielded an AUC ...

The papers used in this review are given as representative examples for the potential of breath analysis to contribute in cancer medicine, rather than presenting breath analysis as a tool ready to be used. Comparisons between clinical capabilities of breath analysis studies and gold standard procedures are given in table 1. For example, the ...

Breathomics is a branch of metabolomics that analyzes various volatile organic compounds (VOCs) from exhaled breath samples. It has been rapidly growing as a non-invasive diagnostic tool to probe or infer the pathogenic or physiological status of the human body, often yielding crucial information for disease diagnostics. Unlike traditional diagnostic methods that often require invasive ...

Biomarkers and breath. The origin of modern breath research is widely attributed to Linus Pauling and colleagues in the early 1970s [Citation 20], although the history of breath and disease dates to the Ancient Greeks, who described fetor hepaticus - a distinct malodourous breath associated with liver disease [Citation 21].In Eastern medicine, the smell of breath has been used for disease ...

Indeed, there are multiple reviews in this topic but one must understand that this is a rapidly growing field of research. Righettoni et al. 25 reported that since the year 2000, ∼140000 research papers have been published only on the topic of breath analysis itself. Therefore, comprehensive reviews must come up every year so as to keep the ...

Your breath gives away a lot of information. Besides betraying that you've had garlic or onions for lunch, it also contains volatile organic compounds (VOCs) that provide quite telling biomarkers of disease. Building on the potential capability of VOCs to detect illness, the U.K. company Owlstone Medical is now developing a testing platform called Breath Biopsy [1] as a noninvasive diagnostic ...

Despite promising results obtained in the early diagnosis of several pathologies, breath analysis still remains an unused technique in clinical practice due to the lack of breath sampling standardized procedures able to guarantee a good repeatability and comparability of results. The most diffuse on an international scale breath sampling method uses polymeric bags, but, recently, devices named ...

The random-effects analysis yielded a significant small-to-medium mean effect size, g = − 0.35 [95% CI − 0.55, − 0.14], z = 3.32, p = 0.0009, showing breathwork was associated with lower ...

breath [1,9,10]. Decreased sample complexity, the highly developed appropriate analytical techniques, and the ability of direct or continuous breath analysis using gas sensors render exhaled breath as an exceptional source of gas-biomarkers (VOCs predominantly but also inorganic gases) [8,11].

The cited studies suggest a work:rest ratio of 1:1.5 or 1:2 (e.g., 10 s hold followed by 20 s running) for 10-12 repetitions. Notably, participant instructions often include counting cycles per breath to "pace" BH duration; this is could facilitate use of the "hold" tool in the field.

Abstract. Breath research is now well established and is solving some of the applications in the area of identifying volatiles for medical diagnosis. This paper looks at how this research has been taken to an end-user market. It is not intended to be an indepth study of the science but simply to draw attention to the role of the commercial link ...

The aim of this pilot study is to determine whether exhaled VOCs can be used to distinguish controls from MCI, controls from AD, and MCI from AD in breath. Confounding factors, such as age, smoking habits, gender and alcohol consumption are investi-gated to demonstrate the ef ficacy of results. 2.

Titles and abstracts were screened, and 2,303 studies were removed either because they were duplicated or of no interest for the systematic review. The remaining 158 full-text papers were checked for the eligibility criteria. At the end of the analysis, 15 articles meeting the eligibility criteria were retained and included in the review.