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How to read and understand a scientific paper

How to read and understand a scientific paper: a guide for non-scientists, london school of economics and political science, jennifer raff.

From vaccinations to climate change, getting science wrong has very real consequences. But journal articles, a primary way science is communicated in academia, are a different format to newspaper articles or blogs and require a level of skill and undoubtedly a greater amount of patience. Here  Jennifer Raff   has prepared a helpful guide for non-scientists on how to read a scientific paper. These steps and tips will be useful to anyone interested in the presentation of scientific findings and raise important points for scientists to consider with their own writing practice.

My post,  The truth about vaccinations: Your physician knows more than the University of Google  sparked a very lively discussion, with comments from several people trying to persuade me (and the other readers) that  their  paper disproved everything that I’d been saying. While I encourage you to go read the comments and contribute your own, here I want to focus on the much larger issue that this debate raised: what constitutes scientific authority?

It’s not just a fun academic problem. Getting the science wrong has very real consequences. For example, when a community doesn’t vaccinate children because they’re afraid of “toxins” and think that prayer (or diet, exercise, and “clean living”) is enough to prevent infection, outbreaks happen.

“Be skeptical. But when you get proof, accept proof.” –Michael Specter

What constitutes enough proof? Obviously everyone has a different answer to that question. But to form a truly educated opinion on a scientific subject, you need to become familiar with current research in that field. And to do that, you have to read the “primary research literature” (often just called “the literature”). You might have tried to read scientific papers before and been frustrated by the dense, stilted writing and the unfamiliar jargon. I remember feeling this way!  Reading and understanding research papers is a skill which every single doctor and scientist has had to learn during graduate school.  You can learn it too, but like any skill it takes patience and practice.

I want to help people become more scientifically literate, so I wrote this guide for how a layperson can approach reading and understanding a scientific research paper. It’s appropriate for someone who has no background whatsoever in science or medicine, and based on the assumption that he or she is doing this for the purpose of getting a  basic  understanding of a paper and deciding whether or not it’s a reputable study.

The type of scientific paper I’m discussing here is referred to as a  primary research article . It’s a peer-reviewed report of new research on a specific question (or questions). Another useful type of publication is a  review article . Review articles are also peer-reviewed, and don’t present new information, but summarize multiple primary research articles, to give a sense of the consensus, debates, and unanswered questions within a field.  (I’m not going to say much more about them here, but be cautious about which review articles you read. Remember that they are only a snapshot of the research at the time they are published.  A review article on, say, genome-wide association studies from 2001 is not going to be very informative in 2013. So much research has been done in the intervening years that the field has changed considerably).

Before you begin: some general advice

Reading a scientific paper is a completely different process than reading an article about science in a blog or newspaper. Not only do you read the sections in a different order than they’re presented, but you also have to take notes, read it multiple times, and probably go look up other papers for some of the details. Reading a single paper may take you a very long time at first. Be patient with yourself. The process will go much faster as you gain experience.

Most primary research papers will be divided into the following sections: Abstract, Introduction, Methods, Results, and Conclusions/Interpretations/Discussion. The order will depend on which journal it’s published in. Some journals have additional files (called Supplementary Online Information) which contain important details of the research, but are published online instead of in the article itself (make sure you don’t skip these files).

Before you begin reading, take note of the authors and their institutional affiliations. Some institutions (e.g. University of Texas) are well-respected; others (e.g.  the Discovery Institute ) may appear to be legitimate research institutions but are actually agenda-driven.  Tip:  g oogle  “Discovery Institute” to see why you don’t want to use it as a scientific authority on evolutionary theory.

Also take note of the journal in which it’s published. Reputable (biomedical) journals will be indexed by  Pubmed . [EDIT: Several people have reminded me that non-biomedical journals won’t be on Pubmed, and they’re absolutely correct! (thanks for catching that, I apologize for being sloppy here). Check out  Web of Science  for a more complete index of science journals. And please feel free to share other resources in the comments!]  Beware of  questionable journals .

As you read, write down  every single word  that you don’t understand. You’re going to have to look them all up (yes, every one. I know it’s a total pain. But you won’t understand the paper if you don’t understand the vocabulary. Scientific words have extremely precise meanings).

Step-by-step instructions for reading a primary research article

1. Begin by reading the introduction, not the abstract.

The abstract is that dense first paragraph at the very beginning of a paper. In fact, that’s often the only part of a paper that many non-scientists read when they’re trying to build a scientific argument. (This is a terrible practice—don’t do it.).  When I’m choosing papers to read, I decide what’s relevant to my interests based on a combination of the title and abstract. But when I’ve got a collection of papers assembled for deep reading, I always read the abstract last. I do this because abstracts contain a succinct summary of the entire paper, and I’m concerned about inadvertently becoming biased by the authors’ interpretation of the results.

2. Identify the BIG QUESTION.

Not “What is this paper about”, but “What problem is this entire field trying to solve?”

This helps you focus on why this research is being done.  Look closely for evidence of agenda-motivated research.

3. Summarize the background in five sentences or less.

Here are some questions to guide you:

What work has been done before in this field to answer the BIG QUESTION? What are the limitations of that work? What, according to the authors, needs to be done next?

The five sentences part is a little arbitrary, but it forces you to be concise and really think about the context of this research. You need to be able to explain why this research has been done in order to understand it.

4.   Identify the SPECIFIC QUESTION(S)

What  exactly  are the authors trying to answer with their research? There may be multiple questions, or just one. Write them down.  If it’s the kind of research that tests one or more null hypotheses, identify it/them.

Not sure what a null hypothesis is? Go read this one  and try to identify the null hypotheses in it. Keep in mind that not every paper will test a null hypothesis.

5. Identify the approach

What are the authors going to do to answer the SPECIFIC QUESTION(S)?

6. Now read the methods section. Draw a diagram for each experiment, showing exactly what the authors did.

I mean  literally  draw it. Include as much detail as you need to fully understand the work.  As an example, here is what I drew to sort out the methods for a paper I read today ( Battaglia et al. 2013: “The first peopling of South America: New evidence from Y-chromosome haplogroup Q” ). This is much less detail than you’d probably need, because it’s a paper in my specialty and I use these methods all the time.  But if you were reading this, and didn’t happen to know what “process data with reduced-median method using Network” means, you’d need to look that up.

Image credit: author

You don’t need to understand the methods in enough detail to replicate the experiment—that’s something reviewers have to do—but you’re not ready to move on to the results until you can explain the basics of the methods to someone else.

7.   Read the results section. Write one or more paragraphs to summarize the results for each experiment, each figure, and each table. Don’t yet try to decide what the results  mean , just write down what they  are.

You’ll find that, particularly in good papers, the majority of the results are summarized in the figures and tables. Pay careful attention to them!  You may also need to go to the Supplementary Online Information file to find some of the results.

 It is at this point where difficulties can arise if statistical tests are employed in the paper and you don’t have enough of a background to understand them. I can’t teach you stats in this post, but  here , and here   are some basic resources to help you.  I STRONGLY advise you to become familiar with them.

Things to pay attention to in the results section:

  • Any time the words “significant” or “non-significant” are used. These have precise statistical meanings. Read more about this  here .
  • If there are graphs, do they have  error bars  on them? For certain types of studies, a lack of confidence intervals is a major red flag.
  • The sample size. Has the study been conducted on 10, or 10,000 people? (For some research purposes, a sample size of 10 is sufficient, but for most studies larger is better).

8. Do the results answer the SPECIFIC QUESTION(S)? What do you think they mean?

Don’t move on until you have thought about this. It’s okay to change your mind in light of the authors’ interpretation—in fact you probably will if you’re still a beginner at this kind of analysis—but it’s a really good habit to start forming your own interpretations before you read those of others.

9. Read the conclusion/discussion/Interpretation section.

What do the authors think the results mean? Do you agree with them? Can you come up with any alternative way of interpreting them? Do the authors identify any weaknesses in their own study? Do you see any that the authors missed? (Don’t assume they’re infallible!) What do they propose to do as a next step? Do you agree with that?

10. Now, go back to the beginning and read the abstract.

Does it match what the authors said in the paper? Does it fit with your interpretation of the paper?

11. FINAL STEP:  (Don’t neglect doing this)  What do other researchers say about this paper?

Who are the (acknowledged or self-proclaimed) experts in this particular field? Do they have criticisms of the study that you haven’t thought of, or do they generally support it?

Here’s a place where I do recommend you use google! But do it last, so you are better prepared to think critically about what other people say.

(12. This step may be optional for you, depending on why you’re reading a particular paper. But for me, it’s critical! I go through the “Literature cited” section to see what other papers the authors cited. This allows me to better identify the important papers in a particular field, see if the authors cited my own papers (KIDDING!….mostly), and find sources of useful ideas or techniques.)

UPDATE: If you would like to see an example of how to read a science paper using this framework, you can find one  here .

I gratefully acknowledge Professors José Bonner and Bill Saxton for teaching me how to critically read and analyze scientific papers using this method. I’m honored to have the chance to pass along what they taught me.

I’ve written a shorter version of this guide for teachers to hand out to their classes. If you’d like a PDF, shoot me an email: jenniferraff (at) utexas (dot) edu. For further comments and additional questions on this guide, please see the Comments Section on  the original post .

This piece originally appeared on the  author’s personal blog  and is reposted with permission.

Featured image credit:  Scientists in a laboratory of the University of La Rioja  by  Urcomunicacion  (Wikimedia CC BY3.0)

Note: This article gives the views of the authors, and not the position of the LSE Impact blog, nor of the London School of Economics. Please review our  Comments Policy  if you have any concerns on posting a comment below.

Jennifer Raff (Indiana University—dual Ph.D. in genetics and bioanthropology) is an assistant professor in the Department of Anthropology, University of Kansas, director and Principal Investigator of the KU Laboratory of Human Population Genomics, and assistant director of KU’s Laboratory of Biological Anthropology. She is also a research affiliate with the University of Texas anthropological genetics laboratory. She is keenly interested in public outreach and scientific literacy, writing about topics in science and pseudoscience for her blog ( violentmetaphors.com ), the Huffington Post, and for the  Social Evolution Forum .

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Reference management. Clean and simple.

How to read a scientific paper: a step-by-step guide

tips how to read an academic paper

Scientific paper format

How to read a scientific paper in 3 steps, step 1: identify your motivations for reading a scientific paper, step 2: use selective reading to gain a high-level understanding of the scientific paper, step 3: read straight through to achieve a deep understanding of a scientific paper, frequently asked questions about reading a scientific paper efficiently, related articles.

A scientific paper is a complex document. Scientific papers are divided into multiple sections and frequently contain jargon and long sentences that make reading difficult. The process of reading a scientific paper to obtain information can often feel overwhelming for an early career researcher.

But the good news is that you can acquire the skill of efficiently reading a scientific paper, and you can learn how to painlessly obtain the information you need.

In this guide, we show you how to read a scientific paper step-by-step. You will learn:

  • The scientific paper format
  • How to identify your reasons for reading a scientific paper
  • How to skim a paper
  • How to achieve a deep understanding of a paper.

Using these steps for reading a scientific paper will help you:

  • Obtain information efficiently
  • Retain knowledge more effectively
  • Allocate sufficient time to your reading task.

The steps below are the result of research into how scientists read scientific papers and our own experiences as scientists.

Firstly, how is a scientific paper structured?

The main sections are Abstract, Introduction, Methods, Results, and Discussion. In the table below, we describe the purpose of each component of a scientific paper.

Because the structured format of a scientific paper makes it easy to find the information you need, a common technique for reading a scientific paper is to cherry-pick sections and jump around the paper.

In a YouTube video, Dr. Amina Yonis shows this nonlinear practice for reading a scientific paper. She justifies her technique by stating that “By reading research papers like this, you are enabling yourself to have a disciplined approach, and it prevents yourself from drowning in the details before you even get a bird’s-eye view”.

Selective reading is a skill that can help you read faster and engage with the material presented. In his article on active vs. passive reading of scientific papers, cell biologist Tung-Tien Sun defines active reading as "reading with questions in mind" , searching for the answers, and focusing on the parts of the paper that answer your questions.

Therefore, reading a scientific paper from start to finish isn't always necessary to understand it. How you read the paper depends on what you need to learn. For example, oceanographer Ken Hughes suggests that you may read a scientific paper to gain awareness of a theory or field, or you may read to actively solve a problem in your research.

3 steps for reading a scientific paper.

To successfully read a scientific paper, we advise using three strategies:

  • Identify your motivations for reading a scientific paper
  • Use selective reading to gain a high-level understanding of the scientific paper
  • Read straight through to achieve a deep understanding of a scientific paper .

All 3 steps require you to think critically and have questions in mind.

Before you sit down to read a scientific paper, ask yourself these three questions:

  • Why do I need to read this paper?
  • What information am I looking for?
  • Where in the paper am I most likely to find the information I need?

Is it background reading or a literature review for a research project you are currently working on? Are you getting into a new field of research? Do you wish to compare your results with the ones presented in the paper? Are you following an author’s work, and need to keep up-to-date on their current research? Are you keeping tabs on emerging methods in your field?

All of these intentions require a different reading approach.

For example, if you're delving into a new field of research, you'll want to read the introduction to gather background information and seminal references. The discussion section will also be important to understand the broader context of the findings.

If you aim to extend the work presented in a paper, and this study will be the starting point for your work, it's crucial to read the paper deeply.

If your focus is on the study design and techniques used by the authors, you'll spend most of your time reading and understanding the methods section.

Sometimes you'll need to read a paper to discuss it in your own research. This may be to compare or contrast your work with the paper's content, or to stimulate a discussion on future applications of your work.

If you are following an author’s work, a quick skim might suffice to understand how the paper fits into their overall research program.

Tip: Knowing why you want to read the paper facilitates how you will read the paper. Depending on your needs, your approach may take the form of a surface-level reading or a deep and thorough reading.

Knowing your motivations will guide your navigation through the paper because you have already identified which sections are most likely to contain the information you need. Approaching reading a paper in this way saves you time and makes the task less daunting.

➡️ Learn more about how to write a literature review

Begin by gaining an overview of the paper by following these simple steps:

  • Read the title. What type of paper is it? Is it a journal article, a review, a methods paper, or a commentary?
  • Read the abstract . The abstract is a summary of the study. What is the study about? What question was addressed? What methods were used? What did the authors find, and what are the key findings? What do the authors think are the implications of the work? Reading the abstract immediately tells you whether you should invest the time to read the paper fully.
  • Look at the headings and subheadings, which describe the sections and subsections of the paper. The headings and subheadings outline the story of the paper.
  • Skim the introduction. An introduction has a clear structure. The first paragraph is background information on the topic. If you are new to the field, you will read this closely, whereas an expert in that field will skim this section. The second component defines the gap in knowledge that the paper aims to address. What is unknown, and what research is needed? What problem needs to be solved? Here, you should find the questions that will be addressed by the study, and the goal of the research. The final paragraph summarizes how the authors address their research question, for example, what hypothesis will be tested, and what predictions the authors make. As you read, make a note of key references. By the end of the introduction, you should understand the goal of the research.
  • Go to the results section, and study the figures and tables. These are the data—the meat of the study. Try to comprehend the data before reading the captions. After studying the data, read the captions. Do not expect to understand everything immediately. Remember, this is the result of many years of work. Make a note of what you do not understand. In your second reading, you will read more deeply.
  • Skim the discussion. There are three components. The first part of the discussion summarizes what the authors have found, and what they think the implications of the work are. The second part discusses some (usually not all!) limitations of the study, and the final part is a concluding statement.
  • Glance at the methods. Get a brief overview of the techniques used in the study. Depending on your reading goals, you may spend a lot of time on this section in subsequent readings, or a cursory reading may be sufficient.
  • Summarize what the paper is about—its key take-home message—in a sentence or two. Ask yourself if you have got the information you need.
  • List any terminology you may need to look up before reading the paper again.
  • Scan the reference list. Make a note of papers you may need to read for background information before delving further into the paper.

Congratulations, you have completed the first reading! You now have gained a high-level perspective of the study, which will be enough for many research purposes.

Now that you have an overview of the work and you have identified what information you want to obtain, you are ready to understand the paper on a deeper level. Deep understanding is achieved in the second and subsequent readings with note-taking and active reflection. Here is a step-by-step guide.

Notetaking on a scientific paper

  • Active engagement with the material
  • Critical thinking
  • Creative thinking
  • Synthesis of information
  • Consolidation of information into memory.

Highlighting sentences helps you quickly scan the paper and be reminded of the key points, which is helpful when you return to the paper later.

Notes may include ideas, connections to other work, questions, comments, and references to follow up on.

There are many ways for taking notes on a paper. You can:

  • Print out the paper, and write your notes in the margins.
  • Annotate the paper PDF from your desktop computer, or mobile device .
  • Use personal knowledge management software, like Notion , Obsidian, or Evernote, for note-taking. Notes are easy to find in a structured database and can be linked to each other.
  • Use reference management tools to take notes. Having your notes stored with the scientific papers you’ve read has the benefit of keeping all your ideas in one place. Some reference managers, like Paperpile, allow you to add notes to your papers, and highlight key sentences on PDFs .

Note-taking facilitates critical thinking and helps you evaluate the evidence that the authors present. Ask yourself questions like:

  • What new contribution has the study made to the literature?
  • How have the authors interpreted the results? (Remember, the authors have thought about their results more deeply than anybody else.)
  • What do I think the results mean?
  • Are the findings well-supported?
  • What factors might have affected the results, and have the authors addressed them?
  • Are there alternative explanations for the results?
  • What are the strengths and weaknesses of the study?
  • What are the broader implications of the study?
  • What should be done next?

Note-taking also encourages creative thinking . Ask yourself questions like:

  • What new ideas have arisen from reading the paper?
  • How does it connect with your work?
  • What connections to other papers can you make?
  • Write a summary of the paper in your own words. This is your attempt to integrate the new knowledge you have gained with what you already know from other sources and to consolidate that information into memory. You may find that you have to go back and re-read some sections to confirm some of the details.
  • Discuss the paper with others. You may find that even at this stage, there are still aspects of the paper that you are striving to understand. It is now a good time to reach out to others—peers in your program, your advisor, or even on social media. In their 10 simple rules for reading a scientific paper , Maureen Carey and coauthors suggest that participating in journal clubs, where you meet with peers to discuss interesting or important scientific papers, is a great way to clarify your understanding.
  • A scientific paper can be read over many days. According to research presented in the book " Make it Stick: The Science of Successful Learning " by writer Peter Brown and psychology professors Henry Roediger and Mark McDaniel, "spaced practice" is more effective for retaining information than focusing on a single skill or subject until it is mastered. This involves breaking up learning into separate periods of training or studying. Applying this research to reading a scientific paper suggests that spacing out your reading by breaking the work into separate reading sessions can help you better commit the information in a paper to memory.

A dense journal article may need many readings to be understood fully. It is useful to remember that many scientific papers result from years of hard work, and the expectation of achieving a thorough understanding in one sitting must be modified accordingly. But, the process of reading a scientific paper will get easier and faster with experience.

The best way to read a scientific paper depends on your needs. Before reading the paper, identify your motivations for reading a scientific paper, and pinpoint the information you need. This will help you decide between skimming the paper and reading the paper more thoroughly.

Don’t read the paper from beginning to end. Instead, be aware of the scientific paper format. Take note of the information you need before starting to read the paper. Then skim the paper, jumping to the appropriate sections in the paper, to get the information you require.

It varies. Skimming a scientific paper may take anywhere between 15 minutes to one hour. Reading a scientific paper to obtain a deep understanding may take anywhere between 1 and 6 hours. It is not uncommon to have to read a dense paper in chunks over numerous days.

First, read the introduction to understand the main thesis and findings of the paper. Pay attention to the last paragraph of the introduction, where you can find a high-level summary of the methods and results. Next, skim the paper by jumping to the results and discussion. Then carefully read the paper from start to finish, taking notes as you read. You will need more than one reading to fully understand a dense research paper.

To read a scientific paper critically, be an active reader. Take notes, highlight important sentences, and write down questions as you read. Study the data. Take care to evaluate the evidence presented in the paper.

reading research scientific papers

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May 9th, 2016

How to read and understand a scientific paper: a guide for non-scientists.

95 comments | 1998 shares

Estimated reading time: 7 minutes

jennifer raff

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My post,  The truth about vaccinations: Your physician knows more than the University of Google  sparked a very lively discussion, with comments from several people trying to persuade me (and the other readers) that their paper disproved everything that I’d been saying. While I encourage you to go read the comments and contribute your own, here I want to focus on the much larger issue that this debate raised: what constitutes scientific authority?

It’s not just a fun academic problem. Getting the science wrong has very real consequences. For example, when a community doesn’t vaccinate children because they’re afraid of “toxins” and think that prayer (or diet, exercise, and “clean living”) is enough to prevent infection, outbreaks happen .

“Be skeptical. But when you get proof, accept proof.” –Michael Specter

What constitutes enough proof? Obviously everyone has a different answer to that question. But to form a truly educated opinion on a scientific subject, you need to become familiar with current research in that field. And to do that, you have to read the “primary research literature” (often just called “the literature”). You might have tried to read scientific papers before and been frustrated by the dense, stilted writing and the unfamiliar jargon. I remember feeling this way!  Reading and understanding research papers is a skill which every single doctor and scientist has had to learn during graduate school.  You can learn it too, but like any skill it takes patience and practice.

I want to help people become more scientifically literate, so I wrote this guide for how a layperson can approach reading and understanding a scientific research paper. It’s appropriate for someone who has no background whatsoever in science or medicine, and based on the assumption that he or she is doing this for the purpose of getting a  basic understanding of a paper and deciding whether or not it’s a reputable study.

The type of scientific paper I’m discussing here is referred to as a primary research article . It’s a peer-reviewed report of new research on a specific question (or questions). Another useful type of publication is a review article . Review articles are also peer-reviewed, and don’t present new information, but summarize multiple primary research articles, to give a sense of the consensus, debates, and unanswered questions within a field.  (I’m not going to say much more about them here, but be cautious about which review articles you read. Remember that they are only a snapshot of the research at the time they are published.  A review article on, say, genome-wide association studies from 2001 is not going to be very informative in 2013. So much research has been done in the intervening years that the field has changed considerably).

Before you begin: some general advice

Reading a scientific paper is a completely different process than reading an article about science in a blog or newspaper. Not only do you read the sections in a different order than they’re presented, but you also have to take notes, read it multiple times, and probably go look up other papers for some of the details. Reading a single paper may take you a very long time at first. Be patient with yourself. The process will go much faster as you gain experience.

Most primary research papers will be divided into the following sections: Abstract, Introduction, Methods, Results, and Conclusions/Interpretations/Discussion. The order will depend on which journal it’s published in. Some journals have additional files (called Supplementary Online Information) which contain important details of the research, but are published online instead of in the article itself (make sure you don’t skip these files).

Before you begin reading, take note of the authors and their institutional affiliations. Some institutions (e.g. University of Texas) are well-respected; others (e.g. the Discovery Institute ) may appear to be legitimate research institutions but are actually agenda-driven. Tip: g oogle “Discovery Institute” to see why you don’t want to use it as a scientific authority on evolutionary theory.

Also take note of the journal in which it’s published. Reputable (biomedical) journals will be indexed by Pubmed . [EDIT: Several people have reminded me that non-biomedical journals won’t be on Pubmed, and they’re absolutely correct! (thanks for catching that, I apologize for being sloppy here). Check out Web of Science for a more complete index of science journals. And please feel free to share other resources in the comments!]  Beware of questionable journals .

As you read, write down every single word that you don’t understand. You’re going to have to look them all up (yes, every one. I know it’s a total pain. But you won’t understand the paper if you don’t understand the vocabulary. Scientific words have extremely precise meanings).

how to read a sci paper

Step-by-step instructions for reading a primary research article

1. Begin by reading the introduction, not the abstract.

The abstract is that dense first paragraph at the very beginning of a paper. In fact, that’s often the only part of a paper that many non-scientists read when they’re trying to build a scientific argument. (This is a terrible practice—don’t do it.).  When I’m choosing papers to read, I decide what’s relevant to my interests based on a combination of the title and abstract. But when I’ve got a collection of papers assembled for deep reading, I always read the abstract last. I do this because abstracts contain a succinct summary of the entire paper, and I’m concerned about inadvertently becoming biased by the authors’ interpretation of the results.

2. Identify the BIG QUESTION.

Not “What is this paper about”, but “What problem is this entire field trying to solve?”

This helps you focus on why this research is being done.  Look closely for evidence of agenda-motivated research.

3. Summarize the background in five sentences or less.

Here are some questions to guide you:

What work has been done before in this field to answer the BIG QUESTION? What are the limitations of that work? What, according to the authors, needs to be done next?

The five sentences part is a little arbitrary, but it forces you to be concise and really think about the context of this research. You need to be able to explain why this research has been done in order to understand it.

4. Identify the SPECIFIC QUESTION(S)

What exactly are the authors trying to answer with their research? There may be multiple questions, or just one. Write them down.  If it’s the kind of research that tests one or more null hypotheses, identify it/them.

Not sure what a null hypothesis is? Go read this , then go back to my last post and read one of the papers that I linked to (like this one ) and try to identify the null hypotheses in it. Keep in mind that not every paper will test a null hypothesis.

5. Identify the approach

What are the authors going to do to answer the SPECIFIC QUESTION(S)?

6. Now read the methods section. Draw a diagram for each experiment, showing exactly what the authors did.

I mean literally draw it. Include as much detail as you need to fully understand the work.  As an example, here is what I drew to sort out the methods for a paper I read today ( Battaglia et al. 2013: “The first peopling of South America: New evidence from Y-chromosome haplogroup Q” ). This is much less detail than you’d probably need, because it’s a paper in my specialty and I use these methods all the time.  But if you were reading this, and didn’t happen to know what “process data with reduced-median method using Network” means, you’d need to look that up.

Image credit: author

You don’t need to understand the methods in enough detail to replicate the experiment—that’s something reviewers have to do—but you’re not ready to move on to the results until you can explain the basics of the methods to someone else.

7. Read the results section. Write one or more paragraphs to summarize the results for each experiment, each figure, and each table. Don’t yet try to decide what the results mean , just write down what they are.

You’ll find that, particularly in good papers, the majority of the results are summarized in the figures and tables. Pay careful attention to them!  You may also need to go to the Supplementary Online Information file to find some of the results.

 It is at this point where difficulties can arise if statistical tests are employed in the paper and you don’t have enough of a background to understand them. I can’t teach you stats in this post, but here , here , and here are some basic resources to help you.  I STRONGLY advise you to become familiar with them.

Things to pay attention to in the results section:

  • Any time the words “significant” or “non-significant” are used. These have precise statistical meanings. Read more about this here .
  • If there are graphs, do they have error bars on them? For certain types of studies, a lack of confidence intervals is a major red flag.
  • The sample size. Has the study been conducted on 10, or 10,000 people? (For some research purposes, a sample size of 10 is sufficient, but for most studies larger is better).

8. Do the results answer the SPECIFIC QUESTION(S)? What do you think they mean?

Don’t move on until you have thought about this. It’s okay to change your mind in light of the authors’ interpretation—in fact you probably will if you’re still a beginner at this kind of analysis—but it’s a really good habit to start forming your own interpretations before you read those of others.

9. Read the conclusion/discussion/Interpretation section.

What do the authors think the results mean? Do you agree with them? Can you come up with any alternative way of interpreting them? Do the authors identify any weaknesses in their own study? Do you see any that the authors missed? (Don’t assume they’re infallible!) What do they propose to do as a next step? Do you agree with that?

10. Now, go back to the beginning and read the abstract.

Does it match what the authors said in the paper? Does it fit with your interpretation of the paper?

11. FINAL STEP: (Don’t neglect doing this) What do other researchers say about this paper?

Who are the (acknowledged or self-proclaimed) experts in this particular field? Do they have criticisms of the study that you haven’t thought of, or do they generally support it?

Here’s a place where I do recommend you use google! But do it last, so you are better prepared to think critically about what other people say.

(12. This step may be optional for you, depending on why you’re reading a particular paper. But for me, it’s critical! I go through the “Literature cited” section to see what other papers the authors cited. This allows me to better identify the important papers in a particular field, see if the authors cited my own papers (KIDDING!….mostly), and find sources of useful ideas or techniques.)

UPDATE: If you would like to see an example of how to read a science paper using this framework, you can find one here .

I gratefully acknowledge Professors José Bonner and Bill Saxton for teaching me how to critically read and analyze scientific papers using this method. I’m honored to have the chance to pass along what they taught me.

I’ve written a shorter version of this guide for teachers to hand out to their classes. If you’d like a PDF, shoot me an email: jenniferraff (at) utexas (dot) edu. For further comments and additional questions on this guide, please see the Comments Section on the original post .

This piece originally appeared on the author’s personal blog and is reposted with permission.

Featured image credit:  Scientists in a laboratory of the University of La Rioja  by Urcomunicacion  (Wikimedia CC BY3.0)

Note: This article gives the views of the authors, and not the position of the LSE Impact blog, nor of the London School of Economics. Please review our  Comments Policy  if you have any concerns on posting a comment below.

About the Author

Jennifer Raff (Indiana University—dual Ph.D. in genetics and bioanthropology) is an assistant professor in the Department of Anthropology, University of Kansas, director and Principal Investigator of the KU Laboratory of Human Population Genomics, and assistant director of KU’s Laboratory of Biological Anthropology. She is also a research affiliate with the University of Texas anthropological genetics laboratory. She is keenly interested in public outreach and scientific literacy, writing about topics in science and pseudoscience for her blog ( violentmetaphors.com ), the Huffington Post , and for the Social Evolution Forum .

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95 Comments

Very good Indeed.I always Read Abstract First Time always ……Thanks

Great information and guide to reading and understanding scientific paper. However, there are non-scientific student asked to do scientific research and it would be great to actually give an example and you point out the answers to the steps in the sample article or journal cited. Thank you.

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I can summarize it eve further: three stars by a number in a table = good, no stars = bad

within the context of the fact that a very sizable portion of scientific papers are falsified, what does this article mean?

Your “fact” needs explanation and evidence, otherwise it can be considered alternative.

That’s why you don’t skip step 11

I think it would be useful also to point out that, even after diligently pursuing all of these excellent steps, the reader is usually still unable to determine whether the subjects or materials even existed. Unlike with lay media, where most important stories are covered by multiple sources, and where facts are sometimes checkable from primary sources – even by readers – it is rare indeed that a reader can go beyond the words on the page.

Is the fact that you read instructions on how to read a paper not evidence that there is something wrong with the way we write papers?

The issue of scientific literacy is always challenging for my students. But this is the most practical and helpful guide I’ve ever seen on the web, thanks for this. I usually share with my students the following tips already mentioned above: – Learn the vocabulary before reading – Summarize the background in five sentences or less – Identify the BIG QUESTION

But the pieces of advice this guide gives are structured better and easier. I especially love this one: Don’t yet try to decide what the results mean, just write down what they are. Thanks again for writing this piece!

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you left out ask for the data, so you can check for yourself… (ie trust but verify)

an example a psychology paper that surveyed a group of people about conspiracy theories (n=137) and it’s main/only novel finding was that people that believed in conspiracies theories, there was a tendency for people to believe in mutually contradictory conspiracy theories. ie individual could believe that Princess Diana faked her own death, whilst at the same time had been murdered by MI5

The paper, was duly called – Dead and Alive – M Wood et al…

However. after requesting the data. there was not a single individual person that ticked the survey boxes, that simultaneously believed this finding. Not one person.

The problem, most people surveyed did not believe either of those conspiracies, and inappropriate stats method was applied to data, that assumed a non skewed dataset. Thus, not believing in A and not believing in B correlated, but it also gave a ‘result that believing in A, and Believing in B also correlated..

A very dumb paper… Author still hasn’t retracted it yet.

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I love this! Great simmered-down resource for my undergrads- both science and non-science majors. Thanks for sharing!

“Web of Science” link is broken (at least for me) but a useable alternative is webofknowledge.com (same resource, different name).

I think it is important to note that the journal in which a paper is published is no proof as to the rigor of that paper. A listing in PubMed does not guarantee quality; thus, you need to focus on teaching people how to interpret the paper without relying on a simple JTASS approach to initial assessment. This may be a guide, but nothing more. I say this as a former editor of a MEDLINE journal. There can be good papers in bad journals and bad papers in good ones. But you are correct. Key questions are: What is the question? How will we answer the question? What answer did we get? Did we use the right tools to answer the question? What do we think it means? What else could we do? And thus we can train people to watch for sleights of hand, such as shifting primary outcomes, data mining, salami slicing, etc.

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Yikes! This is a lot of work just to read a single paper! It’s almost the same as writing a paper! I understand the logic in why you recommend this, but the average person is going to be willing to spend 20-30 minutes reading and trying to learn. This method calls for multiple hours of effort and I just don’t seem many non-scientist people being willing to do that when they’re more curious than actually invested. I was really hoping this entry was going to make it easier to navigate the foreign and confusing world that these papers represent, and it probably will if someone does this process repeatedly for quite some time…..like a scientist…..but most of us aren’t scientists and don’t have that kind of time to dedicate to something that’s not our work or family.

By tradition, we expect our scientists to report their findings by codifying them in unreadable gobbledygook. Then we write instructions on how to decode that unreadable nonsense!!

We need to encourage papers to be written in everyday language so it is easier for all. Problem solved.

I wholeheartedly agree with Kaveh Bazargan. From personal experience as a non-scientist trying to do this with medical research papers is a very intimidating and isolating experience. Most people don’t have the time spare to even try to learn this skill. It would be great if systematic reviewers who are acknowledged experts in reading and analysing papers could find a way of communicating the important information about individual papers to non-scientists before – or instead of – burying them in systematic reviews and meta-analyses which are even more difficult to understand. Structured plain language summaries of primary research would be very helpful rather than individuals having to teach themselves how to read and understand a scientific paper which is written for other scientists in “unreadable goggledygook”. Many (most?) papers conceal methodogical flaws in the research conduct which are almost impossible to spot without years of scientific training.

I love this! Extraordinary cooled off assets for my students both science and non-science majors. A debt of gratitude is in order for sharing!

Regarding step 11, if you have access to Web of Science I recommend looking up how many citations the paper has (this will also vary depending on the age of the paper) and who cites it, and whether there even any replies to it in the peer-reviewed literature.

Do you literally do this for every paper you read? I’m curious how much time it takes you to go from start to finish on what you would consider a typical paper. How often do you read new articles a week?

This post has the laudable goal of helping nonscientists understand the primary literature, but the recommendations seem even more onerous than they have to be. For example, the idea that one should write down every single word that he/she doesn’t know? That sounds more like a task for a scientist scrutinizing the work of a rival. For a nonscientist, there may be dozens and dozens of unknown words, and chasing down the meaning of each one may cause a serious forest/trees problem. I agree that there’s no substitute for the hard work of digging into a paper, but following the prescribed advice to the letter would be utterly exhausting for almost any lay reader. I base these comments on my experiences as a biology researcher and undergraduate instructor.

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I really like your post and the effort, but much of the problem wouldn’t exist if we, academics, did a better job in writing down the correct conclusions. Researcher degrees of freedom are seldom properly understood and we keep on having the tendency to be overdeterministic about statistics that are not intended as such. Of course we want to communicate in black and white about our tests (significance!) because it is a human tendency to persuade the reader. Most of the research probably is not as inconsistent as it first seems but we forget to report the proper statistics to see so (CI around the ES)

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Thank you very much for sharing a guide that will help me to follow the best standards for writing a scientific paper even I am not a scientist.

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Reading the abstract last is one, not the, way to read a paper. It it biases the naive reader, then they are not reviewing with a level of skepticism required to evaluate science. We put abstracts first because they lay out the problem, overview the sample and design, and tersely describe what they think they discovered. Then, as I read, I have a roadmap in my head of what to look for to determine for myself whether or not they found something noteworthy.

What is the problem? Are hypotheses to be tested likely to illuminate/clarify the problem? Is the sample appropriate for testing and was it sampled without imputing bias? Were measures appropriate and do they have a history of validity? We the analytics applied appropriate for testing at the level of power needed give the sample size? [Here even many scientist are ill-equipped to judge.] After enumerating results, do the authors list weaknesses in their design that might suggest replication is necessary? If not, check for snow – as in snowjob. If significance levelsare low or variables correlate with one another too much, are moderators discussed? [e.g., results hold for males but not females, old vs young, fat vs skinny, etc.). If so, why were data not re-analyzed to control for moderator effects on results?

Lastly, if the word “prove” appears anywhere in the paper, assume it is junk science (like fake news). Research is never ever done to prove anything. Research is only done to find out. Once a preponderance of studies report a similar finding looking at the same problem with different people, measures, designs, and statistical analyses, then you have something like proof; consensus.

Lastly, if you are a conspiracy theory believer, you will disbelieve any scientific study that does not support your word view. Keep this in mind. A few studies that run counter to the prevailing consensus is not PROOF that your conspiracy is correct, and mainstream science is wrong. I do not know a single scientist (and I know thousands globally) who do not consider climate change to be well-evidenced. Similarly, evolutionary theory remains useful – our current understanding of genomic medicine hinges on cellular mutation, which is evolution on a microscopic scale.

This is a very useful set of instructions, but I found the following statement highly amusing: “Before you begin reading, take note of the authors and their institutional affiliations. Some institutions (e.g. University of Texas) are well-respected; others (e.g. the Discovery Institute) may appear to be legitimate research institutions but are actually agenda-driven.”

All research institutions are agenda driven (including my alma mater, the University of Texas), because funding and professional advancement depend on results. Researchers are fallible humans and subject to temptation and error. There is a very big lawsuit pending against Duke University (see below) for falsifying data.

When I read any research (especially medical), I now search for evidence of legal or professional action. So you might add that as #12: “Lawsuits? Retractions?” Caveat lector.

http://science.sciencemag.org/content/353/6303/977.full

http://www.dukechronicle.com/article/2016/09/experts-address-research-fabrication-lawsuit-against-duke-note-litigation-could-be-protracted

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Weird advice, like: ‘I always read the abstract last’ . This is advice for referees, not for general readers. I always read the abstract first.

An abstract can be misleading, but I am often not qualified enough to judge that. Actually, this blog post title and abstract are misleading too: your advice is for referees, not for non-scientists. So you wanted to provide an immersive experience into a misleading piece, well done 😉

First thing, get rid of the word proof. This is a huge error in that even if you have reputable scientists, journals, institutions, etc. that what is published, especially in a single article, is anything resembling a fact. It is merely research findings from one instance and in no way forms a fact. This is the next level of misinterpretation of science, even among those able to comprehend the journal article, that science produces or discovers facts. There is nothing that is factual that we know of.

Several comments:

For the mid-term exam in a graduate class I took in experimental design the professor would select half a dozen articles from the peer reviewed literature, tell her students to pick three and explain what they had done wrong. New articles for every class and she never ran out.

Beware of articles published in inappropriate journals, no matter how respectable (E.g., something about sociology or criminology published in a medical journal). This is a strategy for sneaking agenda driven research past the peer review process by going to a journal whose reviewers are likely to be unfamiliar with the subject while the editors are sympathetic to the agenda.

There is a reason research papers are written in what looks like “scientific gobbledygook” to lay persons. They are not intended for a lay audience and the goal is to be extremely precise with the technical details of what was done and found so other scientists can examine the results and, most important, attempt to replicate them.. There is no way to simplify the language and put it in lay terms without losing the precision required for a scientific study. E.g., a particle physicist may give a lay explanation of an experiment in metaphorical terms of little balls of energy smashing into each other, but their peers are going to want to see the pages and pages of mathematics that really describe what was happening.

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I would add “Check the source of funding for the research.” If paper on the safety of glyphosate is funded by Bayer or Monsanto, or a paper on climactic change is funded by Exxon, read no further.

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Get the dissertation writing service students look for these days with the prime focus being creating a well researched and lively content on any topic.

The non-scientist should pay extra attention towards this article for the non-technical writing and understanding for them.

A lot of a researcher’s work includes perusing research papers, regardless of whether it’s to remain progressive in their field, propel their logical comprehension, survey compositions, or assemble data for a task proposition or concede application. Since logical articles are not the same as different writings, similar to books or daily paper stories, they ought to be perused in an unexpected way.

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Thanks, I’ll use this a lot for my MSc Thesis.

Those are some great tips but please don’t forget that each school has its own requirements to academic papers.

Clarifying your methodology for reading science paper: excellent idea and great information. Thanks a lot!

Thanks for sharing this blog. Its very helpful for me and I bookmarked this for future

Excelente trabajo, original. Lo recomendaré para mis estudiantes de Posgrado. Si no hay problema, me gustaría hacer una traducción al castellano para el uso de mis estudiantes de pregrado de Sociología.

Excellent work,original. I will recommend it for my graduate students. If there is no problem, I would like to make a translation into Spanish for the use of my undergraduate Sociology students.

Hi Luis, all our works are CC licensed so you are more than welcome to make a translation provided you link back to the original source. See here for details: https://creativecommons.org/licenses/by/3.0/deed.en_GB

Great information , it is very helpful thanks for sharing the blog .

Step 1 and 10 is a great idea, but I still think it’s possible to read the abstract with the introduction and still keep an open mind? and shouldn’t they keep their results for the interpretation section? sorry new to reading scientific papers

Step 1 and 10 is a great idea, but I still think it’s possible to read the abstract with the introduction and still keep an open mind? and shouldn’t they keep their results for the interpretation section? sorry new to reading scientific papers

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Thank you for sharing the tips, they were very helpful.

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The article is extremely helpful. Considering that scientific research are not as easy, the tips in the article are great.

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Thank you for posting this. It has really helped a lot, especially for those of us who always read the abstract first haha

Thanks for writing this blog. It is very much informative and at the same time useful for me

Yeah, great advice on how to be objective from someone who openly declares their prejudice in the opening statement.

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Do you in a real sense do this for each paper you read? I’m interested what amount of time it requires for you to go beginning to end on what you would think about an average paper. How frequently do you read new articles seven days?

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That is literally my question too, I see it as quite time consuming to conduct such a lengthy process for all scientific articles we come across especially as one has other responsibilities to give attention too

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There is a reason research papers are written in what looks like “scientific gobbledygook” to lay persons. They are not intended for a lay audience and the goal is to be extremely precise with the technical details of what was done and found so other scientists can examine the results and, most important, attempt o replicate them.

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Thanks for posting this. You are doing a service to the general public and also graduate students by not only posting this but answering all sincere questions. I have a Ph. D. in Zoology and have been a peer-reviewer for at least 12 papers and am first author of three peer-reviewed papers. I have taught statistics in two universities as a contract professor and all of my papers rely on use of statistics. To answer a frequently asked question, yes, personally it can take me a couple of hours or several more to read some papers. This is true for my colleagues as well. Scientific papers are written so as to be as concise as possible and this can make them hard to read. They often also use technical terms which one has to look up. At least biology and statistics. nothing I have read (or written) has been in “goobledygook” or purposely incomprehensible jargon but they do use terms and concepts that are probably unfamiliar to the layman. I think what the author means, by her comment on absstracts can be intepreted as “don’t JUST read the abstract. Be sure to read the introduction. Personally I go to the discussion and conclusion next.

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Your writing skills and passion for sharing your knowledge and experiences are truly outstanding. . Keep writing and inspiring others with your words.

I would add, look at who funded the study and their financial interests. Most science is not independent it is funded by those with an agenda. Look at the demographic data, length of time the study took place, what was left out, where you might need more information. Look at who was included and excluded in the data set. Anyone that has taken statistics knows what you include or exclude in the data set can skew and or outright change the outcome.

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Reading Scientific Papers

Understanding and analyzing empirical articles, understanding scientific papers, reading as a process, step 1: preview the scientific paper, introduction, step 3: reflect and take notes.

The first step to reading more critically and efficiently is to understand the structure of the source you’re reading. Thankfully, scientific papers, a.k.a. articles, typically follow a standard format that you may already be familiar with from writing lab reports—both are based on the scientific method and typically contain the following four sections: The introduction is where the authors present their research question and explain their hypotheses and predictions. The methods section details how they conducted the study and analyzed the data, and the results section summarizes the key findings. Finally, scientific papers end with a discussion where the authors interpret the results, explain whether they support the hypothesis, and relate the study to the broader field of research. This common structure helps scientists better communicate their research with one another and the larger public—armed with an understanding of this structure, you’ll now be able to better understand and analyze scientific research.

You likely think of reading as a one-step event: you pick up a book or article and read it. Experts on reading, however, suggest that a multi-step process can make you a more efficient and critical reader.

Step 1: Preview the source to get a sense of what it will offer

Step 2: Read for understanding and analysis

Step 3: Reflect and takes notes on the reading

Keep in mind that how you accomplish each of these steps will differ depending on what kind of source you are reading. The remainder of this guide details how to approach each step when reading scientific papers.

Before you begin to read a scientific paper, consider how it relates to the course, your experiment, or your research project. Next, preview the source itself to determine its main goal, method, and findings. Your first step should be to read the abstract, which provides a brief summary of the paper . As you read, ask

  • WHAT did the authors want to find out?
  • WHY did they want to know this?
  • HOW did they answer the question?
  • WHAT did they find out?
  • SO WHAT? Why is this research important?

Keep in mind that reading the abstract alone will not provide you with an understanding of the source. You must read the article in full, section by section: the next portion of this guide will help you focus your reading to both understand what the author is trying to say and to analyze and evaluate the source.

Step 2: Read for Understanding and Analysis

Each section of a scientific paper is carefully organized to present information in an expected format—as you become familiar with this standard structure, you’ll be able to easily locate the specific information you seek. Use the following descriptions and guiding questions to navigate each section as you read. You may also want to use our  Template for Taking Notes on Scientific Papers to organize your notes after you read each section.

A careful reading of the introduction is essential to understanding the reasons for and goals of a scientific study. In this section, authors provide an overview of the general topic, summarizing  background information from the existing literature. The authors explain how their research adds to current knowledge and convey its importance. The introduction is also where you’ll find the research question(s) and expected answer(s)—in scientific papers, these answers come in the form of hypotheses and predictions (to learn more about these, check out our guide to  Understanding Hypotheses and Predictions . Introductions often conclude with a brief summary of how the authors tested their hypotheses—a preview of the methods section.

Questions to Check Your Understanding

  • What is the research question?
  • Why should it be studied (what gap does this research fill)?
  • How has it been studied before?
  • What are the hypotheses and predictions?

Questions to Guide Your Analysis & Evaluation

  • Is the question clear?
  • How does the work compare to other studies in the field?
  • Will this research contribute to our knowledge in an important way?
  • Is the hypothesis justified?

In the methods section, the authors provide a detailed account of how they completed their study or experiment, the materials and/or participants they used, how they measured particular variables, and how they analyzed their data. As a reader, you will want to pay careful attention to this section and determine the strengths and weaknesses of the study’s design.

  • How did the authors conduct the study or experiment?
  • What materials and measures did they use?
  • How did they sample the study area, subjects, or population?
  • How did they analyze the collected data?
  • Are the measures appropriate and clearly related to the research question? Do they adequately test the hypothesis?
  • Does the sampling (e.g., study areas, subjects, participants) fairly represent the larger population of the study?
  • Is the analysis appropriate for the data?
  • Are there noticeable flaws in the method?

The results section summarizes the data in text, figures, and tables. As a careful reader, you should examine this section and consider not only what the authors found but also what findings they chose to present and how (for example, which results warranted display in a figure? which didn’t?).

  • What are the major findings?
  • How are the findings presented/displayed?
  • Are enough data displayed to demonstrate the results?
  • How do the findings relate to the hypotheses?
  • Are the statistics appropriately presented?
  • Did you note patterns that the author does not mention?

In this section, the authors analyze their findings and explain whether their results support their hypotheses and predictions. The authors explain why (or why not) by comparing not only their results but also their approach to those of other related studies, providing essential context and grounding their work in the existing literature. They also discuss the limitations, importance, and implications of their results and detail possible applications, extensions, or revisions of their study.

  • Did the data support the hypothesis?
  • If not, does the author explain why?
  • How do the results compare to those of other studies?
  • Are the findings significant?
  • What are the limitations and applications?
  • Did the authors interpret the results appropriately?
  • Are you persuaded by the findings?
  • How significant are the limitations of the study?
  • Do the authors offer plausible applications for their research?
  • Does the discussion reflect the major points from the introduction?

Taking notes while you read is time consuming and can even distract you from focusing on the ideas you are reading. Instead, separate the acts of reading and notetaking by reading a section or a few pages and then stopping to take notes. Make sure that your notes provide answers to the questions posed in each of the sections above. Again, you may want to use our Template for Taking Notes on Scientific Papers to organize your notes as you go.

After you have read and taken notes on the paper, be sure to reflect on it. How does it compare to other papers you’ve read on this topic? How does it relate to your experiment or research project? How might you use it in your course work, lab report, or paper?

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  • Chicago Manual of Style
  • Writing Research Papers
  • How to Read a Citation
  • How to read and understand a scientific paper
  • Skimming an article
  • Workshop presentation powerpoint
  • Post-Workshop Quiz
  • Post-Workshop Reflection

How to Read a Scientific Paper overview

Below, you'll find two different articles about how to read a scientific paper. The second one is written by a science journalist and was added to this guide in 2024. We hope you find both articles useful. They overlap and bring useful techniques to light. 

How to read and understand a scientific paper: a guide for non-scientists

  • Handout for How to Read and Understand a Scientific Paper: A Guide for Non-Scientists

Reprinted by permission of the author, Jennifer Raff, Assistant Professor, Department of Anthropology, University of Kansas,  https://about.me/jenniferraff  ::  original URL:  https://violentmetaphors.com/2013/08/25/how-to-read-and-understand-a-scientific-paper-2/ Last week’s post ( The truth about vaccinations: Your physician knows more than the University of Google ) sparked a very lively discussion, with comments from several people trying to persuade me (and the other readers) that  their  paper disproved everything that I’d been saying. While I encourage you to go read the comments and contribute your own, here I want to focus on the much larger issue that this debate raised: what constitutes scientific authority?

It’s not just a fun academic problem. Getting the science wrong has very real consequences. For example, when a community doesn’t vaccinate children because they’re afraid of “toxins” and think that prayer (or diet, exercise, and “clean living”) is enough to prevent infection,  outbreaks happen .

“Be skeptical. But when you get proof, accept proof.” –Michael Specter

What constitutes enough proof? Obviously everyone has a different answer to that question. But to form a truly educated opinion on a scientific subject, you need to become familiar with current research in that field.  And to do that, you have to read the “primary research literature” (often just called “the literature”). You might have tried to read scientific papers before and been frustrated by the dense, stilted writing and the unfamiliar jargon. I remember feeling this way!  Reading and understanding research papers is a skill which every single doctor and scientist has had to learn during graduate school.  You can learn it too, but like any skill it takes patience and practice.

I want to help people become more scientifically literate, so I wrote this guide for how a layperson can approach reading and understanding a scientific research paper. It’s appropriate for someone who has no background whatsoever in science or medicine, and based on the assumption that he or she is doing this for the purpose of getting a basic  understanding of a paper and deciding whether or not it’s a reputable study.

The type of scientific paper I’m discussing here is referred to as a  primary research article . It’s a peer-reviewed report of new research on a specific question (or questions). Another useful type of publication is a  review article . Review articles are also peer-reviewed, and don’t present new information, but summarize multiple primary research articles, to give a sense of the consensus, debates, and unanswered questions within a field.  (I’m not going to say much more about them here, but be cautious about which review articles you read. Remember that they are only a snapshot of the research at the time they are published.  A review article on, say, genome-wide association studies from 2001 is not going to be very informative in 2013. So much research has been done in the intervening years that the field has changed considerably).

Before you begin: some general advice Reading a scientific paper is a completely different process than reading an article about science in a blog or newspaper. Not only do you read the sections in a different order than they’re presented, but you also have to take notes, read it multiple times, and probably go look up other papers for some of the details. Reading a single paper may take you a very long time at first. Be patient with yourself. The process will go much faster as you gain experience.

Most primary research papers will be divided into the following sections: Abstract, Introduction, Methods, Results, and Conclusions/Interpretations/Discussion. The order will depend on which journal it’s published in. Some journals have additional files (called Supplementary Online Information) which contain important details of the research, but are published online instead of in the article itself (make sure you don’t skip these files).

Before you begin reading, take note of the authors and their institutional affiliations. Some institutions (e.g. University of Texas) are well-respected; others (e.g.  the Discovery Institute ) may appear to be legitimate research institutions but are actually agenda-driven.  Tip: g oogle “Discovery Institute” to see why you don’t want to use it as a scientific authority on evolutionary theory.

Also take note of the journal in which it’s published. Reputable (biomedical) journals will be indexed by  Pubmed . [ EDIT: Several people have reminded me that non-biomedical journals won’t be on Pubmed, and they’re absolutely correct! (thanks for catching that, I apologize for being sloppy here). Check out  Web of Science  for a more complete index of science journals. And please feel free to share other resources in the comments!]    Beware of  questionable journals .

  As you read, write down  every single word  that you don’t understand. You’re going to have to look them all up (yes, every one. I know it’s a total pain. But you won’t understand the paper if you don’t understand the vocabulary. Scientific words have extremely precise meanings).

Step-by-step instructions for reading a primary research article

1. Begin by reading the introduction, not the abstract.

The abstract is that dense first paragraph at the very beginning of a paper. In fact, that’s often the  only  part of a paper that many non-scientists read when they’re trying to build a scientific argument. (This is a terrible practice—don’t do it.).  When I’m choosing papers to read, I decide what’s relevant to my interests based on a combination of the title and abstract. But when I’ve got a collection of papers assembled for deep reading, I always read the abstract  last . I do this because abstracts contain a succinct summary of the entire paper, and I’m concerned about inadvertently becoming biased by the authors’ interpretation of the results.

2. Identify the BIG QUESTION.

Not “What is this paper about”, but “What problem is this entire field trying to solve?”

This helps you focus on why this research is being done.  Look closely for evidence of agenda-motivated research.

3. Summarize the background in five sentences or less.

Here are some questions to guide you:

What work has been done before in this field to answer the BIG QUESTION? What are the limitations of that work? What, according to the authors, needs to be done next?

The five sentences part is a little arbitrary, but it forces you to be concise and really think about the context of this research. You need to be able to explain  why  this research has been done in order to understand it.

4.   Identify the SPECIFIC QUESTION(S)

What  exactly  are the authors trying to answer with their research? There may be multiple questions, or just one. Write them down.  If it’s the kind of research that tests one or more null hypotheses, identify it/them.

Not sure what a null hypothesis is? Go read  this , then go back to my last post and read one of the papers that I linked to (like  this one ) and try to identify the null hypotheses in it. Keep in mind that not every paper will test a null hypothesis.

5. Identify the approach

What are the authors going to do to answer the SPECIFIC QUESTION(S)?

  6. Now read the methods section. Draw a diagram for each experiment, showing exactly what the authors did.

I mean  literally  draw it. Include as much detail as you need to fully understand the work.  As an example, here is what I drew to sort out the methods for a paper I read today ( Battaglia et al. 2013: “The first peopling of South America: New evidence from Y-chromosome haplogroup Q” ). This is much less detail than you’d probably need, because it’s a paper in my specialty and I use these methods all the time.  But if you were reading this, and didn’t happen to know what “process data with reduced-median method using Network” means, you’d need to look that up.

Battaglia et al. methods

You don’t need to understand the methods in enough detail to replicate the experiment—that’s something reviewers have to do—but you’re not ready to move on to the results until you can explain the basics of the methods to someone else.

7.   Read the results section. Write one or more paragraphs to summarize the results for each experiment, each figure, and each table. Don’t yet try to decide what the results  mean , just write down what they  are.

You’ll find that, particularly in good papers, the majority of the results are summarized in the figures and tables. Pay careful attention to them!  You may also need to go to the Supplementary Online Information file to find some of the results.

 It is at this point where difficulties can arise if statistical tests are employed in the paper and you don’t have enough of a background to understand them. I can’t teach you stats in this post, but  here ,  here , and  here  are some basic resources to help you.  I STRONGLY advise you to become familiar with them.

  THINGS TO PAY ATTENTION TO IN THE RESULTS SECTION:

-Any time the words “ significant ” or “ non-significant ” are used. These have precise statistical meanings. Read more about this  here .

-If there are graphs, do they have  error bars  on them? For certain types of studies, a lack of confidence intervals is a major red flag.

-The sample size. Has the study been conducted on 10, or 10,000 people? (For some research purposes, a sample size of 10 is sufficient, but for most studies larger is better).

8. Do the results answer the SPECIFIC QUESTION(S)? What do you think they mean?

Don’t move on until you have thought about this. It’s okay to change your mind in light of the authors’ interpretation—in fact you probably will if you’re still a beginner at this kind of analysis—but it’s a really good habit to start forming your own interpretations before you read those of others.

9. Read the conclusion/discussion/Interpretation section.

What do the authors  think  the results mean? Do you agree with them? Can you come up with any  alternative  way of interpreting them? Do the authors identify any weaknesses in their own study? Do you see any that the authors missed? (Don’t assume they’re infallible!) What do they propose to do as a next step? Do you agree with that?

10. Now, go back to the beginning and read the abstract.

Does it match what the authors said in the paper? Does it fit with your interpretation of the paper?

11. FINAL STEP:  (Don’t neglect doing this)  What do other researchers say about this paper?

Who are the (acknowledged or self-proclaimed) experts in this particular field? Do they have criticisms of the study that you haven’t thought of, or do they generally support it?

Here’s a place where I do recommend you use google! But do it last, so you are better prepared to think critically about what other people say.

(12. This step may be optional for you, depending on why you’re reading a particular paper. But for me, it’s critical! I go through the “Literature cited” section to see what other papers the authors cited. This allows me to better identify the important papers in a particular field, see if the authors cited my own papers (KIDDING!….mostly), and find sources of useful ideas or techniques.)

Now brace for more conflict– next week we’re going to use this method to go through a paper on a controversial subject! Which one would you like to do? Shall we critique one of the papers I posted last week?

UPDATE: If you would like to see an example, you can find one  here ———————————————————————————————————

I gratefully acknowledge Professors José Bonner and Bill Saxton for teaching me how to critically read and analyze scientific papers using this method. I’m honored to have the chance to pass along what they taught me.

How to Read a Scientific Paper by a science journalist

How to read a scientific paper.

  • Alexandra Witze
  • November 6, 2018

   Léelo en español

Screenshot of a paragraph of a paper with an annotation in red.

It’s one of the first, and likely most intimidating, assignments for a fledgling science reporter. “Here,” your editor says. “Write up this paper that’s coming out in  Science  this week.” And suddenly you’re staring at an impenetrable PDF—pages of scientific jargon that you’re supposed to understand, interview the author and outside commenters about, and describe in ordinary English to ordinary readers.

Fear not!  The Open Notebook  is here with a primer on how to read a scientific paper. These tips and tricks will work whether you’re covering developmental biology or deep-space exploration. The key is to familiarize yourself with the framework in which scientists describe their discoveries, and to not let yourself get bogged down in detail as you’re trying to understand the overarching point of it all. As a specific example, we’ve marked up a  Science  paper in the accompanying image.

But first, let’s break down what a typical scientific paper contains. Most include these basic sections, usually in this order:

The  author list  is as it sounds, a roster of the scientists involved in the discovery. But hidden within the names are  clues that will help you navigate the politics  of reporting the story. The first name in the list is often (but not always) the person who did the most work, perhaps the graduate student or postdoc who is the lead on the project. This person is usually (but not always) designated as the “corresponding author” by an asterisk by their name, or by their email address being given on the first or last page of the paper. If the corresponding author is not the first name in the author list, then take extra care to Google the various authors and figure out how they relate to one another. (In many fields, such as biology and psychology, the last author in the list is typically the senior author or lab head. In others, such as experimental physics where the author list can number in the dozens or hundreds, authors are usually listed alphabetically.) The senior author might be able to provide some broad perspective as to why and how the study was undertaken. But the first or corresponding author is much more likely to be the person who actually did the work, and therefore your better request for an interview.

The  abstract  is a summary of the paper’s conclusions. Always read this first, several times over. Usually the significance of the paper will be laid out here, albeit in technical terms. A good abstract will summarize what research was undertaken, what the scientists found, and why it’s important. (Compare the abstract of  this recent  Nature  paper , on the discovery of a prehistoric human hybrid, to the first three paragraphs of  Sarah Kaplan’s  Washington Post  story reporting the discovery . Kaplan clearly captures the essence of the new findings as described in the abstract.) Relevant numbers such as the statistical significance of the finding are often highlighted here as well. Abstracts are prone to typographical errors, so be sure to double-check numbers against the body of the paper as well as your interview with the author.

The  body  of the paper lays out the bulk of the scientific findings. Pay special attention to the first couple of paragraphs, which often serve as an introduction, describing previous research in the field and why the new work is important. This is an excellent place to hunt for references to other papers that can serve as your guidepost for outside commenters (more on that later). Next will come the details of how the research was done; sometimes much of this is broken out into a later  methods  section (see below). Then come the  results , which may be lengthy. Look for phrases such as “we concluded” to clue you in to their most important points. If statistics are involved, see Rachel Zamzow’s  primer on how to spot shady statistics.

The final section (sometimes labeled as  discussion ) often summarizes the new findings, puts them in context, and describes the likely next steps to be taken. If your reading has been dragging through the results section, now is the time to refocus. “That sort of information will help a writer answer the nearly inevitable “so what?” question for their readers as well as their editors,” says Sid Perkins, a freelance science writer in Crossville, Tennessee, who writes for outlets including  Science  and  Science News for Students .

The  figures  are the data, graphics, or other visual representations of the discovery. Read these and their captions carefully, as they often contain the bulk of the new findings. If you don’t understand the figures, ask the scientist to walk you through them during your interview. Don’t be afraid to say things like, “I don’t understand what  the x-axis  means.”

The  references  are your portal into a world of additional inscrutable PDFs. You need to plow through at least a couple of the citations, because they are your initial guide in figuring out who you need to call for outside comment. The references are referenced (usually by number) within the body of the text, so you can pinpoint the ones that will be most helpful. For instance, if the text talks about how previous studies have found the opposite of this new one, go look up the cited references, because those authors would be excellent outside commenters. If you do not have access to the journals described in the references, you can at least look at the paper abstract, which is always  outside the paywall , to get a sense of what those earlier studies concluded. (For further caveats on references, see below.)

The  acknowledgments  are meant for transparency, to show the contributions of the various authors and where they got their funding from. Things to look for in here are whether they thank other scientists for “discussions” or “review” of the work; sometimes peer reviewers are explicitly acknowledged as such, in which case you can call those people right away for outside comment. Occasionally there are humorous tidbits that  you can pick up on for a story , such as when authors thank the field-camp guards who kept them  safe from predatory polar bears . The funding section is usually pro forma, but it is worth scanning for mention of unusual sources of income, such as from a science-loving philanthropist. If the authors declare competing financial interests (such as a patent filing) you will need to report those out and make sure you understand what financial conflicts of interest may be clouding their objectivity.

The  methods  often appear in a ridiculously small typeface after the body of the paper. These lay out how the actual experiments were done. Scour these for any details that will bring your story to life. For instance, they might describe how the climate models were so complicated that they took more than a year to run on one of the world’s most powerful supercomputers.

Supplementary information  comes with some but not all papers. In most cases it is extra material that the journal did not want to devote space to describing in the paper itself. Always check it out, because there may be hidden gems. In  a 2015 study of global lake warming , the only way to find out which specific lakes were warming—and  talk about the nearest ones for readers —was to wade through the supplementary information. In another recent example, Harvard researchers left it to the supplementary information to explain  that they cranked up a leaf-blower  to see how lizards fared during hurricanes, a fact that the Associated Press’s Seth Borenstein  turned into his lede .

So now you’re armed with the basics of what makes up a science paper. How should you tackle reading for your next assignment? The task will be more manageable if you break it into a series of jobs.

Strategize During the First Pass

Your first dive into a paper should be aimed at gathering the most important information for your story—that is, what the research found and why anyone should care. For that, consider following the approach of Mark Peplow, a freelance science journalist in Cambridge, England, who writes for publications including  Nature  and  Chemical & Engineering News .

If it’s a field he’s relatively familiar with, such as chemistry or materials science, Peplow takes a first pass through the paper, underlining with a red pen all the facts that are likely to make it into his initial draft. “That means I can produce a skeleton first draft of the story by simply writing a series of sentences containing what I’ve underlined, and then go into editing mode to jigsaw them into the right order,” he says. (In my annotated example, I’ve done this for the abstract using a purple pen.)

reading research scientific papers

As Peplow reads, he looks for numbers to help make the story sing (“… so porous that a chunk of material the size of a sugar cube contains the surface area of 17 tennis courts”—see orange highlighter in the annotated paper) and methodological details that might prompt a fun interview question (“How scary was it to be pouring that very hazardous liquid into another one?”). He also keeps an eye out for anything indicating an emerging trend or other examples of the same phenomenon, which can be useful for context within the story or as a forward-looking kicker (see how he pulls this off in  this  Chemical & Engineering News  story) .

But what if the paper is in a field you’re not experienced with, and you don’t understand the terminology? Peplow has a plan for that too. “I read the abstract, bathe in my lack of understanding, and mentally throw the abstract away,” he says.

Then he goes through the paper, underlining fragments he understands and putting wiggly lines next to paragraphs that he thinks sound important, but doesn’t actually know what they mean. Jargon words get circled, and equations ignored. He forges onward, paying attention to phrases such as “our findings,” “revealed,” “established,” or “our measurements show”—signs that these are the new and important bits. “Once I’ve reached the end of the paper, and I’m sure I don’t understand it, I remind myself it’s not my fault,” Peplow says.

At that point, Peplow starts looking up definitions for the jargon words, either with Google or Wikipedia or in a stack of science reference books he picked up for free when a local library closed. He jots definitions of the words on the paper. To understand concepts, he sometimes searches  EurekAlert!  for past press releases that explain core concepts, or Googles a string of keywords and adds “review” to hunt for a more comprehensible description.

By this point, Peplow can circle back to the paragraphs marked with wiggly lines and start to understand them better. What he doesn’t yet comprehend, he marks down as an interview question for the researcher.

Circle Back for What You May Have Missed

Before picking up the phone for that interview, it’s worth making a second pass through the paper to see what else you need to help you in your reporting. Check, usually near the end of the paper, to see whether the scientists discuss what the next steps should be—either for their own team or for other groups following up to confirm or expand on the new results, says Perkins. That can provide a ready-made kicker for your story.

Susan Milius, a reporter who covers the life sciences for  Science News , often makes a beeline straight for the references to try to start identifying outside commenters for a piece. She will find those PDFs and then look within the references’ references to build a broad understanding of the field. One caveat, though: Be sure to research how these possible commenters are connected to the author of the current study. Once, Milius phoned an outside commenter who had published on the topic in question some years earlier—but that scientist turned out to be the spouse of the new paper’s author. She had a different last name than her husband.

It’s also worth remembering that the authors may well be biased in which references they include in the paper. Self-citations, in which authors try to boost their citation count by adding their previous publications to the reference list, are common. And sometimes authors deliberately omit papers by competing groups, a fact that is not always caught during the peer-review process. So don’t rely on the references within the PDF to be comprehensive; try a Google Scholar search using keywords from the paper to unearth whether there are competing groups out there.

Other clues may lie in how long the manuscript took to make it through the peer-review process. For many journals these dates come at the very end of the paper, marked something like “submitted” and “accepted.” Different journals have different timescales for publishing, but it is always worth looking to see whether the manuscript languished an extraordinary amount of time (like many months) in the review process. If so, ask the author why things took so long. (A fairly innocuous way to do this is to say something like, “I noticed it took a while for this paper to be accepted. Can you tell me how that process went?” Then be prepared for the authors to go on a rant about peer review.)

reading research scientific papers

Hunt for Extra Details

Finally, see if there are additional sources of information you can sweep into your reporting. Check to see if the author’s institution is issuing a press release about the work; if this isn’t already posted on EurekAlert!, ask the author during the interview if they are preparing additional press materials and, if so, how you can get hold of those. This is also a good time to ask for any art, such as photos or videos to illustrate your story. You will of course have already looked at all their figures in detail, so you’ll be well placed to request the art that is most relevant to what you and your editor are looking for.

With these tools at your side, you should be well suited to tackle your next scientific paper.

reading research scientific papers

Alexandra Witze  is a science journalist in Boulder, Colorado, and a member of  The Open Notebook ’s board of directors.  Her news story on the Martian subglacial lake  (marked up above) appeared in  Nature . Follow her on 

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Open Access

Ten simple rules for reading a scientific paper

* E-mail: [email protected]

Affiliation Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America

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  • Maureen A. Carey, 
  • Kevin L. Steiner, 
  • William A. Petri Jr

PLOS

Published: July 30, 2020

  • https://doi.org/10.1371/journal.pcbi.1008032
  • Reader Comments

Table 1

Citation: Carey MA, Steiner KL, Petri WA Jr (2020) Ten simple rules for reading a scientific paper. PLoS Comput Biol 16(7): e1008032. https://doi.org/10.1371/journal.pcbi.1008032

Editor: Scott Markel, Dassault Systemes BIOVIA, UNITED STATES

Copyright: © 2020 Carey et al. This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Funding: MAC was supported by the PhRMA Foundation's Postdoctoral Fellowship in Translational Medicine and Therapeutics and the University of Virginia's Engineering-in-Medicine seed grant, and KLS was supported by the NIH T32 Global Biothreats Training Program at the University of Virginia (AI055432). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing interests: The authors have declared that no competing interests exist.

Introduction

“There is no problem that a library card can't solve” according to author Eleanor Brown [ 1 ]. This advice is sound, probably for both life and science, but even the best tool (like the library) is most effective when accompanied by instructions and a basic understanding of how and when to use it.

For many budding scientists, the first day in a new lab setting often involves a stack of papers, an email full of links to pertinent articles, or some promise of a richer understanding so long as one reads enough of the scientific literature. However, the purpose and approach to reading a scientific article is unlike that of reading a news story, novel, or even a textbook and can initially seem unapproachable. Having good habits for reading scientific literature is key to setting oneself up for success, identifying new research questions, and filling in the gaps in one’s current understanding; developing these good habits is the first crucial step.

Advice typically centers around two main tips: read actively and read often. However, active reading, or reading with an intent to understand, is both a learned skill and a level of effort. Although there is no one best way to do this, we present 10 simple rules, relevant to novices and seasoned scientists alike, to teach our strategy for active reading based on our experience as readers and as mentors of undergraduate and graduate researchers, medical students, fellows, and early career faculty. Rules 1–5 are big picture recommendations. Rules 6–8 relate to philosophy of reading. Rules 9–10 guide the “now what?” questions one should ask after reading and how to integrate what was learned into one’s own science.

Rule 1: Pick your reading goal

What you want to get out of an article should influence your approach to reading it. Table 1 includes a handful of example intentions and how you might prioritize different parts of the same article differently based on your goals as a reader.

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https://doi.org/10.1371/journal.pcbi.1008032.t001

Rule 2: Understand the author’s goal

In written communication, the reader and the writer are equally important. Both influence the final outcome: in this case, your scientific understanding! After identifying your goal, think about the author’s goal for sharing this project. This will help you interpret the data and understand the author’s interpretation of the data. However, this requires some understanding of who the author(s) are (e.g., what are their scientific interests?), the scientific field in which they work (e.g., what techniques are available in this field?), and how this paper fits into the author’s research (e.g., is this work building on an author’s longstanding project or controversial idea?). This information may be hard to glean without experience and a history of reading. But don’t let this be a discouragement to starting the process; it is by the act of reading that this experience is gained!

A good step toward understanding the goal of the author(s) is to ask yourself: What kind of article is this? Journals publish different types of articles, including methods, review, commentary, resources, and research articles as well as other types that are specific to a particular journal or groups of journals. These article types have different formatting requirements and expectations for content. Knowing the article type will help guide your evaluation of the information presented. Is the article a methods paper, presenting a new technique? Is the article a review article, intended to summarize a field or problem? Is it a commentary, intended to take a stand on a controversy or give a big picture perspective on a problem? Is it a resource article, presenting a new tool or data set for others to use? Is it a research article, written to present new data and the authors’ interpretation of those data? The type of paper, and its intended purpose, will get you on your way to understanding the author’s goal.

Rule 3: Ask six questions

When reading, ask yourself: (1) What do the author(s) want to know (motivation)? (2) What did they do (approach/methods)? (3) Why was it done that way (context within the field)? (4) What do the results show (figures and data tables)? (5) How did the author(s) interpret the results (interpretation/discussion)? (6) What should be done next? (Regarding this last question, the author(s) may provide some suggestions in the discussion, but the key is to ask yourself what you think should come next.)

Each of these questions can and should be asked about the complete work as well as each table, figure, or experiment within the paper. Early on, it can take a long time to read one article front to back, and this can be intimidating. Break down your understanding of each section of the work with these questions to make the effort more manageable.

Rule 4: Unpack each figure and table

Scientists write original research papers primarily to present new data that may change or reinforce the collective knowledge of a field. Therefore, the most important parts of this type of scientific paper are the data. Some people like to scrutinize the figures and tables (including legends) before reading any of the “main text”: because all of the important information should be obtained through the data. Others prefer to read through the results section while sequentially examining the figures and tables as they are addressed in the text. There is no correct or incorrect approach: Try both to see what works best for you. The key is making sure that one understands the presented data and how it was obtained.

For each figure, work to understand each x- and y-axes, color scheme, statistical approach (if one was used), and why the particular plotting approach was used. For each table, identify what experimental groups and variables are presented. Identify what is shown and how the data were collected. This is typically summarized in the legend or caption but often requires digging deeper into the methods: Do not be afraid to refer back to the methods section frequently to ensure a full understanding of how the presented data were obtained. Again, ask the questions in Rule 3 for each figure or panel and conclude with articulating the “take home” message.

Rule 5: Understand the formatting intentions

Just like the overall intent of the article (discussed in Rule 2), the intent of each section within a research article can guide your interpretation. Some sections are intended to be written as objective descriptions of the data (i.e., the Results section), whereas other sections are intended to present the author’s interpretation of the data. Remember though that even “objective” sections are written by and, therefore, influenced by the authors interpretations. Check out Table 2 to understand the intent of each section of a research article. When reading a specific paper, you can also refer to the journal’s website to understand the formatting intentions. The “For Authors” section of a website will have some nitty gritty information that is less relevant for the reader (like word counts) but will also summarize what the journal editors expect in each section. This will help to familiarize you with the goal of each article section.

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https://doi.org/10.1371/journal.pcbi.1008032.t002

Rule 6: Be critical

Published papers are not truths etched in stone. Published papers in high impact journals are not truths etched in stone. Published papers by bigwigs in the field are not truths etched in stone. Published papers that seem to agree with your own hypothesis or data are not etched in stone. Published papers that seem to refute your hypothesis or data are not etched in stone.

Science is a never-ending work in progress, and it is essential that the reader pushes back against the author’s interpretation to test the strength of their conclusions. Everyone has their own perspective and may interpret the same data in different ways. Mistakes are sometimes published, but more often these apparent errors are due to other factors such as limitations of a methodology and other limits to generalizability (selection bias, unaddressed, or unappreciated confounders). When reading a paper, it is important to consider if these factors are pertinent.

Critical thinking is a tough skill to learn but ultimately boils down to evaluating data while minimizing biases. Ask yourself: Are there other, equally likely, explanations for what is observed? In addition to paying close attention to potential biases of the study or author(s), a reader should also be alert to one’s own preceding perspective (and biases). Take time to ask oneself: Do I find this paper compelling because it affirms something I already think (or wish) is true? Or am I discounting their findings because it differs from what I expect or from my own work?

The phenomenon of a self-fulfilling prophecy, or expectancy, is well studied in the psychology literature [ 2 ] and is why many studies are conducted in a “blinded” manner [ 3 ]. It refers to the idea that a person may assume something to be true and their resultant behavior aligns to make it true. In other words, as humans and scientists, we often find exactly what we are looking for. A scientist may only test their hypotheses and fail to evaluate alternative hypotheses; perhaps, a scientist may not be aware of alternative, less biased ways to test her or his hypothesis that are typically used in different fields. Individuals with different life, academic, and work experiences may think of several alternative hypotheses, all equally supported by the data.

Rule 7: Be kind

The author(s) are human too. So, whenever possible, give them the benefit of the doubt. An author may write a phrase differently than you would, forcing you to reread the sentence to understand it. Someone in your field may neglect to cite your paper because of a reference count limit. A figure panel may be misreferenced as Supplemental Fig 3E when it is obviously Supplemental Fig 4E. While these things may be frustrating, none are an indication that the quality of work is poor. Try to avoid letting these minor things influence your evaluation and interpretation of the work.

Similarly, if you intend to share your critique with others, be extra kind. An author (especially the lead author) may invest years of their time into a single paper. Hearing a kindly phrased critique can be difficult but constructive. Hearing a rude, brusque, or mean-spirited critique can be heartbreaking, especially for young scientists or those seeking to establish their place within a field and who may worry that they do not belong.

Rule 8: Be ready to go the extra mile

To truly understand a scientific work, you often will need to look up a term, dig into the supplemental materials, or read one or more of the cited references. This process takes time. Some advisors recommend reading an article three times: The first time, simply read without the pressure of understanding or critiquing the work. For the second time, aim to understand the paper. For the third read through, take notes.

Some people engage with a paper by printing it out and writing all over it. The reader might write question marks in the margins to mark parts (s)he wants to return to, circle unfamiliar terms (and then actually look them up!), highlight or underline important statements, and draw arrows linking figures and the corresponding interpretation in the discussion. Not everyone needs a paper copy to engage in the reading process but, whatever your version of “printing it out” is, do it.

Rule 9: Talk about it

Talking about an article in a journal club or more informal environment forces active reading and participation with the material. Studies show that teaching is one of the best ways to learn and that teachers learn the material even better as the teaching task becomes more complex [ 4 – 5 ]; anecdotally, such observations inspired the phrase “to teach is to learn twice.”

Beyond formal settings such as journal clubs, lab meetings, and academic classes, discuss papers with your peers, mentors, and colleagues in person or electronically. Twitter and other social media platforms have become excellent resources for discussing papers with other scientists, the public or your nonscientist friends, or even the paper’s author(s). Describing a paper can be done at multiple levels and your description can contain all of the scientific details, only the big picture summary, or perhaps the implications for the average person in your community. All of these descriptions will solidify your understanding, while highlighting gaps in your knowledge and informing those around you.

Rule 10: Build on it

One approach we like to use for communicating how we build on the scientific literature is by starting research presentations with an image depicting a wall of Lego bricks. Each brick is labeled with the reference for a paper, and the wall highlights the body of literature on which the work is built. We describe the work and conclusions of each paper represented by a labeled brick and discuss each brick and the wall as a whole. The top brick on the wall is left blank: We aspire to build on this work and label this brick with our own work. We then delve into our own research, discoveries, and the conclusions it inspires. We finish our presentations with the image of the Legos and summarize our presentation on that empty brick.

Whether you are reading an article to understand a new topic area or to move a research project forward, effective learning requires that you integrate knowledge from multiple sources (“click” those Lego bricks together) and build upwards. Leveraging published work will enable you to build a stronger and taller structure. The first row of bricks is more stable once a second row is assembled on top of it and so on and so forth. Moreover, the Lego construction will become taller and larger if you build upon the work of others, rather than using only your own bricks.

Build on the article you read by thinking about how it connects to ideas described in other papers and within own work, implementing a technique in your own research, or attempting to challenge or support the hypothesis of the author(s) with a more extensive literature review. Integrate the techniques and scientific conclusions learned from an article into your own research or perspective in the classroom or research lab. You may find that this process strengthens your understanding, leads you toward new and unexpected interests or research questions, or returns you back to the original article with new questions and critiques of the work. All of these experiences are part of the “active reading”: process and are signs of a successful reading experience.

In summary, practice these rules to learn how to read a scientific article, keeping in mind that this process will get easier (and faster) with experience. We are firm believers that an hour in the library will save a week at the bench; this diligent practice will ultimately make you both a more knowledgeable and productive scientist. As you develop the skills to read an article, try to also foster good reading and learning habits for yourself (recommendations here: [ 6 ] and [ 7 ], respectively) and in others. Good luck and happy reading!

Acknowledgments

Thank you to the mentors, teachers, and students who have shaped our thoughts on reading, learning, and what science is all about.

  • 1. Brown E. The Weird Sisters. G. P. Putnam’s Sons; 2011.
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On reading research papers

We’ll be reading a lot of research papers in this course, so over the semester you will naturally develop your own way to read a research paper. Use these guides to get started.

First, some basic points; then, concrete reading guides.

A research paper encapsulates enormous effort

A good research paper distills significant work by its authors. My group has worked for years on tens of thousands of lines of code and huge numbers of experiments, most of which got thrown away, to produce a single 12-page paper. A paper’s authors are trying to boil down everything they learned into something you can digest. A single sentence may represent a full year of misdirected effort.

Of course, there are many kinds of effort, and a great research paper may represent a flash of insight rather than toil. That insight still required real work, namely everything the researcher did to prepare themselves to receive it.

A research paper encapsulates a moment in history

Any research paper is a picture of its time. The paper was written in a context shaped by technology and society. What hardware was available? What kinds of research were exciting to the community at the time? What kinds of research were being funded? An open reading can teach you a lot about what people were thinking in the months and years before publication.

A research paper deserves critical attention

As of 2019, more than 7 million scientific papers are published per year . They are not all equally good; some are outright fraudulent. We will try to avoid the really bad ones, but you will still find that all research papers have weaknesses, and for some papers the weaknesses may overwhelm the strengths. Some papers fail on their own terms when read carefully; some will fail to interest you because of your own cast of mind. Nevertheless, you can and should learn something from each paper.

You owe a research paper nothing

When you read a paper, your goal is extractive : What can this paper teach you , now ? A paper is not a precious artwork demanding a respectful, hushed approach. Skim it, skip around in it, disagree with it, rip it apart—whatever it takes to learn what you can—and when you’ve learned what you can, drop it. Despite the effort and history that formed the paper, you owe the paper nothing.

I read best when I read with curiosity, openness, and skepticism. The skepticism keeps me curious: What’s really going on in these experiments? The openness keeps me interested: even if I’m not interested in the topic, maybe there’s some trick I could learn from; and maybe the paper will show me why I should care about the topic after all.

Concrete reading guides

These guides have concrete advice on the reading process. Keshav’s is especially well known in the systems community.

  • S. Keshav’s “How to Read a Paper”
  • Michael Mitzenmacher’s “How to Read a Research Paper”
  • Jennifer Raff’s “How to Read and Understand a Scientific Article”

These guides are great. They also contradict. (Keshav says to read the abstract first; Raff says to never read the abstract until the end.) There’s no one right way to read a paper. The literatures in different sciences have different qualities (for example, unfortunately for you, computer systems papers tend to be verbose), and our minds are different. We also read for different goals. Reading a paper in order to review it requires more antagonism than reading a long-published, well-cited work. And particularly at the beginning of this course, when we are reading multiple historical papers per course meeting rather than one current paper, I expect you to spend less than “three to four hours” per paper!

Public reading groups

You may be interested in these public examples of reading research papers.

  • Adrian Colyer’s “The Morning Paper” blog (on hiatus, but great archives)
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  • 01 May 2024

Plagiarism in peer-review reports could be the ‘tip of the iceberg’

  • Jackson Ryan 0

Jackson Ryan is a freelance science journalist in Sydney, Australia.

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Time pressures and a lack of confidence could be prompting reviewers to plagiarize text in their reports. Credit: Thomas Reimer/Zoonar via Alamy

Mikołaj Piniewski is a researcher to whom PhD students and collaborators turn when they need to revise or refine a manuscript. The hydrologist, at the Warsaw University of Life Sciences, has a keen eye for problems in text — a skill that came in handy last year when he encountered some suspicious writing in peer-review reports of his own paper.

Last May, when Piniewski was reading the peer-review feedback that he and his co-authors had received for a manuscript they’d submitted to an environmental-science journal, alarm bells started ringing in his head. Comments by two of the three reviewers were vague and lacked substance, so Piniewski decided to run a Google search, looking at specific phrases and quotes the reviewers had used.

To his surprise, he found the comments were identical to those that were already available on the Internet, in multiple open-access review reports from publishers such as MDPI and PLOS. “I was speechless,” says Piniewski. The revelation caused him to go back to another manuscript that he had submitted a few months earlier, and dig out the peer-review reports he received for that. He found more plagiarized text. After e-mailing several collaborators, he assembled a team to dig deeper.

reading research scientific papers

Meet this super-spotter of duplicated images in science papers

The team published the results of its investigation in Scientometrics in February 1 , examining dozens of cases of apparent plagiarism in peer-review reports, identifying the use of identical phrases across reports prepared for 19 journals. The team discovered exact quotes duplicated across 50 publications, saying that the findings are just “the tip of the iceberg” when it comes to misconduct in the peer-review system.

Dorothy Bishop, a former neuroscientist at the University of Oxford, UK, who has turned her attention to investigating research misconduct, was “favourably impressed” by the team’s analysis. “I felt the way they approached it was quite useful and might be a guide for other people trying to pin this stuff down,” she says.

Peer review under review

Piniewski and his colleagues conducted three analyses. First, they uploaded five peer-review reports from the two manuscripts that his laboratory had submitted to a rudimentary online plagiarism-detection tool . The reports had 44–100% similarity to previously published online content. Links were provided to the sources in which duplications were found.

The researchers drilled down further. They broke one of the suspicious peer-review reports down to fragments of one to three sentences each and searched for them on Google. In seconds, the search engine returned a number of hits: the exact phrases appeared in 22 open peer-review reports, published between 2021 and 2023.

The final analysis provided the most worrying results. They took a single quote — 43 words long and featuring multiple language errors, including incorrect capitalization — and pasted it into Google. The search revealed that the quote, or variants of it, had been used in 50 peer-review reports.

Predominantly, these reports were from journals published by MDPI, PLOS and Elsevier, and the team found that the amount of duplication increased year-on-year between 2021 and 2023. Whether this is because of an increase in the number of open-access peer-review reports during this time or an indication of a growing problem is unclear — but Piniewski thinks that it could be a little bit of both.

Why would a peer reviewer use plagiarized text in their report? The team says that some might be attempting to save time , whereas others could be motivated by a lack of confidence in their writing ability, for example, if they aren’t fluent in English.

The team notes that there are instances that might not represent misconduct. “A tolerable rephrasing of your own words from a different review? I think that’s fine,” says Piniewski. “But I imagine that most of these cases we found are actually something else.”

The source of the problem

Duplication and manipulation of peer-review reports is not a new phenomenon. “I think it’s now increasingly recognized that the manipulation of the peer-review process, which was recognized around 2010, was probably an indication of paper mills operating at that point,” says Jennifer Byrne, director of biobanking at New South Wales Health in Sydney, Australia, who also studies research integrity in scientific literature.

Paper mills — organizations that churn out fake research papers and sell authorships to turn a profit — have been known to tamper with reviews to push manuscripts through to publication, says Byrne.

reading research scientific papers

The fight against fake-paper factories that churn out sham science

However, when Bishop looked at Piniewski’s case, she could not find any overt evidence of paper-mill activity. Rather, she suspects that journal editors might be involved in cases of peer-review-report duplication and suggests studying the track records of those who’ve allowed inadequate or plagiarized reports to proliferate.

Piniewski’s team is also concerned about the rise of duplications as generative artificial intelligence (AI) becomes easier to access . Although his team didn’t look for signs of AI use, its ability to quickly ingest and rephrase large swathes of text is seen as an emerging issue.

A preprint posted in March 2 showed evidence of researchers using AI chatbots to assist with peer review, identifying specific adjectives that could be hallmarks of AI-written text in peer-review reports .

Bishop isn’t as concerned as Piniewski about AI-generated reports, saying that it’s easy to distinguish between AI-generated text and legitimate reviewer commentary. “The beautiful thing about peer review,” she says, is that it is “one thing you couldn’t do a credible job with AI”.

Preventing plagiarism

Publishers seem to be taking action. Bethany Baker, a media-relations manager at PLOS, who is based in Cambridge, UK, told Nature Index that the PLOS Publication Ethics team “is investigating the concerns raised in the Scientometrics article about potential plagiarism in peer reviews”.

reading research scientific papers

How big is science’s fake-paper problem?

An Elsevier representative told Nature Index that the publisher “can confirm that this matter has been brought to our attention and we are conducting an investigation”.

In a statement, the MDPI Research Integrity and Publication Ethics Team said that it has been made aware of potential misconduct by reviewers in its journals and is “actively addressing and investigating this issue”. It did not confirm whether this was related to the Scientometrics article.

One proposed solution to the problem is ensuring that all submitted reviews are checked using plagiarism-detection software. In 2022, exploratory work by Adam Day, a data scientist at Sage Publications, based in Thousand Oaks, California, identified duplicated text in peer-review reports that might be suggestive of paper-mill activity. Day offered a similar solution of using anti-plagiarism software , such as Turnitin.

Piniewski expects the problem to get worse in the coming years, but he hasn’t received any unusual peer-review reports since those that originally sparked his research. Still, he says that he’s now even more vigilant. “If something unusual occurs, I will spot it.”

doi: https://doi.org/10.1038/d41586-024-01312-0

Piniewski, M., Jarić, I., Koutsoyiannis, D. & Kundzewicz, Z. W. Scientometrics https://doi.org/10.1007/s11192-024-04960-1 (2024).

Article   Google Scholar  

Liang, W. et al. Preprint at arXiv https://doi.org/10.48550/arXiv.2403.07183 (2024).

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Why writing by hand beats typing for thinking and learning

Jonathan Lambert

A close-up of a woman's hand writing in a notebook.

If you're like many digitally savvy Americans, it has likely been a while since you've spent much time writing by hand.

The laborious process of tracing out our thoughts, letter by letter, on the page is becoming a relic of the past in our screen-dominated world, where text messages and thumb-typed grocery lists have replaced handwritten letters and sticky notes. Electronic keyboards offer obvious efficiency benefits that have undoubtedly boosted our productivity — imagine having to write all your emails longhand.

To keep up, many schools are introducing computers as early as preschool, meaning some kids may learn the basics of typing before writing by hand.

But giving up this slower, more tactile way of expressing ourselves may come at a significant cost, according to a growing body of research that's uncovering the surprising cognitive benefits of taking pen to paper, or even stylus to iPad — for both children and adults.

Is this some kind of joke? A school facing shortages starts teaching standup comedy

In kids, studies show that tracing out ABCs, as opposed to typing them, leads to better and longer-lasting recognition and understanding of letters. Writing by hand also improves memory and recall of words, laying down the foundations of literacy and learning. In adults, taking notes by hand during a lecture, instead of typing, can lead to better conceptual understanding of material.

"There's actually some very important things going on during the embodied experience of writing by hand," says Ramesh Balasubramaniam , a neuroscientist at the University of California, Merced. "It has important cognitive benefits."

While those benefits have long been recognized by some (for instance, many authors, including Jennifer Egan and Neil Gaiman , draft their stories by hand to stoke creativity), scientists have only recently started investigating why writing by hand has these effects.

A slew of recent brain imaging research suggests handwriting's power stems from the relative complexity of the process and how it forces different brain systems to work together to reproduce the shapes of letters in our heads onto the page.

Your brain on handwriting

Both handwriting and typing involve moving our hands and fingers to create words on a page. But handwriting, it turns out, requires a lot more fine-tuned coordination between the motor and visual systems. This seems to more deeply engage the brain in ways that support learning.

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"Handwriting is probably among the most complex motor skills that the brain is capable of," says Marieke Longcamp , a cognitive neuroscientist at Aix-Marseille Université.

Gripping a pen nimbly enough to write is a complicated task, as it requires your brain to continuously monitor the pressure that each finger exerts on the pen. Then, your motor system has to delicately modify that pressure to re-create each letter of the words in your head on the page.

"Your fingers have to each do something different to produce a recognizable letter," says Sophia Vinci-Booher , an educational neuroscientist at Vanderbilt University. Adding to the complexity, your visual system must continuously process that letter as it's formed. With each stroke, your brain compares the unfolding script with mental models of the letters and words, making adjustments to fingers in real time to create the letters' shapes, says Vinci-Booher.

That's not true for typing.

To type "tap" your fingers don't have to trace out the form of the letters — they just make three relatively simple and uniform movements. In comparison, it takes a lot more brainpower, as well as cross-talk between brain areas, to write than type.

Recent brain imaging studies bolster this idea. A study published in January found that when students write by hand, brain areas involved in motor and visual information processing " sync up " with areas crucial to memory formation, firing at frequencies associated with learning.

"We don't see that [synchronized activity] in typewriting at all," says Audrey van der Meer , a psychologist and study co-author at the Norwegian University of Science and Technology. She suggests that writing by hand is a neurobiologically richer process and that this richness may confer some cognitive benefits.

Other experts agree. "There seems to be something fundamental about engaging your body to produce these shapes," says Robert Wiley , a cognitive psychologist at the University of North Carolina, Greensboro. "It lets you make associations between your body and what you're seeing and hearing," he says, which might give the mind more footholds for accessing a given concept or idea.

Those extra footholds are especially important for learning in kids, but they may give adults a leg up too. Wiley and others worry that ditching handwriting for typing could have serious consequences for how we all learn and think.

What might be lost as handwriting wanes

The clearest consequence of screens and keyboards replacing pen and paper might be on kids' ability to learn the building blocks of literacy — letters.

"Letter recognition in early childhood is actually one of the best predictors of later reading and math attainment," says Vinci-Booher. Her work suggests the process of learning to write letters by hand is crucial for learning to read them.

"When kids write letters, they're just messy," she says. As kids practice writing "A," each iteration is different, and that variability helps solidify their conceptual understanding of the letter.

Research suggests kids learn to recognize letters better when seeing variable handwritten examples, compared with uniform typed examples.

This helps develop areas of the brain used during reading in older children and adults, Vinci-Booher found.

"This could be one of the ways that early experiences actually translate to long-term life outcomes," she says. "These visually demanding, fine motor actions bake in neural communication patterns that are really important for learning later on."

Ditching handwriting instruction could mean that those skills don't get developed as well, which could impair kids' ability to learn down the road.

"If young children are not receiving any handwriting training, which is very good brain stimulation, then their brains simply won't reach their full potential," says van der Meer. "It's scary to think of the potential consequences."

Many states are trying to avoid these risks by mandating cursive instruction. This year, California started requiring elementary school students to learn cursive , and similar bills are moving through state legislatures in several states, including Indiana, Kentucky, South Carolina and Wisconsin. (So far, evidence suggests that it's the writing by hand that matters, not whether it's print or cursive.)

Slowing down and processing information

For adults, one of the main benefits of writing by hand is that it simply forces us to slow down.

During a meeting or lecture, it's possible to type what you're hearing verbatim. But often, "you're not actually processing that information — you're just typing in the blind," says van der Meer. "If you take notes by hand, you can't write everything down," she says.

The relative slowness of the medium forces you to process the information, writing key words or phrases and using drawing or arrows to work through ideas, she says. "You make the information your own," she says, which helps it stick in the brain.

Such connections and integration are still possible when typing, but they need to be made more intentionally. And sometimes, efficiency wins out. "When you're writing a long essay, it's obviously much more practical to use a keyboard," says van der Meer.

Still, given our long history of using our hands to mark meaning in the world, some scientists worry about the more diffuse consequences of offloading our thinking to computers.

"We're foisting a lot of our knowledge, extending our cognition, to other devices, so it's only natural that we've started using these other agents to do our writing for us," says Balasubramaniam.

It's possible that this might free up our minds to do other kinds of hard thinking, he says. Or we might be sacrificing a fundamental process that's crucial for the kinds of immersive cognitive experiences that enable us to learn and think at our full potential.

Balasubramaniam stresses, however, that we don't have to ditch digital tools to harness the power of handwriting. So far, research suggests that scribbling with a stylus on a screen activates the same brain pathways as etching ink on paper. It's the movement that counts, he says, not its final form.

Jonathan Lambert is a Washington, D.C.-based freelance journalist who covers science, health and policy.

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U.S. Tightens Rules on Risky Virus Research

A long-awaited new policy broadens the type of regulated viruses, bacteria, fungi and toxins, including those that could threaten crops and livestock.

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A view through a narrow window of a door into a biosafety area of a lab with a scientist in protective gear working with a sample.

By Carl Zimmer and Benjamin Mueller

The White House has unveiled tighter rules for research on potentially dangerous microbes and toxins, in an effort to stave off laboratory accidents that could unleash a pandemic.

The new policy, published Monday evening, arrives after years of deliberations by an expert panel and a charged public debate over whether Covid arose from an animal market or a laboratory in China.

A number of researchers worried that the government had been too lax about lab safety in the past, with some even calling for the creation of an independent agency to make decisions about risky experiments that could allow viruses, bacteria or fungi to spread quickly between people or become more deadly. But others warned against creating restrictive rules that would stifle valuable research without making people safer.

The debate grew sharper during the pandemic, as politicians raised questions about the origin of Covid. Those who suggested it came from a lab raised concerns about studies that tweaked pathogens to make them more dangerous — sometimes known as “gain of function” research.

The new policy, which applies to research funded by the federal government, strengthens the government’s oversight by replacing a short list of dangerous pathogens with broad categories into which more pathogens might fall. The policy pays attention not only to human pathogens, but also those that could threaten crops and livestock. And it provides more details about the kinds of experiments that would draw the attention of government regulators.

The rules will take effect in a year, giving government agencies and departments time to update their guidance to meet the new requirements.

“It’s a big and important step forward,” said Dr. Tom Inglesby, the director of the Johns Hopkins Center for Health Security and a longtime proponent of stricter safety regulations. “I think this policy is what any reasonable member of the public would expect is in place in terms of oversight of the world’s most transmissible and lethal organisms.”

Still, the policy does not embrace the most aggressive proposals made by lab safety proponents, such as creating an independent regulatory agency. It also makes exemptions for certain types of research, including disease surveillance and vaccine development. And some parts of the policy are recommendations rather than government-enforced requirements.

“It’s a moderate shift in policy, with a number of more significant signals about how the White House expects the issue to be treated moving forward,” said Nicholas Evans, an ethicist at University of Massachusetts Lowell.

Experts have been waiting for the policy for more than a year. Still, some said they were surprised that it came out at such a politically fraught moment . “I wasn’t expecting anything, especially in an election year,” Dr. Evans said. “I’m pleasantly surprised.”

Under the new policy, scientists who want to carry out experiments will need to run their proposals past their universities or research institutions, which will to determine if the work poses a risk. Potentially dangerous proposals will then be reviewed by government agencies. The most scrutiny will go to experiments that could result in the most dangerous outcomes, such as those tweaking pathogens that could start a pandemic.

In a guidance document , the White House provided examples of research that would be expected to come under such scrutiny. In one case, they envisioned scientists trying to understand the evolutionary steps a pathogen needed to transmit more easily between humans. The researchers might try to produce a transmissible strain to study, for example, by repeatedly infecting human cells in petri dishes, allowing the pathogens to evolve more efficient ways to enter the cells.

Scientists who do not follow the new policy could become ineligible for federal funding for their work. Their entire institution may have its support for life science research cut off as well.

One of the weaknesses of existing policies is that they only apply to funding given out by the federal government. But for years , the National Institutes of Health and other government agencies have struggled with stagnant funding, leading some researchers to turn instead to private sources. In recent years, for example, crypto titans have poured money into pandemic prevention research.

The new policy does not give the government direct regulation of privately funded research. But it does say that research institutions that receive any federal money for life-science research should apply a similar oversight to scientists doing research with support from outside the government.

“This effectively limits them, as the N.I.H. does a lot of work everywhere in the world,” Dr. Evans said.

The new policy takes into account the advances in biotechnology that could lead to new risks. When pathogens become extinct, for example, they can be resurrected by recreating their genomes. Research on extinct pathogens will draw the highest levels of scrutiny.

Dr. Evans also noted that the new rules emphasize the risk that lab research can have on plants and animals. In the 20th century, the United States and Russia both carried out extensive research on crop-destroying pathogens such as wheat-killing fungi as part of their biological weapons programs. “It’s significant as a signal the White House is sending,” Dr. Evans said.

Marc Lipsitch, an epidemiologist at Harvard and a longtime critic of the government’s policy, gave the new one a grade of A minus. “I think it’s a lot clearer and more specific in many ways than the old guidance,” he said. But he was disappointed that the government will not provide detailed information to the public about the risky research it evaluates. “The transparency is far from transparent,” he said.

Scientists who have warned of the dangers of impeding useful virus research were also largely optimistic about the new rules.

Gigi Gronvall, a biosafety specialist at the Johns Hopkins Bloomberg School of Public Health, said the policy’s success would depend on how federal health officials interpreted it, but applauded the way it recognized the value of research needed during a crisis, such as the current bird flu outbreak .

“I was cautiously optimistic in reading through it,” she said of the policy. “It seems like the orientation is for it to be thoughtfully implemented so it doesn’t have a chilling effect on needed research.”

Anice Lowen, an influenza virologist at Emory University, said the expanded scope of the new policy was “reasonable.” She said, for instance, that the decision not to create an entirely new review body helped to alleviate concerns about how unwieldy the process might become.

Still, she said, ambiguities in the instructions for assessing risks in certain experiments made it difficult to know how different university and health officials would police them.

“I think there will be more reviews carried out, and more research will be slowed down because of it,” she said.

Carl Zimmer covers news about science for The Times and writes the Origins column . More about Carl Zimmer

Benjamin Mueller reports on health and medicine. He was previously a U.K. correspondent in London and a police reporter in New York. More about Benjamin Mueller

reading research scientific papers

AI Assistance in Scientific Research Raises Concerns

Research indicates that generative AI is being used in scientific writing at a significant rate some of the researchers are treating it as a valid approach that can pose a threat to real research and the true nature of scholarly work.

AI’s growing influence on scientific writing

Scholars have discovered that the volume of AI-produced writing is quite substantial compared to other kinds of writing, like journals and books. Such analysis based on linguistics hints that the use of words typically associated with large language models (LLMs) like “intricate,” “pivotal,” and “meticulously” has increased substantially in the text.

The data collected by Andrew Gray from University College London reveal that after 2023, just 1% of papers in certain fields are assisted by AI. Subsequently, in April, another study from Stanford University found that the number of biased reviews falls between 6.3 and 17.5 percent based on the research subject.

Detecting AI influence

Language tests, and statistical analysis were amongst the tools used to link words or phrases to AI assistance. Despite the fact that modifying words, like ‘red’,’result’, and ‘after’ observed less variation till 2023 and then spikes in the use of some adjectives and adverbs associated with LLM-generated content begin to happen.

Precisely, the words “meticulous,” “commendable,” and “intricate” increased that much by 117%, having hit the highest rate post-2022. The Stanford study observed a Shift in Language usage in Artificial Intelligence, which indicated that AI language continues to improve in its usage in all scientific disciplines.

The research also disclosed that AI linguistic discrimination is consistent with the disciplinary disparities in AI adoption. Fields like computer science and electrical engineering are in the teaching front of AI charter language. However, fields such as mathematics, physics, or Nature didn’t feature more dramatic shifts but rather more conservative raises.

Ethical challenges in AI-assisted academic writing

The authors, being more prolific in preprints, working in the research areas where the competition is high, and whetting an appetite for short papers, were shown to be more prone to AI-assisted writing. It is evident that this pattern throws light on the presumed relationship between time limitation and the increased amount of published content as the result of AI-generated content.

AI has been a key facilitator in speeding up research processes. However, it still raises issues of ethics when the technology is used in diverse tasks such as abstracts and other sections of scientific papers. Certain publishers consider it plagiarism, and to some extent unethical, if employed agents of LLMs discuss a scientific paper in which they are not the sole human authors.

The necessary nature of avoiding inaccuracies in AI-generated text, such as imagined quotations and examples, is yet a key feature of scholars’ communication, one should not fail to be transparent and honest. Authors who employ LLM-driven material are required to let the readers know about the research method they used to maintain research integrity and standard acts.

With AI’s increasing influence in academic writing, the architects of the academic community are confronted with the serious challenge of solving ethical implications and ensuring the reliability of research articles. AI is a great technology that significantly facilitates research activities, but honesty and integrity still ought to be maintained in order to preserve scientific integrity.

AI Assistance in Scientific Research Raises Concerns 

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reading research scientific papers

Some scientists can't stop using AI to write research papers

If you read about 'meticulous commendable intricacy' there's a chance a boffin had help.

Linguistic and statistical analyses of scientific articles suggest that generative AI may have been used to write an increasing amount of scientific literature.

Two academic papers assert that analyzing word choice in the corpus of science publications reveals an increasing usage of AI for writing research papers. One study , published in March by Andrew Gray of University College London in the UK, suggests at least one percent – 60,000 or more – of all papers published in 2023 were written at least partially by AI.

A second paper published in April by a Stanford University team in the US claims this figure might range between 6.3 and 17.5 percent, depending on the topic.

Both papers looked for certain words that large language models (LLMs) use habitually, such as “intricate,” “pivotal,” and “meticulously." By tracking the use of those words across scientific literature, and comparing this to words that aren't particularly favored by AI, the two studies say they can detect an increasing reliance on machine learning within the scientific publishing community.

reading research scientific papers

In Gray's paper, the use of control words like "red," "conclusion," and "after" changed by a few percent from 2019 to 2023. The same was true of other certain adjectives and adverbs until 2023 (termed the post-LLM year by Gray).

In that year use of the words "meticulous," "commendable," and "intricate," rose by 59, 83, and 117 percent respectively, while their prevalence in scientific literature hardly changed between 2019 and 2022. The word with the single biggest increase in prevalence post-2022 was “meticulously”, up 137 percent.

The Stanford paper found similar phenomena, demonstrating a sudden increase for the words "realm," "showcasing," "intricate," and "pivotal." The former two were used about 80 percent more often than in 2021 and 2022, while the latter two were used around 120 and almost 160 percent more frequently respectively.

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The researchers also considered word usage statistics in various scientific disciplines. Computer science and electrical engineering were ahead of the pack when it came to using AI-preferred language, while mathematics, physics, and papers published by the journal Nature, only saw increases of between five and 7.5 percent.

The Stanford bods also noted that authors posting more preprints, working in more crowded fields, and writing shorter papers seem to use AI more frequently. Their paper suggests that a general lack of time and a need to write as much as possible encourages the use of LLMs, which can help increase output.

Potentially the next big controversy in the scientific community

Using AI to help in the research process isn't anything new, and lots of boffins are open about utilizing AI to tweak experiments to achieve better results. However, using AI to actually write abstracts and other chunks of papers is very different, because the general expectation is that scientific articles are written by actual humans, not robots, and at least a couple of publishers consider using LLMs to write papers to be scientific misconduct.

Using AI models can be very risky as they often produce inaccurate text, the very thing scientific literature is not supposed to do. AI models can even fabricate quotations and citations, an occurrence that infamously got two New York attorneys in trouble for citing cases ChatGPT had dreamed up.

"Authors who are using LLM-generated text must be pressured to disclose this or to think twice about whether doing so is appropriate in the first place, as a matter of basic research integrity," University College London’s Gray opined.

The Stanford researchers also raised similar concerns, writing that use of generative AI in scientific literature could create "risks to the security and independence of scientific practice." ®

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Opal Sandy

UK toddler has hearing restored in world first gene therapy trial

Opal Sandy can hear almost perfectly after groundbreaking surgery that took just 16 minutes

A British toddler has had her hearing restored after becoming the first person in the world to take part in a pioneering gene therapy trial, in a development that doctors say marks a new era in treating deafness.

Opal Sandy was born unable to hear anything due to auditory neuropathy, a condition that disrupts nerve impulses travelling from the inner ear to the brain and can be caused by a faulty gene.

But after receiving an infusion containing a working copy of the gene during groundbreaking surgery that took just 16 minutes, the 18-month-old can hear almost perfectly and enjoys playing with toy drums.

Her parents were left “gobsmacked” when they realised she could hear for the first time after the treatment. “I couldn’t really believe it,” Opal’s mother, Jo Sandy, said. “It was … bonkers.”

The girl, from Oxfordshire, was treated at Addenbrooke’s hospital, part of Cambridge university hospitals NHS foundation trust, which is running the Chord trial . More deaf children from the UK, Spain and the US are being recruited to the trial and will all be followed up for five years.

Prof Manohar Bance, an ear surgeon at the trust and chief investigator for the trial, said the initial results were “better than I hoped or expected” and could cure patients with this type of deafness.

“We have results from [Opal] which are very spectacular – so close to normal hearing restoration. So we do hope it could be a potential cure.”

He added: “There’s been so much work, decades of work … to finally see something that actually worked in humans …. It was quite spectacular and a bit awe-inspiring really. It felt very special.”

Auditory neuropathy can be caused by a fault in the OTOF gene, which makes a protein called otoferlin. This enables cells in the ear to communicate with the hearing nerve. To overcome the fault, the new therapy from biotech firm Regeneron sends a working copy of the gene to the ear.

A second child has also recently received the gene therapy treatment at Cambridge university hospitals, with positive results.

The overall Chord trial consists of three parts, with three deaf children including Opal receiving a low dose of gene therapy in one ear only.

A different set of three children will get a high dose on one side. Then, if that is shown to be safe, more children will receive a dose in both ears at the same time. In total, 18 children worldwide will be recruited to the trial.

Opal is the first patient globally to receive the therapy and is “the youngest globally that’s been done to date as far as we know”, Bance said.

The gene therapy – DB-OTO – is specifically for children with OTOF mutations. A harmless virus is used to carry the working gene into the patient.

The trial is “just the beginning of gene therapies”, Bance said. “It marks a new era in the treatment for deafness.”

Martin McLean, a senior policy adviser at the National Deaf Children’s Society, said deafness should never be a barrier to happiness or fulfilment. “Many families will welcome these developments, and we look forward to learning about the long-term outcomes for the children treated.”

With Opal’s hearing restored, her parents now have a fresh problem to contend with: their daughter’s new favourite hobby is slamming cutlery on the table to make as much noise as possible.

  • Medical research
  • Deafness and hearing loss

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  1. How to (seriously) read a scientific paper

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  3. How to read and understand a scientific paper

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  17. Ten simple rules for reading a scientific paper

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