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Found 32 jobs

Cell Biology jobs in the US , Canada , Europe and Asia for postdocs , researchers , and faculty . Explore more jobs in developmental biology , stem cells and genetics .

Postdoc fellow/Neuropharmacology and Drug Discovery

• Columbia City
• Salary will be followed by NIH stipend levels for postdoctoral fellow but competitive.
• University of South Carolina,

A postdoc training position is immediately available in the College of Pharmacy, University of South Carolina.

View details Postdoc fellow/Neuropharmacology and Drug Discovery

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Post-Doctoral Fellow, Associate Research Scholar, Staff Scientist: Cell signaling, Cell movement

• Oklahoma City, Oklahoma
• Salary to be commensurate with experience
• University of Oklahoma Health Sciences Center

Post-Doctoral Fellow, Associate Research Scholar or Staff Scientist positions to study cell signaling, cell movement, and colon cancer

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Post-doctoral scholar in cancer biology

• San Francisco, California
• compensation according to years of experience per institutional payscales
• University of California, San Francisco (UCSF)

Postdoctoral position in basic and translational cancer biology at the University of California, San Francisco.

View details Post-doctoral scholar in cancer biology

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Research Technician III - Genome Editing for Cell Therapy

• Houston, TX
• Baylor College of Medicine

View details Research Technician III - Genome Editing for Cell Therapy

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Postdoctoral Associate- Genome Editing for Cell Therapy

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Assistant/Associate/Full Professor in Stem Cell Editing and Cell Engineering

• San Francisco
• See job description.
• University of California, San Francisco

Assistant/Associate/Full Professor in Stem Cell Editing and Cell Engineering The Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell

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Pulmonary Research Assistant Professor

• Iowa City, Iowa
• Commensurate
• The University of Iowa Health Care

seeking a Research Assistant Professor. For this position, we seek qualified candidates with research interests

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Postdoctoral Research Scientist

• New York City, New York
• $72,100 - $75,000
• Columbia University Irving Medical Center - Pediatrics

The Department of Pediatrics is seeking a Postdoctoral Research Scientist for our Critical Care & Hospital Medicine Division.

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Postdoctoral Fellow Positions in Cell Biology

• Albert Einstein College of Medicine

The Department of Cell Biology invites applications for Postdoctoral Fellow positions from outstanding candidates with a recent Ph.D. or M.D & Ph.D.

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Assistant Scientist/Professor Position, Sanford Research

• Sioux Falls, South Dakota
• Commensurate with experience
• Sanford Research

Assistant Scientist/Professor Positions, Sanford Research Sanford Research invites applications for full-time faculty at the rank of Assistant Scie...

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Tenure-Track Position for Assistant Professor in Biotechnology

• Singapore (SG)
• Commencing salary will depend on qualifications, experience, and the level of appointment offered
• Nanyang Technological University, Singapore

The School of Chemistry, Chemical Engineering and Biotechnology, NTU invites outstanding candidates to apply for Assistant Professor in Biotechnology

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Assistant Professor in Cell Biology & Metabolism (Designated Posting)

• Halifax (City), Nova Scotia (CA)
• Salary commensurate with qualifications and experience.
• The Dept. of Biochemistry & Molecular Biology, Faculty of Medicine, Dalhousie University

Experience in cell biology & metabolism or related fields are invited to apply. This position is designated for applicants who self-identify as women.

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Tenure-Track Assistant Professor, Associate Professor, and Professor

• Hangzhou, Zhejiang (CN)
• Salary will be comparable and competitive to international standards
• Westlake University

Tenure-Track Assistant Professor, Associate Professor, and Professor   Westlake Center for Genome Editing is an established research center at West...

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Assistant Professor Faculty Position in Cell Biology

• Weill Cornell Medicine - Qatar

Assistant Professor Faculty Position in Cell Biology   In a pioneering international initiative, Cornell University and Weill Cornell Medical Colle...

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Director, Single Cell Sequencing/Spatial Transcriptomics Core

• Chicago, Illinois
• Up to $120,000
• University of Illinois at Chicago, OVCR

The Core is a state-of-the-art facility offering instrumentation access, training and technical expertise to researchers at UIC.

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Research Scientist in Biofilm Imaging

• Hamburg (DE)
• German TV-AVH

For our location in Hamburg we are seeking: Research Scientist in Biofilm Imaging Limited: 2 years | Starting date: 01.07.2024 | ID: FSMA021/2024 ...

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Research Associate, Radiation Oncology

• Charlottesville, Virginia
• Dependent on Qualifications
• University of Virginia Dept of Radiation Oncology

RA to study the role of the ubiquitin system in regulating cell cycle progression, genomic stability and cellular response to ionizing radiation.

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Assistant/Associate Professor Tenure Track Faculty

• Texas Tech School of Medicine, Lubbock
• Salary commensurate with related education, experience and/or skills
• Texas Tech University Health Sciences Center/Pharmacology and Neuroscience

Tenure track faculty position in the Department of Pharmacology and Neuroscience

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Postdoctoral Fellow in cancer research

• Cleveland, Ohio (US)
• standard NIH-recommended postdoc salary levels
• Case Western Reserve University--GI cancer research

Study metastatic GI cancer (wet lab). Skills: cell culture, patient tissue, DNA/RNA/protein assays, cell growth/death assays, tumor growth in mice

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Postdoctoral Research Positions: Host-Pathogen Interactions / Inflammation / Immunity

• Philadelphia, Pennsylvania (US)
• NIH salary scale
• Temple University Lewis Katz School of Medicine

Research on host-pathogen interactions, inflammation and innate immunity in health and disease.

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PostDoc/Scientist

• Research Institute to be located in Florida which has no income tax and the location is inexpensive.
• If you already have a PhD then expect the starting in the range $65,000 to $99,342 plus benefits

Completely "open" to new ideas for research in a biomedical field which is quintessential everyday and someone needs it every two seconds in the USA.

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Postdoc - Department of Pharmacology and Toxicology

• Dayton, Ohio
• Wright State University Boonshoft School of Medicine

A Postdoctoral Position is available in the Department of Pharmacology and Toxicology, Wright State University School

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Molecular and Cell Biology

Doctoral Program

The Department of Molecular & Cell Biology at the University of California, Berkeley offers a Ph.D. program focused on the molecular mechanisms inherent to life. This program integrates research with a modern training curricula, teaching, and career mentorship. Our Department is highly interdisciplinary - comprising the Divisions of Cell Biology, Development & Physiology, Immunology and Molecular Medicine, Neurobiology, Biochemistry, Biophysics & Structural Biology, and Genetics, Genomics, and Development – and this is reflected in our students and training. The program is also highly collaborative with related programs and Institutes on campus, thus allowing students the flexibility to explore all aspects of modern biological research. Please click on the links below to learn more about our areas of research on the main department website or use the menu at the top to navigate to areas of interest within the graduate program.

Cell Biology, Development & Physiology

Immunology and molecular medicine, neurobiology, biochemistry, biophysics & structural biology, molecular therapeutics, genetics, genomics, evolution, and development.

Molecular & Cell Biology PhD

The Department of Molecular and Cell Biology offers a program of graduate study leading to the PhD in molecular and cell biology. This program provides advanced training in the research methods and concepts of the study of the molecular structures and processes of cellular life. The training is intellectually focused, but at the same time offers an unusually wide range of opportunities for varied disciplinary specialization.

The teaching and research activities of the Department of Molecular and Cell Biology (MCB) concern the molecular structures and processes of cellular life and their roles in the function, reproduction, and development of living organisms.

This agenda covers a broad range of specialized disciplines, including biochemistry, biophysics, molecular biology, structural biology, genetics, genomics, bioinformatics, cell biology, developmental biology, tumor biology, microbiology, immunology, molecular medicine, and neurobiology.

The types of living organisms from which the departmental faculty draws its working materials are as diverse as its disciplinary specializations, ranging from viruses and microbes through plants, roundworms, annelids, arthropods, and mollusks to fish, amphibia, and mammals.

The faculty is organized into six divisions: Biochemistry, Biophysics, and Structural Biology; Cell Biology, Development, and Physiology; Genetics, Genomics, Evolution, and Development; Immunology and Molecular Medicine; Neurobiology; and Molecular Therapeutics.

Contact Info

[email protected]

299 Weill Hall, UC Berkeley, #3200

Berkeley, CA 94720

At a Glance

Department(s)

Molecular & Cell Biology

Admit Term(s)

Application Deadline

November 27, 2023

Degree Type(s)

Doctoral / PhD

Degree Awarded

GRE Requirements

• Doctor of Philosophy in Cell and Developmental Biology (PhD)
• Graduate School
• Prospective Students
• Graduate Degree Programs

Canadian Immigration Updates

Applicants to Master’s and Doctoral degrees are not affected by the recently announced cap on study permits. Review more details

Go to programs search

The graduate program in Cell and Developmental Biology offers M.Sc. and Ph.D. degrees to students undertaking advanced study and research in cell and developmental biology. The program is flexible and is designed to accommodate the diverse backgrounds of students and the broad nature of research in cell and developmental biology.

The program's courses provide a thorough understanding of the scientific fundamentals and methodologies of contemporary cell and developmental biology. All students also undertake original and significant research from the start of their studies. With nearly 50 faculty members engaged in cutting-edge research in cell and developmental biology, a wide range of research topics is available to students.

The program also aims to enhance linkages and facilitate research interactions between the larger community of cell and developmental biologists in British Columbia by acting as a common forum for scholarly exchange in cell and developmental biology through its student-led seminar series, research retreats and other activities.

For specific program requirements, please refer to the departmental program website

What makes the program unique?

The Program is administered through the Life Sciences Institute (LSI), Canada's largest Institute for life science research which houses over 80 laboratories conducting internationally recognized research in areas such as cell and molecular biology, cancer biology, diabetes and microbiology & immunology.

Program faculty and students also conduct research at hospital-based research Institutes and Centres, including the BC Cancer Research Centre, the Biomedical Research Centre, the Centre for Brain Health, BC Children's Hospital Research Institute, the Centre for Molecular Medicine and Therapeutics,and the Centre for Macular Research. All of these Institutes and Centres offer highly collaborative research environments and provide outstanding facilities and resources to the ~ 70 graduate students who call the program home.

Given the number of researchers associated with the program and their varied Departmental and Faculty affiliations, the potential range of research topics available to students in the Program is very large.

Minimum level of financial support for M.Sc. and Ph.D. students of $25,000 per year, with top-ups for students who receive scholarships.

I was admitted into several universities but chose UBC as it offered the best combination of a supportive advisor, stimulating environment, and a great city to live in.

Jigyasa Verma

Quick Facts

Program enquiries, admission information & requirements, program instructions.

Acceptance into the Program is dependent upon a prospective student getting written agreement from a Faculty member that he/she will be their Research Supervisor.

1) Check Eligibility

Minimum academic requirements.

The Faculty of Graduate and Postdoctoral Studies establishes the minimum admission requirements common to all applicants, usually a minimum overall average in the B+ range (76% at UBC). The graduate program that you are applying to may have additional requirements. Please review the specific requirements for applicants with credentials from institutions in:

• Canada or the United States
• International countries other than the United States

Each program may set higher academic minimum requirements. Please review the program website carefully to understand the program requirements. Meeting the minimum requirements does not guarantee admission as it is a competitive process.

English Language Test

Applicants from a university outside Canada in which English is not the primary language of instruction must provide results of an English language proficiency examination as part of their application. Tests must have been taken within the last 24 months at the time of submission of your application.

Minimum requirements for the two most common English language proficiency tests to apply to this program are listed below:

TOEFL: Test of English as a Foreign Language - internet-based

Overall score requirement : 100

IELTS: International English Language Testing System

Overall score requirement : 7.0

Other Test Scores

Some programs require additional test scores such as the Graduate Record Examination (GRE) or the Graduate Management Test (GMAT). The requirements for this program are:

The GRE is not required.

2) Meet Deadlines

January 2025 intake, application open date, canadian applicants, international applicants, may 2025 intake, deadline explanations.

Deadline to submit online application. No changes can be made to the application after submission.

Deadline to upload scans of official transcripts through the applicant portal in support of a submitted application. Information for accessing the applicant portal will be provided after submitting an online application for admission.

Deadline for the referees identified in the application for admission to submit references. See Letters of Reference for more information.

3) Prepare Application

Transcripts.

All applicants have to submit transcripts from all past post-secondary study. Document submission requirements depend on whether your institution of study is within Canada or outside of Canada.

Letters of Reference

A minimum of three references are required for application to graduate programs at UBC. References should be requested from individuals who are prepared to provide a report on your academic ability and qualifications.

Statement of Interest

Many programs require a statement of interest , sometimes called a "statement of intent", "description of research interests" or something similar.

Supervision

Students in research-based programs usually require a faculty member to function as their thesis supervisor. Please follow the instructions provided by each program whether applicants should contact faculty members.

Instructions regarding thesis supervisor contact for Doctor of Philosophy in Cell and Developmental Biology (PhD)

Citizenship verification.

Permanent Residents of Canada must provide a clear photocopy of both sides of the Permanent Resident card.

4) Apply Online

All applicants must complete an online application form and pay the application fee to be considered for admission to UBC.

Tuition & Financial Support

Financial support.

Applicants to UBC have access to a variety of funding options, including merit-based (i.e. based on your academic performance) and need-based (i.e. based on your financial situation) opportunities.

Program Funding Packages

Research Supervisors must commit to supporting you financially during the course of your training. The minimum level of financial support is $25,000 per year, for a minimum of 4 years. As a general rule, financial support continues to the completion of your degree, so long as performance is satisfactory and you remain in good academic standing. Students are expected to pay tuition from their stipend.

Financial support is in the form of a minimum funding package which can be made up from several sources – usually a combination of a Scholarship/Award, a Teaching Assistantship (from teaching duties as a graduate student, to a maximum of two 0.5 TAships per year) and a Research Assistantship (paid from a Supervisor’s research funds). There are no citizenship requirements for Teaching or Research Assistantships.

Average Funding

• 7 students received Teaching Assistantships. Average TA funding based on 7 students was $4,297.
• 29 students received Research Assistantships. Average RA funding based on 29 students was $24,124.
• 6 students received Academic Assistantships. Average AA funding based on 6 students was $563.
• 29 students received internal awards. Average internal award funding based on 29 students was $7,088.
• 5 students received external awards. Average external award funding based on 5 students was $17,133.

Scholarships & awards (merit-based funding)

All applicants are encouraged to review the awards listing to identify potential opportunities to fund their graduate education. The database lists merit-based scholarships and awards and allows for filtering by various criteria, such as domestic vs. international or degree level.

Graduate Research Assistantships (GRA)

Many professors are able to provide Research Assistantships (GRA) from their research grants to support full-time graduate students studying under their supervision. The duties constitute part of the student's graduate degree requirements. A Graduate Research Assistantship is considered a form of fellowship for a period of graduate study and is therefore not covered by a collective agreement. Stipends vary widely, and are dependent on the field of study and the type of research grant from which the assistantship is being funded.

Graduate Teaching Assistantships (GTA)

Graduate programs may have Teaching Assistantships available for registered full-time graduate students. Full teaching assistantships involve 12 hours work per week in preparation, lecturing, or laboratory instruction although many graduate programs offer partial TA appointments at less than 12 hours per week. Teaching assistantship rates are set by collective bargaining between the University and the Teaching Assistants' Union .

Graduate Academic Assistantships (GAA)

Academic Assistantships are employment opportunities to perform work that is relevant to the university or to an individual faculty member, but not to support the student’s graduate research and thesis. Wages are considered regular earnings and when paid monthly, include vacation pay.

Financial aid (need-based funding)

Canadian and US applicants may qualify for governmental loans to finance their studies. Please review eligibility and types of loans .

All students may be able to access private sector or bank loans.

Foreign government scholarships

Many foreign governments provide support to their citizens in pursuing education abroad. International applicants should check the various governmental resources in their home country, such as the Department of Education, for available scholarships.

Working while studying

The possibility to pursue work to supplement income may depend on the demands the program has on students. It should be carefully weighed if work leads to prolonged program durations or whether work placements can be meaningfully embedded into a program.

International students enrolled as full-time students with a valid study permit can work on campus for unlimited hours and work off-campus for no more than 20 hours a week.

A good starting point to explore student jobs is the UBC Work Learn program or a Co-Op placement .

Tax credits and RRSP withdrawals

Students with taxable income in Canada may be able to claim federal or provincial tax credits.

Canadian residents with RRSP accounts may be able to use the Lifelong Learning Plan (LLP) which allows students to withdraw amounts from their registered retirement savings plan (RRSPs) to finance full-time training or education for themselves or their partner.

Please review Filing taxes in Canada on the student services website for more information.

Cost Estimator

Applicants have access to the cost estimator to develop a financial plan that takes into account various income sources and expenses.

Career Outcomes

40 students graduated between 2005 and 2013: 1 graduate is seeking employment; for 4 we have no data (based on research conducted between Feb-May 2016). For the remaining 35 graduates:

Sample Employers in Higher Education

Sample employers outside higher education, sample job titles outside higher education, phd career outcome survey, career options.

Our graduates are well-prepared and highly competitive for the next step in their careers, whether in academia or in other sectors (e.g. biotechnology, health care, government, business, finance) where an in-depth knowledge of modern cell and developmental biology is required.

Alumni on Success

Perveen Biln

Job Title Senior Specialist, Medical Affairs

Employer Merck Canada

Geoffroy Noel

Job Title Associate Professor

Employer McGill University

Enrolment, Duration & Other Stats

These statistics show data for the Doctor of Philosophy in Cell and Developmental Biology (PhD). Data are separated for each degree program combination. You may view data for other degree options in the respective program profile.

ENROLMENT DATA

Completion rates & times.

• Research Supervisors

Advice and insights from UBC Faculty on reaching out to supervisors

These videos contain some general advice from faculty across UBC on finding and reaching out to a supervisor. They are not program specific.

This list shows faculty members with full supervisory privileges who are affiliated with this program. It is not a comprehensive list of all potential supervisors as faculty from other programs or faculty members without full supervisory privileges can request approvals to supervise graduate students in this program.

• Accili, Eric (molecular mechanisms responsible for cellular pacemaking behavior )
• Allan, Douglas (Nervous system)
• Auld, Vanessa (Neurosciences, biological and chemical aspects; Neurosciences, medical and physiological and health aspects; Zoology; Cell; Cell Biology; Development; Developmental Genetics; epithelia; Genetics; glia; in vivo imaging; Molecular Genetics; nervous system; Neurogenesis and Gliogenesis; permeability barriers)
• Bamji, Shernaz (Medical and biomedical engineering; Neurosciences, biological and chemical aspects; Neurosciences, medical and physiological and health aspects; neurodevelopmental disease; primary neuronal cultures; synapse biology; transgenic mouse models)
• Beristain, Alexander Guillermo (Healthy Starts; cellular and molecular processes that direct trophoblast cell biology in early placental development; Examining the A Disintegrin And Metalloproteinase (ADAM) family in trophoblast biology; Examining the effects of obesity-associated inflammation on the maternal-fetal interface; Identifying gene expression differences in subpopulations of trophoblasts in normal and pathological pregnancies )
• Cembrowski, Mark Steven (Molecular neuroscience; Mathematical modelling and simulation; Mechanisms of memory in the brain; Anxiety; Big Data; Bioinformatics; Cell types; Computation; CRISPR-Cas9; Fear; Genetics; modeling; Neural circuits; neuroscience; Neuroscience of memory; PTSD; RNAseq)
• Conibear, Elizabeth (Other basic medicine and life sciences; Protein trafficking in cell biology; Molecular genetics; Functional genomics; Membranes; Enzymes and Proteins; Vesicle Trafficking; Molecular Genetics; Neurodegenerative diseases; Protein Palmitoylation; Cell Signaling and Cancer)
• Coombs, Daniel (Mathematical biology; Cellular immunology; Complex physical systems; Epidemiology (except nutritional and veterinary epidemiology); Cell Signaling and Infectious and Immune Diseases; Cell biophysics; Disease models; Epidemiology; Immune cell signalling; Mathematics)
• Dong, Xuesen (Cancer progression and metastasis; Gene and molecular therapy; Prostate Cancer; RNA splicing and Gene Regulation; Drug development; Hormone Dependent Cancers; Endocrine Regulation; Premature Labour)
• Gold, Michael (understanding cell signaling, morphology, trafficking, and effector function of immune cells and tumour cells)
• Gordon, Michael (Neurosciences, biological and chemical aspects; Neurosciences, medical and physiological and health aspects; Zoology; Chemosensation; Drosophila; Feeding; Gustation; Neural circuits; Neuronal Systems; neuroscience; Sensory systems; Taste)
• Graf, Daniel (Bone, skin and cartilage science; Cell differentiation, proliferation and death; Developmental genetics (including sex determination); Developmental and degenerative pathologies associated with cartilage, bone, and teeth)
• Greenblatt, Ethan
• Haas, Kurt (Medical and biomedical engineering; Neurosciences, biological and chemical aspects; Neurosciences, medical and physiological and health aspects; Autism; Brain Circuit Development; Dendritogenesis; Epilepsy; Genetics of Neurological and Psychiatric Diseases; Neurodevelopmental disorders; Neurological diseases; Neuronal Communication and Neurotransmission; Neuronal Computation; Neuronal Modeling; Neuronal Systems; Neuronal and Synaptic Activity; Plasticity / Neuronal Regeneration; Synaptic Plasticity)
• Hakkinen, Lari (Dentistry and oral health; Cell signaling; Cell therapy; Cell to cell communication; Connective Tissue; Extracellular matrix; Fibroblasts, MSC; Oral mucosa and skin; Tissue regeneration; Wound Healing)
• Hilton, Brett (Neurosciences, medical and physiological and health aspects; neuroscience; neuroplasticity; Axon regeneration; Spinal cord injury)
• Hoffman, Bradford (Understanding how the genes critical to endocrine pancreas development, as well as ?-cell function and proliferation are regulated is essential for the development of novel strategies for the production of insulin-secreting cells, and for improving the efficacy of available transplantable material. )
• Hoodless, Pamela (Computational cell biology; Cancer; Genomics; Medical and biomedical engineering; Nucleic acids studies; Developmental Genetics; Embryology; Embryonic Development; Epigenetics; Heart Valve / Valvular Diseases; Heart valve formation; Liver; Liver development; Stem Cells and Organogenesis; transcriptional regulation)
• Johnson, James (diabetes, hormones, cell biology, signal transduction, apoptosis or programmed cell death, heart failure, heart disease, calcium signalling, pancreatic cancer, obesity, longevity, imaging, Causes of type 1 and type 2 diabetes at a molecular level discovery of genes and associated gene networks linked to diabetes risk and by known risk factors that predispose individuals to diabetes)
• Kieffer, Tim (Diabetes)
• Kopp, Janel (Genomics; Modeling cancer; Pancreas; Pancreatic cancer; Pancreatic development)
• Krentz, Nicole (Human development and organogenesis; Pharmacology and pharmaceutical sciences, n.e.c.; Human physiology, n.e.c.; Diabetes; Developmental biology; Genetics)
• Lange, Philipp (Bioinformatics; Genomics; Pathology (except oral pathology); Cell Signaling and Cancer; mass spectrometry; pediatric cancer; personalized medicine; post translational protein modification; Proteomics)
• Lansdorp, Peter (Genetic medicine; Application of single cell Strand-seq in precision medicine; Applied Genetics; cellular aging; Cellular Degeneration; Cellular Division; Complex Trait Genetics; DNA replication, epigenetics and stem cells; Gene Regulation and Expression; Genetic Diseases; Stem Cells and Organogenesis; telomeres; Telomeres, genomic instability, aging and cancer)
• Li, Xin (Molecules in plants, plants defence against pathogen infection, plant genes)

Doctoral Citations

Sample thesis submissions.

• Investigating the role of podocalyxin in solid tumour collective invasion
• Investigating the role of the putative lipid transport protein Fmp27 at ER-PM membrane contact sites
• The mRNA deadenylase PAN complex plays an evolutionarily conserved role in M-phase of the cell cycle during microtubule stress
• Mutations in Frizzled2 and Dishevelled1 inhibit skeletogenesis and disturb WNT signaling during the craniofacial development in the chicken embryo
• TBX3 advances the developmental chromatin landscape towards the hepatic fate
• Corticosteroid-binding globulin shapes the sexual dimorphism of adrenal, hepatic, and neuroendocrine responses
• In vivo analysis of blood progenitor differentiation and hematopoietic niche maintenance in Drosophila melanogaster
• The role of Connexin43 carboxyl terminal domain in regulating various signaling-induced cytoskeleton-dependent cellular processes in B-lymphocytes
• Origin, fate, and function of embryonic Hic1-positive mesenchymal progenitors in the developing limb
• Scn9a Na⁺ channels in beta-cell survival and type 1 diabetes
• Activity-regulated genes in pancreatic islets and neurons of the arcuate nucleus
• Persistence of targetable genomes and proteomes through disease evolution in pediatric acute lymphoblastic leukemia
• Delineating migratory events in liver and heart development using single-cell transcriptomics
• The cell autonomous and cell non-automous roles of YAP1 during pancreatogenesis
• BRCA1 regulates the PLK1-mediated spindle positioning pathway that promotes luminal features and may suppress tumorigenesis in mammary epithelial cells

Related Programs

Same specialization.

• Master of Science in Cell and Developmental Biology (MSc)

At the UBC Okanagan Campus

• Doctor of Philosophy (PhD), Biology

Further Information

Specialization.

Cell and Developmental Biology courses provide a thorough understanding of the scientific fundamentals and methodologies of contemporary cell and developmental biology.

UBC Calendar

Program website, faculty overview, academic unit, program identifier, classification, social media channels, supervisor search.

Departments/Programs may update graduate degree program details through the Faculty & Staff portal. To update contact details for application inquiries, please use this form .

Alexander Garner

World class research and an amazing city. UBC has the benefit of having cutting edge researchers who allow me to participate in landmark research. On top of this, the UBC campus and Vancouver are surrounded by parks and the mountains providing the opportunities of a big city without having to...

Curious about life in Vancouver?

Find out how Vancouver enhances your graduate student experience—from the beautiful mountains and city landscapes, to the arts and culture scene, we have it all. Study-life balance at its best!

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Positions Available

Biochemistry & cell biology faculty position available – assistant professor.

The Department of Biochemistry and Cell Biology at the Boston University Chobanian and Avedisian School of Medicine ( https://www.bumc.bu.edu/biochemcellbio/ ) invites application for a faculty position at the Assistant Professor level. The position comes with competitive salary, generous start-up support, and ample lab and office space.

We are seeking scientists with a demonstrated record of productivity and scientific excellence, addressing important and challenging problems across a broad range of research areas, including, but not limited to, cell biology, systems biology, epigenetics and chromatin biology, RNA biology, and metabolism. Candidates must have a Ph.D. and/or M.D. degree, with relevant postdoctoral experience, and plans to develop a creative and independent research program. We especially welcome applications from members of all groups underrepresented in STEM.

The successful candidate will join a welcoming and vibrant Department that in the last decade has enjoyed a major transformation in its personnel and infrastructure, including hiring new faculty members at all levels and renovation of 35,000 square feet of research space. Research currently encompasses six main themes: Development, Cell Biology, Genomics, Neuroscience, Metabolism, and Proteomics/Glycomics.

Applicants should upload the following items to https://academicjobsonline.org/ajo/jobs/25282 :

• Cover letter (max 1 page),
• Curriculum vitae including full list of publications,
• Research statement with a description of significant research accomplishments and future research plans (max 3 pages)
• Diversity, Equity, and Inclusion (DEI) statement highlighting the commitment to mentoring diverse trainees and contributing to increasing inclusiveness and diversity in the Department (max 1 page)
• Names and email addresses of three persons who will provide letters of recommendation (to be submitted online by the reference writers)

Applications will be reviewed on a rolling basis through the Fall until the position is filled. Please direct email queries to [email protected] .

Boston University is an equal opportunity and affirmative action employer

Zaia Lab (CBMS) – Postdoctoral Associate Position

Postdoctoral associate position

Laboratory of Joe Zaia

Department of Biochemistry- Center for Biomedical Mass Spectrometry

We are recruiting a post-doctoral associate to work on NIH supported projects in the Zaia group at Boston University.

https://www.bumc.bu.edu/biochemcellbio/profiles/joseph-zaia/

Our group uses mass spectrometry methods for studying disease processes in tissue using combined proteomics, glycomics and glycoproteomics.   We have an opening for a postdoctoral scientist to work on combined proteomics and glycomics from brain tissue.   The work will involve combined glycomics and proteomics to determine the roles of glycoprotein and proteoglycan expression in neurological diseases.

Competitive salary and benefits are available commensurate with experience.  Fluent spoken English, a strong publication track record, and a cooperative attitude are a must for this position.  The Zaia group is part of the Center for Biomedical Mass Spectrometry at Boston University.  This highly collaborative group provides excellent opportunities for career development of a young Ph.D. scientist.

Candidates should have a recent Ph.D. in analytical chemistry, biochemistry, or a related biomedical field with strong experience with mass spectrometry.  Glycomics and/or proteomics experience is strongly recommended.

Candidates should send curriculum vitae, cover letter, and contact information for three letters of reference to Joe Zaia  ( [email protected] ) .

Boston University prohibits discrimination against any individual on the basis of race, color, religion, sex, age, national origin, physical or mental disability, sexual orientation, gender identity, genetic information, military service, pregnancy or pregnancy-related condition, or because of marital, parental, or veteran status.

Harris Laboratory

POSTDOCTORAL POSITION (BOSTON, MA) - NEURODEGENERATIVE DISEASES

Our laboratory is seeking a postdoctoral researcher with a Ph.D. and/or M.D. to study the cellular and molecular mechanisms underlying Alzheimer's disease, prion diseases, and other disorders caused by protein aggregation. Our goal is to understand how these aggregates harm the brain and develop new ways to stop them.

Our team is multi-disciplinary, multi-cultural, and highly interactive, working on a range of projects from basic biology to drug discovery. Team members are highly motivated, collaborate frequently, and learn from each other. We are located in Boston, Massachusetts, a premier center for academic research and a hub for the biotech and pharma industries.

If you have experience in biochemistry, cell biology, chemical biology, protein structure, or iPSC models, and you want to join a vibrant research group that has a long-standing reputation and impactful publications in the field of neurodegenerative disorders, consider joining us.

Please submit your curriculum vitae, statement of research interests, and the names of three references to:

David A. Harris, M.D., Ph.D. Professor and Chair Department of Biochemistry Boston University/Chobanian & Avedisian School of Medicine 72 East Concord Street, K225 Boston, MA 02118 USA E-mail: [email protected] Website: https://www.bumc.bu.edu/biochemcellbio/profiles/david-a-harris/

Garcia-Marcos Laboratory

POSTDOCTORAL POSITION, CELL BIOLOGY/ SIGNALING

Our laboratory investigates signal transduction mechanisms with the ultimate goal of elucidating the molecular basis of human diseases and developing novel therapeutic approaches. Our main interest is in heterotrimeric G proteins, which are molecular switches primarily activated by G protein-coupled receptors (GPCRs) located at the plasma membrane. In the recent years, we have pioneered the characterization of novel mechanisms of G protein regulation that deviate from the canon and that have important implications in cancer, embryonic development, and neurotransmission. Our multidisciplinary approach includes   in vitro   biochemistry to characterize protein complexes, culture cells and model organisms (yeast, frog embryos) for functional studies and synthetic biology tools to manipulate and monitor signaling with exquisite spatiotemporal resolution and fidelity.

There are several open projects in the laboratory that could accommodate new postdoctoral fellows. These involve the study of spatiotemporal control of   GPCR / G protein signaling with live-cell biosensors and other synthetic biology tools, and investigating the role of   GPCR -independent G protein signaling in epithelial tissues   in vitro   and vertebrate embryos (zebrafish,   Xenopus )   in vivo . It is also expected that the applicant will be engaged in related secondary projects and collaborative efforts within and/or outside our laboratory.

QUALIFICATIONS   REQUIRED -   We are looking for candidates with a recent Ph.D. and experience in   Cell Biology and Biochemistry , as demonstrated by a strong publication record. Prior knowledge of   GPCR /G protein signal transduction is preferred but not essential. We are looking for   motivated   and   creative   individuals with a commitment to academic research who can work   independently   as well as in   team-based   projects. Good oral and written communication skill are a must.

The atmosphere in the laboratory is   collaborative   and   multidisciplinary . The successful candidate will interact on a daily basis with colleagues carrying out studies on different areas of research (cancer, development, neurobiology) and approaches (purified proteins, structural biology, primary and cell line cultures,   BRET , mice, frogs, etc). Our laboratory is highly committed to the career development of trainees.

The Department of Biochemistry at Boston University offers a highly collegial atmosphere and a first rate research environment.

Skills:   Experience with several of the techniques listed below is required:

• Cellular and Molecular Biology: Cell culture, confocal and live cell fluorescence microscopy, molecular cloning, genetic manipulation of cell lines by   CRISPR   and RNAi, lentivirus production, etc
• Biochemistry: Protein purification, protein-protein interaction assays such as pulldowns and immunoprecipitations, immunoblotting, enzymatic assays, etc.
• Animal Models: zebrafish and/or   Xenopus

Interested candidates should send a CV, cover letter and contact information for 3 references.

Mikel Garcia-Marcos, PhD. Associate Professor.  [email protected]

RECENT   RELATED   PUBLICATIONS

• Maziarz M, Park J-C, Leyme A, Marivin A, Garcia-Lopez A, Patel PP, Garcia-Marcos M. Revealing the Activity of Trimeric G-proteins in Live Cells with a Versatile Biosensor Design.   Cell : published: July 06, 2020.
• DiGiacomo V, Maziarz M, Luebbers A, Norris JM, Laksono P, Garcia-Marcos M. Probing the mutational landscape of regulators of G Protein signaling proteins in cancer.   Science Signaling . 2020 Feb 4;13(617). pii: eaax8620.   PMID : 32019900.
• Marivin A, Morozova V, Walawalkar I, Leyme A, Kretov DA, Cifuentes D, Dominguez I, Garcia-Marcos M.   GPCR -independent activation of G proteins promotes apical cell constriction in vivo.   Journal of Cell Biology . 2019; May 6;218(5):1743-1763.   PMID : 30948426.
• Leyme A et al. Specific inhibition of   GPCR -independent G protein signaling by a rationally engineered protein.   Proceedings of the National Academy of Sciences   USA   ( PNAS ).   2017 Nov 28;114(48):E10319-E10328. doi: 10.1073/pnas.1707992114. Epub 2017 Nov 13.
• de Opakua AI, et al.  Molecular mechanism of Gαi activation by non- GPCR   proteins with a Gα-Binding and Activating motif.   Nature Communications.   2017 May 18;8:15163. doi: 10.1038/ncomms15163.
• Marivin A. et al. Dominant negative Gα subunits as a novel mechanism of trimeric G protein signaling dysregulation in human disease.   Science Signaling.   2016.   Apr 12;9(423):ra37.   PMID : 27072656.
• Leyme A. et al. Integrins activate trimeric G proteins via the nonreceptor protein   GIV /Girdin.   Journal of Cell Biology . 2015 Sep 28;210(7):1165-84.   PMID : 26391662.

Cifuentes Laboratory

Postdoctoral positions are available for highly talented and motivated candidates willing to address fundamental questions of RNA regulation in viruses and vertebrate systems .

The available projects focus on the study of post-transcriptional RNA regulators such as microRNA and other small non-coding regulatory RNAs, RNA-binding proteins and epitranscriptomic modifications with the goal to integrate these mechanisms into a single post-transcriptional regulatory framework. To address this goal, the lab combines high-throughput genetic, genomic, and proteomic approaches applied to two independent but technically interconnected areas: vertebrate development and viral replication, using zebrafish and filoviruses as primary model systems. Additional information can be found at www.bumc.bu.edu/biochemcellbio/people/faculty/daniel-cifuentes/

Candidates should have a Ph.D., M.D., or equivalent degree and at least a first author publication. Strong experience in molecular biology is required and knowledge of computational biology will be a plus, but even more important is their motivation to learn and problem-solving skills to adapt to the scientific challenges and become positive members of the lab. The position is funded for at least two years, contingent on performance.

To apply please send to Dr. Cifuentes ( [email protected] ) a cover letter stating research interests, CV, and contact for three references.

Varelas laboratory

Graduate student positions.

Interested students should apply to the PiBS program at Boston University ( BU-PiBS ). Once accepted to the program please email Dr. Varelas ( xvarelas )  to arrange a meeting to discuss projects and opportunities.

Postdoctoral Positions

Postdoctoral positions are available in the Varelas Lab to work on funded, multi-year, cell signaling projects. The overall goal of the Lab is to understand the roles and regulation of the Hippo pathway in a variety of areas, including stem cell biology, development, and diseases such as cancer. The successful candidate(s) will have opportunities to work with a vibrant group to learn and utilize a number of experimental approaches, including molecular biology and cell biology methods, and various animal models.

Candidates should hold a Ph.D. and/or M.D. degree, or the equivalent, and preferably have expertise in developmental mouse models. Qualified candidates must also be able to work independently, demonstrate excellent communication skills and work well within a group. To apply send a cover letter, curriculum vitae, and the names of three references to Dr. Varelas by email ( xvarelas ). Please note that only candidates selected for an interview will be contacted.

Heidelberg Biosciences International Graduate School (HBIGS)

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PhD Positions in Cancer Research

Are you looking for excellent research opportunities for your PhD studies at the forefront of cancer research? The German Cancer Research Center (DKFZ) in Heidelberg invites international students holding a Master’s degree in (molecular) biology, ...

Upcoming PhD Positions at the International Max Planck Research School for Molecules of Life in Autumn 2024

More information for the new call-out will come up during Autumn 2024. Stay tuned!The International Max Planck Research School for Molecules of Life (IMPRS-ML) will have an open call for fully-funded PhD student positions in the areas of biochemis...

Upcoming PhD positions at the CGA

Call for applications for up to 12 PhD positions at the Cologne Graduate School of Ageing Research opens soon! The Cologne Graduate School of Ageing Research (CGA) in Germany is a joint venture of the University of Cologne Excellence Cluster on St...

International Fully Funded PhD Positions in the Life Sciences in Switzerland

*New application deadlines for two open calls per year: November 1 and May 1!Life Science Zurich Graduate School offers more than 100 funded PhD positions. With around 500 research groups and more than 1600 Ph.D. students, the Life Science Zurich ...

Upcoming PhD positions at the IMPRS for Molecular Organ Biology in Autumn 2024

Thanks to all the academics who submitted their application!The application deadline has passed and the selection process started. More information for the new call-out will come up during this Autumn 2024. Stay tuned!PhD Studies in the Heart of E...

Fellow within the team consequences of cancer treatment

PhD Student - Department of Biomedical Molecular Biology

Last application date Jun 30, 2024 00:00Department WE14 - Department of Biomedical Molecular BiologyContract Limited durationDegree Master of Science in Bioscience Engineering, Bioinformatics, Biochemistry and Biotechnology - Major Bioinformatics ...

Job opportunity for a highly motivated PhD researcher in integrative oncology

The research group led by Prof. Dr. Ann Smeets (Surgical Oncology, Department of Oncology, KU Leuven) is seeking a doctoral candidate to strengthen the research team. The research group focuses on ...

PhD Student - Department of Human Structure and Repair

Last application date Jun 02, 2024 00:00Department GE38 - Department of Human Structure and RepairContract Limited durationDegree Master degree in Bioscience engineering, Biochemistry & Biotechnology, Biomedical Sciences, Pharmaceutical Sciences o...

PhD Research position: multi-omics liquid biopsy platform to advance precision cancer medicine.

About the team: The laboratory of Prof. Vermeesch translates and implements novel precision technologies to improve patient care. We use liquid biopsies as a biomarker to monitor and provide early ...

Fully funded PhD position to work on centrosome dynamics

We are looking for a highly motivated student with a strong background in molecular and cell biology, to join our team. We offer a fully funded PhD position, to work on centrosome dynamics and homeostasis of centrosome-associated proteins.The Mike...

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• Institute of Cell Biology
• The Huber Laboratory
• The Vietor Laboratory
• The Vogel Laboratory
• The Schmidt Laboratory
• The Valovka Laboratory
• The Araujo Laboratory
• The Stasyk Laboratory

Open Positions

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Open PhD position at the Institute of Cell Biology, Medical University of Innsbruck, Austria.

A fully funded PhD position is available in the research group of Ilja Vietor at the Institute of Cell Biology , within the PhD program Molecular and Cellular Basis of Diseases (MCBD) at the Medical University of Innsbruck, Austria.

In our recent publication PMID: 37603466 looking for the physiological function of IFRD1 and its orthologue IFRD2 using ubiquitous double knockout mice we identified that IFRD1 and 2 are essential regulators of nutritional fat uptake and adipogenesis.

We are looking for a highly motivated  PhD student  with experience in molecular biology and/or genetic mouse models. The selected candidate will investigate the exact mechanisms of action of IFRD proteins in regulation of fat metabolism and adipogenesis. We will make use of mouse genetic technology, cell culture, mass spectrometry analysis and bioinformatics to study the regulatory mechanisms and new targets of IFRD1 and IFRD2 in the adipogenesis and resistance against diet-induced obesity. The applicant will be involved in generation of novel, tissue-specific knockout mouse strains followed by gene expression profiling and proteomic analyses during the adipogenic differentiation and fat uptake in response to diet and cold treatment. The successful candidate will be integrated into our multidisciplinary team. Good communication skills, independence, and a sense of responsibility are required. English is the working language.

Applications should be addressed to: [email protected]

Applicants should submit: a cover letter, CV, names and contact details of 2 referees. Short listed candidates will be notified and invited for interview.

https://cellbiology.i-med.ac.at/research-groups/the-vietor-laboratory/

https://scholar.google.at/citations?hl=en&user=DlkzUUgAAAAJ

Open PhD position at the Institute of Cell Biology, Medical University of Innsbruck, Austria

We offer 1 fully funded PhD position with immediate effect located at the Institute of Cell Biology, Biocenter, Medical University of Innsbruck and supervised by Ass.-Prof. Georg-Friedrich Vogel (Cell Biology, Paediatrics I). The project is embedded within the PhD program Molecular and Cellular Basis of Diseases (MCBD) at the Medical University of Innsbruck, Austria. This interdisciplinary PhD program addresses the molecular control of metabolism & inflammation and connect basic life science and computational biology with medicine.

To read more about the program and the requirements, please use the following link: https://phd-cbdiseases.i-med.ac.at/

Project: Delineating hepatocytic apical trafficking defects in cholestatic liver disease

In enterocytes, myo5b dependent apical trafficking has been precisely characterised in several studies, including our own. Myo5b interacts with the Rab small GTPases rab8a and rab11a in order to transport cargo vesicles to the apical plasma membrane. There, interaction with the exocyst subunit sec15 allows tethering of the vesicle and subsequent vesicle-plasma membrane fusion is mediated via a SNARE complex formed by vamp8, slp4a, STXBP2 and syntaxin3. The resulting cargo-mislocalisation gives rise to MVIDs enteropathy. Recently, our genetic analysis further identified mutations in STX3 and STXBP2 genes causative for microvillus inclusion disease (MVID).

In hepatocytes however, cargo trafficking to the apical bile canaliculus is understood to a far lesser degree. A study could show that both myo5B and rab11 are required for the formation of bile canaliculi. Defects in the establishment of proper hepatocyte polarity can result in liver disease. Further evidence was published recently showing that only missense, presumably via a dominant-negative effect, rather than nonsense mutations or loss of MYO5B cause MVID associated cholestatic liver disease (CLD). This implies that loss of myo5b does not affect apical trafficking. Furthermore, the apical SNARE protein syntaxin3 seems not be expressed in hepatocytes. How vesicles are shuttled towards the apical plasma membrane, hence the patho-mechanism of myo5b related CLD remains to be elucidated.

We hypothesize that apical cargo trafficking in hepatocytes is orchestrated by a protein machinery of different composition as compared to enterocytes. In order to better understand and develop potential disease modifying compounds, we plan to study the subcellular pathophysiology in detail. This project aims to characterize the several essential constituents of apical cargo transport in hepatocytes:

(i) Which motor protein is responsible for transport of vesicles leaving the Golgi/trans-Golgi compartments? (ii) Which are the vesicle-motor-adaptors involved (e.g. Rab small GTPases)? (iii) What is the composition of the trans-SNARE-complex at the apical face of the hepatocytes (that form the bile canaliculus)? (iv) How does experimental cholestasis match the clinical, serological and histopathological presentation of CLD patients?

The proposed research project will be carried out in the human hepatocyte cell line HepG2 which grows polarised and forms proper bile canaliculi between the cells, and will comprise protein localization and interaction studies, as well as functional assays on proper hepatocyte polarity formation and apical cargo transport.

Contact: [email protected]

Master Thesis: TOPIC: Functional implications of LAMTOR1 phosphorylation

Advisor: Prof Lukas A. Huber and MSc Isabel Singer Institution: Institute of Cell Biology, Biocenter MUI, https://cellbiology.i-med.ac.at/ Contact: [email protected] , [email protected] Start: Any time from March 2023 onwards

Project description:

In recent years, the view of lysosomes as a cellular garbage disposal system has been extended by data underlying its importance in orchestrating cellular metabolism. Lysosomes are crucial for cell growth, proliferation, differentiation and cell-type specific processes, rendering proper lysosomal function indispensable for cellular homeostasis.

Lysosomes harbor a complex nutrient sensing machinery that integrates information about extra- and intracellular nutrient availability and activates corresponding signaling pathways, causing changes in the cell’s metabolic program. The LAMTOR [late endosomal/lysosomal adaptor and MAPK (mitogen-activated protein kinase) and mTOR (mechanistic target of Rapamycin) activator] complex plays a central role in these processes by recruiting and/or activating AMPK (AMP-activated protein kinase), MAPK and mTOR on the lysosomal surface.  

In order to regulate these processes, LAMTOR associates with a number of partners including the Rag-GTPases, SLC38A9, the lysosomal v-ATPase, MEK, BORC, AXIN, LKB1, and many more. We know that some of these associations are mutually exclusive, whereas others occur under the same physiological conditions. We could show in previous work, that phosphorylation of the N-terminus of LAMTOR1 plays a role in regulating these interactions, however the functional trigger(s) for these events and their physiological consequences for the cell remain largely unknown.

The aim of this Master thesis , is to investigate these phosphorylation sites functionally. A large number of cell lines with different mutations are available for this purpose. Methods to be used include biochemical analysis, high resolution microscopy and basic molecular biology techniques.

Requirements: We are looking for motivated young scientists to join our lab at the CCB Innsbruck for their Master thesis. We offer a collaborative lab atmosphere and thorough training in molecular cell biology, protein biochemistry and microscopy.

Master Thesis: TOPIC: A comparative analysis of different mTORopathies

Advisor: Mariana Eca Guimaraes de Araujo Institution: Institute of Cell Biology, Biocenter, Mui, https://cellbiology.i-med.ac.at/ Contact: [email protected] Start: Any time from March 2023 onwards

Most organisms have mechanisms for efficiently transitioning between anabolic and catabolic states, allowing them to survive and grow in environments in which nutrient availability is limited. In mammals, an example of such a mechanism is the signaling network coordinated by mTOR (Mechanistic target of rapamycin). Because mTORC1 triggers a rather resource-intensive anabolic program (growth/mass accumulation and proliferation), cells have evolved mechanisms to ensure that it becomes active only when sufficient resources are available. As such, lysosomal mTORC1 is activated as a coordinated response to amino acids, cholesterol and glucose availability. Despite decades of research, we are only now beginning to unravel the intricate cascade of events that control this cellular gatekeeper.

mTOR is involved in a wide variety of diseases, including cancer, obesity, type 2 diabetes, and neurodegeneration. Moreover, mutations in genes encoding for mTOR regulators (TSC1, TSC2, PTEN, AKT,

GATOR and KICSTOR components) result in a collection of neurodevelopmental disorders commonly known as mTORopathies. These diseases can affect multiple organs, but all have distinct neurological clinical presentations, including mental retardation, autism, and epilepsy.

Despite the mentioned similarities, there are obvious differences between the identified mTORopathies and it remains unclear if these arise from the degree of mTOR hyperactivation or if other deregulated pathways also contribute to the specific phenotypes

The aim of this project is , to perform a detailed comparative characterization of patient fibroblasts with mutations in different mTOR regulators. The analysis will include biochemical, molecular biology and fluorescence imaging methods.

Requirements: We are looking for a highly motivated student with an interest in understanding the pathological mechanisms underlying rare human diseases. We offer a collaborative lab atmosphere and thorough training in molecular cell biology, protein biochemistry and microscopy.  

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PhD position in cell biology

A 3-year PhD position is now available in the Trypanosome Cell Biology unit at the Institut Pasteur (INSERM U1201) in Paris, funded by an “Équipe FRM” grant (starting date 1 st October 2022)

Context. Microtubules are cytoskeletal elements that are central to cell life. Their primary components are tubulins that undergo various post-translational modifications acting as a tubulin code. We wish to investigate a main modification called glutamylation that is over-represented in cilia and flagella. These organelles are composed of 9 doublet microtubules, whose construction takes place at the distal end. New tubulin subunits are delivered to the tip by intraflagellar transport, the movement of protein complexes driven by kinesin and dynein motors 1,2 . This project aims to investigate the significance of tubulin poly-glutamylation in cilia in relationship with kinesin motors. The work will be performed in Trypanosoma brucei, a model organism perfectly suited for the project.

Project . The successful candidate will determine how the code is written by exploiting existing mutant cell lines and developing novel ones. The project relies on our recent breakthrough that allows us to visualise tubulin incorporation in microtubules and to monitor how, where and when tubulin is glutamylated, opening the door to both dynamic and functional studies. The contribution of glutamylation to the control of flagellum assembly and function 3,4 will be scrutinised. The project relies on a combination of imaging (light & electron microscopy, super-resolution, expansion microscopy), reverse genetics (gene replacement/tagging, RNAi), in addition to classic molecular and cellular biology. It will benefit from access to state-of-the-art imaging facilities at the Institut Pasteur, including cryo-electron microscopy.

Host laboratory. The Trypanosome Cell Biology-INSERM U1201 is located at the Institut Pasteur in Paris town centre and is affiliated to the doctoral school “Complexité du Vivant” (CDV, ED515) at Sorbonne Université. The lab investigates trypanosomes both as parasites and as models. More information and a list of recent publications can be found on the lab website and on Twitter .

Candidate profile . The candidates need to have Master degree with some expertise in cell biology. Having worked with trypanosomes and/or cilia is not necessary but will be a bonus.

To apply : Applicants should send their CV, a motivation letter and 3 references in a single pdf file to Philippe Bastin ( [email protected] ) Trypanosome Cell Biology Unit, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris. The application deadline is 30 th June 2022.

References :

• Bertiaux, E., Mallet, A., Fort, C., Blisnick, T., Bonnefoy, S., Jung, J., Lemos, M., Marco, S., Vaughan, S., Trepout, S., et al. (2018). Bidirectional intraflagellar transport is restricted to two sets of microtubule doublets in the trypanosome flagellum. J Cell Biol 217 , 4284-4297. 10.1083/jcb.201805030.
• Bertiaux, E., Mallet, A., Rotureau, B., and Bastin, P. (2020). Intraflagellar transport during assembly of flagella of different length in Trypanosoma brucei isolated from tsetse flies. J Cell Sci 133 . 10.1242/jcs.248989.
• Atkins, M., Tyc, J., Shafiq, S., Ahmed, M., Bertiaux, E., De Castro Neto, A.L., Sunter, J., Bastin, P., Dean, S.D., and Vaughan, S. (2021). CEP164C regulates flagellum length in stable flagella. J Cell Biol 220 . 10.1083/jcb.202001160.
• Bertiaux, E., Morga, B., Blisnick, T., Rotureau, B., and Bastin, P. (2018). A Grow-and-Lock Model for the Control of Flagellum Length in Trypanosomes. Curr Biol 28 , 3802-3814 e3803. 10.1016/j.cub.2018.10.031.

DHVI Faculty Appointments, Promotion, and Tenure - Robert J. Edwards, PhD

The DHVI is pleased to announce that Robert J. Edwards , PhD, has been promoted to the faculty position of associate professor in the Department of Medicine effective November 1, 2021.

Edwards was recently promoted to associate professor. Dr. Edwards graduated from Rice University and obtained his PhD in Cell Biology from Duke University in 1998. He studied state dependent structural transitions in the Z-band of rabbit psoas muscle in Dr. Michael Reedy’s laboratory.  

After receiving his PhD, Edwards returned to Duke in 2007 and was promoted to assistant research professor in the Department of Cell Biology.

In 2017, Edwards joined DHVI and contributed significantly to vaccine development research in the Structural Biology program with his extensive knowledge of negative stain electron microscopy. Edwards’ work is an integral part of the many research projects here at DHVI, notably the recent work in coronavirus research.

We are announcing a part-time position as PhD Student (m/f/d)

Job Information

Offer description.

We are announcing a part-time position as PhD Student (m/f/d) in the Research group Immunology and Cell Biology. Topic: Regulation of the human proteasome network under mitochondrial protein import stress

The successful candidate will work at the Research Center Borstel – Leibniz Lung Center (RCB) in a joint collaborative research project with the Universities in Göttingen and Regensburg. The project is part of the newly funded priority program of the German Research Foundation (DFG) on “Integration of mitochondria into the cellular proteostasis network” (SPP 2453). The RCB is an internationally renowned research institute with more than 380 employees and cutting-edge technologies, financed by the Leibniz Alliance. It is located in close proximity to Hamburg in Northern Germany. The RCB offers its PhD students a structured graduate program within the Borstel Biomedical Research School (BBRS) ensuring optimal training and peer-networking in an international setting.

PROJECT DESCRIPTION Mitochondria play a vital role in human metabolism, and their well-functioning is required to keep the cellular proteostasis network in balance. Impaired import of nuclear encoded mitochondrial proteins results in the accumulation and aggregation of precursors in the cytosol triggering cellular stress that eventually leads to human disorders. To counteract mitochondrial precursor accumulation, the proteasome is activated for efficient degradation of mislocalized precursors. In this project, we will systematically investigate the human proteostasis network activated during acute import stress. Specifically, we will identify the molecular nature of adaptive proteasome changes and how they contribute to the resolution of mitochondrial import stress using genetic, cell biological, biochemical and mass spectrometry based advanced methodologies.

YOU: • are an M. Sc. (or equivalent) in natural or life sciences with a strong background in molecular and cell biology and/or biochemistry • have very good command of the English language • are an independent and creative thinker • are ambitious, have high motivation and scientific enthusiasm • uphold ethical values and scientific research conduct • are motivated to make your contribution to scientific discoveries

WE: • are a workplace located in a top-class research center close to Hamburg • do top notch translational research to develop innovative concepts for diagnosis and therapy of chronic lung diseases • offer you an international, ambitious, and productive lab, personal mentoring, international networking and a great team spirit • pay you according to TVöD-VKA (65%) incl. all benefits usually offered in the public sector • provide family-friendly working conditions including childcare, accommodation on campus and flexible working hours

The Research Center Borstel is an equal opportunity employer that actively supports inclusivity and diversity. We are certified by audit berufundfamilie. We encourage female candidates to apply and will treat them favorably in case of equal qualifications. Disabled applicants with equal qualifications will be preferred. For more information about our certifications, please visit our homepage.

If you have any questions, please do not hesitate to contact Prof. Dr. Silke Meiners ( [email protected] ). Please apply with the usual documents (without photo) by 01.07.2024 on our website www.fz-borstel.de .

For us, your age, gender and sexual identity, your world view, your ethnicity or a handicap are not important. We are solely interested in your knowledge and skills and your ability to work in a team. If attractive work content and a solution- oriented approach are more important to you than formalities, you are in the right place!

Requirements

Additional information, work location(s), where to apply.