vitamin d

Oct 26, 2014

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Vitamin D. Vitamin D. Vitamin D is not strictly a vitamin, since it can be synthesized in the skin, and synthesis into a vitamin.

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  • dietary vitamin
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  • vitd 3 cholecalciferol
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Vitamin D • Vitamin D is not strictly a vitamin, since it can be synthesized in the skin, and synthesis into a vitamin. • it is only when sunlight exposure is inadequate that a dietary source is required. Its main function is in the regulation of calcium absorption and homeostasis; most of its actions are mediated by nuclear receptors that regulate gene expression. • Deficiency, leading to rickets in children and osteomalaciain adults, continues to be a problem in countries where sunlight exposure is poor.

Sources • Liver, beef, veal, eggs yolk , dairy products , some saltwater fish (salmon, tuna and sardine). • Fortified food (milk, yogurt, cheese, margarine, orange juice, breads and cereals). • It is stable in cooking and storage. • Synthesis in skin. 2009 Cengage-Wadsworth

Vitamin D • The normal dietary form of vitamin D is cholecalciferol (also known as calciol). • This is also the compound that is formed in the skin by ultraviolet (UV) irradiation of 7-dehydrocholesterol. • Some foods are enriched or fortified with (synthetic) ergocalciferol, which undergoes the same metabolism as cholecalciferoland has the same biological activity.

International unit • Like vitamin A, vitamin D was originally measured in international units of biological activity before the pure compound was isolated: • 1 IU = 25 ng of cholecalciferol • 1 μg of cholecalciferol = 40 IU.

Vitamin D Chemical nature and properties ﹡types:VitD2(Ergocalciferol) VitD3(Cholecalciferol) ﹡pro-VitD2:Ergosterol Pro-VitD3: 7-hydro-cholesterol Ergosterol→VitD2 cholesterol→7-hydro cholesterol→VitD3 ﹡active form of VitD3: 1, 25- (OH)2-VitD3 transportation: DBP

Absorption and metabolism • Vitamin D is absorbed in lipid micelles and incorporated into chylomicrons; therefore, people on a low fat diet will absorb little of such dietary vitamin D as is available. • Indeed, it is noteworthy that at the time that rickets was a major public health problem in Scotland, herrings (a rich source) were a significant part of the diet: it can only be assumed that the diet was so low in fat that the absorption of the vitamin was impaired.

Synthesis of vitamin D in the skin • The steroid 7-dehydrocholesterol (an intermediate in the synthesis of cholesterol that accumulates in the skin but not other tissues) undergoes a non-enzymic reaction on exposure to UV light, yielding previtamin D, which undergoes a further reaction over a period of hours to form cholecalciferol, which is absorbed into the bloodstream.

Synthesis of vitamin D in the skin • Structurally, Vitamin D is derived from a steroid. • It contains 3 intact rings (A,C and D) with a break between carbon 9 and 10 in the B ring. • The steroid 7- dehydrocholestrol is synthesized and secreted on the skin surface. • The conjugated double bonds (5-7) B allow the absorption of UV light. • In the skin with UV cause ring B opining and forming previtamin D3, followed by rearranged to D3 (cholcalciferol).

Synthesis of vitamin D in the skin • In temperate climates there is a marked seasonal variation in the plasma concentration of vitamin D; it is highest at the end of summer and lowest at the end of winter. • The synthesis of cholecalciferol is low in winter. By contrast, in summer, when the sun is more or less overhead, there is a considerable amount of UV light even on a moderately cloudy day, and enough can penetrate thin clothes to result in significant formation of vitamin D. • In northerly climates, and especially in polluted industrial cities with little sunlight, people may well not be exposed to enough UV light to meet their vitamin D needs, and they will be reliant on the few dietary sources of the vitamin.

Regulation of vitamin D metabolism • The main function of vitamin D is in the control of calcium homeostasis and, in turn, vitamin D metabolism in the kidney is regulated, at the level of 1 or 24-hydroxylation, by factors that respond to plasma concentrations of calcium and phosphate. • In tissues other than the kidney that hydroxylatecalcidiolto calcitriol, the enzyme is not regulated in response to plasma calcium.

Regulation of vitamin D metabolism ● Calcitriol acts to reduce its own synthesis and increase formation of 24-hydroxycalcidiol, by regulating the expression of the genes for the two hydroxylases. ● Parathyroid hormone is secreted in response to a fall in plasma calcium. In the kidney it acts to increase the activity of calcidiol 1-hydroxylase and decrease that of 24-hydroxylase. In turn, both calcitriol and high concentrations of calcium repress the synthesis of parathyroid hormone; calcium also inhibits the secretion of the hormone from the parathyroid gland.

Regulation of vitamin D metabolism • Calcium exerts its main effect on the synthesis and secretion of parathyroid hormone. However, calcium ions also have a direct effect on the kidney, reducing the activity of calcidiol 1-hydroxylase. ● Phosphate also affects calcidiolmetabolism; throughout the day there is an inverse fluctuation of plasma phosphate and calcitriol, and feeding • people on a low-phosphate diet results in increasedcirculating concentrations of calcitriol.

Absorption, transport & storage • Cholecalciferol diffuses from the skin into the blood. • It is transported in the blood by vitamin D binding protein (DBP) (transcalciferin) that is synthesized in the liver. • Dietary vitamin D3 (cholecalceferol) is absorbed from a micelle, in association with fat and with the aid of bile salts, in the intestinal cell. • About 50% of dietary vitamin D3 is absorbed. • The rate if absorption is the most rapid in the duodenum, but the largest amount is absorbed in the distal small intestine.

Absorption, transport & storage • In the intestinal cell: vitamin D is incorporated primarily into chylomicrons, which then enter the lymphatic system with subsequent entry into the blood. • In the blood: Chylomicrons transport around 40% of the cholecalciferol. • Some vitamin D may be transferred from the chylomicron to DBP for delivery to extrahepatic tissues.

Absorption, transport & storage • Cholecalciferol, which slowly diffuse from the skin into the blood, is picked up for transport by DBP . • About 60% of plasma cholecalciferol is bond to DBP for transport. • The vitamin D-DBP complex travels primarily to the liver but may be picked up by other tissues, especially muscle and adipose tissue, before hepatic uptake. • Cholecalciferol reaching the liver either by chylomicron remnant or by DBP typically is metabolized by a couple of different hydrolases to generate active form of the vitamin.

Absorption, transport & storage • In the liver: 25- hydroxylase functions in the mitochondria to hydroxylatecholecalciferol at carbon 25 to form 25-OH (vitamin) D3 (25-OH cholecalciferol). • The efficiency of the liver 25-hydroxylase appears to be related to vitamin D concentrations and its metabolites. • Liver expresses most of 25-hydroxylase, but the enzyme is found also in other organs (lungs, intestine & kidneys).

Vitamin d - Metabolism Synthesis of active form of vitamin D

1- α- hydroxylase

Metabolic functions of vitamin D • The principal function of vitamin D is to maintain the plasma concentration of calcium; calcitriol achieves this in three ways: ● increased intestinal absorption of calcium ● reduced excretion of calcium by stimulating resorption • in the distal renal tubules (due to increased vit. D synthesis)

Metabolic functions of vitamin D ● mobilization of bone mineral. synthesis and secretion of insulin, parathyroid, and thyroid hormones; ● inhibition of production of interleukin by activated T-lymphocytes and of immunoglobulin by activated • B-lymphocytes; differentiation of monocyte precursor cells; ● modulation of cell differentiation, proliferation and • apoptosis.

Vitamin D deficiency:rickets and osteomalacia Historically, rickets is a disease of toddlers, especially in northern industrial cities. Their bones are undermineralized as a result of poor absorption of calcium in the absence of adequate amounts of calcitriol. When the child begins to walk, the long bones of the legs are deformed, leading to bow-legs or knock knees. More seriously, rickets can also lead to collapse of the ribcage and deformities of the bones of the pelvis. Similar problems may also occur in adolescents who are deficient in vitamin D during the adolescent growth spurt, when there is again a high demand for calcium for new bone formation.

Vitamin D deficiency:rickets and osteomalacia • Osteomalacia is the adult equivalent of rickets. It results from the demineralization of bone, rather than the failure to mineralize it in the first place, as is the case with rickets. • Women who have little exposure to sunlight are especially at risk from osteomalacia after several pregnancies, because of the strain that pregnancy places on their marginal reserve of calcium. • Osteomalacia also occurs in the older people. The problem may be inadequate exposure to sunlight, but there is also evidence that the capacity to form 7-dehydrocholesterol in the skin decreases with advancing age, so that older people are more reliant on the few dietary sources of vitamin D.

Interactions with drugs and other nutrients • Iron deficiency decreases in vitamin D absorption. • The interaction of calcitriol and vitamin K dependent protein. 2009 Cengage-Wadsworth

Toxicity • Tolerable upper intake level 50µg (2.000IU) per day. • Sign and symptoms: • Over absorption of calcium (hypercalcemia), increase calcium execration. • Calcium deposits in kidneys, heart and blood vessels. • In infants: anorexia, nausea, vomiting hypertension. 2009 Cengage-Wadsworth

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Home PowerPoint Templates PowerPoint Themes PhD Dissertation PowerPoint Template

PhD Dissertation PowerPoint Template

Research Image Background Cover

The PhD Dissertation PowerPoint Template provides a professional structure and layouts designed for dissertation presentations. A dissertation is the work submitted to support the conclusion of an academic degree or professional qualification, presenting the author’s research and findings in an area of study. The PhD Dissertation PowerPoint Template is designed as an academic presentation slide deck where the PhDc will compile it work in a supporting document of their message.

The educational PowerPoint template of PhD dissertation contains 9 slides, with diagrams, charts, and shapes for describing your research and thesis. These PowerPoint templates will help prepare a compelling dissertation defense. The comprehensive slide deck of dissertation covers a structured approach of documentation. All the diagrams and data charts will be useful for documenting a PhD dissertation following the traditional sections structure:

  • Abstract – Discuss the abstract model of what you are trying to prove. Implemented as a Text slide with abstract background graphics
  • Introduction – A background of work, basic terminologies, and problem description. The layout is created as an Hexagon picture including placeholders and the dissertation presentation agenda theme.
  • Literature Review – Discuss related work, analysis, and interpretation. Designed as 4 segments with infographic icons to discuss thesis literature.
  • Methodology – Describe the methodology used in your research. You can use the 4 steps curved timeline diagram for the research model.
  • Research Findings – It involves proof of model, type of study and tools to gather supporting data. Magnifying glass 4 steps puzzle diagram research metaphor
  • Results – Data collected from various sources and analysis for proof of thesis. Custom stacked data-driven chart template for reports
  • Discussion – 4 sections to display presentation discussion points
  • Conclusion – 6 sections for research questions, answers, contribution, and future work

Every dissertation has its specifics, but this structure will help you diagram your presentation, following best practices. You will be able to tell your dissertation story in a compelling way, which will engage your audience.

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How to create a great thesis defense presentation: everything you need to know

Get your team on prezi – watch this on demand video.

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Anete Ezera April 13, 2024

Ready to take on your thesis defense presentation? It’s not just about wrapping up years of study; it’s your moment to share your insights and the impact of your work. A standout presentation can make all the difference. It’s your chance to highlight the essentials and really connect with your audience.

This is where Prezi comes into play. Forget about flipping through slide after slide. With Prezi, you craft a narrative that pulls your audience in. It simplifies the complex, ensuring your key points hit home. Let’s explore how Prezi can help transform your thesis defense into a successful presentation.

Public speaker at science convention.

What is a thesis defense presentation and why are they needed? 

Whether you’re preparing for a master’s thesis defense or a Ph.D. thesis defense, this final step in your academic journey is the one with the most significance, as it dramatically influences your final grade. It’s also your chance to display the dedication and effort you’ve put into your research, a way to demonstrate how significant your work is. 

So, why is this such a big deal? A good presentation helps convince your teachers that your research is solid and makes a difference in your field. It’s your time to answer questions, show that your research methods were sound, and point out what’s new and interesting about your work. In the end, a great thesis defense presentation helps you finish strong and makes sure you leave a lasting impression as you wrap up this chapter of your academic life.

Best practices for making a successful thesis defense presentation 

In order to craft a standout thesis defense presentation, you need to do more than just deliver research findings. Here are some key strategies to ensure success, and how Prezi can play a crucial role in elevating your presentation.

Start with a strong introduction

Kick-off with an engaging introduction that lays out your research question, its significance, and your objectives. This initial segment grabs attention and sets the tone. Using Prezi’s zoom feature can make your introduction pop by visually underscoring key points, helping your audience grasp the importance of your work right from the start.

Organize your presentation clearly

A coherent structure is essential for guiding your audience through your thesis defense presentation. Prezi can help by offering a map view of your content’s layout upfront, providing a clear path through your introduction, methodology, results, and conclusion. This clarity keeps your audience engaged and makes your arguments easier to follow.

Incorporate multimedia elements

Adding multimedia elements like videos, audio clips, and animations can greatly improve the appeal of your thesis defense presentation. Prezi supports the seamless integration of these elements, allowing you to bring your research to life in a more vibrant and engaging way. Videos can serve as powerful testimonials or demonstrations, while animations can help illustrate complex processes or changes over time. This variety keeps your audience engaged and helps convey your message in a more exciting way.

Smiling african woman giving presentation at startup. Happy female professional standing in front of a large television screen with a graph.

Simplify complex data

Your findings need to be presented in a way that’s easy for your audience to understand. Prezi shines here, with tools that transform intricate data into clear, engaging visuals. By implementing charts and graphs into your presentation, you can make your data stand out and support your narrative effectively.

Engage your audience

Make your thesis defense a two-way conversation by interacting with your audience. Whether it’s through questions, feedback, or direct participation, engagement is key. Prezi allows for a flexible presentation style, letting you navigate sections in response to audience input, creating a dynamic and engaging experience.

Highlight key takeaways

Emphasize the key takeaways of your research throughout your presentation to ensure your audience grasps the most critical aspects of your work. With Prezi, you can use spotlighting and strategic zooming to draw attention to these takeaways, making them stand out. This method helps reinforce your main points, ensuring they stick with your audience long after your presentation concludes. By clearly defining what your audience should remember, you guide their understanding and appreciation of your research’s value and implications.

Practice makes perfect

Confidence in delivery comes from thorough practice. Familiarize yourself with every aspect of your thesis defense presentation, including timing, voice control, and gestures. Prezi Video is a great tool for rehearsing, as it allows you to blend your presentation materials with your on-camera performance, mirroring the live defense setting and helping you polish your delivery.

Cropped shot of a businesswoman delivering a speech during a conference

End with a lasting impression

Conclude your presentation powerfully by summarizing your main findings, their implications, and future research directions. Prezi’s ability to zoom out and show the big picture at your conclusion helps reinforce how each section of your presentation contributes to your overall thesis, ensuring your research leaves a memorable impact on your audience.

By using these tips and taking advantage of what Prezi offers, you can make your thesis defense presentation really stand out. It’ll not only hit the mark with your audience but also clearly show why your research matters.

Meeting tight deadlines with Prezi 

Facing a looming deadline for your thesis defense presentation? Prezi offers smart solutions to help you create a polished and engaging presentation quickly, even if it feels like you’re down to the wire.

A closer look at Prezi AI features

Prezi AI is a standout feature for those pressed for time. It assists in structuring your presentation efficiently, suggesting design elements and layouts that elevate your content. This AI-driven approach means you can develop a presentation that looks meticulously planned and executed in a fraction of the time it would normally take. The result? A presentation that communicates the depth and value of your research clearly and effectively, without the last-minute rush being evident. Here’s what Prezi AI can do:

  • Streamlined creation process: At the core of Prezi’s efficiency is the AI presentation creator . Perfect for those last-minute crunch times, it’s designed to tackle tight deadlines with ease.
  • Easy start: Kick off your presentation creation with just a click on the “Create with AI” button. Prezi AI guides you through a smooth process, transforming your initial ideas or keywords into a structured and visually appealing narrative.
  • Visual impact: There’s no need to dive deep into design details. Simply provide some basic input, and Prezi AI will craft it into a presentation that grabs and holds your audience’s attention, making your thesis defense visually compelling.
  • AI text editing: Spending too much time fine-tuning your message? Prezi AI text editing features can help. Whether you need to expand on a concept, clarify complex terms, or condense your content without losing impact, Prezi AI streamlines these tasks.
  • Content refinement: Adjust text length for deeper explanation, simplify language for better understanding, and ensure your presentation’s content is precise and to the point. Prezi AI editing tools help you refine your message quickly, so you can focus on the essence of your research.

Using Prezi Video for remote thesis defense presentations

For remote thesis defenses, Prezi Video steps up to ensure your presentation stands out. It integrates your on-screen presence alongside your presentation content, creating a more personal and engaging experience for your audience. This is crucial in maintaining attention and interest, particularly in a virtual format where keeping your audience engaged presents additional challenges. Prezi Video makes it seem as though you’re presenting live alongside your slides, helping to simulate the in-person defense experience and keep your audience focused on what you’re saying.

Prezi Video

Using these advanced Prezi features, you can overcome tight deadlines with confidence, ensuring your thesis defense presentation is both impactful and memorable, no matter the time constraints.

The Prezi experience: what users have to say 

Prezi users have shared compelling insights on how the platform’s unique features have revolutionized their presentations. Here’s how their experiences can inspire your thesis defense presentation:

Storytelling with Prezi

Javier Schwersensky highlights the narrative power of Prezi: “This is a tool that is going to put you ahead of other people and make you look professional and make your ideas stand out,” he remarks. For your thesis defense, this means Prezi can help you craft a narrative that not only presents your research but tells a story that captures and retains the committee’s interest.

Flexibility and creativity

Tamara Montag-Smit appreciates Prezi for its “functionality of the presentation that allows you to present in a nonlinear manner.” This flexibility is key in a thesis defense, allowing you to adapt your presentation flow in real time based on your audience’s engagement or questions, ensuring a more dynamic and interactive defense.

The open canvas

Vitek Dočekal values Prezi’s open canvas , which offers “creative freedom” and the ability to “create a mind map and determine how to best present my ideas.” For your thesis defense, this means Prezi lets you lay out and show off your work in a way that makes sense and grabs your audience’s attention, turning complicated details into something easy and interesting to follow.

Engagement and retention

Adam Rose points out the engagement benefits of Prezi: “Being able to integrate videos is extremely effective in capturing their attention.” When you need to defend a thesis, using Prezi to include videos or interactive content can help keep your committee engaged, making your presentation much more memorable.

These real insights show just how effective Prezi is for crafting truly influential presentations. By incorporating Prezi into your thesis defense presentation, you can create a defense that not only shows how strong your research is but also leaves a lasting impression on your audience.

Thesis defense presentations for inspiration 

Prezi is much more than a platform for making presentations; it’s a place where you can find inspiration by browsing presentations that other Prezi users have made. Not only that, but Prezi offers numerous templates that would be useful for thesis defense presentations, making the design process much easier. Here are a few examples that you may find helpful: 

Research project template by Prezi 

This Prezi research project template stands out as an ideal choice for thesis defense presentations due to its well-structured format that facilitates storytelling from start to finish. It begins with a clear introduction and problem statement, setting a solid foundation for the narrative. The inclusion of sections for user research, interviews, demographics, and statistics allows for a detailed presentation of the research process and findings, which are crucial when defending a thesis. 

Visual elements like user mapping and journey maps help make complex information understandable and engaging, which is crucial for maintaining the committee’s attention. Additionally, addressing pain points and presenting prototypes showcases problem-solving efforts and practical applications of the research. The template culminates in a conclusion that ties everything together, emphasizing the research’s impact and future possibilities. Its comprehensive yet concise structure makes it an excellent tool for communicating the depth and significance of your work in a thesis defense.

Civil rights movement Prezi

This Prezi on the Civil Rights Movement exemplifies an effective thesis defense presentation by seamlessly blending structured content, multimedia enhancements, and dynamic navigation. It organizes information into coherent sections like “About,” “Key Events,” and “Key People,” offering a comprehensive view ideal for a thesis presentation. The strategic use of videos adds depth, providing historical context in a dynamic way that text alone cannot, enhancing the audience’s engagement and understanding. 

Furthermore, Prezi’s open canvas feature brings the narrative to life, allowing for a fluid journey through the Civil Rights Movement. This method of presentation, with its zooming and panning across a virtual canvas, not only captivates but also helps to clarify the connections between various elements of the research, showcasing how to effectively communicate complex ideas in a thesis defense.

AI-assisted history template

This AI-assisted presentation template stands out as a great choice for thesis defense presentations, especially for those rooted in historical research. By merging striking visuals with rich, informative content, you can use this template to craft a narrative that breathes life into past events, guiding the audience on an engaging journey through time. Its sequential storytelling approach, empowered by Prezi AI , ensures a smooth transition from one historical point to the next, demonstrating the depth and continuity of your research. This template showcases Prezi AI’s capability to enhance narrative flow. By integrating advanced visuals and text, it captivates audiences and makes it an invaluable tool for presenting complex historical theses in a clear, compelling way.

Master your final grade with a Prezi thesis defense presentation 

Preparing for a thesis defense, whether for a master’s or Ph.D., is a pivotal moment that significantly influences your final grade. It’s your platform to demonstrate the dedication behind your research and its importance in your field. A well-executed presentation convinces your educators of your research’s validity and your ability to bring fresh perspectives to light.

To craft a successful thesis defense presentation, Prezi’s innovative features can be a game-changer. Prezi can empower you to transform presentations into captivating stories and provide you with the flexibility and creative freedom needed to make your presentation an outstanding success. Incorporating videos or utilizing Prezi’s non-linear presentation style can keep your committee engaged and emphasize your research’s significance.

Prezi also serves as a hub of inspiration, offering templates perfect for thesis defenses. From structured research project templates to dynamic historical narratives, Prezi provides tools that communicate your thesis’s depth and significance effectively, ensuring you leave a memorable impact on your audience. So, it’s time to revamp your thesis defense presentation and change it from dull to inspirational with Prezi. 

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Embedd Excel workbook in PPT and modify while presenting

Hi everyone, I have this small economic model that changes according to certain inputs. It is an Excel with some worksheets. I embedded the file in PowerPoint and I display certain bits from the worksheets. If I change data in the input section in Excel, the data on my PPT will also update. I want this to happen also in presentation mode. I want the user to be able to modify the model while presenting, without going through too many steps, cause as of now, the only solution I found is to have the Excel open on one screen, change the data, go on the PPT(the editing window, not the presentation window) and manually updated the excel components by right-clicking and selecting "Update". Is there any other way to embed a similar object or an excel file into a presentation? I can't seem to find anything that works.

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  • Microsoft Agent |

Dear Alexandru Popescu,

I understand your concern and to my knowledge, I would like to convey that there is no setting or feature in the PowerPoint to update the links in the presentation mode.

I agree with you having the ability to update the links in the PowerPoint presentation automatically during the presentation mode in the PowerPoint will benefit the users and I suggest you to add your valuable idea as a feedback in the  PowerPoint · Community (microsoft.com)  which is the best place to share our ideas and improve the Microsoft PowerPoint product.

In addition, I believe your requirement can be achieved with the help of the VBA, I request you give a shot by posting your concern in the Office 365 VBA community to get the detailed help from the Office 365 VBA experts. Reference:  Office VBA support and feedback | Microsoft Learn

In addition, I will keep this thread open so that PowerPoint MVPs and experts in this community can share their ideas on this requirement.

Appreciate your patience and understanding. Have a great day!!

Best Regards,

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