The Wobble Hypothesis: Definition, Statement, Significance
The wobble hypothesis states that the base at 5′ end of the anticodon is not spatially confined as the other two bases allowing it to form hydrogen bonds with any of several bases located at the 3′ end of a codon. This leads to the following conclusions: 1. The first two bases of the codon make normal …
The Wobble Hypothesis: Importance and Examples
Learn how the wobble hypothesis explains the degeneracy of codons and the flexibility of codon-anticodon interactions in protein synthesis. See examples of wobble base pairing …
The Wobble Hypothesis
The wobble hypothesis, proposed by Francis Crick in 1966, provides an explanation for the flexibility observed in the genetic code’s translation process. This hypothesis focuses on the base-pairing rules …
Celebrating wobble decoding: Half a century and still much is new
A simple post-transcriptional modification of tRNA, deamination of adenosine to inosine at the first, or wobble, position of the anticodon, inspired Francis Crick's Wobble Hypothesis 50 years ago.
Wobble base pair
In the genetic code, there are 4 = 64 possible codons (three-nucleotide sequences). For translation, each of these codons requires a tRNA molecule with an anticodon with which it can stably complement. If each tRNA molecule is paired with its complementary mRNA codon using canonical Watson-Crick base pairing, then 64 types of tRNA molecule would be required. In the standard genetic code, three of these 64 mRNA codons (UAA, UAG and UGA) are stop codons…
Novel base-pairing interactions at the tRNA wobble position
The ‘modified wobble hypothesis’ suggested that specific tRNA base modifications evolved to discriminate particular codons—expanding and facilitating an ability of …
Wobble hypothesis
Learn about the wobble hypothesis proposed by Crick to explain how tRNA can recognize more than one codon with wobbling in base pairing. See the pairing relationships between anticodon and codon bases and their …
What is Wobble Hypothesis?
Wobble occurs at position 1 of the anti-codon and position 3 of the codon. The wobble hypothesis states that the third position (3’) of the codon on mRNA and the first position (5’) of the anticodon on tRNA are bound less tightly than the …
Genetic Code
Wobble Hypothesis Crick (1966) presented the wobble hypothesis to explain the potential origin of codon degeneracy (wobble means to sway or move unsteadily). Given that there are 61 codons that specify amino acids, the …
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The wobble hypothesis states that the base at 5′ end of the anticodon is not spatially confined as the other two bases allowing it to form hydrogen bonds with any of several bases located at the 3′ end of a codon. This leads to the following conclusions: 1. The first two bases of the codon make normal …
Learn how the wobble hypothesis explains the degeneracy of codons and the flexibility of codon-anticodon interactions in protein synthesis. See examples of wobble base pairing …
The wobble hypothesis, proposed by Francis Crick in 1966, provides an explanation for the flexibility observed in the genetic code’s translation process. This hypothesis focuses on the base-pairing rules …
A simple post-transcriptional modification of tRNA, deamination of adenosine to inosine at the first, or wobble, position of the anticodon, inspired Francis Crick's Wobble Hypothesis 50 years ago.
In the genetic code, there are 4 = 64 possible codons (three-nucleotide sequences). For translation, each of these codons requires a tRNA molecule with an anticodon with which it can stably complement. If each tRNA molecule is paired with its complementary mRNA codon using canonical Watson-Crick base pairing, then 64 types of tRNA molecule would be required. In the standard genetic code, three of these 64 mRNA codons (UAA, UAG and UGA) are stop codons…
The ‘modified wobble hypothesis’ suggested that specific tRNA base modifications evolved to discriminate particular codons—expanding and facilitating an ability of …
Learn about the wobble hypothesis proposed by Crick to explain how tRNA can recognize more than one codon with wobbling in base pairing. See the pairing relationships between anticodon and codon bases and their …
Wobble occurs at position 1 of the anti-codon and position 3 of the codon. The wobble hypothesis states that the third position (3’) of the codon on mRNA and the first position (5’) of the anticodon on tRNA are bound less tightly than the …
Wobble Hypothesis Crick (1966) presented the wobble hypothesis to explain the potential origin of codon degeneracy (wobble means to sway or move unsteadily). Given that there are 61 codons that specify amino acids, the …