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MD PhD Essay: The Ultimate Guide

MD-PhD programs  combine medical school training with the demands of scientific research. Graduates of these hybrid programs can pursue a variety of career paths, but the ultimate goal of MD PhD programs is to train physician-scientists. The MD PhD program is a long and difficult process, lasting between seven to eight years. On top of your personal statement and  AMCAS Work and Activities  section, you will have to submit two additional essays through AMCAS: The Significant Research Experience Essay and the MD PhD Essay. Many applicants find the MD PhD essay quite challenging since it lacks the definitive expectations of the research experience essay. So in today's blog, you'll learn exactly how to write a strong MD PhD essay.

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Article Contents 15 min read

What is the md phd essay and what is its purpose.

MD PhD admissions offices seek to ensure that the students they admit are ready to commit to many years of rigorous training and study. If you want to apply to MD PhD vs MD programs, keep in mind that there is more work involved in the application process as you'll have two additional essays to complete. The MD PhD essay is a unique component of the application process and it's where you'll discuss your reasons behind pursuing the joint program.

To understand what admissions committees are looking for in this essay, you need to first understand what kind of professionals they are hoping to train. A physician-scientist values medical research and progress above other elements of the medical profession. They will most likely spend their time in clinical settings, but mainly in relation to their research. Due to the large emphasis on research, clinical care is not their primary role. Research, discovery, and the application of new knowledge is their main interest. With this said, their research still directly involves clinical work and patient well-being, otherwise, they could have simply pursued a PhD. This intricate balance between research and medicine must be demonstrated in your MD PhD essay, with a larger emphasis on research.

Your MD PhD essay must show that you wouldn’t be satisfied with a career that didn't involve both medical research and clinical practice. You must demonstrate that pursuing just one or the other is not right for you. Your essay should not make you appear indecisive, as if you cannot choose between MD and PhD programs. Instead, you must show that you will be most fulfilled working as a physician-scientist. Overall, your essay must answer the question “Why did you choose the combined MD PhD program?”

Research experience

Your MD PhD essay should tell the story of how you became involved in scientific research and how you want to apply this research to medical practice. Your personal statement, research essay, and your MD PhD essay may sometimes touch upon the same experiences, but you will want to approach each of them from different angles. While your personal statement typically focuses on how you came to medicine in general, your MD PhD essay should answer how your interests and qualifications combine science and medical practice. Have a look at our blog if you're looking for medical school personal statement examples .

Admissions committees are looking for certain qualities and experiences in their applicants. Every scientist should possess creativity and curiosity. Maturity and critical thinking are also essential, as MD PhD applicants will have to face unexpected problems and challenges during training and throughout their careers. Other valuable qualities include grit, initiative, academic prowess, and of course, a love of research. If you don't like research, then the joint program is definitely not for you! Many MD PhD programs aim to prepare future leaders of research initiatives and projects. Your essay does not need to dive into the fine details of your research experiences but you should highlight 2-3 experiences that were significant while discussing what you learned from them. Demonstrating perseverance is also key since the scientific method is often a repetitive and frustrating process. It’s perfectly acceptable to highlight any setbacks you experienced during the research process as long as you can speak to how you overcame these challenges and what you learned in doing so.

Remember, your MD PhD essay is a tough balancing act. While it is important to describe your solid research background throughout your application, if all your application components focus only on research, you may have a problem. This would be great for someone who wants to pursue a PhD, but research only experience is not suitable if you want to pursue a combined program. Your MD PhD essay must show a crossover between your scientific research and the experiences you have had working with patients and physicians. For example, you could show that your research is inspired by clinical experience or you could discuss a significant patient interaction during your experience working in a clinical setting. Your interest in MD PhD programs may also be inspired by your concern for the medical issues facing your community, your country, or the world.

Why you are pursuing the joint program

The MD PhD essay is the only component of your application process which directly questions your passion for the combination of the two fields. Make sure that your MD PhD essay and Significant Research Experience Essay are not the same. You have a small amount of space to express your desire to become a physician-scientist, so do not waste it by repeating the same information in all your application components. The Significant Research Experience Essay is where you’ll include all the details of your research experience such as your exact duties, results, and where and with whom you conducted your research.

Use your MD PhD essay to show a larger picture. Admissions offices want to see evidence of problem-solving, maturity, independence, and your level of involvement in a project. Think about how your research experiences foster your scientific curiosity. The MD PhD essay is your chance to show admissions committees the important steps of your journey to the MD PhD program. This is your chance to describe components of your experiences and plans, which might not be evident from your other application materials.

Avoid including cliché topics or phrases in your essay. Many applicants indeed have similar stories of how they became interested in the medical profession. While these reasons may be common, your experiences are unique. Your essay must stand out and leave a lasting positive impression on the reader. Similarly, do not include grand statements linking your choice to enter the MD PhD program to destiny. These will only come across as dramatic, which isn't what you want to convey.

Remember not to describe any negative experiences and their effect on your decision to apply to MD PhD programs. For example, don't discuss how you believe that the academic job market does not look promising for a PhD graduate. Discussing failures in research however, is different, and can be a great way to demonstrate resilience. Frustrating experiences in research are common, so rather than describing the negative aspect of your failures in research, try to describe how this experience positively affected your journey.

Another thing you must avoid in your MD PhD essay is listing accomplishments and skills that are already found in your CV. Your personal statement is not meant to be a reiteration of your CV, instead, it should be your story – one that you will share with the admissions committees. Take them on a journey, in chronological order, highlighting the significant experiences that have led you to want to pursue both medicine and research. With each experience, you must reflect on what you've learned and you need to provide evidence to support any statements. It's not enough to simply state “I demonstrated compassion volunteering at a homeless shelter”. You must show the admissions committees how you demonstrated compassion. For example, you could discuss a specific interaction you had, or a specific project you worked on that demonstrates your ability to show compassion.

What to avoid in your MD-PhD essay:

Your MD-PhD essay should be a story! Avoid simply listing what is already in your CV. "}]" code="timeline1">

Check out our video for some more tips on how to write the MD PhD essay:

How to Structure your MD PhD essay

If you’re applying to MD PhD programs through AMCAS, the MD PhD essay must be no longer than 3000 characters, typically, one page in length. Your essay must be well structured and it's important to avoid any fluff or unnecessarily descriptive language. It must be succinct while containing all the necessary information to make a complete impression of your candidacy. Overall, it should follow the structure of an academic essay and should contain an introduction, body paragraphs, and conclusion.

Successful essays will have a powerful introduction, which will introduce the reader to the main message of the letter – your motivation for pursuing the joint program. The opening sentence, in particular, can make or break your entire essay. If it isn’t captivating, unique, and interesting, you risk losing the reader’s attention, which could result in your essay blending in with the thousands of other essays.

To create a unique opening sentence, considering beginning your essay with a personal anecdote. Essentially, you could narrate a personal experience or story that introduces the topic – this is a very common technique in personal essays and it's very effective. For example, you could talk about a time you were ill, an exciting moment during your research, an encounter with the medical system, or even a story of a loved one who was ill or passed away. If you had a specific experience or revelatory “aha” moment, where all of a sudden you just knew you wanted to become a physician-scientist, then this can be a great way to open your essay.

Body paragraphs

The body of your essay has to reveal how your experiences in research and clinical medicine have prepared you for a career as a physician-scientist. Essentially, this is where you provide evidence to the admissions committee to justify your reasons for pursuing the joint program. It’s important that you demonstrate not only your suitability for both research and medicine but that you've taken the steps necessary to test drive your future career. Try to include two or three experiences that demonstrate your expertise as a researcher and future physician.

Remember to always focus on quality, rather than quantity. When deciding which experiences to include, pick the experiences that were most transformative in your journey towards medicine and research. For example, you could highlight a patient interaction that influenced your research interests or a research or lab experience that pushed you towards considering the combined program. If your research made you realize the wider implications of your profession and its relationship to medical practice, it's a great experience to include. It is wise to remember the AAMC’s core competencies when describing your clinical and research experiences. These competencies may help you find connections between your desire to practice both science and medicine.

A strong MD PhD essay conclusion should include a creative reiteration of why you want to pursue training in both medicine and research. Do not make your conclusion into a dry summary of your essay. Rather, it should discuss how your research experience and clinical experience complement each other and should tie together the overall theme of your essay. Your final sentence should leave the reader with a lasting impression that you are a suitable candidate for their MD PhD program.

Once you’ve constructed your essay, be prepared for multiple rounds of revisions and re-edits, ideally, with the help of a medical school advisor . Never underestimate the importance of revision in getting your essay just right. Enlisting the help of a professional who knows exactly what admissions committees are looking for can help you create a powerful essay that will stand out. Family and friends are a good start with your essay, but for a truly unbiased review, it's best to consult a professional with years of experience. Writing your MD PhD essay is a challenge, but do not lose sight of the message you are trying to get across. It is important to keep in mind that the experiences you include in your MD PhD essay must reinforce your desire and need to become a physician-scientist – this is the central purpose of your statement.

MD PhD Essay Example #1:

Amidst crying babies in the neonatal intensive care unit (NICU), I asked my current mentor, “How do physicians and scientists approach a disease differently?” [Name of doctor] with over 30 years of experience in her neonatal practice and perinatal brain research, replied, “A physician looks at disease top-down while a scientist looks at disease bottom-up.” Her answer resonated with me because at that moment I realized the value of converging physician and scientists’ interpretations of disease. My goal as a physician-scientist will be to draw connections between physiopathology of disease and molecular properties of drug candidates in order to characterize its efficacy and mechanism of action in the process of drug development.

My research experience led me toward a career as a physician-scientist as I began to draw connections between the properties of therapeutic proteins in the body and the impact it could have on patients. In [name of doctor] 's lab, I found intercellular adhesion molecule-5 could serve as a diagnostic tool for HIV-associated neurocognitive disorders since its presence in serum meant brain damage. While in [name of doctor]'s lab, my experiments showed overexpression of sigma-1 receptor protein (S1R) in cancer cells causes them to proliferate. PKC inhibitor that suppresses S1R signals to cell could mean a treatment strategy for cancer patients.

As a research assistant in [name of doctor] ’s lab, researching inter-alpha inhibitor protein (IAIP) as a drug candidate for neonatal hypoxia ischemia encephalopathy (HIE), I visited the NICU where I witnessed the distress of both the premature babies and their families. Working in the lab, I was not fully aware of the human impact of HIE but speaking with physicians I began to understand the need for developing a new therapeutic strategy for HIE as the current treatment—hypoxia is only partially protective. It was here I realized a physician-scientist sits in an advantageous position to explore new therapeutic options that being a researcher, or a physician alone could not.

By working in the lab and hospital, I considered the perspectives of both physicians and scientists as I investigated IAIP’s neuroprotective mechanism. From a physician’s point of view, I understood HIE-associated brain injury is caused by inflammation after energy deprivation. From a scientist’s view, IAIP protects the cell by suppressing pro-inflammatory cytokine production. IAIP’s mechanism can be hypothesized and tested by exploring how IAIP’s molecular properties influences HIE’s pathology, so I am currently performing histological and cell culture studies to understand IAIP’s mechanism in tissue and cell.

My intention is to be a physician-scientist because the overlap of the two professions brings out the best of medicine—translation of bench research into medical devices and drugs that can be used in the clinical arena for patient care.

What makes this essay great:

• The essay begins with a personal anecdote, which instantly captivates the reader's attention and transports them into the NICU with the student.
• The student describes their revelations at each point in their story, in particular, where their initial interest in medicine and research began, and when they understood the intricate interconnection between both fields.
• The student demonstrates their curiosity into the mechanisms behind disease, and it's interesting to see how they investigate complex issues from both a physician and scientist point of view.
• The student utilizes excellent transitional sentences allowing for the essay to flow well and the body paragraphs are well constructed. Through strong examples and evidence, the student supports their statements and discussions effectively, ie, showing instead of telling.

Click here to view the example.

MD PhD Essay Example #3:

1. Can I change my research direction during my studies, or will I have to stick to the research field I identified in my personal statement and MD PhD essay?

The majority of applicants only have a general idea of what area of research they want to pursue in the future. For this reason, it is completely normal for you to change direction in your research throughout your studies. Most likely, you will have to get more research experience to realize what type of research you want to follow. In your MD PhD essay, the admissions committees will value the quality of your research experience, rather than the field. They want to see your ability to ask the right questions, design experiments, conduct analysis, and so on. This will show your scientific skills and qualifications, which can be transferred to any field.

2. Do I have a chance of getting accepted into MD PhD programs if I have limited research experience?

Research experience is essential when applying to MD PhD programs. Admissions committees want to select students who have a history of conducting meaningful academic research and have the potential to progress knowledge in the medical profession. It is normal for applicants to be uncertain of what research project they want to pursue in the future, but you must have some background in scientific study. If you have zero research experience, it's best to wait until you can gain some relevant experience before applying. You can, on the other hand, make a positive impression in your MD PhD essay if you convey a strong interest and experience in a research project – even if you have only one experience to reference. Your progress and commitment to a specific research area can make you stand out as long term dedication will always impress admissions committees. It is not necessary to be involved in dozens of research projects or make any groundbreaking scientific discoveries to enter the MD PhD program. Be sure to include and highlight your significant experiences in research throughout your application. Always focus on what you have learned and accomplished and don't be afraid to discuss your setbacks in addition to your accomplishments.

3. Should my research and my clinical experience be in the same field?

It’s great if you have research and clinical experiences that are related - this way you could write about how you worked with patients who had problems related to your scientific research and how you enjoyed helping them in a clinical setting. You can emphasize that you know from experience how fundamental research could be in providing a cure or treating a disease. However, you do not need to have clinical experience related to your research experience and interests. You can create a strong MD PhD essay by describing the research you plan to do in the context of a larger problem you want to solve and not just a question you want to explore. If you are looking to do research where you haven't worked with a related patient population, it could still be good to discuss the broader picture of why you think that research is important and how it might help communities in the future.

4. Do I need to have publications to apply to MD PhD programs?

Publications are not necessary, especially if you are applying directly out of your undergrad degree. Admissions committees and program directors are aware of how difficult it is to contribute to publication at such an early stage in your education. If you do have publications to include in your application – please do! Publications can certainly give you a competitive edge as not every applicant will have this experience. Keep in mind that you must have an in-depth understanding of the research you participate in because you will likely be asked about it during your interviews, regardless of your level of contribution.

5. Are letters of reference important for MD PhD applications?

Absolutely. Admissions committees value outside perspectives on whether or not you will be suitable for their joint program. Research related references are especially important. Try to form good relationships with your research mentors, professors, directors, and principal investigators. Make sure you select referees that know you well. They should be able to give a detailed account of your research involvement and your strengths as a researcher and critical thinker. They should also be able to emphasize your maturity, reliability, and any other strength unique to you.

6. Can I apply to MD and MD PhD programs at the same time?

Yes, you can. You'll be able to indicate which schools and which programs you’re applying to in your AMCAS application. Many schools that reject you for MD PhD programs will still consider you for the regular MD stream. 

7. Is a career as a physician-scientist my only option if I graduate from the MD PhD program?

Not necessarily, however, it is important to think about your future career plans when you apply to any professional program. The MD PhD training is very costly in terms of time and money for you and the institution that admits you, so try to reflect on whether your goals coincide with the goals of the MD PhD program you want to attend. Becoming a full-time physician and tending to patients are amazing goals, but they do not require a PhD in addition to an MD. If you want to become a physician-scientist, then you should plan to spend most of your time and efforts on research and less time in clinical practice. If you want to become a physician who works on making discoveries in the medical field, then the MD PhD program may be for you. Career-wise, most MD PhD graduates end up in careers that combine patient care and research. Many end up at academic medical centers, research institutions, or in the pharmaceutical/biotech industry. A large number of MD PhD graduates end up in academia as well.

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How to Write M.D.-Ph.D. Application Essays

M.D.-Ph.D. applicants should write essays that highlight their scientific curiosity and knowledge.

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M.D.-Ph.D. applicants are usually expected to write more admissions essays than traditional medical school applicants.

Pursuing an M.D.-Ph.D. degree , which combines the rigors of medical school with the difficulty of a doctoral thesis, is not a challenge to be taken lightly. Becoming a physician-scientist requires demanding training; people who pursue this profession must be prepared to both heal sick patients and conduct biomedical research.

M.D.-Ph.D. programs usually last between seven to eight years, so admissions officers for these programs want to ensure that the students they choose are ready to commit to many years of strenuous study.

Admissions officers also want to select students who have a history of conducting meaningful academic research and who have the potential to increase knowledge in the medical profession. Because M.D.-Ph.D. students frequently attend medical school for free through full scholarships and also receive stipends to pay their living expenses, M.D.-Ph.D. programs hold applicants to high academic standards.

Dr. McGreggor Crowley, an admissions counselor at the education consulting firm IvyWise who previously served on the Harvard Medical School admissions commitee, says that M.D.-Ph.D. programs seek students who are diligent and self-motivated.

"They're going to want someone who is going to dive into a project and take ownership of it and take control of it," Crowley says.

M.D.-Ph.D. applicants are typically expected to write more admissions essays than traditional medical school applicants. In addition to the personal comments essay , which is mandatory for all M.D. applicants who submit their credentials using the American Medical College Application Service, M.D.-Ph.D. hopefuls who use this application method are also obligated to write two supplemental essays. They must write an M.D.-Ph.D. essay, where they explain why they want both a traditional medical degree and a Ph.D. degree, and a significant research experience essay, where they describe the scientific research they have conducted.

Learn about how M.D.-Ph.D. programs

M.D.-Ph.D. admissions officers say that when they read these supplemental essays, they are looking for evidence that an applicant has the grit, initiative, academic aptitude and love of science necessary to excel in an M.D.-Ph.D. program.

Dr. Michael Donnenberg, the senior associate dean for research and research training at Virginia Commonwealth University School of Medicine and director of its M.D.-Ph.D program, says when he reads M.D.-Ph.D. applications, he looks for signs that these students wouldn't be satisfied by a career that didn't involve both clinical medicine and research medicine.

Pursue a medical career

"I'm always looking for that, not that they can't decide which one they want to do, but that they can't imagine giving one up for the other," he says. "I think that's a really essential quality of a physician scientist."

Dr. Andrew Zinn, director of the Medical Scientist Training Program and dean of the graduate school of biomedical sciences at University of Texas Southwestern Medical Center , says he appreciates when M.D.-Ph.D. applicants demonstrate strong interest in a particular area of medicine. Ideally, applicants have completed a series of significant research projects on a specific topic, he says.

"I like to see somebody who has prioritized depth over breadth," Zinn says.

With that in mind, below are two M.D.-Ph.D. admissions essays that impressed admissions officers. The first is an M.D.-Ph.D. motivation essay submitted by a student who was accepted to the M.D.-Ph.D. program at University of Texas Southwestern Medical Center but ultimately decided to go elsewhere.

Zinn says one key reason why this M.D.-Ph.D. motivation essay made a positive impression is because it conveyed the applicant's strong interest in investigating treatments for a specific disease, which in this case was multiple sclerosis. Zinn says very few M.D.-Ph.D. applicants have identified the particular medical problem that they want to solve using their research.

"That's unusual for an individual at his stage of training," Zinn says. "It indicates a sophistication, a maturity. It's not absolutely essential, but it does stand out. It's unusual to see somebody who really found their passion in 10th grade and has worked toward that passion."

The second essay is a significant research experience submission authored by an incoming M.D.-Ph.D. student at Virginia Commonwealth University.

Donnenberg says the aspect of this significant research experience essay that impressed him the most was how it conveyed the applicant's persistence when faced with research challenges.

While he personally doesn't care if an M.D.-Ph.D. applicant knows what field they want to study in the Ph.D, portion of an M.D.-Ph.D. program, he is focused on finding students who are prepared to handle the rigors of scientific research.

Donnenberg says he was especially intrigued by the applicant's description of the problems she faced in her various research projects, what she did to address those problems and the lessons she learned from those difficult circumstances. Many M.D.-Ph.D. applicants avoid discussing lab failures to only highlight the experiments that went well, but he was impressed that this applicant took the opposite approach.

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Approaching the question “Why MD-PhD”

The “Why MD-PhD?” question should be approached thoughtfully and well in advance in order to best explain your career aspirations and unique journey. Let’s dive into some dos and don’ts about approaching this classic interview question!

DON’T say you couldn’t choose between science and medicine

If you’re applying for an MD-PhD program, it’s clear that you are passionate about both the lab and the clinic. With that said, an MD-PhD program is not only about pursuing both science and medicine, but also about actively finding ways to integrate them through your education and the years beyond. Interviewers want to make sure that you will take advantage of an interdisciplinary MD-PhD training by finding ways in which your research can influence your interactions with patients, and vice versa. 

DO focus on describing what you think the benefits are of an integrated physician-scientist training program

For example, you might discuss your excitement about being able to draw off your clinical experiences to inform how you prioritize designing new therapies for heart disease, as you will be able to directly learn which symptoms patients' find most debilitating. Alternatively, perhaps you will talk about how you wish to utilize artificial intelligence to enhance clinical decision-making, both for other physicians and for yourself. Regardless of your exact interests, make sure you convey how passionate you are about obtaining an MD-PhD, and not just a MD and PhD, individually. 

DON’T say you want to pursue an MD-PhD to pursue a career of 50% research and 50% clinical responsibilities

As mentioned above, an MD-PhD program provides amazing opportunities to grow as a physician, scientist, and, most importantly, physician-scientist. Applicants to MD-PhD programs should be genuinely passionate about pursuing a career that combines both science and medicine. With that said, it is also important that applicants recognize that the traditional MD-PhD research/clinical split is 80-20, respectively. After all, it takes time to dive into the science, apply for grants, and manage a lab! Now, that’s not to say that every MD-PhD follows this split, or that you have to. However, you should make sure that you are able to cogently express that you are aware of what an MD-PhD career path looks like and the demands both research and science will place on your time. An MD-PhD program is a long commitment, and interviewers want to ensure that you have a good understanding of the career trajectories most MD-PhDs take before offering you a spot in their program. 

DO discuss how you plan to integrate research and medicine in your career

This is an excellent opportunity to not only discuss your long-term professional aspirations, but also to show you have a firm grasp of what an MD-PhD program is for. Talk specifically about how you envision balancing science and medicine in the future. For example, perhaps you hope to see patients once a week in the psychiatry clinic while primarily running a lab that researches neuropsychiatric disorders. You might envision your time split 80% research and 20% clinical, as you follow the traditional physician-scientist path. On the other hand, maybe you see a slightly different vision for your MD-PhD. Some students, for example, are extremely passionate about surgery and hope to unite both surgery and science, while also recognizing that this means they will spend more time in the clinic than a non-surgical physician-scientist. It is totally okay, and even encouraged, to discuss these interests. The point here is not to force yourself to fit into some mold of what you think a physician-scientist should be, but rather to show that you clearly understand the demands and training path of an MD-PhD program and have also given serious thought to how you see balancing science and medicine in your future career. 

DON’T just discuss abstract reasons for wanting to pursue an MD-PhD

All people applying for an MD-PhD program have many shared reasons for doing so, especially in regards to the general theme of uniting science and medicine in order to further human health. This is great, and a key reason why MD-PhD programs are so unique in terms of the education they offer. However, remember that your interviewer is probably interviewing many of these other students as well. If your answer to why MD-PhD only hits on the broad training goals of their program, it will likely blend together with that of many other students, costing you a valuable opportunity to stand out.

DO focus on unique and specific experiences you’ve had that have motivated your decision to pursue an MD-PhD

Rather than saying that you think MD-PhDs are able to translate research from the bench to the bedside, discuss how you have personally united your research and clinical interests. How have you personally seen the power of bridging medicine and clinical work, and how would you like to continue this journey? This is also a great time to briefly mention why you are excited about interviewing at a particular program. For example, you might begin by discussing your experience both volunteering with patients on dialysis and doing research on the kidneys, ending with a segue to your excitement about the opportunities to further explore renal pathophysiology with Lab X at the institution you are interviewing at. This is also a great time to reflect on how your personal traits and philosophy might fit in well with an MD-PhD program. If you’re drawn to science because you love problem-solving or want to pursue medical school because you believe in the power of personal interaction to advance human health, say so! This is a great chance to show how your interest in an MD-PhD is motivated by both professional and personal desires.

The “Why MD-PhD?” question is a great chance to display your knowledge of the physician-scientist training path, your motivations for pursuing an MD-PhD in the present and future, and why you are excited about the opportunity to train at a specific program. By taking the time to craft an authentic and polished response to this classic interview question, you’ll be well on your way to becoming a MD-PhD trainee!

Cambridge Coaching has the most qualified team of medical school writing coaches available anywhere.  Our team is composed of MD, MD-PhDs, and professional writers because we understand that the best coach is going to help you produce a dazzling AMCAS essay, as well as a suite of supplementary materials that provides a persuasive, integrated argument for why you belong in medical school.

The challenge of the medical school application process isn’t just due to the workload, either. It has to do with the sheer competitiveness of the system. You can’t take anything for granted; every aspect of your application has to be solid - your GPA, your MCAT, your recommendations, your interviews, your activities, and your personal statement. That’s why we go beyond the usual options and offer coaching that covers the entire application, not just your personal statement. While we are happy to work with clients on a single essay or drafts, we find that we achieve the best results with clients who work with us throughout their application process - from the MCAT through to the admissions deadlines.

Maya graduated Columbia University with dual degrees in Biology and Computer Science. She began her first year at the Harvard-MIT MD/PhD program (Health Sciences and Technology MD track) in 2020.

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How to write your md phd essays.

Reviewed by:

Luke Hartstein

Former Admissions Committee Member, NYU Grossman School of Medicine

Reviewed: 4/25/22

Suppose you’ve decided that pursuing the MD PhD dual degree is right for you. In that case, you may have noticed that the application process is slightly different than applying to MD programs at allopathic medical schools. Namely, besides submitting the required application materials through the AMCAS, MD PhDs must also write two additional essays: the MD PhD essay and the significant research experience essay.

Today’s guide will review what an MD PhD is, what you can expect from MD PhD dual degree programs, and how to apply to MD PhD programs in the United States. You will also learn how to write compelling MD PhD essays by utilizing our tips for making your essays stand out. 

Are you ready to succeed? Let’s dive right in.

Get The Ultimate Guide on Writing an Unforgettable Personal Statement

What is an MD PhD?

An MD PhD is also known as a physician-scientist or a medical scientist. An MD PhD holds both the Doctor of Medicine degree (MD) and the Doctor of Philosophy degree (PhD) in scientific research. 

The difference between MDs and MD PhDs is that while MDs are typically in medical school for the traditional four years, MD PhDs must complete four years of medical training in addition to three to four years of training to become physician-scientists. 

In total, MD PhDs complete their dual degrees in seven to eight years, making their pathway long and challenging but ultimately rewarding for those who are passionate about conducting biomedical scientific research. 

In short, MD PhDs combine clinical medicine with scientific research and have comprehensive knowledge of important topics in medicine. According to the AAMC , physician-scientists research various topics in the following disciplines:

• Biochemistry and Macromolecular Biophysics
• Bioengineering and Biomedical Imaging
• Cell and Developmental Biology
• Chemical and Physical Sciences
• Computational Biology and Bioinformatics
• Microbiology and Infectious Disease
• Molecular Biology and Genetics
• Neuroscience
• Pathology and Mechanisms of Disease
• Pharmacology
• Public Health, Epidemiology, and Preventative Medicine
• Social and Behavioral Sciences

What are MD PhD Programs?

MD PhD programs are dual degree programs that allow students to obtain their MD and PhD degrees simultaneously. The MD PhD curriculum is continuous, meaning you will work on both degrees throughout your medical and graduate school education. The following infographic provided by the AAMC breaks down what a typical MD PhD program looks like:

Of course, there may be variations depending on the school’s curriculum, so be sure to check with the programs to which you apply to learn more about year-to-year coursework, training, and research. 

Currently, there are over 100 MD PhD programs in the United States, and over 40 programs are partially or fully funded by training grants known as MSTPs (Medical Science Training Programs). Because of these grants, most MD PhD students complete their dual degrees with very little or zero student debt. 

To decide which MD PhD program is right for you, you will have to do some preliminary research. Use the following checklist of questions to determine which program is a good fit:

• Does the program have ample funding?
• Is the location of the school desirable?
• Is there a good balance between clinical training and research?
• Does the school have a reputable history of strong publications and research?
• Is the program multi-disciplinary, and will it provide plentiful topics to research?
• Is clinical training introduced early in the program?
• Are there mentors available to oversee research projects?
• Are current MD PhD students satisfied with the program?
• Are the school’s alumni performing high-level research and frequently publishing?
• Does the program’s mission statement/culture align with your academic and career goals?

How to Apply to MD PhD Programs

Take a leaf out of Patrick's book: he got into six fully funded MD/ Phd programs with our help! 

The application process for MD PhD programs is similar to applying to MD programs. For most allopathic medical schools, you will use the AMCAS (American Medical College Application Service). 

Of course, not every medical school uses the AMCAS—osteopathic schools use the AACOMAS (American Association of Colleges of Osteopathic Medicine Application Service), and Texas medical schools use the TMDSAS (Texas Medical & Dental Schools Application Service). Be sure to verify that you are using the correct application service for the school to which you’re applying.

So, let’s revisit the AMCAS, as that will be the main application service you will use to apply to MD PhD programs. In the AMCAS, you must select “MD PhD” as the program to which you’re applying.

There are nine sections that you must complete in the AMCAS: ‍

Sections 1, 2, and 3

The first three sections in the AMCAS are where you will enter your basic information such as your name, background information, biographical information, identifiers, and the previous schools you have attended.

In section 4, you will enter all your information about course requirements (prerequisites) and school transcripts. 

In section 5, the AMCAS work and activities section, you will enter your relevant extracurricular activities , work experience, and hobbies . Strong extracurricular activities include, but are not limited to, clinical experience , medical shadowing , and volunteering .

However, the most important extracurricular you can participate in before applying to the MD PhD program is research . This goes without saying: You must showcase substantive research experience to gain a competitive edge over other candidates. Gaining substantive research experience requires some effort and commitment on your part. 

You should aim to have multiple summers of research experience throughout your undergrad program, and it is beneficial to have at least one year of continuous research experience. This may mean that you take a gap year before applying to the MD PhD program, but it will be well worth it to boost your application and show admissions officers your dedication and passion for research.

In section 6, you will upload all of your letters of recommendation . 

In section 7, you will select that you are applying to the MD PhD program. You will also enter any other information about the school, such as whether you’re applying for an early decision.

In section 8, you will enter your personal statement . For the MD PhD program, you will also submit two essays in addition to the personal statement. They are the MD PhD essay and the significant research experience essay. 

Section 9 ‍

In section 9, you will enter all information about standardized test scores, such as the MCAT .

How to Write Your MD PhD Essays

The overall purpose of the MD PhD essay is to answer the question, “Why did you choose to apply to the MD PhD combined program?”

The MD PhD Essay

• Demonstrates your reasons for pursuing the MD PhD dual degree program.
• Focuses on why the combination of research and clinical medicine is right for you. (In other words, you can’t see yourself having just an MD or just a PhD. To feel the most fulfilled, you must combine both.) 
• Shows that you are prepared for the rigors of both research and clinical medicine, not just one or the other.

Admissions committees want to ensure that the applicants they accept into the MD PhD program are devoted to the field. After all, why would anyone spend seven to eight years in research if they didn’t absolutely love it? 

To that end, the MD PhD essay must convince the admissions officers that you are passionate about research and can’t imagine doing anything except the work of a physician-scientist. 

To structure your MD PhD essay, follow academic and professional standards of writing. There should be a consistent format of an introduction, body, and conclusion. View the table below for a general outline of the MD PhD essay:

A strong introduction immediately pulls the reader in and briefly summarizes your motivations for pursuing the MD PhD program. You can achieve this with a personal anecdote that neatly ties in your experience and goals. 

The body paragraphs are the meat of the content. You should detail how you prepared for a career as a physician-scientist by demonstrating your clinical and research experiences. Because of limited space, you should aim to write about two to three substantive experiences that showcase your strengths and what you learned. The body paragraphs should focus on quality rather than the number of experiences. The body paragraphs should also reinforce why the MD PhD path is right for you.

Finally, a strong conclusion leaves the reader with the impression that you are a strong candidate for the MD PhD program. You can achieve this by reiterating your motivations and goals, calling back to the introduction/personal anecdote, and concisely tying together your experiences. 

The Significant Research Experience Essay

The purpose of the significant research experience essay is right there in the title—to provide details about your significant research experiences. 

The significant research experience essay . . .

• Provides details about your research projects and contributions.
• Describes what you investigated and learned.
• Discusses the durations of your research experiences.
• Includes information about your mentors, such as their names and affiliations.

For the format of your significant research essay, you can structure it as a narrative that adheres to a general introduction, body, and conclusion. Or, you can structure the essay in entry format where each research experience has a subheading that includes identifying information about the research projects, mentors, and affiliations.

For example:

1. Professor X, MD/PhD, Columbia University Department of Psychiatry, February 2019 – March 2021

[Enter details about the experience here.]

If you prefer the entry format for your essay, it’s still a good idea to write one or two introductory sentences and a strong conclusion to tie everything together. Just because it is in entry format doesn’t mean it should be overly technical or indifferent. You should still aim to tell a compelling, unique narrative.

Tips for Making Your MD PhD Essays Stand Out ‍

To make your MD PhD essays stand out, use the following tips for success:

• Be specific, not generic. While you shouldn’t weigh down your essays with overly technical jargon, it’s important to be specific in what you learned in terms of lessons and skills.
• If you faced challenges, don’t write about the negative aspects, but emphasize a growth mindset and what you did to overcome the obstacles. 
• According to the US News & World Report, very few MD PhD applicants identify a medical problem that they want to solve with their research. Use this to your advantage to stand out—admissions officers want to see a level of maturity and sophistication from applicants. It would go a long way if you described research experiences about a medical issue that you have personal connections with and aspire to solve with research.
• Show, don’t tell. For example, instead of saying, “I improved my critical thinking and analytical skills while completing X research project,” demonstrate what that project was, your process of investigation, the outcomes you learned, and your flexibility in absorbing new information. If you show interesting narratives rather than tell, your essays will leave a lasting impression on the admissions committee.

1. What is the best pre-med major for MD PhD programs? ‍

Surprisingly, there is no best pre-med major for MD PhD programs, as medical schools do not have requirements for majors. Students are encouraged to pursue their passions and unique interests, even if that means majoring in non-science subjects (such as the liberal arts or the social sciences). That said, the most popular undergrad majors are in the biological sciences.

Whether you choose to major in the sciences or not, the only requirement you must fulfill is completing all prerequisite coursework. Every medical school has its own prerequisite coursework requirements, so verify that you are on track to complete all coursework, including labs. If you are unsure or need help with building your course schedule, speak with a pre-health advisor. 

2. Does it look better to have numerous research experiences? ‍

Yes and no. Find a balance. While you should have multiple substantive research experiences, the emphasis should be on “substantive.” In other words, aim for quality over quantity. What you learn and gain from your research experiences is more important than the number of experiences you have. 

Furthermore, having quality research experiences will make it easier for you to network with supervisors, mentors, colleagues, and peers. You can tap into this support system when you ask for letters of recommendation for your med school application. 

3. Can I have someone look at my essays before submitting them through the AMCAS? ‍

Yes! We strongly recommend that you spend time crafting your essays. Don’t simply type your essays in the application service and hit send. Write your essays over time, and expect to revise your drafts. Ask trusted peers, mentors, friends, or colleagues for their objective feedback. You can also consult with our team of experts.  ‍

4. What should I avoid in my MD PhD essays? ‍ ‍

• Avoid clichés. You want your essays to be memorable to admissions committees who read thousands of these applications every year. Use language that’s compelling, descriptive, and tells a story. Make connections from your personal and professional experiences to the MD PhD program.
• Avoid restating what’s already in your CV. You only have 3,000 characters, so every word counts. 
• Avoid writing about negative experiences. Focus on positive reasons for pursuing the MD PhD and show a growth mindset. 
• Avoid using a casual tone or language. Your essays should be academic and professional. 

5. Do I need to have publications before applying to MD PhD programs? ‍

Publications are not required for MD PhD programs, but having publications gives you a competitive edge over other candidates. Admissions officers are aware of how difficult it is to publish so early in your education, but if you do have publications, be sure to list them in your application. 

Also, keep in mind that regardless of your current contributions in research, whether or not you have publications, you must be knowledgeable about your research topics and have substantial research experience.  ‍

6. How many research experiences should I write about in my research experience essay? ‍

You should aim to write about two to three significant research experiences. This will give you a good balance of different research experiences to discuss, including what you learned and your contributions. Writing about two to three experiences will also ensure that you remain within the essay length requirement of the AMCAS, which is 3,000 characters.

Conclusion ‍

If you’re passionate about scientific research, the MD PhD dual degree is a great way to combine your love of clinical medicine and research. For most MD PhD programs, you will apply using the AMCAS. 

The application process is similar to traditional MD programs, but with the MD PhD, you will have to select that program within the application service. Additionally, you will have to write two essays specifically for the MD PhD program: the MD PhD essay and the significant research experience essay. 

To write strong, compelling MD PhD essays, persuade the admissions committee of your reasons for combining clinical medicine with research and why it’s the best pathway for you. Demonstrate how your research experiences have prepared you for a rewarding career as a physician-scientist. We wish you the best of luck as you pursue your MD PhD.

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The Complete MD/PhD Applicant Guide pp 59–60 Cite as

The MD/PhD Essay

• Jonathan Sussman 4 ,
• Jordan Setayesh 5 &
• Amitej Venapally 6  
• First Online: 23 September 2020

1865 Accesses

The second essay required in the AMCAS primary application asks applicants to articulate why they want to pursue the MD/PhD combined degree. In other words, it is asking the question: “How have your clinical and research experiences shaped your career goals, and why are clinical medicine and academic research both indispensable to these aspirations?” This chapter provides several suggestions regarding how to approach this essay and what content is appropriate to include and discuss within the essay.

• Why MD/PhD essay
• MD/PhD motivation essay
• Personal statement
• AMCAS application
• Primary application
• MD/PhD application
• Medical school application

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2020 AMCAS Applicant Guide. American Association of Medical Colleges. 2020. https://aamc-orange.global.ssl.fastly.net/production/media/filer_public/14/6f/146f366e-d54a-4792-9870-ffe451b2e473/aamc-2020-amcas-applicant-guide041119.pdf . Accessed 11 June 2020.

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Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

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University of Michigan Medical School, University of Michigan, Ann Arbor, MI, USA

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Emory School of Medicine, Emory University, Atlanta, GA, USA

Amitej Venapally

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Sussman, J., Setayesh, J., Venapally, A. (2021). The MD/PhD Essay. In: The Complete MD/PhD Applicant Guide. Springer, Cham. https://doi.org/10.1007/978-3-030-55625-9_7

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Tabitha Moses

Md/phd student at wayne state university, my md/phd application (& reapplication).

The current Twitter storm about grad school applications made me consider my own applications. My thoughts span more than a 280 character length, so I decided to write a blog post that I have toyed with writing for a while but was never certain about how it would impact me professionally.

The first time I applied to MD/PhD programs I got rejected. Completely. Not a single interview. It hurt – a lot. I applied again the following year and ended up turning down interviews. So, what changed?

There were a few factors. I finished my Masters program in that time and had been able to present my research at a few conferences, but I made another major change: my essays. For those who don’t know, MD/PhD applicants in the USA write 3 primary essays whose prompts, for all intents and purposes, are:

• Why medicine?
• Why MD/PhD?
• Describe your research experience.

The first time I applied I naively followed the advice of those around me:

• Don’t be cliche
• Don’t tell them you’ve always wanted to be a doctor
• Don’t tell them that you want to help people
• Don’t tell them that you love research
• Don’t tell them about your personal experiences

Over and over, I was told these things were cliche and would bore admissions officers. So I trod carefully, tried to be honest and interested but not cliche. Unfortunately, in doing so, I couldn’t write about me and my motivations. Instead, my essays were devoid of personality and said very little about me (obviously, I didn’t really think that when I submitted them, but it is clear to me looking back). I was so scared of being cliche because I was told that would get me rejected immediately and I was desperate to avoid personal anecdotes because supposedly that’s what everyone did and it was boring.

“ We were told that in writing “I have always wanted to be a doctor” we were assuring rejection. So I tried to hide this fact in my initial applications, feeling that admitting my passion would make me appear naive and uninformed. I realize now that my prolonged dedication to practicing medicine has always been one of my greatest strengths .” – A portion of my “Why MD?” essay (second attempt)

The second time I applied (after my pre-med advisor told me not to bother because I wouldn’t get in), I figured “screw them;” I wanted to be honest and I was giving it one more chance, so I would be myself.

I wrote and re-wrote many times. I am lucky enough to have a patient partner who is a fantastic editor. In my “why medicine” essay, I did write that I have wanted to be a physician for as long as I can remember, that I wanted to help people, and that I like science. In my “why MD/PhD” essay I talked about my curiosity and interest in science. I didn’t have defined ideas of how I could contribute to the field; I just knew I wanted to. Of course, my first drafts were terrible piles of cliched phrases and analogies but by the end they were a little better (though they are still painful for me to read now).

Those aren’t the only topics I wrote in the essays. I framed my “why MD” essay with a personal anecdote (not related to familial sickness, although that had been an earlier draft). My MD/PhD essay began with an example of my curiosity; I had to be hammered over the head with the idea of “showing, not telling” and by the 100th draft I finally got a little better at it.

“ I had my first coherent (but decidedly unethical) research idea when I was 13. I wanted to have identical quintuplets and then charge each of my best friends to raise them separately and watch how they developed. I knew that it neither practical nor ethical, but was interested in the nature/nurture debate and this seemed like a fantastic way to study it. ” – The beginning of my MD/PhD essay (second attempt)

What is the point of this post? 

I think there are many things you could take away from this. At this moment, the purpose of writing this is to speak to those students writing and submitting essays and worrying about sounding cliched and boring. Reading conversations on Twitter and being scared that their applications are being thrown into the reject pile for sounding too much like everyone else. Reading conversations from faculty about how all essays sound the same certainly don’t help these feelings.

I do not mean to imply they should be ignored. There is an important point to be found in the unpleasantness: we need to find a way to stand out. Don’t let those types of comments stop you writing about the reasons that you want to enter a program. If people say your reasons are cliched, that’s okay. You can still write about them. Instead of being concerned about your reasons being “wrong” or “boring,” focus on finding a way to share your curiosity and passions in a way that illustrates who you are and why someone would want to accept you.

Note: I am not going into all of the details of what changed between my applications or providing my full essays, but if you are interested in reading them, or want advice on reapplying, feel free to reach out. Also, I do not think the essays I wrote the second time around were amazing in any way, but they reflected personality, and I think that made a difference.

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2 thoughts on “ my md/phd application (& reapplication) ”.

• Pingback: MD/PhD Log – Tabitha Moses

This information is helpful to me. Currently, I am in the process of applying for PhD programs. I just completed my Master Degree this past December. I have been procrastinating with the essays. But, I must submit them soon to meet the deadlines. I plan to start tomorrow writing the four essays to the four programs.

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How to Write Successful Md-PhD and Significant Research Experience Essays

MD-PhD Essay

The MD-PhD Essay is a straightforward “ Why essay ” — in other words, admissions is hoping to learn why you’re pursuing the combined MD-PhD degree. This essay is limited to 3,000 characters, which comes out to about 500-600 words or one page single-spaced. 

In order to submit a winning MD-PhD essay, we recommend getting creative. Since these essays are so straightforward, it’s very easy for them to read as dry and impersonal. See if instead, you can tell admissions a story that will both answer the question, “Why are you pursuing a combined MD-PhD degree?” and reveal more information about yourself.

Maybe you want to open your essay with an anecdote from your dinner table in the late 90s, when you took your first stab at Operation (pun intended). Or perhaps your story starts at a cabin with your favorite relative, who encouraged you to find meaningful, rewarding work that serves your community. Regardless of where your story begins, try your best to frame it as just that: a story.  

Significant Research Essay

In addition to the MD-PhD Essay, you are required to write an essay that is frequently referred to as the Significant Research Experience Essay, which — you guessed it! — describes your noteworthy research experiences. In this essay, AMCAS asks applicants to specify their research supervisor’s name and affiliation, the duration of the study, the nature of the issue examined, and their specific contributions to the research effort. This essay is limited to 10,000 characters.

If your research resulted in a publication of which you were an author, you will also be asked to enter the full citation in the Work/Activities section of your application.

The Significant Research Experience essay is about as academic as they come, and for that reason, we advise you to stick to the facts. If you have notes, now is the time to reference them. If your research experience is lacking, use any extra space you have to focus on why the research experience was significant to you, and how you might continue to research this problem or event in the future.

Ultimately, like with all admissions essays, your goal for both of these assignments should be to give admissions a clear understanding of your background and the next steps you will take if you are accepted!

About Kat Stubing

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Written by Kat Stubing

Category: Admissions , Uncategorized

Tags: MD-PhD essay , med school , med school admissions , medical school , medical school applications , medical school secondaries , Significant Research essay

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Everything You Need to Know About MD-PhD Programs

Posted in: Applying to Medical School

Table of Contents

MD-PhD programs are dual-degree programs for pre-medical students who want to both practice medicine and conduct extensive research.

In an MD-PhD program, the medical education of the MD program is combined with the in-depth research training of a PhD program. Students learn to practice medicine, diagnosing and treating patients all while gaining research experience to investigate medical conditions and diseases.

These programs are more intense than standard medical school. Students take additional coursework, typically in the biomedical sciences, graduate training, rotations in different laboratories, and intensive research.

The extra education gives students the tools to advance in the medical field after graduation. If you are interested in investigating diseases as you treat patients and developing innovative ways to provide care, an MD-PhD path may be for you!

What are MD-PhD programs?

MD-PhD programs are unique dual-degree programs designed for students who have an interest in both patient care and research. In these programs, students complete both a medical degree (MD) and a doctorate (PhD). This prepares graduates to function as physician-scientists, seamlessly bridging the gap between the laboratory and the clinical setting.

What is the difference between an MD and an MD-PhD? The difference between MD and MD-PhD graduates is that while both degrees are conferred to medical doctors, MD programs focus on clinical practice. MD-PhD programs, on the other hand, combine medical education with extensive biomedical research training. 

Is MD-PhD easier than MD? MD-PhD programs are not easier than MD programs. They require a longer time commitment, but in the end, provide graduates with a broader skill set to pursue careers that integrate medicine and scientific research.

How rare is an MD-PhD? Only about 3% of students that enroll in medical school are in MD-PhD programs. There are 122 MD-PhD programs in the U.S. and 13 in Canada listed on the AAMC MD-PhD Degree Programs by State directory .

Graduate programs aren’t confined to a specific area of study. Each school with this type of program has its own options for its PhD degree. PhD students commonly choose to specialize in topics such as:

• Cell biology
• Biochemistry
• Pharmacology
• Neuroscience
• Biomedical engineering

Upon completion of an MD-PhD program, graduates are awarded the dual degree for their proficiency in both clinical practice and research. 

MD-PhD Program Duration

A significant commitment of time is necessary to complete an MD-PhD program, but the career path is rewarding and well-compensated. 

How many years are MD-PhD programs ? Students can expect to spend 7-8 years total between graduate school and med school, but there is no strict timeline for completing an MD-PhD. Some students complete their programs in as little as six years, and others take as long as 10.

Students usually start with the first year to two years of medical school, followed by 3-5 years of research, then finish with another two years of medical training and clinicals. Current students entering into MD-PhD programs are older , on average, than when these programs first began, and many take longer to complete their studies.

How much does an MD-PhD program cost?

Most MD-PhD programs offer enrolled students tuition-free training and a stipend to cover living expenses.

The cost of an MD-PhD program varies widely depending on the institution, but the stipend and tuition-free training makes many of these programs significantly less burdensome financially compared to standalone MD or PhD programs.

Financial support is available through the Medical Scientist Training Program (MSTP) funded by the National Institutes of Health (NIH). Scholarships are offered that cover tuition and provide a stipend for living expenses, making these intensive dual degree programs more attainable.

Not all MD-PhD programs are funded by the MSTP, but some schools offer similar financial support to their MD-PhD students. For any school you plan to apply to, double-check their program website or call an admissions counselor to see if there are options for financial aid. 

MD-PhD Residencies

MD-PhD residencies provide a unique opportunity to bridge the gap between patient care and research. Graduates often enter residency programs to acquire hands-on training in a particular medical specialty. Some even opt for a fellowship in a subspecialty after that. This training phase can range from 3 -7 years, depending on the specialty.

Although they can enter any medical specialty, they frequently gravitate towards specialties with a strong research component. Here are a few common residencies that MD-PhDs typically enter:

• Internal Medicine: This field covers a broad range of diseases in adults and often involves solving complex medical problems. It’s a popular choice for MD-PhD graduates because of the diversity of patients and conditions, which provides many opportunities for research.
• Neurology: The complexity and the largely untapped understanding of the nervous system provide abundant research opportunities. Advances in neuroimaging, AI , and genetics also offer tools for physician-scientists to explore the nervous system in unprecedented ways.
• Psychiatry: Studying the pathophysiology of mental disorders, exploring new therapeutic interventions, and examining the genetic basis of psychiatric conditions are just a sample of the ways an MD-PhD can continue research in this specialty.
• Pathology: Pathologists often work behind the scenes in medicine, studying the causes and effects of diseases. This field is deeply rooted in medical research, which makes it a good fit for many MD-PhD graduates.
• Pediatrics : Pediatric physician-scientists research a wide array of topics, including childhood diseases, growth and development, pediatric therapies, and many other areas related to child health.

The choice of residency program should align with each graduate’s clinical interests, research interests, and career goals. There is great flexibility in the MD-PhD pathway, and physician-scientists span all specialties in medicine.

MD-PhD Career Path & Salary

Careers for MD-PhD’s often sit at the intersection of healthcare, academic medicine, and industry. Roles vary from practicing physicians, medical researchers, educators, and policy advisors to leaders in biotech and pharmaceutical companies.

After completing their residency, MD-PhDs typically divide their professional time between research and clinical practice. They often work in academic medical centers or research institutions where they can see patients and conduct research. Their research may be basic, translational, or clinical, depending on their interests and training.

MD-PhDs may also grow to take on teaching roles, educating the next generation of physicians and scientists. This path can bring them to leadership roles such as department chair, dean of a medical college, or even hospital CEO with their unique understanding of both medicine and research.

The salary for MD-PhDs does vary depending on the chosen career path. Earning potential is generally high due to the advanced and specialized nature of their training.

On average, physician-scientists in the US earn a median salary that is well above the national average for all occupations. According to Doximity’s 2023 Physician’s Compensation Report , the average salary for physicians in the Pharmaceutical/Industry employment setting is highest at $392,534.

Those working in academia or research may have different salary scales. These salaries are frequently dependent on research grants, but still typically fall within a comfortable range.

An MD-PhD opens up a wide range of career options, particularly in the intersecting areas of healthcare and research. Below are careers someone with an MD-PhD might pursue:

• Academic Physician: They divide their time between seeing patients, conducting research, and teaching students and residents. These professionals usually work at medical schools or teaching hospitals.
• Biomedical Researcher: MD-PhDs often find employment as researchers in the field of biomedical sciences. They can work in research institutions, pharmaceutical companies, or government organizations such as the NIH.
• Clinical Investigator: These are physicians who conduct research involving human subjects (clinical trials). They develop and implement studies to understand the effects of new drugs or therapeutic strategies.
• Pharmaceutical/Biotech Industry Professional : Many MD-PhDs work in the pharmaceutical or biotechnology industry. They may be involved in drug development, clinical trials, regulatory affairs, or medical affairs.
• Medical Director: In this role, an individual would oversee the medical aspect of a healthcare facility, biotech company, or department in a hospital. This position often requires both a medical and research background.
• Science Policy Analyst/Advisor: They can work in government or nonprofit organizations, helping to shape policies that affect scientific research and healthcare.
• Public Health Official: Some MD-PhDs choose to work in the public sector, addressing health issues at the population level. They may work for entities like the Centers for Disease Control and Prevention (CDC) or World Health Organization (WHO).
• Medical Science Liaison: This role often involves serving as a bridge between pharmaceutical companies and healthcare professionals, explaining new therapies and scientific findings to physicians, researchers, and other stakeholders.
• Medical Educator: MD-PhDs are uniquely qualified to educate future doctors and researchers, teaching in areas such as pharmacology, pathology, genetics, or any other medical specialty. They may design and implement courses, advise students, and contribute to the educational mission of their institution.

These are just a few of the potential career paths. A career choice often depends on an individual’s specific interests, such as which medical specialties they are drawn to, whether they prefer working with patients or in a laboratory, and how they want to contribute to advancing medical science.

Medical Science Training Programs

Some MD-PhD programs in the United States are funded by the National Institutes of Health (NIH) through the Medical Scientist Training Program (MSTP). This means that students receive full tuition remission, health insurance, and a living stipend throughout their training.

Because of this financial support, admission to an MSTP is very competitive. Many schools have financial support available to MD-PhD students even if they are not part of the Medical Scientist Training Program to allow them to focus on their studies and research.

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4 Benefits of Becoming an MD-PhD

Earning dual degrees in medicine and research is an ambitious endeavor, but the impacts you can make on patient care and scientific research are significant and valuable to public health. An MD-PhD degree comes with some great benefits.

1. Interdisciplinary Perspective

The duality of the MD-PhD training allows graduates the ability to translate clinical observations into research questions, then taking research findings to enhance patient care. You will essentially be a bridge to the gap between the laboratory and the clinic.

2. Career Flexibility

Graduates can become practicing physicians, medical researchers, educators, and/or policy advisors. They may also take on leadership roles within academic institutions, hospitals, biotech companies, or pharmaceutical firms. 

The wide range of possible careers allows the flexibility to pursue a path that aligns with your passion.

3. Influential Impact 

The rigorous training in MD-PhD programs allows graduates to drive innovation in healthcare and medical science. This advanced education will have you asking critical questions and finding answers that can change the course of medical treatment and patient care. 

The potential to make significant contributions to the field of medicine is a rewarding and prestigious aspect of this career path.

4. Community and Mentorship

During their training, MD-PhD students join a tight-knit community of fellow dual-degree students, mentors, and faculty. This network can provide valuable support, guidance, and camaraderie during the demanding years of study. 

Post-graduation, this network continues to serve as a resource for collaboration, mentorship, and career advancement.

Are MD-PhD programs more competitive than MD programs?

In general, yes, MD-PhD programs are more competitive than MD programs. 

The statistics here can be a little confusing, though. 10% of applicants are accepted to an MD-PhD program, which is higher than the 3% that get accepted into MD programs. Acceptance rates are nearly the same as traditional medical programs, too.

But the quality of application for MD-PhD programs is inherently higher than traditional pre-meds. Your GPA and MCAT need to be higher, with well-developed extracurricular experiences and glowing letters of recommendation to have a chance at an MD-PhD program. 

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Preparing to Apply to MD-PhD Programs

Applying for an MD-PhD program is done through AMCAS, just like MD programs. Preparation is key in the application process .

Being proactive, getting relevant experiences, understanding the requirements, and applying to multiple programs will significantly enhance your chances of success in securing a spot in an MD-PhD program. Applicants must be prepared to showcase themselves as doctor material and make a case for their desire to take part in research.

Here are a few tips for increasing your chances at acceptance.

Make sure you have the right extracurriculars under your belt.

Gaining relevant experiences beyond the classroom is crucial to showcase your commitment to a career in medical research. Admissions committees are looking for candidates with experience in research projects. 

It is absolutely necessary to have taken part in research to have a chance at getting into an MD-PhD program.

Check application requirements well in advance.

You’ll be required to meet all the AMCAS application requirements of MD programs. This includes the prerequisite coursework, your MCAT score and GPA, letters of evaluation, and personal statement . 

There are also two additional essays that are required on MD-PhD applications, which we’ll cover later.

We advise checking with each specific medical school on the requirements for their applications . Non-medical graduate programs may ask for your GRE scores. You want to make sure you’ve taken this test well in advance of the AMCAS open date. 

Our advisors can help you craft a personal statement for your MD-PhD that will stand out.

Apply to several programs.

Because of the limited number of programs and the competitive nature of MD-PhD programs, you should apply to multiple programs. Students who have gotten into these programs report applying to as many as 30 programs for the best chance to be accepted. 

Along with MD-PhD programs, we also recommend applying to some MD programs as well. On your AMCAS application, you can easily designate as an MD candidate or MD-PhD candidate.

Even if you don’t make it into the MD-PhD program of a medical school, you will still have the opportunity to be considered for their MD program.

MD-PhD Application Timeline

Get your medical school application in early — the same goes for MD-PhD applications. In fact, it’s even more important to have your primary application in as soon as possible to give yourself plenty of time to write your secondary essays. 

The MD-PhD application process follows the AMCAS application timeline :

• May: AMCAS application opens. You’ll receive your secondary application shortly after you submit your primary. 
• July-August: Submit your supplemental application within two weeks.
• October-March: Prepare for and attend all scheduled interviews.
• December-March: Application committees make final decisions. For schools with rolling admissions, this may happen shortly after an interview. Other institutions wait until after all interviews are complete to make decisions.
• March-April: Applicant decisions are made.
• June-August: Your MD-PhD begins.

Additional Essays in the MD-PhD Application

The MD-PhD application process includes two additional essays that showcase your commitment to a career as a physician-scientist. 

MD-PhD Essay

The MD-PhD Essay is your opportunity to express why you have chosen the dual-degree path and how it aligns with your career goals. Discuss your motivation for pursuing the ambitious MD-PhD degree. You should explain why both clinical practice and research are integral to your career vision and share personal experiences that ignite your interest in this path.

Describe your career goals and how integrating clinical practice and scientific research will allow you to achieve those goals. If you’re interested in a particular field, discuss how the blend of clinical and research training in the MD-PhD program will enhance your contributions to this field.

Significant Research Experience Essay

This essay is your chance to elaborate on your research experiences and demonstrate your scientific curiosity, perseverance, and ability to work independently. You’ll explain the objectives of the research project you have been involved in, your role in achieving these objectives, and the significance of the research.

You can also write about instances where you faced challenges and had to use your problem-solving skills, perseverance, and critical thinking to overcome them. Highlight your ability to learn from others, like your mentors, how you can collaborate, and contribute to a team-oriented goal.

If your work led to any significant findings, presentations, or publications, be sure to include this. Use this opportunity to communicate your passion for research and how these experiences have prepared you for a career that combines patient care and scientific investigation.

MD-PhD: The career path that moves medicine forward.

MD-PhD candidates have a commitment to both medical practice and research on this path. The journey is long and at times challenging, but for those driven by a passion for both clinical medicine and biomedical research, the reward lies in the unique ability to contribute to the advancement of healthcare as a physician-scientist.

Speak with a member of our enrollment team who can help you prepare your MD-PhD application.

Kachiu Lee, MD

Dr. Lee specializes in BS/MD admissions. She was accepted into seven combined bachelor-medical degree programs. She graduated Summa Cum Laude from Northwestern University and proceeded to Northwestern University’s Feinberg School of Medicine in Chicago, IL. After completing a dermatology residency at Brown University, Dr. Lee pursued a fellowship in Photomedicine, Lasers, and Cosmetics at Massachusetts General Hospital and was a Clinical Fellow at Harvard Medical School. Academically, she has over 100 peer-reviewed publications and lectures internationally.

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Why Pursue an MD-PhD?

New section.

Just some of the reasons why people choose a career as a physician-scientist.

• The career of a physician-scientist is unique. There are few comparable careers that allow one to experience the passion of solving a patient's medical struggles while pursuing research that may define the mechanism of that patient’s disease and may ultimately translate into a clinical cure for the disease.
• MD-PhD trainees are research scientists who solve mechanisms underlying disease, combined with their passion to treat patients in a clinical setting.
• MD-PhD training efficiently integrates the scientific and medical education of the physician-scientist.
• During the PhD training years, MD-PhD students take the coursework and formal training in research methodology that are important for the development of the research scientist.
• Most MD-PhD programs provide trainees with a stipend and tuition scholarships. This financial support recognizes the time that a student must spend in training for the MD-PhD career. The extent of financial support varies among programs and may only support U.S. citizens and permanent residents.

Areas of Research Interest for MD-PhD Training

• Most MD-PhD candidates earn their PhD in biomedical laboratory disciplines such as cell biology, biochemistry, genetics, immunology, pharmacology, physiology, neuroscience, and biomedical engineering.
• Some MD-PhD Programs also allow trainees to do their graduate work in fields outside of laboratory disciplines, including computational biology, economics, epidemiology, health care policy, anthropology, sociology, or the history of medicine.
• The spectrum of graduate degree programs offered is an important element to consider when applying to specific MD-PhD Programs.
• @AAMCpremed

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Emily battled viral encephalitis for years during college, and now as a MD/PhD student, she reminds premeds that it's okay to ask for help.

Cesar couldn't apply to medical school when he first graduated from college due to his undocumented status. Now he's in a MD-PhD program and hopes to practice in the Southwest where there's a high need for Spanish-speaking physicians.