best research paper of all time

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What Are The Most Cited Research Papers Of All Time?

The writers at Nature News recently put together a list of the 100 most highly cited papers of all time. There are a few surprises in here, including the fact that it takes no fewer than 12,119 citations to rank in the top 100.

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The list, which was created by pulling data from the Science Citation Index (SCI), spans the last 100 years of scholarly publications. The sheer size of the literature — 58 million items — shows that the top 100 papers are true outliers; just three publications have more than 100,000 citations. Many of the world's most famous and influential papers didn't even make the cut.

To help put it all into perspective, Nature News put together a video (above) and this infographic (click to embiggen).

If the cumulative stack of all these papers were scaled to the size of Mount Kilimanjaro, then the 100 most-cited papers would represent just one centimeter at the peak. Only 14,499 papers — about a meter and a half's worth — have more than 1,000 citations. Roughly half of the items have only one citation.

So what's the most cited paper of all time? That distinction goes to a 1951 paper by U.S. biochemist Oliver Lowry and colleagues describing an assay to determine the amount of protein in a solution. To date, it has collect more than 305,000 citations. And no one's entirely sure why...

Here are the top five:

Sexy, right?

Shockingly, Watson and Crick's paper on the structure of DNA missed out (just 5,207 citations... what!? ), along with many other historic breakthroughs (like the 1985 discovery of the ozone hole — just 1,871 citations). Instead, papers on methods and software dominate the list.

Here's a breakdown of the citations by category:

You can browse through the entire list here (.xls spreadsheet) or via Nature News 's interactive graphic . And there's much more at the Nature News article .

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• Int J Environ Res Public Health

The Top 100 Most Cited Scientific Papers in the Public, Environmental & Occupational Health Category of Web of Science: A Bibliometric and Visualized Analysis

Vicenç hernández-gonzález.

1 Human Movement Research Group (RGHM), University of Lleida, Plaça de Víctor Siurana, 25003 Lleida, Spain

2 Physical Education and Sport Section, University of Lleida, Av. De l’Estudi General, 25001 Lleida, Spain

Josep Maria Carné-Torrent

Carme jové-deltell, Álvaro pano-rodríguez, joaquin reverter-masia, associated data.

The Web of Science (WoS) data can be accessed through theWoS’s official website: https://www.webofscience.com/wos/alldb/basic-search (accessed on 14 March 2022).

(1) Background: The main basis for the public recognition of the merits of scientists has always been the system of scientific publications and citations. Our goal is to identify and analyze the most cited articles in the Public, Environmental & Occupational Health category. (2) Methods: We searched the Web of Science for all articles published in the “Public, Environmental & Occupational Health” category up to March 2022 and selected the 100 most cited articles. We recorded the number of citations, the journal, the year of publication, quartile, impact factor, institution, country, authors, topic, type of publication and collaborations. (3) Results: 926,665 documents were analyzed. The top 100 had 401,620 citations. The journal with the most articles was the Journal of Clinical Epidemiology and the one with the highest number of citations was Medical Care. The year with the highest number of articles in the top 100 was 1998. The country with the highest percentage of publications was the USA and the most productive institution was Harvard. The most frequent keywords were bias, quality, and extension. The largest collaboration node was between the USA, Canada, Germany, Spain, Australia, France, and Sweden. (4) Conclusions: This bibliometric study on Public, Environmental & Occupational Health provides valuable information not only to identify topics of interest in the analyzed category, but also to identify the differences in the topics they study.

1. Introduction

Bibliometrics is a science that uses statistical and mathematical procedures to track the general trend of research in a specific field [ 1 ]. Various authors have targeted the participation of researchers in scientific activities, as well as differences and conditioning factors from the different fields of scientific knowledge [ 2 ]. These authors attribute different frequency and different publication practices between scientific disciplines [ 2 ]. The Web of Science (WoS) online database includes all important research papers and provides integrated analysis tools to produce representative figures, that is, it is the reference database of institutions, researchers and actors linked to science [ 3 , 4 , 5 ].

Within bibliometrics, citation analysis is one of the most used tools to assess the academic impact of an article in a specific area of knowledge [ 6 ]. The number of citations a publication receives does not necessarily reflect the quality of the research or the relevance of its authors [ 7 ], but it has been suggested that articles with the highest number of citations may have the ability to generate changes in practice, controversy, discussion and more research [ 6 , 8 , 9 ], or, as suggested by Zhu et al. [ 1 ], the number of citations can measure the article’s influence and merit. In addition, WoS search results could be exported to software for later analysis such as VOS-viewer [ 10 ], which could provide important information associated with collaboration networks between countries, institutions or authors.

Although there have been bibliometric analyses of articles in the field of food safety [ 11 , 12 ]; environmental health [ 13 , 14 ]; health promotion [ 15 , 16 ]; health education [ 17 ]; mental health [ 18 , 19 ]; sport health [ 20 ]; and occupational health [ 21 , 22 ], the entire category of Public, Environmental & Occupational Health has never been studied worldwide.

Few studies have a standardized measure of the wide range of dissemination activities in a scientific category that allows a detailed observation of production, collaboration and interrelation in a scientific field. No explorations have been performed based on quantitative methodologies aimed at building indicators on which to be able to empirically test the scientific productivity of the Public, Environmental & Occupational Health category.

To our knowledge, there is no study that bibliometrically analyzes high citation articles that evaluate the Public, Environmental & Occupational Health category. Therefore, this study aimed to identify and analyze the 100 most cited articles in the Public, Environmental & Occupational Health category to understand the historical perspective and promote discussion and scientific progress in this specialty.

2. Materials and Methods

2.1. search strategy and eligible criteria.

Bibliometric analysis was performed on 14 March 2022. Two independent researchers, who searched the Web of Science Core Collection (Clarivate Analytics), a research platform that provides a substantial bibliographic database through of Science Citation Index Expanded (SCIE) using the search category, identified articles. The search strategy was performed through the “Public, Environmental & Occupational Health” category. We refined the research by selecting original research articles and reviews. The 100 articles with the most citations were eligible for bibliometric analysis, arranged in descending order of citation count. Any disagreement between the reviewers was discussed between them to reach a final decision. Author in descending order according to the number of citations ordered these articles.

2.2. Data Extraction

Two authors independently retrieved information from all articles. Through the Web of Science, the 100 articles with the highest number of citations were selected and exported. Later, they were exported into an Excel document where the following were recorded: the number of citations, name of the journal, year of publication, first and last author and co-authors, total number of authors, geographical location, origin and associated institute, the title of the article, type of document (article or review), abstract and corresponding author. For the analysis of authors, all the authors who participated in the study were counted. In the bibliometric analysis by country, each country that participated in the study was taken into account and the citations received were counted. Citations received by a country more than once were not counted if several authors from different institutions but from the same country had participated in the same study. The number of articles per country was counted as long as there was an author from the country in the study. If the first author was affiliated with two institutions, then the first institute was selected for inclusion.

2.3. Statical Analysis

We used IBM SPSS Statistics for Windows, Version 27.0 (Armonk, NY, USA: IBM Corp.) for correlation analysis. Correlation was determined using Pearson’s correlation coefficient (r), and when p < 0.05, the difference was considered statistically significant. We used a popular bibliometric analysis tool, VOSviewer 1.6.18 software (CWTS, Leiden, The Netherlands) [ 23 ], for cooperative network identification and keyword co-occurrence analysis. In addition, it could generate visual maps of knowledge. We also used the MapChart program [ 24 ], a platform from which a personalized map of different regions of the world was created, using colors and descriptions.

The study flowchart is shown in Figure 1 , and included studies that were published from 1900 to 2022 for the Public, Environmental & Occupational Health category of Web of Science. The search topic, after applying the strategy, produced 926,665 documents. For the analysis of the study, only articles or review articles were taken into consideration, which led to the exclusion of 294,361 documents. Of the remaining 632,304, the 100 documents with the highest number of citations were considered for the study. A total of 632,204 documents were excluded.

Flowchart of study.

3.1. Publication Year, Citation and Bibliometric Analysis of the Keywords

The 100 most cited publications in the Public, Environmental & Occupational Health category were published between 1938 and 2020, of which 70% were published after 2018. We performed an analysis of publication trends by 6-year intervals based on a ranking of publication dates. Between 1998 and 2003, 29 documents were published, with the year 1998 ( n = 11) being the year of greatest production. There has been a visible improvement in the quantity of the data, since, of the 100 articles, before 1998 a total of 29 documents were published, making a big difference with the period 1998 to 2003, when 29 articles were published ( Figure 2 ).

Pattern of distribution of top-cited articles (number of articles per year).

The top 100 articles were cited 401,620 times in total, and the average total number of citations was 4016 citations (ranging from 1846 to 30,229). No significant correlation was found between the total number of citations and the age of the articles (r = −0.121, p = 0.229). The most cited article (30,229 citations) was “A new method of classifying prognostic co-morbidity in longitudinal-studies-development and validation” by Charlson et al. [ 25 ] published in the Journal of Chronic Diseases . Based on the number of publications in the 100 articles, and analyzing the citations per publication, 1998 was the most productive year with 11 articles (42,320 citations and an average of 3847 citations/article) in the top 100 list ( Table 1 ).

The top 100 articles with most total citations in Public, Environmental & Ocupational Health category.

The oldest study included in the list was published by Miles et al. [ 26 ] in 1938 entitled “The estimation of the bactericidal power of the blood”, with 3246 citations. The last study included was published in 2020 by Wang et al. [ 27 ], the paper entitled “Immediate Psychological Responses and Associated Factors during the Initial Stage of the 2019 Coronavirus Disease (COVID-19) Epidemic among the General Population in China”, with 2485 citations, published in the International Journal of Environmental Research and Public Health ( Table 1 ).

Eighty-six of the 100 publications were original research, and the remaining 14 were reviews. The average number of citations per article in the review works was 3285 citations/article compared to 4135 citations/article in the original works ( Table 1 ). The most common important keywords included quality of life, comorbidity, disease, cancer, clinical-trials, bias and epidemiology, and the keywords that appeared the most were “bias” (total link strength of 14), “quality” (total link strength of 11) and “extension” (total link strength of 10), which had a strong link with “epidemiology”, “metaanalysis” and “cancer” ( Figure 3 ).

The co-occurrence network of keywords. Note : The size of the nodes indicates the frequency of occurrence. The curves between the nodes represent their co-occurrence in the same publication. The smaller the distance between two nodes, the higher the number of co-occurrence of the two keywords.

3.2. Authors and Bibliometric Analysis of the Co-Authorship

A total of 487 authors contributed the 100 most cited. The number of authors in an article ranged from 1 to 26 (mean 5.53). Analysis of the 10 most productive authors based on their number of articles in the top 100, regardless of their authorship positions, showed that Ware, J.E., Altman, D.G. and Horan, T.C. were the authors with the highest number of articles.

Ware, J.E., from the USA, had a maximum of 46,062 citations with five articles listed and an h-index of 100. The average number of citations/article was 9212 citations. However, Altman, D.G. from England, published four papers, the total index of citations was 36,420 and the average per article was 9105; their h-index was 182. The third position is for the researcher Horan, T.C. from the USA, with four published documents, an h-index of 25, and with more than 13,500 total citations ( Table 2 ).

The top authors with the most articles in the top 100.

The total number of citations was not related to the number of authors (r = −0.118, p = 0.058). However, the average number of citations per article was associated with the number of authors (r = 0.210, p < 0.001).

There was low collaboration between most of the main authors, creating only one cooperation research network. Authors with a minimum of three papers per author were considered for analysis. Of the 487 authors, seven reached the threshold ( Figure 4 ). Altman, D.G. formed a collaborative network with five other researchers with a link strength of 15.

The author collaboration network. Note: The collaboration map of authors reflects the scientific research cooperation between them. The circle/node signifies the authors; size of the circle/node signifies the number of articles. The lines denote the authors’ collaboration strength, and each color signifies a cluster.

3.3. Countries, Institutions and Bibliometric Analysis of the Collaboration

A total of 26 countries published the 100 most cited articles in the Public, Environmental & Occupational Health category. Table 3 shows the twelve most productive countries, with the USA being the one that contributes the most, with 65 documents, followed by England with 21 and Canada with 17 articles. These three same countries obtain also the greatest number of citations. However, the country with the highest rate of citations per article is Italy, with an average of 5151 citations/article, followed by England with an average of 4724 citations/article.

The top countries with the most highly cited articles.

Two collaboration nodes were established. A larger one, involving seven countries and where the USA had the most active partnership (a liaison force of 45 and collaborated on 57 documents); its major research cooperators included Canada, Germany, Spain, Australia, France, Sweden. The other node was where England (with a link strength of 37 and 20 documents) had a strong collaboration with mainly European countries such as Denmark, The Netherlands and Switzerland. We found that Italy and Norway rarely cooperated with other countries in investigations. ( Figure 5 ).

The country collaboration network.

The world map revealed that the articles were mainly concentrated in North American and western Europe, and less so in Oceania. Specifically, the USA was the country with the highest production of documents, followed by England and Canada ( Figure 6 ).

The distribution map of the number of published articles worldwide for countries (MapChart).

In total, 228 institutions participated in the 100 articles. The number of institutions per article ranged between 1 and 21. The average institutional collaboration was 3.8 institutions/article. The article with 21 participating institutions was a review on toxic equivalency factors (TEFs) published in 1998 with 2592 citations. The World Health Organization, with eight articles included in this bibliometric analysis, was the institution with the greatest scientific representation ( Table 4 ). In four of the eight papers, it was included as the main institution of the study. The total number of citations was 20,339 and the average number of citations per article was 2542 citations. The second institution was the University of Harvard in the USA with six documents and one as the main institution. The total number of citations was more than 25,000 with an average of 4209 citations per article.

The top institutions with the most highly cited articles.

There was a strong and significant correlation between the number of institutions and authors (r = 0.848, p < 0.001). There was a negative correlation between the total citations and the number of participating institutions (r = −0.115, p = 0.286).

In the collaboration network analysis ( Figure 7 ), a minimum of three collaborations between institutions were established, 19 reached the threshold and three cooperation network nodes were formed. In the first of them, McMaster University cooperated with institutions such as Harvard University, University of Washington and the University of Toronto and collaborated on five articles. The University of Washington had a strong partnership and cooperation with the University of Minnesota, NCI, and Wake Forest University. Collaboration network analysis also highlighted the institutional collaboration network that the World Health Organization has with University of Toronto, Wisconsin University and US EPA, with more than seven documents shared.

The institution collaboration network.

3.4. Journal Analysis

The Web of Science “Public, Environmental & Occupational Health” category had 204 indexed journals, of which 35 made it to the top 100 most cited articles list. A total of 16 journals were in the first quartile (approximately 45%), 9 journals in the second quartile, 3 in the third quartile, and 5 were from Q4. Two journals were out of print or had changed their name. A total of 79% of the studies were published in high-impact journals (Q1 or Q2).

The IFs of the 35 journals ranged from 0.875, Malawi Medical Journal , to 59.769, MMWR Surveillance Summaries . There were up to 22 journals with an IF < 5.000, seven between 5.000 and 10.000, and four journals with an IF > 10.000.

Table 5 shows the top nine journals that published three or more articles.

The top journals that published the top 100 highly cited literature in Public, Environmental & Occupacional Health category.

Journal of Clinical Epidemiology was the most productive journal ( n = 15), followed by Medical Care and Statistics in Medicine ( n = 12). The top five journals published 54% of the articles and account for more than 59% of the total citations. The self-citation rate for the top nine journals ranged from 1.7% for the Bulletin of the World Health Organization to 10.3% for the Journal of Clinical Epidemiology . The journal with the highest number of citations was Medical Care ( n = 74,189) and its mean number of citations per article was 6182 citations/article.

4. Discussion

This is the first paper that analyzes the 100 most cited papers in the Public, Environmental & Occupational Health category of Web of Science. This article identifies the authors, journals, countries, institutions, etc., with the greatest impact in this category from the beginning of the 20th century to the present. The sample size was set at 100 manuscripts to provide a manageable and significant number of articles to be analyzed, in accordance with several published works [ 1 , 6 , 8 , 9 , 28 , 29 ].

The period of the greatest publication of articles starts in 1998; a clear upward trend in the production of works started during the period 1989–2010, but then it disappears in the last decade. A stochastic process is observed. The Mann–Kendall trend test ( Figure 3 ) revealed a significant positive trend towards a greater number of articles over the years starting in 1985 ( p = 0.055, Kendell’s Tauβ). Our results would be in line with those found by the authors of [ 6 , 29 , 30 ]. They contrasts with recent reviews, on other topics and specialties, in which most of the most cited papers were published earlier in the 1980s [ 31 ] or later, from the year 2000 [ 32 , 33 ]. The socioeconomic growth of recent years may be one of the causes of the advancement in scientific research, an evolution that the dissemination and communication of science has already been experiencing as an exponential change for some time. To understand these changes, it is necessary to know how science spreads. In the professional field, one of the main ways that the research community has to disseminate its work is the publication of scientific articles; however, on the other hand, they also use social networks and all Internet options (scientific forums, blogs, etc.). These tools are also protagonists in recent years, which encourage more dissemination of science and, therefore, more knowledge of what is published [ 34 ]. Some experts believe that studies that are more recent are cited today due to the advancement in scientific dissemination [ 10 ]. It may seem surprising that the studies with the highest number of citations are recent studies; among other factors, this could be due to the appearance of scientific journals in an electronic format, facilitating access and thus favoring circulation in the scientific community [ 6 ].

Some specialists consider that research goes further, suggesting the publication of an article ends when it is read and understood by a large part of society, that is, it is not enough just to publish, it is necessary for the audience to clearly understand its content and, thus, be able to cite it [ 35 ].

The keyword co-occurrence analysis found that the words “cancer”, “quality of life”, “comorbidity”, “epidemilogy” and “disease” had the highest frequency of co-occurrence in the research in the analyzed category. Our work reflects, in part, a growing trend in public health research. Studies on quality of life, comorbidity or cancer have been the focus of research in the scientific community and specifically within the Public, Environmental & Occupational Health category [ 36 , 37 ]. Performing a quick bibliographic search in WoS, these terms occupy the fourth, eighth and fourteenth position, respectively, with more records among the different categories.

Metadata from all documents were used to reveal the most productive authors and the most impactful sources. The high number of authors (487) contributing to the 100 articles, with more than an average of five authors per article, made it difficult to determine the individual contribution and, consequently, the role of each author [ 38 ]. As suggested by Bruni et al. [ 33 ], traditionally, in multi-author articles, the first position is occupied by the main contributor, while the last position is reserved for the supervisor. The authors with most impact in the studied category generally held relevant positions, either as main author or as supervisor. This is becoming more common due to the influence of experimental sciences, considering the same importance to the first and last author, based on the author/director relationship. This interpretation is known as the FLAE approach, an expression of first last author emphasis [ 39 ].

The h-index quantifies the research performance of individual scientists, incorporating both the number and visibility of publications [ 40 ]. In the work, we can see an unequal distribution of the h index among the authors of the 100 articles, where the number of citations that a scientific subcommunity grants to a manuscript is undoubtedly and directly related to the number of researchers that make up such a sub-community [ 41 ]. The analyzed category is a very broad field of knowledge; therefore, the number of citations of the articles will be very different depending on the topic analyzed.

As indicated by Jung et al. [ 42 ], in a context in which there is great interest in intensifying international collaboration within scientific practice, this paper proposes an approach on how to measure and visualize international collaborative work at the institutional level. The low collaboration observed between the different authors in our work contrasts with that found in studies such as by Zhu et al. [ 1 ] or Yu et al. [ 10 ]. The joint analysis of the collaboration indexes of the relationships between the different authors of the documents allows us to make a better interpretation of the structure of international scientific collaboration networks in the category of study [ 43 ]. One of the variables handled in our work was the possibility of identifying whether there was a high level of international and potentially multinational collaboration with other institutions that could affect the visibility of the research and the frequency of citations of a category [ 44 ]. This was not the case, but we have been able to map and identify the existing collaborations within the Public, Environmental & Occupational Health field, as well as the main citation sources.

The most relevant works were mainly in North America, specifically the USA and Canada, and Western Europe. Similarly, citation analysis showed this same trend in previous studies [ 45 , 46 ]. This trend can be explained by several reasons, first of all, by the cumulative geographical advantage, since citations originate more frequently from institutions located in the same country as the place of residence of the author [ 47 , 48 ]. Second, as suggested by Wang et al. [ 49 ], the USA can count on a broad scientific community and generous science funding policies. In fact, the most productive institutions in our study are geographically located in the USA and Europe. A third reason may be that larger universities provide greater opportunities for scientists to collaborate and work on similar topics, and co-authorship may lead to higher citation rates.

Most items originated from two major advanced economies: North America and Western Europe. These are undoubtedly economically developed continents with more access to early research and they can support medical research [ 29 ]. This can be seen in the data published by WHO in a report published in 2020, in which high-income countries spend a higher percentage of GDP on R&D in the health sector [ 50 ].

The cooperative network of research institutions can reveal the distribution of research forces in the field of Public, Environmental & Occupational Health. The USA has the most extensive cooperative relationships and prefers to cooperate with Canada and some European countries. England, with the second highest number of co-authored articles, prefers to work with other European countries. Our results would be in line with those found by Song et al. [ 51 ] in the Entrepreneurship research area. In the field of science, collaborative work, institutional and disciplinary structures face the challenge of a global context. This challenge has led to the creation of initiatives such as e-Science in the United Kingdom, which was announced as a global collaboration program in key areas of science, and the development of the next generation of infrastructure. These types of initiatives show that contemporary scientific practice is characterized by being very collaborative, multidisciplinary, global work with intensive data management [ 52 ].

According to the results, more than half of the classified articles were published in only five journals, collecting more than half of the total citations. These results demonstrate that a significant number of studies concentrated on a limited core of journals, in accordance with Bradford’s law [ 53 ]. As indicated by Highhouse et al. [ 54 ], authors tend to send their work to the most prestigious journals, attracted, according to Bruni et al. [ 33 ], due to the greater visibility in the search results, as well as the greater probability of being cited.

If we look at the quartiles of the journals, works mostly appears on first and second quartile journals. As stated by Torres-Salinas and Cabezas-Calvijo [ 55 ], publication in high-impact journals generates benefits, starting with the fact that a scientist who regularly publishes in these journals will be able to advance smoothly in his scientific career and will be recognized as an expert in his field. Other authors affirm that publication in high-impact journals helps to develop one’s own criteria, increases self-esteem, strengthens the confidence of the researcher, and feeds the desire to continue researching and publishing, in addition to guaranteeing quality through arbitration, such as peer review demonstrates [ 35 , 56 ].

There is no doubt that the use of the JIF as an evaluation measure generates debate, but today it is a useful way to measure the prestige and importance of scientific journals in the international system, as well as for their researchers [ 57 ]. Many authors have pointed out that the JIF has some limitations such as: (a) a built-in bias that favors American journals (in the case of our study, six of the nine journals in the ranking are published in the USA), (b) scoring highly variable IF between fields and specialties within fields, (c) vulnerability to inflation due to self-citation of journals, (d) vulnerability to inflation due to the publication of review articles and meta-analyses, and, finally, (e) an arbitrary citation window that penalizes some fields or specialties within them [ 54 , 57 ].

Finally, we wanted to also compare the JIF without the self-citations. In this sense, the level of self-citation of the analyzed journals was relatively low, with some exceptions. The abuse of self-citations is another element that can substantially affect the JIF. The self-citation rate in the presented list was low (8.1%) compared with other studies [ 33 , 58 , 59 ]. This is a bias that many platforms have been working on for years to solve [ 60 , 61 ].

5. Conclusions

The work allows the identification of relevant aspects in order to encourage scientific mapping in the Public, Environmental & Occupational Health category. The analysis can help the governance of specific areas or it can outline an institution’s research. The category analyzed has very varied topics; however, it allowed us to identify the most cited authors, institutions with greater visibility, and the most notable articles.

It has also made it possible to analyze the researchers who are forming national and international collaboration networks, as well as to identify the most collaborative authors and institutions.

Currently, the publication rate of American researchers is the highest in the category studied and its institutions are among the most productive. In addition, the collaborative network of countries, institutions and authors shows the influence of European and American countries in the Public, Environmental & Occupational Health category.

Keyword analysis was an effective method to identify interesting topics among researchers and mark research trend lines.

The results of this research open up new possibilities to identify new strategies and institutional policies that allow them to consolidate their research networks.

Although there has been an exponential growth in work, greater efforts are still required from both researchers and institutions.

In this article, valuable information is provided not only to identify topics of interest in the analyzed category, but also to identify the differences on topics studied between the areas that form the category.

Funding Statement

This research was funded by Human Movement Research Group: SGR-Cat 2021 grant number SGR 1463. Generalitat de Catalunya.

Author Contributions

Conceptualization, V.H.-G. and J.M.C.-T.; methodology, V.H.-G., C.J.-D. and J.M.C.-T.; formal analysis, V.H.-G. and J.R.-M.; investigation, J.M.C.-T., C.J.-D. and Á.P.-R.; data curation, V.H.-G. and J.M.C.-T.; writing—original draft preparation, V.H.-G. and J.R.-M.; writing—review and editing, V.H.-G., Á.P.-R. and J.R.-M.; visualization, J.M.C.-T. and Á.P.-R.; supervision, J.R.-M.; project administration, J.R.-M.; funding acquisition, V.H.-G., C.J.-D., Á.P.-R. and J.R.-M. All authors have read and agreed to the published version of the manuscript.

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Data availability statement, conflicts of interest.

The authors declare no conflict of interest.

Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.

The most influential climate science paper of all time

Professor of Physical Climate Change; Director of the Priestley International Centre for Climate, University of Leeds

Disclosure statement

Piers Forster receives funding from UK Research Councils and the EU Horizon 2020 programme. He is Trustee of the United Bank of Carbon Forest Charity.

University of Leeds provides funding as a founding partner of The Conversation UK.

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After the second world war, many of Japan’s smartest scientists found jobs in North American laboratories. Syukuro (Suki) Manabe, a 27-year-old physicist, was part of this brain drain. He was working on weather forecasting but left Japan in 1958 to join a new research project by the US Weather Service to develop a numerical model that could be used to study the climate .

Working alongside Joseph Smagorinsky, the Geophysical Fluid Dynamics Laboratory’s visionary first director, Manabe led a team of computer programmers to add missing physics to the lab’s weather model. Even the best computers in the world at the time were far less powerful than today’s mobile phones. So to get the model to work, Manabe needed to make the physics as simple as possible. This meant making a range of coding approximations to quantify how the air exchanged heat and water vapour with the land, ocean and ice.

This climate model development – the first of its kind – was an ambitious 20-year project that ultimately earned Manabe a share of the 2021 Nobel prize in physics . The key paper came mid-way through this period: Manabe and Wetherald (1967) .

Manabe is typically modest about intentions behind the work and from reading its title, “Thermal Equilibrium of the Atmosphere with a Given Distribution of Relative Humidity”, you might be forgiven for thinking it could be a bit dull. Yet the Nobel committee, myself and the hundreds of colleagues around the world that voted it the most influential climate science paper of all time , would beg to differ.

In trying to simplify the code, Manabe and his colleague Richard Wetherald wanted to know the minimum number of discrete levels to use in his model atmosphere. They also wanted to know which greenhouse gases it was necessary to include in the model to adequately represent the way temperatures vary with altitude, as these gases absorb heat emitted from the Earth’s surface, but at different levels. Their three-dimensional climate model was too computer-intensive to run these model tests, so they had to build a simpler one-dimensional model. They wanted to simulate how radiation and clouds interact to redistribute heat and water vapour through the atmosphere.

The bulk of the paper concerns itself with building the simple model and doing these tests. But they also do two other experiments in the paper to quantify how greenhouse gas might alter climate. And this is where the breakthrough occurred: they found they had built the perfect model to accurately estimate how human activities could alter the Earth’s surface temperature.

Their first such climate-change experiment wasn’t to look at the role of carbon dioxide, but was to look at the effects of water vapour injected high into the stratosphere from a potential fleet of supersonic jets, as this and a possible nuclear winter were the immediate concerns of the time. However, their Table 5 goes down in history as the first robust estimate of how much the world would warm if carbon dioxide concentrations doubled. Manabe and Wetherald estimated 2.36°C of warming, not far off today’s best estimate of 3°C .

Earlier attempts to estimate the warming from carbon dioxide increases had floundered, as scientists struggled to work out how water vapour, the most important greenhouse gas in the atmosphere, would respond as the Earth warmed. Manabe and Wetherald’s simple model could accurately redistribute water vapour in a way that real deep clouds do, with water vapour broadly increasing in concentration up to a certain level of humidity. This increase was found to amplify the warming from carbon dioxide by around 75%. This water vapour feedback estimate has also stood the test of time.

Manabe, working with various colleagues, went on to write many more seminal climate modelling papers . He set the foundation for today’s global climate modelling efforts. The physics was beguilingly simple so his models could run on these early computers. Yet, by being simple, the results could be understood and tested. His application of these simple models to the pressing problems of today was insightful.

After graduating with a degree in physics over 30 years ago, I chose a career in atmospheric science over particle physics. I always worried about how my applied physics was viewed by mainstream physics colleagues. With a Nobel prize in physics under our discipline’s belt, it gives me and climate modelling colleagues the credibility and recognition we have yearned for: climate science is real science.

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Roz Pidcock

Which of the many thousands of papers on climate change published each year in scientific journals are the most successful? Which ones have done the most to advance scientists’ understanding, alter the course of climate change research, or inspire future generations?

On Wednesday, Carbon Brief will reveal the results of our analysis into which scientific papers on the topic of climate change are the most “cited”. That means, how many times other scientists have mentioned them in their own published research. It’s a pretty good measure of how much impact a paper has had in the science world.

But there are other ways to measure influence. Before we reveal the figures on the most-cited research, Carbon Brief has asked climate experts what they think are the most influential papers.

We asked all the coordinating lead authors, lead authors and review editors on the last Intergovernmental Panel on Climate Change (IPCC) report to nominate three papers from any time in history. This is the exact question we posed:

What do you consider to be the three most influential papers in the field of climate change?

As you might expect from a broad mix of physical scientists, economists, social scientists and policy experts, the nominations spanned a range of topics and historical periods, capturing some of the great climate pioneers and the very latest climate economics research.

Here’s a link to our summary of who said what . But one paper clearly takes the top spot.

Winner: Manabe & Wetherald ( 1967 )

With eight nominations, a seminal paper by Syukuro Manabe and Richard. T. Wetherald published in the Journal of the Atmospheric Sciences in 1967 tops the Carbon Brief poll as the IPCC scientists’ top choice for the most influential climate change paper of all time.

Entitled, “Thermal Equilibrium of the Atmosphere with a Given Distribution of Relative Humidity”, the work was the first to represent the fundamental elements of the Earth’s climate in a computer model, and to explore what doubling carbon dioxide (CO2) would do to global temperature.

Manabe & Wetherald (1967), Journal of the Atmospheric Sciences

The Manabe & Wetherald paper is considered by many as a pioneering effort in the field of climate modelling, one that effectively opened the door to projecting future climate change. And the value of climate sensitivity is something climate scientists are still grappling with today .

Prof Piers Forster , a physical climate scientist at Leeds University and lead author of the chapter on clouds and aerosols in working group one of the last IPCC report, tells Carbon Brief:

This was really the first physically sound climate model allowing accurate predictions of climate change.

The paper’s findings have stood the test of time amazingly well, Forster says.

Its results are still valid today. Often when I’ve think I’ve done a new bit of work, I found that it had already been included in this paper.

Prof Steve Sherwood , expert in atmospheric climate dynamics at the University of New South Wales and another lead author on the clouds and aerosols chapter, says it’s a tough choice, but Manabe & Wetherald (1967) gets his vote, too. Sherwood tells Carbon Brief:

[The paper was] the first proper computation of global warming and stratospheric cooling from enhanced greenhouse gas concentrations, including atmospheric emission and water-vapour feedback.

Prof Danny Harvey , professor of climate modelling at the University of Toronto and lead author on the buildings chapter in the IPCC’s working group three report on mitigation, emphasises the Manabe & Wetherald paper’s impact on future generations of scientists. He says:

[The paper was] the first to assess the magnitude of the water vapour feedback, and was frequently cited for a good 20 years after it was published.

Tomorrow, Carbon Brief will be publishing an interview with Syukuro Manabe, alongside a special summary by Prof John Mitchell , the Met Office Hadley Centre’s chief scientist from 2002 to 2008 and director of climate science from 2008 to 2010, on why the paper still holds such significance today.

Joint second: Keeling, C.D et al. ( 1976 )

Jumping forward a decade, a classic paper by Charles Keeling and colleagues in 1976 came in joint second place in the Carbon Brief survey.

Published in the journal Tellus under the title, “Atmospheric carbon dioxide variations at Mauna Loa observatory,” the paper documented for the first time the stark rise of carbon dioxide in the atmosphere at the Mauna Loa observatory in Hawaii.

A photocopy of Keeling et al., (1976) Source: University of California, Santa Cruz

Dr Jorge Carrasco , Antarctic climate change researcher at the University of Magallanes  in Chile and lead author on the cryosphere chapter in the last IPCC report, tells Carbon Brief why the research underpinning the “Keeling Curve’ was so important.

This paper revealed for the first time the observing increased of the atmospheric CO2 as the result of the combustion of carbon, petroleum and natural gas.

Prof David Stern , energy and environmental economist at the Australian National University and lead author on the Drivers, Trends and Mitigation chapter of the IPCC’s working group three report, also chooses the 1976 Keeling paper, though he notes:

This is a really tough question as there are so many dimensions to the climate problem – natural science, social science, policy etc.

With the Mauna Loa measurements continuing today , the so-called “Keeling curve” is the longest continuous record of carbon dioxide concentration in the world. Its historical significance and striking simplicity has made it one of the most iconic visualisations of climate change.

Source: US National Oceanic and Atmospheric Administration (NOAA)

Also in joint second place: Held, I.M. & Soden, B.J. ( 2006 )

Fast forwarding a few decades, in joint second place comes a paper by Isaac Held and Brian Soden published in the journal Science in 2006.

The paper, “Robust Responses of the Hydrological Cycle to Global Warming”, identified how rainfall from one place to another would be affected by climate change. Prof Sherwood, who nominated this paper as well as the winning one from Manabe and Wetherald, tells Carbon Brief why it represented an important step forward. He says:

[This paper] advanced what is known as the “wet-get-wetter, dry-get-drier” paradigm for precipitation in global warming. This mantra has been widely misunderstood and misapplied, but was the first and perhaps still the only systematic conclusion about regional precipitation and global warming based on robust physical understanding of the atmosphere.

Held & Soden (2006), Journal of Climate

Honourable mentions

Rather than choosing a single paper, quite a few academics in our survey nominated one or more of the Working Group contributions to the last IPCC report. A couple even suggested the Fifth Assessment Report in its entirety, running to several thousands of pages. The original IPCC report , published in 1990, also got mentioned.

It was clear from the results that scientists tended to pick papers related to their own field. For example, Prof Ottmar Edenhofer , chief economist at the Potsdam Institute for Climate Impact Research and co-chair of the IPCC’s Working Group Three report on mitigation, selected four papers from the last 20 years on the economics of climate change costs versus risks, recent emissions trends, the technological feasibility of strong emissions reductions and the nature of international climate cooperation.

Taking a historical perspective, a few more of the early pioneers of climate science featured in our results, too. For example, Svante Arrhenius’ famous 1896 paper  on the Greenhouse Effect, entitled “On the influence of carbonic acid in the air upon the temperature of the ground”, received a couple of votes.

Prof Jonathan Wiener , environmental policy expert at Duke University in the US and lead author on the International Cooperation chapter in the IPCC’s working group three report, explains why this paper should be remembered as one of the most influential in climate policy. He says:

[This is the] classic paper showing that rising greenhouse gas concentrations lead to increasing global average surface temperature.

Svante Arrhenius (1896), Philosophical Magazine

A few decades later, a paper by Guy Callendar in 1938  linked the increase in carbon dioxide concentration over the previous 50 years to rising temperatures. Entitled, “The artificial production of carbon dioxide and its influence on temperature,” the paper marked an important step forward in climate change research, says Andrew Solow , director of the Woods Hole Marine Policy centre and lead author on the detection and attribution of climate impacts chapter in the IPCC’s working group two report. He says:

There is earlier work on the greenhouse effect, but not (to my knowledge) on the connection between increasing levels of CO2 and temperature.

Though it may feature in the climate change literature hall of fame, this paper raises a question about how to define a paper’s influence, says Forster. Rather than being celebrated among his contemporaries, Callendar’s work achieved recognition a long time after it was published. Forster says:

I would loved to have chosen Callendar (1938) as the first attribution paper that changed the world. Unfortunately, the 1938 effort of Callendar was only really recognised afterwards as being a founding publication of the field … The same comment applies to earlier Arrhenius and Tyndall efforts. They were only influential in hindsight.

Guy Callendar and his 1938 paper in Quarterly Journal of the Royal Meteorological Society

Other honourable mentions in the Carbon Brief survey of most influential climate papers go to Norman Phillips, whose 1956 paper described the first general circulation model, William Nordhaus’s 1991 paper on the economics of the greenhouse effect, and a paper by Camile Parmesan and Gary Yohe in 2003 , considered by many to provide the first formal attribution of climate change impacts on animal and plant species.

Finally, James Hansen’s 2012 paper , “Public perception of climate change and the new climate dice”, was important in highlighting the real-world impacts of climate change, says Prof Andy Challinor , expert in climate change impacts at the University of Leeds and lead author on the food security chapter in the working group two report. He says:

[It] helped with demonstrating the strong links between extreme events this century and climate change. Result: more clarity and less hedging.

Marc Levi , a political scientist at Columbia University and lead author on the IPCC’s human security chapter, makes a wider point, telling Carbon Brief:

The importance is in showing that climate change is observable in the present.

Indeed, attribution of extreme weather continues to be at the forefront of climate science, pushing scientists’ understanding of the climate system and modern technology to their limits.

Look out for more on the latest in attribution research as Carbon Brief reports on the Our Common Futures Under Climate Change conference taking place in Paris this week.

Pinning down which climate science papers most changed the world is difficult, and we suspect climate scientists could argue about this all day. But while the question elicits a range of very personal preferences, stories and characters, one paper has clearly stood the test of time and emerged as the popular choice among today’s climate experts – Manabe and Wetherald, 1967.

Main image: Satellite image of Hurricane Katrina.

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Most Influential NATURE Papers (2022-02)

Nature is a British weekly scientific journal founded and based in London, England. As a multidisciplinary publication, Nature features peer-reviewed research from a variety of academic disciplines, mainly in science, technology, and the natural sciences. Paper Digest Team analyze all papers published on NATURE in the past years, and presents the 10 most influential papers for each year (based on when the paper became available online). This ranking list is automatically constructed based upon citations from both research papers and granted patents, and will be frequently updated to reflect the most recent changes. To find the most influential papers from other conferences/journals, visit Best Paper Digest page. Note: the most influential papers may or may not include the papers that won the best paper awards. (Last updated on: 2022-02-05)

If you do not want to miss any interesting academic paper, you are welcome to sign up our free daily paper digest service to get updates on new papers published in your area every day. To search for papers with highlights, related papers, patents, grants, experts and organizations, please visit our search console . You are also welcome to follow us on Twitter and Linkedin to get updated with new conference digests.

Paper Digest Team [email protected]

TABLE 1: Most Influential NATURE Papers (2022-02)

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Which is the best research paper of all time?

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• Braden O’Neill , DPhil candidate, University of Oxford and medical student, University of Calgary, Alberta, Canada ,
• Helen Macdonald , assistant editor, BMJ

Experts discuss the papers that have shaped their careers

Asking someone to choose their favourite research paper of all time is a lot like asking someone what their favourite food is. We found this out when we ran a workshop at the BMJ ’s recent conference on evidence based medicine, asking experts what they thought were the best research papers of all time. The answer, in short, is that it depends, just like your favourite food depends on your mood, how hungry you are, who you are with, and what else you are doing that day. So when you get some serious people together from the world of evidence based medicine, and ask them what their favourite paper is, perhaps its not surprising that their answers run the gamut from classic cuisine to cutting edge gastronomy.

Peter Gøtzsche on the paper that made his career

If his choice of paper is anything to go by, Professor Peter Gøtzsche’s favourite food is probably a dish cooked by himself. Gøtzsche is a Danish medical researcher and leader of the Nordic Cochrane Center, which conducts systematic reviews and meta-analyses of evidence in healthcare. You have to be fairly self assured to claim your own paper is the best of all time, but he made a compelling case for his choice. Gøtzsche, possibly the world’s most convincing sceptic of breast cancer screening, was the first to make fun of his self nomination. His research concludes with the bold and controversial headline that breast cancer screening does more harm than good. “For every 1000 women screened biennially throughout 12 years, one breast cancer death is avoided whereas the total number of deaths is increased by six.” 1 It’s a message he has broadcast for over a decade and an argument he has taken to the establishment, asking for screening policies to be reversed. But Gøtzsche did not set out to ruffle feathers, just to answer the question: ‘is breast screening worth it?’ Behind his headline is a complex body of careful research. He stressed to students the importance of diligence and accurately interpreting the risk of bias and quality of studies that go into a meta-analysis, such as his.

What advice did he have for tomorrow’s researchers? When the journal Science comes calling, just say yes. Gøtzsche turned down the offer of a 1000 word article in Science to describe his findings, baulking that the word count was insufficient. Science withdrew their offer and Gøtzsche ended up with 800 words in a journal with a lower impact.

Carl Heneghan on simple evidence

How do you start equipping medical students with the skills needed to assess the importance and quality of papers? Carl Heneghan, director of the Centre for Evidence Based Medicine, a centre at Oxford that teaches and promotes evidence based healthcare, nominated his favourite paper for teaching to evidence based medicine-naive medical students. 2 It is not all about fancy tests and clever maths. Sometimes it’s just a matter of common sense and reading carefully. In the case of the DREAM trial, which examined the efficacy of rosiglitazone in preventing diabetes in those with impaired fasting glucose, you don’t need to go beyond the abstract to spot something rather odd:

“Cardiovascular event rates were much the same in both groups, although 14 (0.5%) participants in the rosiglitazone group and two (0.1%) in the placebo group developed heart failure (P=0.01).”

Can you spot the oxymoron? Since when was heart failure not a cardiovascular event?

And it turned out to be a rather ominous sentence, not just in the in its abstract of this paper, but in the story and fate of the drug and the patients who took it. Rosiglitazone was later withdrawn because of concerns about cardiovascular side effects. From its downfall we can learn about what is wrong with our research system and the ways in which we license medicines for use. 3

Mike Clarke on making research count

Sometimes research can be divisive and never more so than over a research question that sets two specialties and their treatments head to head. Professor Mike Clarke, director of the Medical Research Council Methodology Hub in Belfast, a centre for research into trial methodology, is rightly proud of a collaboration between neurosurgeons and radiologists with which he was involved. They set out to discover whether neurosurgical clipping or endovascular coiling was better for patients with ruptured intracranial aneurysms. Without collaboration each specialty might have then worked in isolation, territorially nurturing their own preferred technique for years—perhaps collecting small scale, inconclusive evidence that their approach was better. But as it happened, they didn’t.

With neurosurgeons and radiologists united, Clarke designed a trial that broke through the deadlock of clinical equipoise and answered the question for the most important people—the patients. If you are going to conduct a trial, Clarke told students, you should do it right, so that it has the best chance of being conclusive and informing practice. And this is what they did. The study was large and powered to detect a clinically meaningful difference in a hard outcome—death and dependence at one year after the intervention.

Clarke and his team got their answer: “250 (23.5%) of 1063 patients allocated to endovascular treatment were dead or dependent at one year, compared with 326 (30.9%) of 1055 patients allocated to neurosurgery, an absolute risk reduction of 7.4% (95% confidence interval 3.6 to 11.2, P=0.0001).” 4 It quickly changed practice, which is an all too rare outcome of important trials, Clarke explained. It often takes 10 years or more for the findings of a study to be implemented. His inspiring story of mutual respect and hard work was in stark contrast to a darker side of research that followed.

An-Wen Chan on why a classic sadly never dies

When your mind is numb, memorising the Krebs cycle, it can be hard to imagine a future publishing groundbreaking research in leading medical journals. Chan—a young consultant dermatologist and surgeon—has done it and shared some stories and tips, including how chance encounters with people, and his chosen paper 5 shaped his research career on hidden data and clinical trial reporting.

When a drug is licensed for use, drug companies must submit data about its benefits and harms to regulatory authorities for inspection. But many of the data they share with licensing authorities are never published and remains unavailable to doctors, researchers, and the public. This hidden information forms part of a problem, widely referred to as “missing data.” It is a threat to scientific progress and compromises the ethical duties that researchers have to their participants. And Chan’s choice of paper is a 1980 classic that is sadly as relevant today as ever. The problem continues to this day, along with debate about how to solve it. 6

Tom Jefferson and the road to Damascus

Ex-GP turned systematic reviewer Jefferson swapped patients with coughs and colds for research on the influenza vaccine, and treatments for influenza such as oseltamivir. But if he thought that research would provide an escape from the messy and unpredictable world of general practice, his experience would prove to be quite the opposite.

Recalling his experience coming to understand the layers and layers of conflicts of interest underpinning a 2003 systematic review on the impact of oseltamivir on complications and hospitalisation related to influenza-like illness, 7 Jefferson describes how he had a moment similar to Paul’s conversion on the road to Damascus. As he began to uncover the extent to which data had been systematically hidden from public view, and that the authors were drug company employees and consultants without proper disclosure of conflicts of interest, Jefferson realised that current methods of systematic review using published data are simply not fit for purpose. For him, this produced a complete paradigm shift, and his work has gone on to systematically identify massive gaps in the data available for decision making on this and other antivirals. As a result of this paper, he has gone on to become a leader in an emerging movement to make all clinical trial data accessible.

The BMJ has been a major supporter of the AllTrials campaign, which involves a petition to governments, regulators, and research bodies to register and report all past and present clinical trials. 8 If you haven’t already signed up to this important initiative, you should (alltrials.net), and thank Tom Jefferson and his favourite paper for pushing you to do so.

Let’s face it: learning about evidence at medical school can be dull, dry, sterile, and a far cry from the dynamism of ward banter, adrenaline, and the guts and gore that clinical medicine has to offer. But away from the clinical front line there are important battles that are being fought by our experts, scattered across international academic institutions, media outlets, and online tweets. Why not join them, or at least listen to what they have to say? After all when you hit the wards and rush to your first acutely ill patient you want to know, or be able to find out, if what you say or do to them is helpful and true.

Originally published as: Student BMJ 2013;21:f2662

Competing interests: None declared.

Provenance and peer review: Commissioned; not externally peer reviewed.

You can watch the talks delivered to the student session at Evidence Live INSERT LINK The authors designed the session for students at the Evidence conference.

• ↵ Gøtzsche PC, Olsen O. Is screening for breast cancer with mammography justifiable? Lancet 2000 ; 355 : 129 -34, doi: 10.1016/S0140-6736(99)06065-1 . OpenUrl CrossRef PubMed Web of Science
• ↵ DREAM (Diabetes REduction Assessment with ramipril and rosiglitazone Medication) Trial Investigators, Gerstein HC, Yusuf S, Bosch J, Pogue J, Sheridan P, Dinccag N, et al. Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial. Lancet 2006 ; 368 : 1096 -105, doi: 10.1016/S0140-6736(06)69420-8 . OpenUrl CrossRef PubMed Web of Science
• ↵ Cohen D. Rosiglitazone: what went wrong? BMJ 2010 ; 341 : c4848 . OpenUrl FREE Full Text
• ↵ Molyneux AJ, Kerr RS, Yu LM, Clarke M, Sneade M, Yarnold JA, et al. International Subarachnoid Aneurysm Trial (ISAT) Collaborative Group. International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomized comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and aneurysm occlusion. Lancet 2005 ; 366 : 809 -17, doi: 10.1016/S0140-6736(05)67214-5 . OpenUrl CrossRef PubMed Web of Science
• ↵ Hemminki E. Study of information submitted by drug companies to licensing authorities. BMJ 1980 ; 280 : 833 -6. OpenUrl Abstract / FREE Full Text
• ↵ Cohen D. Complications: tracking down the data on oseltamivir. BMJ 2009 ; 339 : b5387 . OpenUrl FREE Full Text
• ↵ Kaiser L, Wat C, Mills T, Mahoney P, Ward P, Hayden F. Impact of oseltamivir treatment on influenza-related lower respiratory tract complications and hospitalizations. Arch Intern Med 2003 Jul 28;163:1667-72, doi: 10.1001/archinte.163.14.1667 .
• ↵ AllTrials Collaboration. All Trials Registered | All Results Reported. 2013 http://www.alltrials.net/ .

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The Most Popular — and Impactful — HBR Articles of All Time

• Kelsey Hansen

HBR’s 100th anniversary marks a century of publishing ideas that improve the practice of management. In that time, what have our readers found most impactful? What have they shared with their networks? And what have they read the most? We rounded up our top articles by a few different measures to revisit readers’ favorites over the years — and the ones they come back to again and again.

Highlights from a century of management insights.

Your time is valuable, and at HBR we know that you’ll give it only to articles that are truly useful. They have to present solutions to problems you’ve been grappling with, pique your curiosity, tap into your emotions, and show you, your team, or your organization the right way forward.

As HBR turns 100, we look back on our original mission, how we’ve changed, and what the future holds.

• Kelsey Hansen is the senior associate editor for audience engagement at Harvard Business Review.

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How To Write A Research Paper

Step-By-Step Tutorial With Examples + FREE Template

By: Derek Jansen (MBA) | Expert Reviewer: Dr Eunice Rautenbach | March 2024

For many students, crafting a strong research paper from scratch can feel like a daunting task – and rightly so! In this post, we’ll unpack what a research paper is, what it needs to do , and how to write one – in three easy steps. 🙂 

Overview: Writing A Research Paper

What (exactly) is a research paper.

• How to write a research paper
• Stage 1 : Topic & literature search
• Stage 2 : Structure & outline
• Stage 3 : Iterative writing
• Key takeaways

Let’s start by asking the most important question, “ What is a research paper? ”.

Simply put, a research paper is a scholarly written work where the writer (that’s you!) answers a specific question (this is called a research question ) through evidence-based arguments . Evidence-based is the keyword here. In other words, a research paper is different from an essay or other writing assignments that draw from the writer’s personal opinions or experiences. With a research paper, it’s all about building your arguments based on evidence (we’ll talk more about that evidence a little later).

Now, it’s worth noting that there are many different types of research papers , including analytical papers (the type I just described), argumentative papers, and interpretative papers. Here, we’ll focus on analytical papers , as these are some of the most common – but if you’re keen to learn about other types of research papers, be sure to check out the rest of the blog .

With that basic foundation laid, let’s get down to business and look at how to write a research paper .

Overview: The 3-Stage Process

While there are, of course, many potential approaches you can take to write a research paper, there are typically three stages to the writing process. So, in this tutorial, we’ll present a straightforward three-step process that we use when working with students at Grad Coach.

These three steps are:

• Finding a research topic and reviewing the existing literature
• Developing a provisional structure and outline for your paper, and
• Writing up your initial draft and then refining it iteratively

Let’s dig into each of these.

Need a helping hand?

Step 1: Find a topic and review the literature

As we mentioned earlier, in a research paper, you, as the researcher, will try to answer a question . More specifically, that’s called a research question , and it sets the direction of your entire paper. What’s important to understand though is that you’ll need to answer that research question with the help of high-quality sources – for example, journal articles, government reports, case studies, and so on. We’ll circle back to this in a minute.

The first stage of the research process is deciding on what your research question will be and then reviewing the existing literature (in other words, past studies and papers) to see what they say about that specific research question. In some cases, your professor may provide you with a predetermined research question (or set of questions). However, in many cases, you’ll need to find your own research question within a certain topic area.

Finding a strong research question hinges on identifying a meaningful research gap – in other words, an area that’s lacking in existing research. There’s a lot to unpack here, so if you wanna learn more, check out the plain-language explainer video below.

Once you’ve figured out which question (or questions) you’ll attempt to answer in your research paper, you’ll need to do a deep dive into the existing literature – this is called a “ literature search ”. Again, there are many ways to go about this, but your most likely starting point will be Google Scholar .

If you’re new to Google Scholar, think of it as Google for the academic world. You can start by simply entering a few different keywords that are relevant to your research question and it will then present a host of articles for you to review. What you want to pay close attention to here is the number of citations for each paper – the more citations a paper has, the more credible it is (generally speaking – there are some exceptions, of course).

Ideally, what you’re looking for are well-cited papers that are highly relevant to your topic. That said, keep in mind that citations are a cumulative metric , so older papers will often have more citations than newer papers – just because they’ve been around for longer. So, don’t fixate on this metric in isolation – relevance and recency are also very important.

Beyond Google Scholar, you’ll also definitely want to check out academic databases and aggregators such as Science Direct, PubMed, JStor and so on. These will often overlap with the results that you find in Google Scholar, but they can also reveal some hidden gems – so, be sure to check them out.

Once you’ve worked your way through all the literature, you’ll want to catalogue all this information in some sort of spreadsheet so that you can easily recall who said what, when and within what context. If you’d like, we’ve got a free literature spreadsheet that helps you do exactly that.

Step 2: Develop a structure and outline

With your research question pinned down and your literature digested and catalogued, it’s time to move on to planning your actual research paper .

It might sound obvious, but it’s really important to have some sort of rough outline in place before you start writing your paper. So often, we see students eagerly rushing into the writing phase, only to land up with a disjointed research paper that rambles on in multiple

Now, the secret here is to not get caught up in the fine details . Realistically, all you need at this stage is a bullet-point list that describes (in broad strokes) what you’ll discuss and in what order. It’s also useful to remember that you’re not glued to this outline – in all likelihood, you’ll chop and change some sections once you start writing, and that’s perfectly okay. What’s important is that you have some sort of roadmap in place from the start.

At this stage you might be wondering, “ But how should I structure my research paper? ”. Well, there’s no one-size-fits-all solution here, but in general, a research paper will consist of a few relatively standardised components:

• Introduction
• Literature review
• Methodology

Let’s take a look at each of these.

First up is the introduction section . As the name suggests, the purpose of the introduction is to set the scene for your research paper. There are usually (at least) four ingredients that go into this section – these are the background to the topic, the research problem and resultant research question , and the justification or rationale. If you’re interested, the video below unpacks the introduction section in more detail. 

The next section of your research paper will typically be your literature review . Remember all that literature you worked through earlier? Well, this is where you’ll present your interpretation of all that content . You’ll do this by writing about recent trends, developments, and arguments within the literature – but more specifically, those that are relevant to your research question . The literature review can oftentimes seem a little daunting, even to seasoned researchers, so be sure to check out our extensive collection of literature review content here .

With the introduction and lit review out of the way, the next section of your paper is the research methodology . In a nutshell, the methodology section should describe to your reader what you did (beyond just reviewing the existing literature) to answer your research question. For example, what data did you collect, how did you collect that data, how did you analyse that data and so on? For each choice, you’ll also need to justify why you chose to do it that way, and what the strengths and weaknesses of your approach were.

Now, it’s worth mentioning that for some research papers, this aspect of the project may be a lot simpler . For example, you may only need to draw on secondary sources (in other words, existing data sets). In some cases, you may just be asked to draw your conclusions from the literature search itself (in other words, there may be no data analysis at all). But, if you are required to collect and analyse data, you’ll need to pay a lot of attention to the methodology section. The video below provides an example of what the methodology section might look like.

By this stage of your paper, you will have explained what your research question is, what the existing literature has to say about that question, and how you analysed additional data to try to answer your question. So, the natural next step is to present your analysis of that data . This section is usually called the “results” or “analysis” section and this is where you’ll showcase your findings.

Depending on your school’s requirements, you may need to present and interpret the data in one section – or you might split the presentation and the interpretation into two sections. In the latter case, your “results” section will just describe the data, and the “discussion” is where you’ll interpret that data and explicitly link your analysis back to your research question. If you’re not sure which approach to take, check in with your professor or take a look at past papers to see what the norms are for your programme.

Alright – once you’ve presented and discussed your results, it’s time to wrap it up . This usually takes the form of the “ conclusion ” section. In the conclusion, you’ll need to highlight the key takeaways from your study and close the loop by explicitly answering your research question. Again, the exact requirements here will vary depending on your programme (and you may not even need a conclusion section at all) – so be sure to check with your professor if you’re unsure.

Step 3: Write and refine

Finally, it’s time to get writing. All too often though, students hit a brick wall right about here… So, how do you avoid this happening to you?

Well, there’s a lot to be said when it comes to writing a research paper (or any sort of academic piece), but we’ll share three practical tips to help you get started.

First and foremost , it’s essential to approach your writing as an iterative process. In other words, you need to start with a really messy first draft and then polish it over multiple rounds of editing. Don’t waste your time trying to write a perfect research paper in one go. Instead, take the pressure off yourself by adopting an iterative approach.

Secondly , it’s important to always lean towards critical writing , rather than descriptive writing. What does this mean? Well, at the simplest level, descriptive writing focuses on the “ what ”, while critical writing digs into the “ so what ” – in other words, the implications . If you’re not familiar with these two types of writing, don’t worry! You can find a plain-language explanation here.

Last but not least, you’ll need to get your referencing right. Specifically, you’ll need to provide credible, correctly formatted citations for the statements you make. We see students making referencing mistakes all the time and it costs them dearly. The good news is that you can easily avoid this by using a simple reference manager . If you don’t have one, check out our video about Mendeley, an easy (and free) reference management tool that you can start using today.

Recap: Key Takeaways

We’ve covered a lot of ground here. To recap, the three steps to writing a high-quality research paper are:

• To choose a research question and review the literature
• To plan your paper structure and draft an outline
• To take an iterative approach to writing, focusing on critical writing and strong referencing

Remember, this is just a b ig-picture overview of the research paper development process and there’s a lot more nuance to unpack. So, be sure to grab a copy of our free research paper template to learn more about how to write a research paper.

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• How to write a research paper

Last updated

11 January 2024

Reviewed by

With proper planning, knowledge, and framework, completing a research paper can be a fulfilling and exciting experience. 

Though it might initially sound slightly intimidating, this guide will help you embrace the challenge. 

By documenting your findings, you can inspire others and make a difference in your field. Here's how you can make your research paper unique and comprehensive.

• What is a research paper?

Research papers allow you to demonstrate your knowledge and understanding of a particular topic. These papers are usually lengthier and more detailed than typical essays, requiring deeper insight into the chosen topic.

To write a research paper, you must first choose a topic that interests you and is relevant to the field of study. Once you’ve selected your topic, gathering as many relevant resources as possible, including books, scholarly articles, credible websites, and other academic materials, is essential. You must then read and analyze these sources, summarizing their key points and identifying gaps in the current research.

You can formulate your ideas and opinions once you thoroughly understand the existing research. To get there might involve conducting original research, gathering data, or analyzing existing data sets. It could also involve presenting an original argument or interpretation of the existing research.

Writing a successful research paper involves presenting your findings clearly and engagingly, which might involve using charts, graphs, or other visual aids to present your data and using concise language to explain your findings. You must also ensure your paper adheres to relevant academic formatting guidelines, including proper citations and references.

Overall, writing a research paper requires a significant amount of time, effort, and attention to detail. However, it is also an enriching experience that allows you to delve deeply into a subject that interests you and contribute to the existing body of knowledge in your chosen field.

• How long should a research paper be?

Research papers are deep dives into a topic. Therefore, they tend to be longer pieces of work than essays or opinion pieces. 

However, a suitable length depends on the complexity of the topic and your level of expertise. For instance, are you a first-year college student or an experienced professional? 

Also, remember that the best research papers provide valuable information for the benefit of others. Therefore, the quality of information matters most, not necessarily the length. Being concise is valuable.

Following these best practice steps will help keep your process simple and productive:

1. Gaining a deep understanding of any expectations

Before diving into your intended topic or beginning the research phase, take some time to orient yourself. Suppose there’s a specific topic assigned to you. In that case, it’s essential to deeply understand the question and organize your planning and approach in response. Pay attention to the key requirements and ensure you align your writing accordingly. 

This preparation step entails

Deeply understanding the task or assignment

Being clear about the expected format and length

Familiarizing yourself with the citation and referencing requirements 

Understanding any defined limits for your research contribution

Where applicable, speaking to your professor or research supervisor for further clarification

2. Choose your research topic

Select a research topic that aligns with both your interests and available resources. Ideally, focus on a field where you possess significant experience and analytical skills. In crafting your research paper, it's crucial to go beyond summarizing existing data and contribute fresh insights to the chosen area.

Consider narrowing your focus to a specific aspect of the topic. For example, if exploring the link between technology and mental health, delve into how social media use during the pandemic impacts the well-being of college students. Conducting interviews and surveys with students could provide firsthand data and unique perspectives, adding substantial value to the existing knowledge.

When finalizing your topic, adhere to legal and ethical norms in the relevant area (this ensures the integrity of your research, protects participants' rights, upholds intellectual property standards, and ensures transparency and accountability). Following these principles not only maintains the credibility of your work but also builds trust within your academic or professional community.

For instance, in writing about medical research, consider legal and ethical norms , including patient confidentiality laws and informed consent requirements. Similarly, if analyzing user data on social media platforms, be mindful of data privacy regulations, ensuring compliance with laws governing personal information collection and use. Aligning with legal and ethical standards not only avoids potential issues but also underscores the responsible conduct of your research.

3. Gather preliminary research

Once you’ve landed on your topic, it’s time to explore it further. You’ll want to discover more about available resources and existing research relevant to your assignment at this stage. 

This exploratory phase is vital as you may discover issues with your original idea or realize you have insufficient resources to explore the topic effectively. This key bit of groundwork allows you to redirect your research topic in a different, more feasible, or more relevant direction if necessary. 

Spending ample time at this stage ensures you gather everything you need, learn as much as you can about the topic, and discover gaps where the topic has yet to be sufficiently covered, offering an opportunity to research it further. 

4. Define your research question

To produce a well-structured and focused paper, it is imperative to formulate a clear and precise research question that will guide your work. Your research question must be informed by the existing literature and tailored to the scope and objectives of your project. By refining your focus, you can produce a thoughtful and engaging paper that effectively communicates your ideas to your readers.

5. Write a thesis statement

A thesis statement is a one-to-two-sentence summary of your research paper's main argument or direction. It serves as an overall guide to summarize the overall intent of the research paper for you and anyone wanting to know more about the research.

A strong thesis statement is:

Concise and clear: Explain your case in simple sentences (avoid covering multiple ideas). It might help to think of this section as an elevator pitch.

Specific: Ensure that there is no ambiguity in your statement and that your summary covers the points argued in the paper.

Debatable: A thesis statement puts forward a specific argument––it is not merely a statement but a debatable point that can be analyzed and discussed.

Here are three thesis statement examples from different disciplines:

Psychology thesis example: "We're studying adults aged 25-40 to see if taking short breaks for mindfulness can help with stress. Our goal is to find practical ways to manage anxiety better."

Environmental science thesis example: "This research paper looks into how having more city parks might make the air cleaner and keep people healthier. I want to find out if more green spaces means breathing fewer carcinogens in big cities."

UX research thesis example: "This study focuses on improving mobile banking for older adults using ethnographic research, eye-tracking analysis, and interactive prototyping. We investigate the usefulness of eye-tracking analysis with older individuals, aiming to spark debate and offer fresh perspectives on UX design and digital inclusivity for the aging population."

6. Conduct in-depth research

A research paper doesn’t just include research that you’ve uncovered from other papers and studies but your fresh insights, too. You will seek to become an expert on your topic––understanding the nuances in the current leading theories. You will analyze existing research and add your thinking and discoveries.  It's crucial to conduct well-designed research that is rigorous, robust, and based on reliable sources. Suppose a research paper lacks evidence or is biased. In that case, it won't benefit the academic community or the general public. Therefore, examining the topic thoroughly and furthering its understanding through high-quality research is essential. That usually means conducting new research. Depending on the area under investigation, you may conduct surveys, interviews, diary studies , or observational research to uncover new insights or bolster current claims.

7. Determine supporting evidence

Not every piece of research you’ve discovered will be relevant to your research paper. It’s important to categorize the most meaningful evidence to include alongside your discoveries. It's important to include evidence that doesn't support your claims to avoid exclusion bias and ensure a fair research paper.

8. Write a research paper outline

Before diving in and writing the whole paper, start with an outline. It will help you to see if more research is needed, and it will provide a framework by which to write a more compelling paper. Your supervisor may even request an outline to approve before beginning to write the first draft of the full paper. An outline will include your topic, thesis statement, key headings, short summaries of the research, and your arguments.

9. Write your first draft

Once you feel confident about your outline and sources, it’s time to write your first draft. While penning a long piece of content can be intimidating, if you’ve laid the groundwork, you will have a structure to help you move steadily through each section. To keep up motivation and inspiration, it’s often best to keep the pace quick. Stopping for long periods can interrupt your flow and make jumping back in harder than writing when things are fresh in your mind.

10. Cite your sources correctly

It's always a good practice to give credit where it's due, and the same goes for citing any works that have influenced your paper. Building your arguments on credible references adds value and authenticity to your research. In the formatting guidelines section, you’ll find an overview of different citation styles (MLA, CMOS, or APA), which will help you meet any publishing or academic requirements and strengthen your paper's credibility. It is essential to follow the guidelines provided by your school or the publication you are submitting to ensure the accuracy and relevance of your citations.

11. Ensure your work is original

It is crucial to ensure the originality of your paper, as plagiarism can lead to serious consequences. To avoid plagiarism, you should use proper paraphrasing and quoting techniques. Paraphrasing is rewriting a text in your own words while maintaining the original meaning. Quoting involves directly citing the source. Giving credit to the original author or source is essential whenever you borrow their ideas or words. You can also use plagiarism detection tools such as Scribbr or Grammarly to check the originality of your paper. These tools compare your draft writing to a vast database of online sources. If you find any accidental plagiarism, you should correct it immediately by rephrasing or citing the source.

12. Revise, edit, and proofread

One of the essential qualities of excellent writers is their ability to understand the importance of editing and proofreading. Even though it's tempting to call it a day once you've finished your writing, editing your work can significantly improve its quality. It's natural to overlook the weaker areas when you've just finished writing a paper. Therefore, it's best to take a break of a day or two, or even up to a week, to refresh your mind. This way, you can return to your work with a new perspective. After some breathing room, you can spot any inconsistencies, spelling and grammar errors, typos, or missing citations and correct them. 

• The best research paper format 

The format of your research paper should align with the requirements set forth by your college, school, or target publication. 

There is no one “best” format, per se. Depending on the stated requirements, you may need to include the following elements:

Title page: The title page of a research paper typically includes the title, author's name, and institutional affiliation and may include additional information such as a course name or instructor's name. 

Table of contents: Include a table of contents to make it easy for readers to find specific sections of your paper.

Abstract: The abstract is a summary of the purpose of the paper.

Methods : In this section, describe the research methods used. This may include collecting data , conducting interviews, or doing field research .

Results: Summarize the conclusions you drew from your research in this section.

Discussion: In this section, discuss the implications of your research . Be sure to mention any significant limitations to your approach and suggest areas for further research.

Tables, charts, and illustrations: Use tables, charts, and illustrations to help convey your research findings and make them easier to understand.

Works cited or reference page: Include a works cited or reference page to give credit to the sources that you used to conduct your research.

Bibliography: Provide a list of all the sources you consulted while conducting your research.

Dedication and acknowledgments : Optionally, you may include a dedication and acknowledgments section to thank individuals who helped you with your research.

• General style and formatting guidelines

Formatting your research paper means you can submit it to your college, journal, or other publications in compliance with their criteria.

Research papers tend to follow the American Psychological Association (APA), Modern Language Association (MLA), or Chicago Manual of Style (CMOS) guidelines.

Here’s how each style guide is typically used:

Chicago Manual of Style (CMOS):

CMOS is a versatile style guide used for various types of writing. It's known for its flexibility and use in the humanities. CMOS provides guidelines for citations, formatting, and overall writing style. It allows for both footnotes and in-text citations, giving writers options based on their preferences or publication requirements.

American Psychological Association (APA):

APA is common in the social sciences. It’s hailed for its clarity and emphasis on precision. It has specific rules for citing sources, creating references, and formatting papers. APA style uses in-text citations with an accompanying reference list. It's designed to convey information efficiently and is widely used in academic and scientific writing.

Modern Language Association (MLA):

MLA is widely used in the humanities, especially literature and language studies. It emphasizes the author-page format for in-text citations and provides guidelines for creating a "Works Cited" page. MLA is known for its focus on the author's name and the literary works cited. It’s frequently used in disciplines that prioritize literary analysis and critical thinking.

To confirm you're using the latest style guide, check the official website or publisher's site for updates, consult academic resources, and verify the guide's publication date. Online platforms and educational resources may also provide summaries and alerts about any revisions or additions to the style guide.

Citing sources

When working on your research paper, it's important to cite the sources you used properly. Your citation style will guide you through this process. Generally, there are three parts to citing sources in your research paper: 

First, provide a brief citation in the body of your essay. This is also known as a parenthetical or in-text citation. 

Second, include a full citation in the Reference list at the end of your paper. Different types of citations include in-text citations, footnotes, and reference lists. 

In-text citations include the author's surname and the date of the citation. 

Footnotes appear at the bottom of each page of your research paper. They may also be summarized within a reference list at the end of the paper. 

A reference list includes all of the research used within the paper at the end of the document. It should include the author, date, paper title, and publisher listed in the order that aligns with your citation style.

10 research paper writing tips:

Following some best practices is essential to writing a research paper that contributes to your field of study and creates a positive impact.

These tactics will help you structure your argument effectively and ensure your work benefits others:

Clear and precise language:  Ensure your language is unambiguous. Use academic language appropriately, but keep it simple. Also, provide clear takeaways for your audience.

Effective idea separation:  Organize the vast amount of information and sources in your paper with paragraphs and titles. Create easily digestible sections for your readers to navigate through.

Compelling intro:  Craft an engaging introduction that captures your reader's interest. Hook your audience and motivate them to continue reading.

Thorough revision and editing:  Take the time to review and edit your paper comprehensively. Use tools like Grammarly to detect and correct small, overlooked errors.

Thesis precision:  Develop a clear and concise thesis statement that guides your paper. Ensure that your thesis aligns with your research's overall purpose and contribution.

Logical flow of ideas:  Maintain a logical progression throughout the paper. Use transitions effectively to connect different sections and maintain coherence.

Critical evaluation of sources:  Evaluate and critically assess the relevance and reliability of your sources. Ensure that your research is based on credible and up-to-date information.

Thematic consistency:  Maintain a consistent theme throughout the paper. Ensure that all sections contribute cohesively to the overall argument.

Relevant supporting evidence:  Provide concise and relevant evidence to support your arguments. Avoid unnecessary details that may distract from the main points.

Embrace counterarguments:  Acknowledge and address opposing views to strengthen your position. Show that you have considered alternative arguments in your field.

7 research tips 

If you want your paper to not only be well-written but also contribute to the progress of human knowledge, consider these tips to take your paper to the next level:

Selecting the appropriate topic: The topic you select should align with your area of expertise, comply with the requirements of your project, and have sufficient resources for a comprehensive investigation.

Use academic databases: Academic databases such as PubMed, Google Scholar, and JSTOR offer a wealth of research papers that can help you discover everything you need to know about your chosen topic.

Critically evaluate sources: It is important not to accept research findings at face value. Instead, it is crucial to critically analyze the information to avoid jumping to conclusions or overlooking important details. A well-written research paper requires a critical analysis with thorough reasoning to support claims.

Diversify your sources: Expand your research horizons by exploring a variety of sources beyond the standard databases. Utilize books, conference proceedings, and interviews to gather diverse perspectives and enrich your understanding of the topic.

Take detailed notes: Detailed note-taking is crucial during research and can help you form the outline and body of your paper.

Stay up on trends: Keep abreast of the latest developments in your field by regularly checking for recent publications. Subscribe to newsletters, follow relevant journals, and attend conferences to stay informed about emerging trends and advancements. 

Engage in peer review: Seek feedback from peers or mentors to ensure the rigor and validity of your research . Peer review helps identify potential weaknesses in your methodology and strengthens the overall credibility of your findings.

• The real-world impact of research papers

Writing a research paper is more than an academic or business exercise. The experience provides an opportunity to explore a subject in-depth, broaden one's understanding, and arrive at meaningful conclusions. With careful planning, dedication, and hard work, writing a research paper can be a fulfilling and enriching experience contributing to advancing knowledge.

How do I publish my research paper? 

Many academics wish to publish their research papers. While challenging, your paper might get traction if it covers new and well-written information. To publish your research paper, find a target publication, thoroughly read their guidelines, format your paper accordingly, and send it to them per their instructions. You may need to include a cover letter, too. After submission, your paper may be peer-reviewed by experts to assess its legitimacy, quality, originality, and methodology. Following review, you will be informed by the publication whether they have accepted or rejected your paper. 

What is a good opening sentence for a research paper? 

Beginning your research paper with a compelling introduction can ensure readers are interested in going further. A relevant quote, a compelling statistic, or a bold argument can start the paper and hook your reader. Remember, though, that the most important aspect of a research paper is the quality of the information––not necessarily your ability to storytell, so ensure anything you write aligns with your goals.

Research paper vs. a research proposal—what’s the difference?

While some may confuse research papers and proposals, they are different documents. 

A research proposal comes before a research paper. It is a detailed document that outlines an intended area of exploration. It includes the research topic, methodology, timeline, sources, and potential conclusions. Research proposals are often required when seeking approval to conduct research. 

A research paper is a summary of research findings. A research paper follows a structured format to present those findings and construct an argument or conclusion.

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Announcing the NeurIPS 2023 Paper Awards 

Communications Chairs 2023 2023 Conference awards , neurips2023

By Amir Globerson, Kate Saenko, Moritz Hardt, Sergey Levine and Comms Chair, Sahra Ghalebikesabi 

We are honored to announce the award-winning papers for NeurIPS 2023! This year’s prestigious awards consist of the Test of Time Award plus two Outstanding Paper Awards in each of these three categories: 

• Two Outstanding Main Track Papers 
• Two Outstanding Main Track Runner-Ups 
• Two Outstanding Datasets and Benchmark Track Papers  

This year’s organizers received a record number of paper submissions. Of the 13,300 submitted papers that were reviewed by 968 Area Chairs, 98 senior area chairs, and 396 Ethics reviewers 3,540  were accepted after 502 papers were flagged for ethics reviews . 

We thank the awards committee for the main track: Yoav Artzi, Chelsea Finn, Ludwig Schmidt, Ricardo Silva, Isabel Valera, and Mengdi Wang. For the Datasets and Benchmarks track, we thank Sergio Escalera, Isabelle Guyon, Neil Lawrence, Dina Machuve, Olga Russakovsky, Hugo Jair Escalante, Deepti Ghadiyaram, and Serena Yeung. Conflicts of interest were taken into account in the decision process.

Congratulations to all the authors! See Posters Sessions Tue-Thur in Great Hall & B1-B2 (level 1).

Outstanding Main Track Papers

Privacy Auditing with One (1) Training Run Authors: Thomas Steinke · Milad Nasr · Matthew Jagielski

Poster session 2: Tue 12 Dec 5:15 p.m. — 7:15 p.m. CST, #1523

Oral: Tue 12 Dec 3:40 p.m. — 4:40 p.m. CST, Room R06-R09 (level 2)

Abstract: We propose a scheme for auditing differentially private machine learning systems with a single training run. This exploits the parallelism of being able to add or remove multiple training examples independently. We analyze this using the connection between differential privacy and statistical generalization, which avoids the cost of group privacy. Our auditing scheme requires minimal assumptions about the algorithm and can be applied in the black-box or white-box setting. We demonstrate the effectiveness of our framework by applying it to DP-SGD, where we can achieve meaningful empirical privacy lower bounds by training only one model. In contrast, standard methods would require training hundreds of models.

Are Emergent Abilities of Large Language Models a Mirage? Authors: Rylan Schaeffer · Brando Miranda · Sanmi Koyejo

Poster session 6: Thu 14 Dec 5:00 p.m. — 7:00 p.m. CST, #1108

Oral: Thu 14 Dec 3:20 p.m. — 3:35 p.m. CST, Hall C2 (level 1) 

Abstract: Recent work claims that large language models display emergent abilities, abilities not present in smaller-scale models that are present in larger-scale models. What makes emergent abilities intriguing is two-fold: their sharpness, transitioning seemingly instantaneously from not present to present, and their unpredictability , appearing at seemingly unforeseeable model scales. Here, we present an alternative explanation for emergent abilities: that for a particular task and model family, when analyzing fixed model outputs, emergent abilities appear due to the researcher’s choice of metric rather than due to fundamental changes in model behavior with scale. Specifically, nonlinear or discontinuous metrics produce apparent emergent abilities, whereas linear or continuous metrics produce smooth, continuous, predictable changes in model performance. We present our alternative explanation in a simple mathematical model, then test it in three complementary ways: we (1) make, test and confirm three predictions on the effect of metric choice using the InstructGPT/GPT-3 family on tasks with claimed emergent abilities, (2) make, test and confirm two predictions about metric choices in a meta-analysis of emergent abilities on BIG-Bench; and (3) show how to choose metrics to produce never-before-seen seemingly emergent abilities in multiple vision tasks across diverse deep networks. Via all three analyses, we provide evidence that alleged emergent abilities evaporate with different metrics or with better statistics, and may not be a fundamental property of scaling AI models.

Outstanding Main Track Runner-Ups

Scaling Data-Constrained Language Models Authors : Niklas Muennighoff · Alexander Rush · Boaz Barak · Teven Le Scao · Nouamane Tazi · Aleksandra Piktus · Sampo Pyysalo · Thomas Wolf · Colin Raffel

Poster session 2: Tue 12 Dec 5:15 p.m. — 7:15 p.m. CST, #813

Oral: Tue 12 Dec 3:40 p.m. — 4:40 p.m. CST, Hall C2 (level 1)  

Abstract : The current trend of scaling language models involves increasing both parameter count and training dataset size. Extrapolating this trend suggests that training dataset size may soon be limited by the amount of text data available on the internet. Motivated by this limit, we investigate scaling language models in data-constrained regimes. Specifically, we run a large set of experiments varying the extent of data repetition and compute budget, ranging up to 900 billion training tokens and 9 billion parameter models. We find that with constrained data for a fixed compute budget, training with up to 4 epochs of repeated data yields negligible changes to loss compared to having unique data. However, with more repetition, the value of adding compute eventually decays to zero. We propose and empirically validate a scaling law for compute optimality that accounts for the decreasing value of repeated tokens and excess parameters. Finally, we experiment with approaches mitigating data scarcity, including augmenting the training dataset with code data or removing commonly used filters. Models and datasets from our 400 training runs are freely available at https://github.com/huggingface/datablations .

Direct Preference Optimization: Your Language Model is Secretly a Reward Model Authors: Rafael Rafailov · Archit Sharma · Eric Mitchell · Christopher D Manning · Stefano Ermon · Chelsea Finn

Poster session 6: Thu 14 Dec 5:00 p.m. — 7:00 p.m. CST, #625

Oral: Thu 14 Dec 3:50 p.m. — 4:05 p.m. CST, Ballroom A-C (level 2)  

Abstract: While large-scale unsupervised language models (LMs) learn broad world knowledge and some reasoning skills, achieving precise control of their behavior is difficult due to the completely unsupervised nature of their training. Existing methods for gaining such steerability collect human labels of the relative quality of model generations and fine-tune the unsupervised LM to align with these preferences, often with reinforcement learning from human feedback (RLHF). However, RLHF is a complex and often unstable procedure, first fitting a reward model that reflects the human preferences, and then fine-tuning the large unsupervised LM using reinforcement learning to maximize this estimated reward without drifting too far from the original model. In this paper, we leverage a mapping between reward functions and optimal policies to show that this constrained reward maximization problem can be optimized exactly with a single stage of policy training, essentially solving a classification problem on the human preference data. The resulting algorithm, which we call Direct Preference Optimization (DPO), is stable, performant, and computationally lightweight, eliminating the need for fitting a reward model, sampling from the LM during fine-tuning, or performing significant hyperparameter tuning. Our experiments show that DPO can fine-tune LMs to align with human preferences as well as or better than existing methods. Notably, fine-tuning with DPO exceeds RLHF’s ability to control sentiment of generations and improves response quality in summarization and single-turn dialogue while being substantially simpler to implement and train.

Outstanding Datasets and Benchmarks Papers

In the dataset category : 

ClimSim: A large multi-scale dataset for hybrid physics-ML climate emulation

Authors:  Sungduk Yu · Walter Hannah · Liran Peng · Jerry Lin · Mohamed Aziz Bhouri · Ritwik Gupta · Björn Lütjens · Justus C. Will · Gunnar Behrens · Julius Busecke · Nora Loose · Charles Stern · Tom Beucler · Bryce Harrop · Benjamin Hillman · Andrea Jenney · Savannah L. Ferretti · Nana Liu · Animashree Anandkumar · Noah Brenowitz · Veronika Eyring · Nicholas Geneva · Pierre Gentine · Stephan Mandt · Jaideep Pathak · Akshay Subramaniam · Carl Vondrick · Rose Yu · Laure Zanna · Tian Zheng · Ryan Abernathey · Fiaz Ahmed · David Bader · Pierre Baldi · Elizabeth Barnes · Christopher Bretherton · Peter Caldwell · Wayne Chuang · Yilun Han · YU HUANG · Fernando Iglesias-Suarez · Sanket Jantre · Karthik Kashinath · Marat Khairoutdinov · Thorsten Kurth · Nicholas Lutsko · Po-Lun Ma · Griffin Mooers · J. David Neelin · David Randall · Sara Shamekh · Mark Taylor · Nathan Urban · Janni Yuval · Guang Zhang · Mike Pritchard

Poster session 4: Wed 13 Dec 5:00 p.m. — 7:00 p.m. CST, #105 

Oral: Wed 13 Dec 3:45 p.m. — 4:00 p.m. CST, Ballroom A-C (level 2)

Abstract: Modern climate projections lack adequate spatial and temporal resolution due to computational constraints. A consequence is inaccurate and imprecise predictions of critical processes such as storms. Hybrid methods that combine physics with machine learning (ML) have introduced a new generation of higher fidelity climate simulators that can sidestep Moore’s Law by outsourcing compute-hungry, short, high-resolution simulations to ML emulators. However, this hybrid ML-physics simulation approach requires domain-specific treatment and has been inaccessible to ML experts because of lack of training data and relevant, easy-to-use workflows. We present ClimSim, the largest-ever dataset designed for hybrid ML-physics research. It comprises multi-scale climate simulations, developed by a consortium of climate scientists and ML researchers. It consists of 5.7 billion pairs of multivariate input and output vectors that isolate the influence of locally-nested, high-resolution, high-fidelity physics on a host climate simulator’s macro-scale physical state. The dataset is global in coverage, spans multiple years at high sampling frequency, and is designed such that resulting emulators are compatible with downstream coupling into operational climate simulators. We implement a range of deterministic and stochastic regression baselines to highlight the ML challenges and their scoring. The data (https://huggingface.co/datasets/LEAP/ClimSim_high-res) and code (https://leap-stc.github.io/ClimSim) are released openly to support the development of hybrid ML-physics and high-fidelity climate simulations for the benefit of science and society.   

In the benchmark category :

DecodingTrust: A Comprehensive Assessment of Trustworthiness in GPT Models

Authors: Boxin Wang · Weixin Chen · Hengzhi Pei · Chulin Xie · Mintong Kang · Chenhui Zhang · Chejian Xu · Zidi Xiong · Ritik Dutta · Rylan Schaeffer · Sang Truong · Simran Arora · Mantas Mazeika · Dan Hendrycks · Zinan Lin · Yu Cheng · Sanmi Koyejo · Dawn Song · Bo Li

Poster session 1: Tue 12 Dec 10:45 a.m. — 12:45 p.m. CST, #1618  

Oral: Tue 12 Dec 10:30 a.m. — 10:45 a.m. CST, Ballroom A-C (Level 2)

Abstract: Generative Pre-trained Transformer (GPT) models have exhibited exciting progress in capabilities, capturing the interest of practitioners and the public alike. Yet, while the literature on the trustworthiness of GPT models remains limited, practitioners have proposed employing capable GPT models for sensitive applications to healthcare and finance – where mistakes can be costly. To this end, this work proposes a comprehensive trustworthiness evaluation for large language models with a focus on GPT-4 and GPT-3.5, considering diverse perspectives – including toxicity, stereotype bias, adversarial robustness, out-of-distribution robustness, robustness on adversarial demonstrations, privacy, machine ethics, and fairness. Based on our evaluations, we discover previously unpublished vulnerabilities to trustworthiness threats. For instance, we find that GPT models can be easily misled to generate toxic and biased outputs and leak private information in both training data and conversation history. We also find that although GPT-4 is usually more trustworthy than GPT-3.5 on standard benchmarks, GPT-4 is more vulnerable given jailbreaking system or user prompts, potentially due to the reason that GPT-4 follows the (misleading) instructions more precisely. Our work illustrates a comprehensive trustworthiness evaluation of GPT models and sheds light on the trustworthiness gaps. Our benchmark is publicly available at https://decodingtrust.github.io/.

Test of Time

This year, following the usual practice, we chose a NeurIPS paper from 10 years ago to receive the Test of Time Award, and “ Distributed Representations of Words and Phrases and their Compositionality ” by Tomas Mikolov, Ilya Sutskever, Kai Chen, Greg Corrado, and Jeffrey Dean, won. 

Published at NeurIPS 2013 and cited over 40,000 times, the work introduced the seminal word embedding technique word2vec. Demonstrating the power of learning from large amounts of unstructured text, the work catalyzed progress that marked the beginning of a new era in natural language processing.

Greg Corrado and Jeffrey Dean will be giving a talk about this work and related research on Tuesday, 12 Dec at 3:05 – 3:25 pm CST in Hall F.  

Related Posts

2023 Conference

Announcing NeurIPS 2023 Invited Talks

Reflections on the neurips 2023 ethics review process, neurips newsletter – november 2023.

Cultural Relativity and Acceptance of Embryonic Stem Cell Research

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Main Article Content

There is a debate about the ethical implications of using human embryos in stem cell research, which can be influenced by cultural, moral, and social values. This paper argues for an adaptable framework to accommodate diverse cultural and religious perspectives. By using an adaptive ethics model, research protections can reflect various populations and foster growth in stem cell research possibilities.

INTRODUCTION

Stem cell research combines biology, medicine, and technology, promising to alter health care and the understanding of human development. Yet, ethical contention exists because of individuals’ perceptions of using human embryos based on their various cultural, moral, and social values. While these disagreements concerning policy, use, and general acceptance have prompted the development of an international ethics policy, such a uniform approach can overlook the nuanced ethical landscapes between cultures. With diverse viewpoints in public health, a single global policy, especially one reflecting Western ethics or the ethics prevalent in high-income countries, is impractical. This paper argues for a culturally sensitive, adaptable framework for the use of embryonic stem cells. Stem cell policy should accommodate varying ethical viewpoints and promote an effective global dialogue. With an extension of an ethics model that can adapt to various cultures, we recommend localized guidelines that reflect the moral views of the people those guidelines serve.

Stem cells, characterized by their unique ability to differentiate into various cell types, enable the repair or replacement of damaged tissues. Two primary types of stem cells are somatic stem cells (adult stem cells) and embryonic stem cells. Adult stem cells exist in developed tissues and maintain the body’s repair processes. [1] Embryonic stem cells (ESC) are remarkably pluripotent or versatile, making them valuable in research. [2] However, the use of ESCs has sparked ethics debates. Considering the potential of embryonic stem cells, research guidelines are essential. The International Society for Stem Cell Research (ISSCR) provides international stem cell research guidelines. They call for “public conversations touching on the scientific significance as well as the societal and ethical issues raised by ESC research.” [3] The ISSCR also publishes updates about culturing human embryos 14 days post fertilization, suggesting local policies and regulations should continue to evolve as ESC research develops. [4]  Like the ISSCR, which calls for local law and policy to adapt to developing stem cell research given cultural acceptance, this paper highlights the importance of local social factors such as religion and culture.

I.     Global Cultural Perspective of Embryonic Stem Cells

Views on ESCs vary throughout the world. Some countries readily embrace stem cell research and therapies, while others have stricter regulations due to ethical concerns surrounding embryonic stem cells and when an embryo becomes entitled to moral consideration. The philosophical issue of when the “someone” begins to be a human after fertilization, in the morally relevant sense, [5] impacts when an embryo becomes not just worthy of protection but morally entitled to it. The process of creating embryonic stem cell lines involves the destruction of the embryos for research. [6] Consequently, global engagement in ESC research depends on social-cultural acceptability.

a.     US and Rights-Based Cultures

In the United States, attitudes toward stem cell therapies are diverse. The ethics and social approaches, which value individualism, [7] trigger debates regarding the destruction of human embryos, creating a complex regulatory environment. For example, the 1996 Dickey-Wicker Amendment prohibited federal funding for the creation of embryos for research and the destruction of embryos for “more than allowed for research on fetuses in utero.” [8] Following suit, in 2001, the Bush Administration heavily restricted stem cell lines for research. However, the Stem Cell Research Enhancement Act of 2005 was proposed to help develop ESC research but was ultimately vetoed. [9] Under the Obama administration, in 2009, an executive order lifted restrictions allowing for more development in this field. [10] The flux of research capacity and funding parallels the different cultural perceptions of human dignity of the embryo and how it is socially presented within the country’s research culture. [11]

b.     Ubuntu and Collective Cultures

African bioethics differs from Western individualism because of the different traditions and values. African traditions, as described by individuals from South Africa and supported by some studies in other African countries, including Ghana and Kenya, follow the African moral philosophies of Ubuntu or Botho and Ukama , which “advocates for a form of wholeness that comes through one’s relationship and connectedness with other people in the society,” [12] making autonomy a socially collective concept. In this context, for the community to act autonomously, individuals would come together to decide what is best for the collective. Thus, stem cell research would require examining the value of the research to society as a whole and the use of the embryos as a collective societal resource. If society views the source as part of the collective whole, and opposes using stem cells, compromising the cultural values to pursue research may cause social detachment and stunt research growth. [13] Based on local culture and moral philosophy, the permissibility of stem cell research depends on how embryo, stem cell, and cell line therapies relate to the community as a whole . Ubuntu is the expression of humanness, with the person’s identity drawn from the “’I am because we are’” value. [14] The decision in a collectivistic culture becomes one born of cultural context, and individual decisions give deference to others in the society.

Consent differs in cultures where thought and moral philosophy are based on a collective paradigm. So, applying Western bioethical concepts is unrealistic. For one, Africa is a diverse continent with many countries with different belief systems, access to health care, and reliance on traditional or Western medicines. Where traditional medicine is the primary treatment, the “’restrictive focus on biomedically-related bioethics’” [is] problematic in African contexts because it neglects bioethical issues raised by traditional systems.” [15] No single approach applies in all areas or contexts. Rather than evaluating the permissibility of ESC research according to Western concepts such as the four principles approach, different ethics approaches should prevail.

Another consideration is the socio-economic standing of countries. In parts of South Africa, researchers have not focused heavily on contributing to the stem cell discourse, either because it is not considered health care or a health science priority or because resources are unavailable. [16] Each country’s priorities differ given different social, political, and economic factors. In South Africa, for instance, areas such as maternal mortality, non-communicable diseases, telemedicine, and the strength of health systems need improvement and require more focus. [17] Stem cell research could benefit the population, but it also could divert resources from basic medical care. Researchers in South Africa adhere to the National Health Act and Medicines Control Act in South Africa and international guidelines; however, the Act is not strictly enforced, and there is no clear legislation for research conduct or ethical guidelines. [18]

Some parts of Africa condemn stem cell research. For example, 98.2 percent of the Tunisian population is Muslim. [19] Tunisia does not permit stem cell research because of moral conflict with a Fatwa. Religion heavily saturates the regulation and direction of research. [20] Stem cell use became permissible for reproductive purposes only recently, with tight restrictions preventing cells from being used in any research other than procedures concerning ART/IVF.  Their use is conditioned on consent, and available only to married couples. [21] The community's receptiveness to stem cell research depends on including communitarian African ethics.

c.     Asia

Some Asian countries also have a collective model of ethics and decision making. [22] In China, the ethics model promotes a sincere respect for life or human dignity, [23] based on protective medicine. This model, influenced by Traditional Chinese Medicine (TCM), [24] recognizes Qi as the vital energy delivered via the meridians of the body; it connects illness to body systems, the body’s entire constitution, and the universe for a holistic bond of nature, health, and quality of life. [25] Following a protective ethics model, and traditional customs of wholeness, investment in stem cell research is heavily desired for its applications in regenerative therapies, disease modeling, and protective medicines. In a survey of medical students and healthcare practitioners, 30.8 percent considered stem cell research morally unacceptable while 63.5 percent accepted medical research using human embryonic stem cells. Of these individuals, 89.9 percent supported increased funding for stem cell research. [26] The scientific community might not reflect the overall population. From 1997 to 2019, China spent a total of $576 million (USD) on stem cell research at 8,050 stem cell programs, increased published presence from 0.6 percent to 14.01 percent of total global stem cell publications as of 2014, and made significant strides in cell-based therapies for various medical conditions. [27] However, while China has made substantial investments in stem cell research and achieved notable progress in clinical applications, concerns linger regarding ethical oversight and transparency. [28] For example, the China Biosecurity Law, promoted by the National Health Commission and China Hospital Association, attempted to mitigate risks by introducing an institutional review board (IRB) in the regulatory bodies. 5800 IRBs registered with the Chinese Clinical Trial Registry since 2021. [29] However, issues still need to be addressed in implementing effective IRB review and approval procedures.

The substantial government funding and focus on scientific advancement have sometimes overshadowed considerations of regional cultures, ethnic minorities, and individual perspectives, particularly evident during the one-child policy era. As government policy adapts to promote public stability, such as the change from the one-child to the two-child policy, [30] research ethics should also adapt to ensure respect for the values of its represented peoples.

Japan is also relatively supportive of stem cell research and therapies. Japan has a more transparent regulatory framework, allowing for faster approval of regenerative medicine products, which has led to several advanced clinical trials and therapies. [31] South Korea is also actively engaged in stem cell research and has a history of breakthroughs in cloning and embryonic stem cells. [32] However, the field is controversial, and there are issues of scientific integrity. For example, the Korean FDA fast-tracked products for approval, [33] and in another instance, the oocyte source was unclear and possibly violated ethical standards. [34] Trust is important in research, as it builds collaborative foundations between colleagues, trial participant comfort, open-mindedness for complicated and sensitive discussions, and supports regulatory procedures for stakeholders. There is a need to respect the culture’s interest, engagement, and for research and clinical trials to be transparent and have ethical oversight to promote global research discourse and trust.

d.     Middle East

Countries in the Middle East have varying degrees of acceptance of or restrictions to policies related to using embryonic stem cells due to cultural and religious influences. Saudi Arabia has made significant contributions to stem cell research, and conducts research based on international guidelines for ethical conduct and under strict adherence to guidelines in accordance with Islamic principles. Specifically, the Saudi government and people require ESC research to adhere to Sharia law. In addition to umbilical and placental stem cells, [35] Saudi Arabia permits the use of embryonic stem cells as long as they come from miscarriages, therapeutic abortions permissible by Sharia law, or are left over from in vitro fertilization and donated to research. [36] Laws and ethical guidelines for stem cell research allow the development of research institutions such as the King Abdullah International Medical Research Center, which has a cord blood bank and a stem cell registry with nearly 10,000 donors. [37] Such volume and acceptance are due to the ethical ‘permissibility’ of the donor sources, which do not conflict with religious pillars. However, some researchers err on the side of caution, choosing not to use embryos or fetal tissue as they feel it is unethical to do so. [38]

Jordan has a positive research ethics culture. [39] However, there is a significant issue of lack of trust in researchers, with 45.23 percent (38.66 percent agreeing and 6.57 percent strongly agreeing) of Jordanians holding a low level of trust in researchers, compared to 81.34 percent of Jordanians agreeing that they feel safe to participate in a research trial. [40] Safety testifies to the feeling of confidence that adequate measures are in place to protect participants from harm, whereas trust in researchers could represent the confidence in researchers to act in the participants’ best interests, adhere to ethical guidelines, provide accurate information, and respect participants’ rights and dignity. One method to improve trust would be to address communication issues relevant to ESC. Legislation surrounding stem cell research has adopted specific language, especially concerning clarification “between ‘stem cells’ and ‘embryonic stem cells’” in translation. [41] Furthermore, legislation “mandates the creation of a national committee… laying out specific regulations for stem-cell banking in accordance with international standards.” [42] This broad regulation opens the door for future global engagement and maintains transparency. However, these regulations may also constrain the influence of research direction, pace, and accessibility of research outcomes.

e.     Europe

In the European Union (EU), ethics is also principle-based, but the principles of autonomy, dignity, integrity, and vulnerability are interconnected. [43] As such, the opportunity for cohesion and concessions between individuals’ thoughts and ideals allows for a more adaptable ethics model due to the flexible principles that relate to the human experience The EU has put forth a framework in its Convention for the Protection of Human Rights and Dignity of the Human Being allowing member states to take different approaches. Each European state applies these principles to its specific conventions, leading to or reflecting different acceptance levels of stem cell research. [44]

For example, in Germany, Lebenzusammenhang , or the coherence of life, references integrity in the unity of human culture. Namely, the personal sphere “should not be subject to external intervention.” [45]  Stem cell interventions could affect this concept of bodily completeness, leading to heavy restrictions. Under the Grundgesetz, human dignity and the right to life with physical integrity are paramount. [46] The Embryo Protection Act of 1991 made producing cell lines illegal. Cell lines can be imported if approved by the Central Ethics Commission for Stem Cell Research only if they were derived before May 2007. [47] Stem cell research respects the integrity of life for the embryo with heavy specifications and intense oversight. This is vastly different in Finland, where the regulatory bodies find research more permissible in IVF excess, but only up to 14 days after fertilization. [48] Spain’s approach differs still, with a comprehensive regulatory framework. [49] Thus, research regulation can be culture-specific due to variations in applied principles. Diverse cultures call for various approaches to ethical permissibility. [50] Only an adaptive-deliberative model can address the cultural constructions of self and achieve positive, culturally sensitive stem cell research practices. [51]

II.     Religious Perspectives on ESC

Embryonic stem cell sources are the main consideration within religious contexts. While individuals may not regard their own religious texts as authoritative or factual, religion can shape their foundations or perspectives.

The Qur'an states:

“And indeed We created man from a quintessence of clay. Then We placed within him a small quantity of nutfa (sperm to fertilize) in a safe place. Then We have fashioned the nutfa into an ‘alaqa (clinging clot or cell cluster), then We developed the ‘alaqa into mudgha (a lump of flesh), and We made mudgha into bones, and clothed the bones with flesh, then We brought it into being as a new creation. So Blessed is Allah, the Best of Creators.” [52]

Many scholars of Islam estimate the time of soul installment, marked by the angel breathing in the soul to bring the individual into creation, as 120 days from conception. [53] Personhood begins at this point, and the value of life would prohibit research or experimentation that could harm the individual. If the fetus is more than 120 days old, the time ensoulment is interpreted to occur according to Islamic law, abortion is no longer permissible. [54] There are a few opposing opinions about early embryos in Islamic traditions. According to some Islamic theologians, there is no ensoulment of the early embryo, which is the source of stem cells for ESC research. [55]

In Buddhism, the stance on stem cell research is not settled. The main tenets, the prohibition against harming or destroying others (ahimsa) and the pursuit of knowledge (prajña) and compassion (karuna), leave Buddhist scholars and communities divided. [56] Some scholars argue stem cell research is in accordance with the Buddhist tenet of seeking knowledge and ending human suffering. Others feel it violates the principle of not harming others. Finding the balance between these two points relies on the karmic burden of Buddhist morality. In trying to prevent ahimsa towards the embryo, Buddhist scholars suggest that to comply with Buddhist tenets, research cannot be done as the embryo has personhood at the moment of conception and would reincarnate immediately, harming the individual's ability to build their karmic burden. [57] On the other hand, the Bodhisattvas, those considered to be on the path to enlightenment or Nirvana, have given organs and flesh to others to help alleviate grieving and to benefit all. [58] Acceptance varies on applied beliefs and interpretations.

Catholicism does not support embryonic stem cell research, as it entails creation or destruction of human embryos. This destruction conflicts with the belief in the sanctity of life. For example, in the Old Testament, Genesis describes humanity as being created in God’s image and multiplying on the Earth, referencing the sacred rights to human conception and the purpose of development and life. In the Ten Commandments, the tenet that one should not kill has numerous interpretations where killing could mean murder or shedding of the sanctity of life, demonstrating the high value of human personhood. In other books, the theological conception of when life begins is interpreted as in utero, [59] highlighting the inviolability of life and its formation in vivo to make a religious point for accepting such research as relatively limited, if at all. [60] The Vatican has released ethical directives to help apply a theological basis to modern-day conflicts. The Magisterium of the Church states that “unless there is a moral certainty of not causing harm,” experimentation on fetuses, fertilized cells, stem cells, or embryos constitutes a crime. [61] Such procedures would not respect the human person who exists at these stages, according to Catholicism. Damages to the embryo are considered gravely immoral and illicit. [62] Although the Catholic Church officially opposes abortion, surveys demonstrate that many Catholic people hold pro-choice views, whether due to the context of conception, stage of pregnancy, threat to the mother’s life, or for other reasons, demonstrating that practicing members can also accept some but not all tenets. [63]

Some major Jewish denominations, such as the Reform, Conservative, and Reconstructionist movements, are open to supporting ESC use or research as long as it is for saving a life. [64] Within Judaism, the Talmud, or study, gives personhood to the child at birth and emphasizes that life does not begin at conception: [65]

“If she is found pregnant, until the fortieth day it is mere fluid,” [66]

Whereas most religions prioritize the status of human embryos, the Halakah (Jewish religious law) states that to save one life, most other religious laws can be ignored because it is in pursuit of preservation. [67] Stem cell research is accepted due to application of these religious laws.

We recognize that all religions contain subsets and sects. The variety of environmental and cultural differences within religious groups requires further analysis to respect the flexibility of religious thoughts and practices. We make no presumptions that all cultures require notions of autonomy or morality as under the common morality theory , which asserts a set of universal moral norms that all individuals share provides moral reasoning and guides ethical decisions. [68] We only wish to show that the interaction with morality varies between cultures and countries.

III.     A Flexible Ethical Approach

The plurality of different moral approaches described above demonstrates that there can be no universally acceptable uniform law for ESC on a global scale. Instead of developing one standard, flexible ethical applications must be continued. We recommend local guidelines that incorporate important cultural and ethical priorities.

While the Declaration of Helsinki is more relevant to people in clinical trials receiving ESC products, in keeping with the tradition of protections for research subjects, consent of the donor is an ethical requirement for ESC donation in many jurisdictions including the US, Canada, and Europe. [69] The Declaration of Helsinki provides a reference point for regulatory standards and could potentially be used as a universal baseline for obtaining consent prior to gamete or embryo donation.

For instance, in Columbia University’s egg donor program for stem cell research, donors followed standard screening protocols and “underwent counseling sessions that included information as to the purpose of oocyte donation for research, what the oocytes would be used for, the risks and benefits of donation, and process of oocyte stimulation” to ensure transparency for consent. [70] The program helped advance stem cell research and provided clear and safe research methods with paid participants. Though paid participation or covering costs of incidental expenses may not be socially acceptable in every culture or context, [71] and creating embryos for ESC research is illegal in many jurisdictions, Columbia’s program was effective because of the clear and honest communications with donors, IRBs, and related stakeholders.  This example demonstrates that cultural acceptance of scientific research and of the idea that an egg or embryo does not have personhood is likely behind societal acceptance of donating eggs for ESC research. As noted, many countries do not permit the creation of embryos for research.

Proper communication and education regarding the process and purpose of stem cell research may bolster comprehension and garner more acceptance. “Given the sensitive subject material, a complete consent process can support voluntary participation through trust, understanding, and ethical norms from the cultures and morals participants value. This can be hard for researchers entering countries of different socioeconomic stability, with different languages and different societal values. [72]

An adequate moral foundation in medical ethics is derived from the cultural and religious basis that informs knowledge and actions. [73] Understanding local cultural and religious values and their impact on research could help researchers develop humility and promote inclusion.

IV.     Concerns

Some may argue that if researchers all adhere to one ethics standard, protection will be satisfied across all borders, and the global public will trust researchers. However, defining what needs to be protected and how to define such research standards is very specific to the people to which standards are applied. We suggest that applying one uniform guide cannot accurately protect each individual because we all possess our own perceptions and interpretations of social values. [74] Therefore, the issue of not adjusting to the moral pluralism between peoples in applying one standard of ethics can be resolved by building out ethics models that can be adapted to different cultures and religions.

Other concerns include medical tourism, which may promote health inequities. [75] Some countries may develop and approve products derived from ESC research before others, compromising research ethics or drug approval processes. There are also concerns about the sale of unauthorized stem cell treatments, for example, those without FDA approval in the United States. Countries with robust research infrastructures may be tempted to attract medical tourists, and some customers will have false hopes based on aggressive publicity of unproven treatments. [76]

For example, in China, stem cell clinics can market to foreign clients who are not protected under the regulatory regimes. Companies employ a marketing strategy of “ethically friendly” therapies. Specifically, in the case of Beike, China’s leading stem cell tourism company and sprouting network, ethical oversight of administrators or health bureaus at one site has “the unintended consequence of shifting questionable activities to another node in Beike's diffuse network.” [77] In contrast, Jordan is aware of stem cell research’s potential abuse and its own status as a “health-care hub.” Jordan’s expanded regulations include preserving the interests of individuals in clinical trials and banning private companies from ESC research to preserve transparency and the integrity of research practices. [78]

The social priorities of the community are also a concern. The ISSCR explicitly states that guidelines “should be periodically revised to accommodate scientific advances, new challenges, and evolving social priorities.” [79] The adaptable ethics model extends this consideration further by addressing whether research is warranted given the varying degrees of socioeconomic conditions, political stability, and healthcare accessibilities and limitations. An ethical approach would require discussion about resource allocation and appropriate distribution of funds. [80]

While some religions emphasize the sanctity of life from conception, which may lead to public opposition to ESC research, others encourage ESC research due to its potential for healing and alleviating human pain. Many countries have special regulations that balance local views on embryonic personhood, the benefits of research as individual or societal goods, and the protection of human research subjects. To foster understanding and constructive dialogue, global policy frameworks should prioritize the protection of universal human rights, transparency, and informed consent. In addition to these foundational global policies, we recommend tailoring local guidelines to reflect the diverse cultural and religious perspectives of the populations they govern. Ethics models should be adapted to local populations to effectively establish research protections, growth, and possibilities of stem cell research.

For example, in countries with strong beliefs in the moral sanctity of embryos or heavy religious restrictions, an adaptive model can allow for discussion instead of immediate rejection. In countries with limited individual rights and voice in science policy, an adaptive model ensures cultural, moral, and religious views are taken into consideration, thereby building social inclusion. While this ethical consideration by the government may not give a complete voice to every individual, it will help balance policies and maintain the diverse perspectives of those it affects. Embracing an adaptive ethics model of ESC research promotes open-minded dialogue and respect for the importance of human belief and tradition. By actively engaging with cultural and religious values, researchers can better handle disagreements and promote ethical research practices that benefit each society.

This brief exploration of the religious and cultural differences that impact ESC research reveals the nuances of relative ethics and highlights a need for local policymakers to apply a more intense adaptive model.

[1] Poliwoda, S., Noor, N., Downs, E., Schaaf, A., Cantwell, A., Ganti, L., Kaye, A. D., Mosel, L. I., Carroll, C. B., Viswanath, O., & Urits, I. (2022). Stem cells: a comprehensive review of origins and emerging clinical roles in medical practice.  Orthopedic reviews ,  14 (3), 37498. https://doi.org/10.52965/001c.37498

[2] Poliwoda, S., Noor, N., Downs, E., Schaaf, A., Cantwell, A., Ganti, L., Kaye, A. D., Mosel, L. I., Carroll, C. B., Viswanath, O., & Urits, I. (2022). Stem cells: a comprehensive review of origins and emerging clinical roles in medical practice.  Orthopedic reviews ,  14 (3), 37498. https://doi.org/10.52965/001c.37498

[3] International Society for Stem Cell Research. (2023). Laboratory-based human embryonic stem cell research, embryo research, and related research activities . International Society for Stem Cell Research. https://www.isscr.org/guidelines/blog-post-title-one-ed2td-6fcdk ; Kimmelman, J., Hyun, I., Benvenisty, N.  et al.  Policy: Global standards for stem-cell research.  Nature   533 , 311–313 (2016). https://doi.org/10.1038/533311a

[4] International Society for Stem Cell Research. (2023). Laboratory-based human embryonic stem cell research, embryo research, and related research activities . International Society for Stem Cell Research. https://www.isscr.org/guidelines/blog-post-title-one-ed2td-6fcdk

[5] Concerning the moral philosophies of stem cell research, our paper does not posit a personal moral stance nor delve into the “when” of human life begins. To read further about the philosophical debate, consider the following sources:

Sandel M. J. (2004). Embryo ethics--the moral logic of stem-cell research.  The New England journal of medicine ,  351 (3), 207–209. https://doi.org/10.1056/NEJMp048145 ; George, R. P., & Lee, P. (2020, September 26). Acorns and Embryos . The New Atlantis. https://www.thenewatlantis.com/publications/acorns-and-embryos ; Sagan, A., & Singer, P. (2007). The moral status of stem cells. Metaphilosophy , 38 (2/3), 264–284. http://www.jstor.org/stable/24439776 ; McHugh P. R. (2004). Zygote and "clonote"--the ethical use of embryonic stem cells.  The New England journal of medicine ,  351 (3), 209–211. https://doi.org/10.1056/NEJMp048147 ; Kurjak, A., & Tripalo, A. (2004). The facts and doubts about beginning of the human life and personality.  Bosnian journal of basic medical sciences ,  4 (1), 5–14. https://doi.org/10.17305/bjbms.2004.3453

[6] Vazin, T., & Freed, W. J. (2010). Human embryonic stem cells: derivation, culture, and differentiation: a review.  Restorative neurology and neuroscience ,  28 (4), 589–603. https://doi.org/10.3233/RNN-2010-0543

[7] Socially, at its core, the Western approach to ethics is widely principle-based, autonomy being one of the key factors to ensure a fundamental respect for persons within research. For information regarding autonomy in research, see: Department of Health, Education, and Welfare, & National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research (1978). The Belmont Report. Ethical principles and guidelines for the protection of human subjects of research.; For a more in-depth review of autonomy within the US, see: Beauchamp, T. L., & Childress, J. F. (1994). Principles of Biomedical Ethics . Oxford University Press.

[8] Sherley v. Sebelius , 644 F.3d 388 (D.C. Cir. 2011), citing 45 C.F.R. 46.204(b) and [42 U.S.C. § 289g(b)]. https://www.cadc.uscourts.gov/internet/opinions.nsf/6c690438a9b43dd685257a64004ebf99/$file/11-5241-1391178.pdf

[9] Stem Cell Research Enhancement Act of 2005, H. R. 810, 109 th Cong. (2001). https://www.govtrack.us/congress/bills/109/hr810/text ; Bush, G. W. (2006, July 19). Message to the House of Representatives . National Archives and Records Administration. https://georgewbush-whitehouse.archives.gov/news/releases/2006/07/20060719-5.html

[10] National Archives and Records Administration. (2009, March 9). Executive order 13505 -- removing barriers to responsible scientific research involving human stem cells . National Archives and Records Administration. https://obamawhitehouse.archives.gov/the-press-office/removing-barriers-responsible-scientific-research-involving-human-stem-cells

[11] Hurlbut, W. B. (2006). Science, Religion, and the Politics of Stem Cells.  Social Research ,  73 (3), 819–834. http://www.jstor.org/stable/40971854

[12] Akpa-Inyang, Francis & Chima, Sylvester. (2021). South African traditional values and beliefs regarding informed consent and limitations of the principle of respect for autonomy in African communities: a cross-cultural qualitative study. BMC Medical Ethics . 22. 10.1186/s12910-021-00678-4.

[13] Source for further reading: Tangwa G. B. (2007). Moral status of embryonic stem cells: perspective of an African villager. Bioethics , 21(8), 449–457. https://doi.org/10.1111/j.1467-8519.2007.00582.x , see also Mnisi, F. M. (2020). An African analysis based on ethics of Ubuntu - are human embryonic stem cell patents morally justifiable? African Insight , 49 (4).

[14] Jecker, N. S., & Atuire, C. (2021). Bioethics in Africa: A contextually enlightened analysis of three cases. Developing World Bioethics , 22 (2), 112–122. https://doi.org/10.1111/dewb.12324

[15] Jecker, N. S., & Atuire, C. (2021). Bioethics in Africa: A contextually enlightened analysis of three cases. Developing World Bioethics, 22(2), 112–122. https://doi.org/10.1111/dewb.12324

[16] Jackson, C.S., Pepper, M.S. Opportunities and barriers to establishing a cell therapy programme in South Africa.  Stem Cell Res Ther   4 , 54 (2013). https://doi.org/10.1186/scrt204 ; Pew Research Center. (2014, May 1). Public health a major priority in African nations . Pew Research Center’s Global Attitudes Project. https://www.pewresearch.org/global/2014/05/01/public-health-a-major-priority-in-african-nations/

[17] Department of Health Republic of South Africa. (2021). Health Research Priorities (revised) for South Africa 2021-2024 . National Health Research Strategy. https://www.health.gov.za/wp-content/uploads/2022/05/National-Health-Research-Priorities-2021-2024.pdf

[18] Oosthuizen, H. (2013). Legal and Ethical Issues in Stem Cell Research in South Africa. In: Beran, R. (eds) Legal and Forensic Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-32338-6_80 , see also: Gaobotse G (2018) Stem Cell Research in Africa: Legislation and Challenges. J Regen Med 7:1. doi: 10.4172/2325-9620.1000142

[19] United States Bureau of Citizenship and Immigration Services. (1998). Tunisia: Information on the status of Christian conversions in Tunisia . UNHCR Web Archive. https://webarchive.archive.unhcr.org/20230522142618/https://www.refworld.org/docid/3df0be9a2.html

[20] Gaobotse, G. (2018) Stem Cell Research in Africa: Legislation and Challenges. J Regen Med 7:1. doi: 10.4172/2325-9620.1000142

[21] Kooli, C. Review of assisted reproduction techniques, laws, and regulations in Muslim countries.  Middle East Fertil Soc J   24 , 8 (2020). https://doi.org/10.1186/s43043-019-0011-0 ; Gaobotse, G. (2018) Stem Cell Research in Africa: Legislation and Challenges. J Regen Med 7:1. doi: 10.4172/2325-9620.1000142

[22] Pang M. C. (1999). Protective truthfulness: the Chinese way of safeguarding patients in informed treatment decisions. Journal of medical ethics , 25(3), 247–253. https://doi.org/10.1136/jme.25.3.247

[23] Wang, L., Wang, F., & Zhang, W. (2021). Bioethics in China’s biosecurity law: Forms, effects, and unsettled issues. Journal of law and the biosciences , 8(1).  https://doi.org/10.1093/jlb/lsab019 https://academic.oup.com/jlb/article/8/1/lsab019/6299199

[24] Wang, Y., Xue, Y., & Guo, H. D. (2022). Intervention effects of traditional Chinese medicine on stem cell therapy of myocardial infarction.  Frontiers in pharmacology ,  13 , 1013740. https://doi.org/10.3389/fphar.2022.1013740

[25] Li, X.-T., & Zhao, J. (2012). Chapter 4: An Approach to the Nature of Qi in TCM- Qi and Bioenergy. In Recent Advances in Theories and Practice of Chinese Medicine (p. 79). InTech.

[26] Luo, D., Xu, Z., Wang, Z., & Ran, W. (2021). China's Stem Cell Research and Knowledge Levels of Medical Practitioners and Students.  Stem cells international ,  2021 , 6667743. https://doi.org/10.1155/2021/6667743

[27] Luo, D., Xu, Z., Wang, Z., & Ran, W. (2021). China's Stem Cell Research and Knowledge Levels of Medical Practitioners and Students.  Stem cells international ,  2021 , 6667743. https://doi.org/10.1155/2021/6667743

[28] Zhang, J. Y. (2017). Lost in translation? accountability and governance of Clinical Stem Cell Research in China. Regenerative Medicine , 12 (6), 647–656. https://doi.org/10.2217/rme-2017-0035

[29] Wang, L., Wang, F., & Zhang, W. (2021). Bioethics in China’s biosecurity law: Forms, effects, and unsettled issues. Journal of law and the biosciences , 8(1).  https://doi.org/10.1093/jlb/lsab019 https://academic.oup.com/jlb/article/8/1/lsab019/6299199

[30] Chen, H., Wei, T., Wang, H.  et al.  Association of China’s two-child policy with changes in number of births and birth defects rate, 2008–2017.  BMC Public Health   22 , 434 (2022). https://doi.org/10.1186/s12889-022-12839-0

[31] Azuma, K. Regulatory Landscape of Regenerative Medicine in Japan.  Curr Stem Cell Rep   1 , 118–128 (2015). https://doi.org/10.1007/s40778-015-0012-6

[32] Harris, R. (2005, May 19). Researchers Report Advance in Stem Cell Production . NPR. https://www.npr.org/2005/05/19/4658967/researchers-report-advance-in-stem-cell-production

[33] Park, S. (2012). South Korea steps up stem-cell work.  Nature . https://doi.org/10.1038/nature.2012.10565

[34] Resnik, D. B., Shamoo, A. E., & Krimsky, S. (2006). Fraudulent human embryonic stem cell research in South Korea: lessons learned.  Accountability in research ,  13 (1), 101–109. https://doi.org/10.1080/08989620600634193 .

[35] Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: interviews with researchers from Saudi Arabia. BMC medical ethics, 21(1), 35. https://doi.org/10.1186/s12910-020-00482-6

[36] Association for the Advancement of Blood and Biotherapies.  https://www.aabb.org/regulatory-and-advocacy/regulatory-affairs/regulatory-for-cellular-therapies/international-competent-authorities/saudi-arabia

[37] Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: Interviews with researchers from Saudi Arabia.  BMC medical ethics ,  21 (1), 35. https://doi.org/10.1186/s12910-020-00482-6

[38] Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: Interviews with researchers from Saudi Arabia. BMC medical ethics , 21(1), 35. https://doi.org/10.1186/s12910-020-00482-6

Culturally, autonomy practices follow a relational autonomy approach based on a paternalistic deontological health care model. The adherence to strict international research policies and religious pillars within the regulatory environment is a great foundation for research ethics. However, there is a need to develop locally targeted ethics approaches for research (as called for in Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: interviews with researchers from Saudi Arabia. BMC medical ethics, 21(1), 35. https://doi.org/10.1186/s12910-020-00482-6), this decision-making approach may help advise a research decision model. For more on the clinical cultural autonomy approaches, see: Alabdullah, Y. Y., Alzaid, E., Alsaad, S., Alamri, T., Alolayan, S. W., Bah, S., & Aljoudi, A. S. (2022). Autonomy and paternalism in Shared decision‐making in a Saudi Arabian tertiary hospital: A cross‐sectional study. Developing World Bioethics , 23 (3), 260–268. https://doi.org/10.1111/dewb.12355 ; Bukhari, A. A. (2017). Universal Principles of Bioethics and Patient Rights in Saudi Arabia (Doctoral dissertation, Duquesne University). https://dsc.duq.edu/etd/124; Ladha, S., Nakshawani, S. A., Alzaidy, A., & Tarab, B. (2023, October 26). Islam and Bioethics: What We All Need to Know . Columbia University School of Professional Studies. https://sps.columbia.edu/events/islam-and-bioethics-what-we-all-need-know

[39] Ababneh, M. A., Al-Azzam, S. I., Alzoubi, K., Rababa’h, A., & Al Demour, S. (2021). Understanding and attitudes of the Jordanian public about clinical research ethics.  Research Ethics ,  17 (2), 228-241.  https://doi.org/10.1177/1747016120966779

[40] Ababneh, M. A., Al-Azzam, S. I., Alzoubi, K., Rababa’h, A., & Al Demour, S. (2021). Understanding and attitudes of the Jordanian public about clinical research ethics.  Research Ethics ,  17 (2), 228-241.  https://doi.org/10.1177/1747016120966779

[41] Dajani, R. (2014). Jordan’s stem-cell law can guide the Middle East.  Nature  510, 189. https://doi.org/10.1038/510189a

[42] Dajani, R. (2014). Jordan’s stem-cell law can guide the Middle East.  Nature  510, 189. https://doi.org/10.1038/510189a

[43] The EU’s definition of autonomy relates to the capacity for creating ideas, moral insight, decisions, and actions without constraint, personal responsibility, and informed consent. However, the EU views autonomy as not completely able to protect individuals and depends on other principles, such as dignity, which “expresses the intrinsic worth and fundamental equality of all human beings.” Rendtorff, J.D., Kemp, P. (2019). Four Ethical Principles in European Bioethics and Biolaw: Autonomy, Dignity, Integrity and Vulnerability. In: Valdés, E., Lecaros, J. (eds) Biolaw and Policy in the Twenty-First Century. International Library of Ethics, Law, and the New Medicine, vol 78. Springer, Cham. https://doi.org/10.1007/978-3-030-05903-3_3

[44] Council of Europe. Convention for the protection of Human Rights and Dignity of the Human Being with regard to the Application of Biology and Medicine: Convention on Human Rights and Biomedicine (ETS No. 164) https://www.coe.int/en/web/conventions/full-list?module=treaty-detail&treatynum=164 (forbidding the creation of embryos for research purposes only, and suggests embryos in vitro have protections.); Also see Drabiak-Syed B. K. (2013). New President, New Human Embryonic Stem Cell Research Policy: Comparative International Perspectives and Embryonic Stem Cell Research Laws in France.  Biotechnology Law Report ,  32 (6), 349–356. https://doi.org/10.1089/blr.2013.9865

[45] Rendtorff, J.D., Kemp, P. (2019). Four Ethical Principles in European Bioethics and Biolaw: Autonomy, Dignity, Integrity and Vulnerability. In: Valdés, E., Lecaros, J. (eds) Biolaw and Policy in the Twenty-First Century. International Library of Ethics, Law, and the New Medicine, vol 78. Springer, Cham. https://doi.org/10.1007/978-3-030-05903-3_3

[46] Tomuschat, C., Currie, D. P., Kommers, D. P., & Kerr, R. (Trans.). (1949, May 23). Basic law for the Federal Republic of Germany. https://www.btg-bestellservice.de/pdf/80201000.pdf

[47] Regulation of Stem Cell Research in Germany . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-germany

[48] Regulation of Stem Cell Research in Finland . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-finland

[49] Regulation of Stem Cell Research in Spain . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-spain

[50] Some sources to consider regarding ethics models or regulatory oversights of other cultures not covered:

Kara MA. Applicability of the principle of respect for autonomy: the perspective of Turkey. J Med Ethics. 2007 Nov;33(11):627-30. doi: 10.1136/jme.2006.017400. PMID: 17971462; PMCID: PMC2598110.

Ugarte, O. N., & Acioly, M. A. (2014). The principle of autonomy in Brazil: one needs to discuss it ...  Revista do Colegio Brasileiro de Cirurgioes ,  41 (5), 374–377. https://doi.org/10.1590/0100-69912014005013

Bharadwaj, A., & Glasner, P. E. (2012). Local cells, global science: The rise of embryonic stem cell research in India . Routledge.

For further research on specific European countries regarding ethical and regulatory framework, we recommend this database: Regulation of Stem Cell Research in Europe . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-europe   

[51] Klitzman, R. (2006). Complications of culture in obtaining informed consent. The American Journal of Bioethics, 6(1), 20–21. https://doi.org/10.1080/15265160500394671 see also: Ekmekci, P. E., & Arda, B. (2017). Interculturalism and Informed Consent: Respecting Cultural Differences without Breaching Human Rights.  Cultura (Iasi, Romania) ,  14 (2), 159–172.; For why trust is important in research, see also: Gray, B., Hilder, J., Macdonald, L., Tester, R., Dowell, A., & Stubbe, M. (2017). Are research ethics guidelines culturally competent?  Research Ethics ,  13 (1), 23-41.  https://doi.org/10.1177/1747016116650235

[52] The Qur'an  (M. Khattab, Trans.). (1965). Al-Mu’minun, 23: 12-14. https://quran.com/23

[53] Lenfest, Y. (2017, December 8). Islam and the beginning of human life . Bill of Health. https://blog.petrieflom.law.harvard.edu/2017/12/08/islam-and-the-beginning-of-human-life/

[54] Aksoy, S. (2005). Making regulations and drawing up legislation in Islamic countries under conditions of uncertainty, with special reference to embryonic stem cell research. Journal of Medical Ethics , 31: 399-403.; see also: Mahmoud, Azza. "Islamic Bioethics: National Regulations and Guidelines of Human Stem Cell Research in the Muslim World." Master's thesis, Chapman University, 2022. https://doi.org/10.36837/ chapman.000386

[55] Rashid, R. (2022). When does Ensoulment occur in the Human Foetus. Journal of the British Islamic Medical Association , 12 (4). ISSN 2634 8071. https://www.jbima.com/wp-content/uploads/2023/01/2-Ethics-3_-Ensoulment_Rafaqat.pdf.

[56] Sivaraman, M. & Noor, S. (2017). Ethics of embryonic stem cell research according to Buddhist, Hindu, Catholic, and Islamic religions: perspective from Malaysia. Asian Biomedicine,8(1) 43-52.  https://doi.org/10.5372/1905-7415.0801.260

[57] Jafari, M., Elahi, F., Ozyurt, S. & Wrigley, T. (2007). 4. Religious Perspectives on Embryonic Stem Cell Research. In K. Monroe, R. Miller & J. Tobis (Ed.),  Fundamentals of the Stem Cell Debate: The Scientific, Religious, Ethical, and Political Issues  (pp. 79-94). Berkeley: University of California Press.  https://escholarship.org/content/qt9rj0k7s3/qt9rj0k7s3_noSplash_f9aca2e02c3777c7fb76ea768ba458f0.pdf https://doi.org/10.1525/9780520940994-005

[58] Lecso, P. A. (1991). The Bodhisattva Ideal and Organ Transplantation.  Journal of Religion and Health ,  30 (1), 35–41. http://www.jstor.org/stable/27510629 ; Bodhisattva, S. (n.d.). The Key of Becoming a Bodhisattva . A Guide to the Bodhisattva Way of Life. http://www.buddhism.org/Sutras/2/BodhisattvaWay.htm

[59] There is no explicit religious reference to when life begins or how to conduct research that interacts with the concept of life. However, these are relevant verses pertaining to how the fetus is viewed. (( King James Bible . (1999). Oxford University Press. (original work published 1769))

Jerimiah 1: 5 “Before I formed thee in the belly I knew thee; and before thou camest forth out of the womb I sanctified thee…”

In prophet Jerimiah’s insight, God set him apart as a person known before childbirth, a theme carried within the Psalm of David.

Psalm 139: 13-14 “…Thou hast covered me in my mother's womb. I will praise thee; for I am fearfully and wonderfully made…”

These verses demonstrate David’s respect for God as an entity that would know of all man’s thoughts and doings even before birth.

[60] It should be noted that abortion is not supported as well.

[61] The Vatican. (1987, February 22). Instruction on Respect for Human Life in Its Origin and on the Dignity of Procreation Replies to Certain Questions of the Day . Congregation For the Doctrine of the Faith. https://www.vatican.va/roman_curia/congregations/cfaith/documents/rc_con_cfaith_doc_19870222_respect-for-human-life_en.html

[62] The Vatican. (2000, August 25). Declaration On the Production and the Scientific and Therapeutic Use of Human Embryonic Stem Cells . Pontifical Academy for Life. https://www.vatican.va/roman_curia/pontifical_academies/acdlife/documents/rc_pa_acdlife_doc_20000824_cellule-staminali_en.html ; Ohara, N. (2003). Ethical Consideration of Experimentation Using Living Human Embryos: The Catholic Church’s Position on Human Embryonic Stem Cell Research and Human Cloning. Department of Obstetrics and Gynecology . Retrieved from https://article.imrpress.com/journal/CEOG/30/2-3/pii/2003018/77-81.pdf.

[63] Smith, G. A. (2022, May 23). Like Americans overall, Catholics vary in their abortion views, with regular mass attenders most opposed . Pew Research Center. https://www.pewresearch.org/short-reads/2022/05/23/like-americans-overall-catholics-vary-in-their-abortion-views-with-regular-mass-attenders-most-opposed/

[64] Rosner, F., & Reichman, E. (2002). Embryonic stem cell research in Jewish law. Journal of halacha and contemporary society , (43), 49–68.; Jafari, M., Elahi, F., Ozyurt, S. & Wrigley, T. (2007). 4. Religious Perspectives on Embryonic Stem Cell Research. In K. Monroe, R. Miller & J. Tobis (Ed.),  Fundamentals of the Stem Cell Debate: The Scientific, Religious, Ethical, and Political Issues  (pp. 79-94). Berkeley: University of California Press.  https://escholarship.org/content/qt9rj0k7s3/qt9rj0k7s3_noSplash_f9aca2e02c3777c7fb76ea768ba458f0.pdf https://doi.org/10.1525/9780520940994-005

[65] Schenker J. G. (2008). The beginning of human life: status of embryo. Perspectives in Halakha (Jewish Religious Law).  Journal of assisted reproduction and genetics ,  25 (6), 271–276. https://doi.org/10.1007/s10815-008-9221-6

[66] Ruttenberg, D. (2020, May 5). The Torah of Abortion Justice (annotated source sheet) . Sefaria. https://www.sefaria.org/sheets/234926.7?lang=bi&with=all&lang2=en

[67] Jafari, M., Elahi, F., Ozyurt, S. & Wrigley, T. (2007). 4. Religious Perspectives on Embryonic Stem Cell Research. In K. Monroe, R. Miller & J. Tobis (Ed.),  Fundamentals of the Stem Cell Debate: The Scientific, Religious, Ethical, and Political Issues  (pp. 79-94). Berkeley: University of California Press.  https://escholarship.org/content/qt9rj0k7s3/qt9rj0k7s3_noSplash_f9aca2e02c3777c7fb76ea768ba458f0.pdf https://doi.org/10.1525/9780520940994-005

[68] Gert, B. (2007). Common morality: Deciding what to do . Oxford Univ. Press.

[69] World Medical Association (2013). World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA , 310(20), 2191–2194. https://doi.org/10.1001/jama.2013.281053 Declaration of Helsinki – WMA – The World Medical Association .; see also: National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research. (1979).  The Belmont report: Ethical principles and guidelines for the protection of human subjects of research . U.S. Department of Health and Human Services.  https://www.hhs.gov/ohrp/regulations-and-policy/belmont-report/read-the-belmont-report/index.html

[70] Zakarin Safier, L., Gumer, A., Kline, M., Egli, D., & Sauer, M. V. (2018). Compensating human subjects providing oocytes for stem cell research: 9-year experience and outcomes.  Journal of assisted reproduction and genetics ,  35 (7), 1219–1225. https://doi.org/10.1007/s10815-018-1171-z https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063839/ see also: Riordan, N. H., & Paz Rodríguez, J. (2021). Addressing concerns regarding associated costs, transparency, and integrity of research in recent stem cell trial. Stem Cells Translational Medicine , 10 (12), 1715–1716. https://doi.org/10.1002/sctm.21-0234

[71] Klitzman, R., & Sauer, M. V. (2009). Payment of egg donors in stem cell research in the USA.  Reproductive biomedicine online ,  18 (5), 603–608. https://doi.org/10.1016/s1472-6483(10)60002-8

[72] Krosin, M. T., Klitzman, R., Levin, B., Cheng, J., & Ranney, M. L. (2006). Problems in comprehension of informed consent in rural and peri-urban Mali, West Africa.  Clinical trials (London, England) ,  3 (3), 306–313. https://doi.org/10.1191/1740774506cn150oa

[73] Veatch, Robert M.  Hippocratic, Religious, and Secular Medical Ethics: The Points of Conflict . Georgetown University Press, 2012.

[74] Msoroka, M. S., & Amundsen, D. (2018). One size fits not quite all: Universal research ethics with diversity.  Research Ethics ,  14 (3), 1-17.  https://doi.org/10.1177/1747016117739939

[75] Pirzada, N. (2022). The Expansion of Turkey’s Medical Tourism Industry.  Voices in Bioethics ,  8 . https://doi.org/10.52214/vib.v8i.9894

[76] Stem Cell Tourism: False Hope for Real Money . Harvard Stem Cell Institute (HSCI). (2023). https://hsci.harvard.edu/stem-cell-tourism , See also: Bissassar, M. (2017). Transnational Stem Cell Tourism: An ethical analysis.  Voices in Bioethics ,  3 . https://doi.org/10.7916/vib.v3i.6027

[77] Song, P. (2011) The proliferation of stem cell therapies in post-Mao China: problematizing ethical regulation,  New Genetics and Society , 30:2, 141-153, DOI:  10.1080/14636778.2011.574375

[78] Dajani, R. (2014). Jordan’s stem-cell law can guide the Middle East.  Nature  510, 189. https://doi.org/10.1038/510189a

[79] International Society for Stem Cell Research. (2024). Standards in stem cell research . International Society for Stem Cell Research. https://www.isscr.org/guidelines/5-standards-in-stem-cell-research

[80] Benjamin, R. (2013). People’s science bodies and rights on the Stem Cell Frontier . Stanford University Press.

Mifrah Hayath

SM Candidate Harvard Medical School, MS Biotechnology Johns Hopkins University

Olivia Bowers

MS Bioethics Columbia University (Disclosure: affiliated with Voices in Bioethics)

Article Details

This work is licensed under a Creative Commons Attribution 4.0 International License .

How to Write a Research Paper 

• Smodin Editorial Team
• Updated: May 17, 2024

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To speed up the process even more, consider using Smodin’s AI summarizer . This tool can help summarize large texts, highlighting key information relevant to your topic. By systematically gathering and filing research materials early in the writing process, you build a strong foundation for your thesis.

3. Write Your Thesis

Creating a solid thesis statement is the most important thing you can do to bring structure and focus to your research paper. Your thesis should express the main point of your argument in one or two simple sentences. Remember, when you create your thesis, you’re setting the tone and direction for the entire paper.

Of course, you can’t just pull a winning thesis out of thin air. Start by brainstorming potential thesis ideas based on your preliminary research. And don’t overthink things; sometimes, the most straightforward ideas are often the best.

You want a thesis that is specific enough to be manageable within the scope of your paper but broad enough to allow for a unique discussion. Your thesis should challenge existing expectations and provide the reader with fresh insight into the topic. Use your thesis to hook the reader in the opening paragraph and keep them engaged until the very last word.

4. Write Your Outline

An outline is an often overlooked but essential tool for organizing your thoughts and structuring your paper. Many students skip the outline because it feels like doing double work, but a strong outline will save you work in the long run.

Here’s how to effectively structure your outline.

• Introduction: List your thesis statement and outline the main questions your essay will answer.
• Literature Review: Outline the key literature you plan to discuss and explain how it will relate to your thesis.
• Methodology: Explain the research methods you will use to gather and analyze the information.
• Discussion: Plan how you will interpret the results and their implications for your thesis.
• Conclusion: Summarize the content above to elucidate your thesis fully.

To further streamline this process, consider using Smodin’s Research Writer. This tool offers a feature that allows you to generate and tweak an outline to your liking based on the initial input you provide. You can adjust this outline to fit your research findings better and ensure that your paper remains well-organized and focused.

5. Write a Rough Draft

Once your outline is in place, you can begin the writing process. Remember, when you write a rough draft, it isn’t meant to be perfect. Instead, use it as a working document where you can experiment with and rearrange your arguments and evidence.

Don’t worry too much about grammar, style, or syntax as you write your rough draft. Focus on getting your ideas down on paper and flush out your thesis arguments. You can always refine and rearrange the content the next time around.

Follow the basic structure of your outline but with the freedom to explore different ways of expressing your thoughts. Smodin’s Essay Writer offers a powerful solution for those struggling with starting or structuring their drafts.

After you approve the outline, Smodin can generate an essay based on your initial inputs. This feature can help you quickly create a comprehensive draft, which you can then review and refine. You can even use the power of AI to create multiple rough drafts from which to choose.

6. Add or Subtract Supporting Evidence

Once you have a rough draft, but before you start the final revision, it’s time to do a little cleanup. In this phase, you need to review all your supporting evidence. You want to ensure that there is nothing redundant and that you haven’t overlooked any crucial details.

Many students struggle to make the required word count for an essay and resort to padding their writing with redundant statements. Instead of adding unnecessary content, focus on expanding your analysis to provide deeper insights.

A good essay, regardless of the topic or format, needs to be streamlined. It should convey clear, convincing, relevant information supporting your thesis. If you find some information doesn’t do that, consider tweaking your sources.

Include a variety of sources, including studies, data, and quotes from scholars or other experts. Remember, you’re not just strengthening your argument but demonstrating the depth of your research.

If you want comprehensive feedback on your essay without going to a writing center or pestering your professor, use Smodin. The AI Chat can look at your draft and offer suggestions for improvement.

7. Revise, Cite, and Submit

The final stages of crafting a research paper involve revision, citation, and final review. You must ensure your paper is polished, professionally presented, and plagiarism-free. Of course, integrating Smodin’s AI tools can significantly streamline this process and enhance the quality of your final submission.

Start by using Smodin’s Rewriter tool. This AI-powered feature can help rephrase and refine your draft to improve overall readability. If a specific section of your essay just “doesn’t sound right,” the AI can suggest alternative sentence structures and word choices.

Proper citation is a must for all academic papers. Thankfully, thanks to Smodin’s Research Paper app, this once tedious process is easier than ever. The AI ensures all sources are accurately cited according to the required style guide (APA, MLA, Chicago, etc.).

Plagiarism Checker:

All students need to realize that accidental plagiarism can happen. That’s why using a Plagiarism Checker to scan your essay before you submit it is always useful. Smodin’s Plagiarism Checker can highlight areas of concern so you can adjust accordingly.

Final Submission

After revising, rephrasing, and ensuring all citations are in order, use Smodin’s AI Content Detector to give your paper one last review. This tool can help you analyze your paper’s overall quality and readability so you can make any final tweaks or improvements.

Mastering Research Papers

Mastering the art of the research paper cannot be overstated, whether you’re in high school, college, or postgraduate studies. You can confidently prepare your research paper for submission by leveraging the AI tools listed above.

Research papers help refine your abilities to think critically and write persuasively. The skills you develop here will serve you well beyond the walls of the classroom. Communicating complex ideas clearly and effectively is one of the most powerful tools you can possess.

With the advancements of AI tools like Smodin , writing a research paper has become more accessible than ever before. These technologies streamline the process of organizing, writing, and revising your work. Write with confidence, knowing your best work is yet to come!

Virome Sequencing Identifies H5N1 Avian Influenza in Wastewater from Nine Cities

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• ORCID record for Michael J. Tisza
• ORCID record for Fuqing Wu
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Avian influenza (serotype H5N1) is a highly pathogenic virus that emerged in domestic waterfowl in 1996. Over the past decade, zoonotic transmission to mammals, including humans, has been reported. Although human to human transmission is rare, infection has been fatal in nearly half of patients who have contracted the virus in past outbreaks. The increasing presence of the virus in domesticated animals raises substantial concerns that viral adaptation to immunologically naïve humans may result in the next flu pandemic. Wastewater-based epidemiology (WBE) to track viruses was historically used to track polio and has recently been implemented for SARS-CoV2 monitoring during the COVID-19 pandemic. Here, using an agnostic, hybrid-capture sequencing approach, we report the detection of H5N1 in wastewater in nine Texas cities, with a total catchment area population in the millions, over a two-month period from March 4 th to April 25 th , 2024. Sequencing reads uniquely aligning to H5N1 covered all eight genome segments, with best alignments to clade 2.3.4.4b. Notably, 19 of 23 monitored sites had at least one detection event, and the H5N1 serotype became dominant over seasonal influenza over time. A variant analysis suggests avian or bovine origin but other potential sources, especially humans, could not be excluded. We report the value of wastewater sequencing to track avian influenza.

Competing Interest Statement

The authors have declared no competing interest.

Funding Statement

This work was supported by S.B. 1780, 87th Legislature, 2021 Reg. Sess. (Texas 2021) (E.B., A.W.M., and J.F.P.), NIH/NIAID (Grant number U19 AI44297) (A.W.M.), Baylor College of Medicine Melnick Seed (A.W.M) and Alkek Foundation Seed (J.F.P.), and Pandemic Threat Technology Center (P.A.P.).

Author Declarations

I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals.

I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).

I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable.

Data Availability

All data produced are available online at https://zenodo.org/doi/10.5281/zenodo.11175923 and NCBI SRA BioProject: PRJNA966185

View the discussion thread.

Thank you for your interest in spreading the word about medRxiv.

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How NASA Tracked the Most Intense Solar Storm in Decades

May 2024 has already proven to be a particularly stormy month for our Sun. During the first full week of May, a barrage of large solar flares and coronal mass ejections (CMEs) launched clouds of charged particles and magnetic fields toward Earth, creating the strongest solar storm to reach Earth in two decades — and possibly one of the strongest displays of auroras on record in the past 500 years.

We’ll be studying this event for years. It will help us test the limits of our models and understanding of solar storms.

Teresa Nieves-Chinchilla

Acting Director of NASA’s Moon to Mars (M2M) Space Weather Analysis Office

“We’ll be studying this event for years,” said Teresa Nieves-Chinchilla, acting director of NASA’s Moon to Mars (M2M) Space Weather Analysis Office. “It will help us test the limits of our models and understanding of solar storms.”

The first signs of the solar storm started late on May 7 with two strong solar flares. From May 7 – 11, multiple strong solar flares and at least seven CMEs stormed toward Earth. Eight of the flares in this period were the most powerful type, known as X-class, with the strongest peaking with a rating of X5.8. (Since then, the same solar region has released many more large flares, including an X8.7 flare — the most powerful flare seen this solar cycle — on May 14.)

Traveling at speeds up to 3 million mph, the CMEs bunched up in waves that reached Earth starting May 10, creating a long-lasting geomagnetic storm that reached a rating of G5 — the highest level on the geomagnetic storm scale, and one that hasn’t been seen since 2003.

“The CMEs all arrived largely at once, and the conditions were just right to create a really historic storm,” said Elizabeth MacDonald, NASA heliophysics citizen science lead and a space scientist at NASA’s Goddard Space Flight Center in Greenbelt, Maryland.

When the storm reached Earth, it created brilliant auroras seen around the globe. Auroras were even visible at unusually low latitudes, including the southern U.S. and northern India. The strongest auroras were seen the night of May 10, and they continued to illuminate night skies throughout the weekend. Thousands of reports submitted to the NASA-funded Aurorasaurus citizen science site are helping scientists study the event to learn more about auroras.

“Cameras — even standard cell phone cameras — are much more sensitive to the colors of the aurora than they were in the past,” MacDonald said. “By collecting photos from around the world, we have a huge opportunity to learn more about auroras through citizen science.”

By one measure of geomagnetic storm strength, called the disturbance storm time index which dates back to 1957, this storm was similar to historic storms in 1958 and 2003. And with reports of auroras visible to as low as 26 degrees magnetic latitude, this recent storm may compete with some of the lowest-latitude aurora sightings on record over the past five centuries, though scientists are still assessing this ranking.

“It’s a little hard to gauge storms over time because our technology is always changing,” said Delores Knipp, a research professor in the Smead Aerospace Engineering Science Department and a senior research associate at the NCAR High Altitude Observatory, in Boulder, Colorado. “Aurora visibility is not the perfect measure, but it allows us to compare over centuries.”

MacDonald encourages people to continue submitting aurora reports to Aurorasaurus.org , noting that even non-sightings are valuable for helping scientists understand the extent of the event.

Leading up to the storm, the National Oceanic and Atmospheric Administration’s Space Weather Prediction Center, which is responsible for forecasting solar storm impacts, sent notifications to operators of power grids and commercial satellites to help them mitigate potential impacts.

Warnings helped many NASA missions brace for the storm, with some spacecraft preemptively powering down certain instruments or systems to avoid issues. NASA's ICESat-2 — which studies polar ice sheets — entered safe mode, likely because of increased drag due to the storm.  

Looking Forward

Better data on how solar events influence Earth's upper atmosphere is crucial to understanding space weather's impact on satellites, crewed missions, and Earth- and space-based infrastructure. To date, only a few limited direct measurements exist in this region. But more are coming. Future missions, such as NASA’s Geospace Dynamics Constellation (GDC) and Dynamical Neutral Atmosphere-Ionosphere Coupling (DYNAMIC), will be able to see and measure exactly how Earth’s atmosphere responds to the energy influxes that occur during solar storms like this one. Such measurements will also be valuable as NASA sends astronauts to the Moon with the Artemis missions and, later, to Mars.

The solar region responsible for the recent stormy weather is now turning around the backside of the Sun, where its impacts can’t reach Earth. However, that doesn’t mean the storm is over. NASA’s Solar TErrestrial RElations Observatory (STEREO), currently located at about 12 degrees ahead of Earth in its orbit, will continue watching the active region an additional day after it is no longer visible from Earth.

“The active region is just starting to come into view of Mars,” said Jamie Favors, director for the NASA Space Weather Program at NASA Headquarters in Washington. “We’re already starting to capture some data at Mars, so this story only continues.”

By Mara Johnson-Groh NASA’s Goddard Space Flight Center, Greenbelt, Md.

Media Contact: Sarah Frazier NASA’s Goddard Space Flight Center, Greenbelt, Md.

Related Terms

• Citizen Science
• Goddard Space Flight Center
• Heliophysics
• Heliophysics Division
• ICESat-2 (Ice, Cloud and land Elevation Satellite-2)
• Science & Research
• Science Mission Directorate
• Skywatching
• Solar Dynamics Observatory (SDO)
• Solar Flares
• Space Weather
• STEREO (Solar TErrestrial RElations Observatory)
• The Solar System
• The Sun & Solar Physics
• Thermosphere

Explore More

Kan Yang: Translating Science Ideas into Engineering Concepts

As team lead of the Instrument Design Laboratory, Kan Yang turns science concepts into engineering reality. Name: Kan YangTitle: Team Lead of the Instrument Design LaboratoryFormal Job Classification: Technical ManagerOrganization: Instrument Systems and Technology Division, Engineering and Technology Directorate (Code 550) What do you do and what is most interesting about your role here at […]

Discovery Alert: Mini-Neptune in Double Star System is a Planetary Puzzle

NASA Tool Gets Ready to Image Faraway Planets

A technology demo on the Nancy Grace Roman Space Telescope will help increase the variety of distant planets scientists can directly image. The Roman Coronagraph Instrument on NASA’s Nancy Grace Roman Space Telescope will help pave the way in the search for habitable worlds outside our solar system by testing new tools that block starlight, […]

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Collection  12 March 2023

Journal Top 100 - 2022

This collection highlights our most downloaded* research papers published in 2022. Featuring authors from around the world, these papers highlight valuable research from an international community.

You can also check out the Top 100 across various subject areas here .

*Data obtained from SN Insights, which is based on Digital Science’s Dimensions.

mRNA vaccine-induced antibodies more effective than natural immunity in neutralizing SARS-CoV-2 and its high affinity variants

• Dominic Esposito

Cats learn the names of their friend cats in their daily lives

• Saho Takagi
• Atsuko Saito
• Hika Kuroshima

Metformin administration is associated with enhanced response to transarterial chemoembolization for hepatocellular carcinoma in type 2 diabetes patients

• Woo Jin Jung
• Sangmi Jang
• Jin-Wook Kim

The impact of digital media on children’s intelligence while controlling for genetic differences in cognition and socioeconomic background

• Bruno Sauce
• Magnus Liebherr
• Torkel Klingberg

Life tables of annual life expectancy and mortality for companion dogs in the United Kingdom

• Kendy Tzu-yun Teng
• Dave C. Brodbelt
• Dan G. O’Neill

Bioarchaeological and palaeogenomic portrait of two Pompeians that died during the eruption of Vesuvius in 79 AD

• Gabriele Scorrano
• Serena Viva
• Fabio Macciardi

Reading on a smartphone affects sigh generation, brain activity, and comprehension

• Motoyasu Honma
• Yuri Masaoka
• Masahiko Izumizaki

Principal Component Analyses (PCA)-based findings in population genetic studies are highly biased and must be reevaluated

• Eran Elhaik

The determinants of COVID-19 morbidity and mortality across countries

• Dianna Chang
• Kelvin Jui Keng Tan

Birdsongs alleviate anxiety and paranoia in healthy participants

• J. Sundermann

Identification of ADS024, a newly characterized strain of Bacillus velezensis with direct Clostridiodes difficile killing and toxin degradation bio-activities

• Michelle M. O’Donnell
• James W. Hegarty
• Laurent Chesnel

Multiple sclerosis genetic and non-genetic factors interact through the transient transcriptome

• Renato Umeton
• Gianmarco Bellucci
• Giovanni Ristori

The effect of metformin on the survival of colorectal cancer patients with type 2 diabetes mellitus

• Zeinab Tarhini
• Kamelia Manceur
• Niki Christou

Chemical characterisation of the vapour emitted by an e-cigarette using a ceramic wick-based technology

• M. Isabel Pinto

Large-magnitude (VEI ≥ 7) ‘wet’ explosive silicic eruption preserved a Lower Miocene habitat at the Ipolytarnóc Fossil Site, North Hungary

• Dávid Karátson
• Imre Szarvas

Far-UVC (222 nm) efficiently inactivates an airborne pathogen in a room-sized chamber

• Waseem Hiwar
• Kenneth Wood

Low dose aspirin associated with greater bone mineral density in older adults

• Hongzhan Liu
• Xungang Xiao

First direct evidence of adult European eels migrating to their breeding place in the Sargasso Sea

• Rosalind M. Wright
• Adam T. Piper
• David Righton

Infections with the SARS-CoV-2 Delta variant exhibit fourfold increased viral loads in the upper airways compared to Alpha or non-variants of concern

• Christian J. H. von Wintersdorff
• Jozef Dingemans
• Paul H. M. Savelkoul

Inappropriate sinus tachycardia in post-COVID-19 syndrome

• Júlia Aranyó
• Victor Bazan
• Roger Villuendas

The microstructure and the origin of the Venus from Willendorf

• Gerhard W. Weber
• Alexander Lukeneder

COVID-19 reinfections among naturally infected and vaccinated individuals

• Sezanur Rahman
• M. Mahfuzur Rahman
• Mustafizur Rahman

Lockdown measures during the COVID-19 pandemic strongly impacted the circulation of respiratory pathogens in Southern China

• Heping Wang
• Yuejie Zheng
• Wenjian Wang

Alzheimer’s disease large-scale gene expression portrait identifies exercise as the top theoretical treatment

• Mason A. Hill
• Stephen C. Gammie

COVID-19 symptoms are reduced by targeted hydration of the nose, larynx and trachea

• Carolin Elizabeth George
• Gerhard Scheuch
• David A. Edwards

SARS-CoV-2 spike protein induces cognitive deficit and anxiety-like behavior in mouse via non-cell autonomous hippocampal neuronal death

• Junyoung Oh
• Woo-Hyun Cho
• Sung Joong Lee

Abdominal pain patterns during COVID-19: an observational study

• Alexandre Balaphas
• Kyriaki Gkoufa
• Christian Toso

Detection of human pathogenic bacteria in rectal DNA samples from Zalophus californianus in the Gulf of California, Mexico

• Francesco Cicala
• David Ramírez-Delgado
• Alexei F. Licea-Navarro

Industrialised fishing nations largely contribute to floating plastic pollution in the North Pacific subtropical gyre

• Laurent Lebreton
• Sarah-Jeanne Royer
• Matthias Egger

Hypertension and diabetes including their earlier stage are associated with increased risk of sudden cardiac arrest

• Seung Young Roh
• Young-Hoon Kim

Utility of an artificial intelligence system for classification of esophageal lesions when simulating its clinical use

• Ayaka Tajiri
• Ryu Ishihara
• Tomohiro Tada

Prevalence, age of decision, and interpersonal warmth judgements of childfree adults

• Zachary P. Neal
• Jennifer Watling Neal

Acute and protracted abstinence from methamphetamine bidirectionally changes intrinsic excitability of indirect pathway spiny projection neurons in the dorsomedial striatum

• Sanghoon Choi
• Steven M. Graves

Indeterminacy of cannabis impairment and ∆ 9 -tetrahydrocannabinol (∆ 9 -THC) levels in blood and breath

• Gregory T. Wurz
• Michael W. DeGregorio

High rates of plasmid cotransformation in E. coli overturn the clonality myth and reveal colony development

• Delia Tomoiaga
• Jaclyn Bubnell
• Paul Feinstein

Metformin sensitizes leukemic cells to cytotoxic lymphocytes by increasing expression of intercellular adhesion molecule-1 (ICAM-1)

• Nerea Allende-Vega
• Joaquin Marco Brualla
• Martin Villalba

Incorporation of machine learning and deep neural network approaches into a remote sensing-integrated crop model for the simulation of rice growth

• Seungtaek Jeong
• Jong-min Yeom

Perceiving societal pressure to be happy is linked to poor well-being, especially in happy nations

• Egon Dejonckheere
• Joshua J. Rhee
• Brock Bastian

The earliest Pleistocene record of a large-bodied hominin from the Levant supports two out-of-Africa dispersal events

• Alon Barash
• Miriam Belmaker

Generation mechanism and prediction of an observed extreme rogue wave

• Johannes Gemmrich

Fitness tracking reveals task-specific associations between memory, mental health, and physical activity

• Jeremy R. Manning
• Gina M. Notaro
• Paxton C. Fitzpatrick

Domestic dogs ( Canis familiaris ) grieve over the loss of a conspecific

• Stefania Uccheddu
• Lucia Ronconi
• Federica Pirrone

Human transgenerational observations of regular smoking before puberty on fat mass in grandchildren and great-grandchildren

• Jean Golding
• Steve Gregory
• Matthew Suderman

Chlamydia pneumoniae can infect the central nervous system via the olfactory and trigeminal nerves and contributes to Alzheimer’s disease risk

• Jenny A. K. Ekberg

Oxycodone/naloxone versus tapentadol in real-world chronic non-cancer pain management: an observational and pharmacogenetic study

• Jordi Barrachina
• Cesar Margarit
• Ana M. Peiró

Cooking methods are associated with inflammatory factors, renal function, and other hormones and nutritional biomarkers in older adults

• Montserrat Rodríguez-Ayala
• José Ramón Banegas
• Pilar Guallar-Castillón

Classification of pig calls produced from birth to slaughter according to their emotional valence and context of production

• Elodie F. Briefer
• Ciara C.-R. Sypherd
• Céline Tallet

Higher emotional awareness is associated with greater domain-general reflective tendencies

• Michelle Persich
• William D. S. Killgore

A large Megaraptoridae (Theropoda: Coelurosauria) from Upper Cretaceous (Maastrichtian) of Patagonia, Argentina

• Alexis M. Aranciaga Rolando
• Matias J. Motta
• Fernando E. Novas

Long COVID occurrence in COVID-19 survivors

• Aya Sugiyama
• Junko Tanaka

Water activated disposable paper battery

• Alexandre Poulin
• Xavier Aeby
• Gustav Nyström

Intestinal preservation in a birdlike dinosaur supports conservatism in digestive canal evolution among theropods

• Yichuan Liu

Antiviral effect of cetylpyridinium chloride in mouthwash on SARS-CoV-2

• Hirofumi Sawa

Evidence of an oceanic impact and megatsunami sedimentation in Chryse Planitia, Mars

• J. Alexis P. Rodriguez
• Darrel K. Robertson
• Mario Zarroca

Curcumin and metformin synergistically modulate peripheral and central immune mechanisms of pain

• Peththa Wadu Dasuni Wasana
• Pasarapa Towiwat

The first occurrence of an avian-style respiratory infection in a non-avian dinosaur

• D. Cary Woodruff
• Ewan D. S. Wolff
• Lawrence M. Witmer

Optimal linear estimation models predict 1400–2900 years of overlap between Homo sapiens and Neandertals prior to their disappearance from France and northern Spain

• Igor Djakovic
• Alastair Key
• Marie Soressi

The influence of time on the sensitivity of SARS-CoV-2 serological testing

• Arturo Torres Ortiz
• Fernanda Fenn Torrente
• Louis Grandjean

Online misinformation is linked to early COVID-19 vaccination hesitancy and refusal

• Francesco Pierri
• Brea L. Perry
• John Bryden

A distinct symptom pattern emerges for COVID-19 long-haul: a nationwide study

• Melissa D. Pinto
• Charles A. Downs
• Natalie Lambert

SARS-CoV-2-reactive IFN-γ-producing CD4 + and CD8 + T cells in blood do not correlate with clinical severity in unvaccinated critically ill COVID-19 patients

• Beatriz Olea
• Eliseo Albert
• David Navarro

Classification of 74 facial emoji’s emotional states on the valence-arousal axes

• Gaku Kutsuzawa
• Hiroyuki Umemura
• Yoshiyuki Kobayashi

The emergence of a new sex-system (XX/XY 1 Y 2 ) suggests a species complex in the “monotypic” rodent Oecomys auyantepui (Rodentia, Sigmodontinae)

• Willam Oliveira da Silva
• Celina Coelho Rosa
• Cleusa Yoshiko Nagamachi

Detection of COVID-19 using multimodal data from a wearable device: results from the first TemPredict Study

• Ashley E. Mason
• Frederick M. Hecht
• Benjamin L. Smarr

Spinal degeneration is associated with lumbar multifidus morphology in secondary care patients with low back or leg pain

• Jeffrey R. Cooley
• Tue S. Jensen
• Jeffrey J. Hebert

Phenomenology and content of the inhaled N , N -dimethyltryptamine ( N , N -DMT) experience

• David Wyndham Lawrence
• Robin Carhart-Harris
• Christopher Timmermann

A gigantic bizarre marine turtle (Testudines: Chelonioidea) from the Middle Campanian (Late Cretaceous) of South-western Europe

• Oscar Castillo-Visa
• Àngel H. Luján
• Albert Sellés

The first experience with fully endoscopic posterior cervical foraminotomy and discectomy for radiculopathy performed in Viet Duc University Hospital

• Son Ngoc Dinh
• Hung The Dinh

Mapping the “catscape” formed by a population of pet cats with outdoor access

• Richard Bischof
• Nina Rosita Hansen
• Torbjørn Haugaasen

Investigation of humans individual differences as predictors of their animal interaction styles, focused on the domestic cat

• Lauren R. Finka
• Lucia Ripari
• Marnie L. Brennan

Genesis of fecal floatation is causally linked to gut microbial colonization in mice

• Syed Mohammed Musheer Aalam
• Daphne Norma Crasta
• Nagarajan Kannan

Young children’s screen time during the first COVID-19 lockdown in 12 countries

• Christina Bergmann
• Nevena Dimitrova
• Nivedita Mani

Cichlids and stingrays can add and subtract ‘one’ in the number space from one to five

• V. Schluessel

Elevated estradiol levels in frozen embryo transfer have different effects on pregnancy outcomes depending on the stage of transferred embryos

• Liming Ruan

Group VR experiences can produce ego attenuation and connectedness comparable to psychedelics

• David R. Glowacki
• Rhoslyn Roebuck Williams
• Mike Chatziapostolou

New therizinosaurid dinosaur from the marine Osoushinai Formation (Upper Cretaceous, Japan) provides insight for function and evolution of therizinosaur claws

• Yoshitsugu Kobayashi
• Ryuji Takasaki
• Yoshinori Hikida

Smartphone-based ecological momentary assessment reveals mental health benefits of birdlife

• Ryan Hammoud
• Stefania Tognin
• Andrea Mechelli

Long-term outcomes of cataract surgery with toric intraocular lens implantation by the type of preoperative astigmatism

• Tetsuro Oshika
• Shinichiro Nakano
• Tsutomu Kaneko

Forest fire detection system using wireless sensor networks and machine learning

• Udaya Dampage
• Lumini Bandaranayake
• Bathiya Jayasanka

Misinformation of COVID-19 vaccines and vaccine hesitancy

• Sun Kyong Lee
• Juhyung Sun
• Shane Connelly

Deep language algorithms predict semantic comprehension from brain activity

• Charlotte Caucheteux
• Alexandre Gramfort
• Jean-Rémi King

Children with autism spectrum disorder show atypical electroencephalographic response to processing contextual incongruencies

• Amparo V. Márquez-García
• Vasily A. Vakorin
• Sam M. Doesburg

A generalizable one health framework for the control of zoonotic diseases

• Ria R. Ghai
• Ryan M. Wallace
• Casey Barton Behravesh

HS3ST2 expression induces the cell autonomous aggregation of tau

• M. B. Huynh
• N. Rebergue
• D. Papy-Garcia

Exceptional warming over the Barents area

• Ketil Isaksen
• Øyvind Nordli
• Tatiana Karandasheva

A new Early Cretaceous lizard in Myanmar amber with exceptionally preserved integument

• Andrej Čerňanský
• Edward L. Stanley
• Susan E. Evans

Coffee consumption and diabetic retinopathy in adults with diabetes mellitus

• Hak Jun Lee
• Daniel Duck-Jin Hwang

Shifts in the foraging tactics of crocodiles following invasion by toxic prey

• Abhilasha Aiyer
• Richard Shine
• Georgia Ward-Fear

Production of high loading insulin nanoparticles suitable for oral delivery by spray drying and freeze drying techniques

• Alberto Baldelli
• Anubhav Pratap-Singh

Cable news and COVID-19 vaccine uptake

• Matteo Pinna
• Christoph Goessmann

Estimating the time of last drinking from blood ethyl glucuronide and ethyl sulphate concentrations

• Zhongyuan Guo

COVID-19 infections in infants

• Małgorzata Sobolewska-Pilarczyk
• Maria Pokorska-Śpiewak
• Małgorzata Pawłowska

COVID-19 increases the risk for the onset of atrial fibrillation in hospitalized patients

• Jakob Wollborn
• Sergey Karamnov
• Jochen D. Muehlschlegel

Childhood temperament and adulthood personality differentially predict life outcomes

• Amanda J. Wright
• Joshua J. Jackson

Antivirus applied to JAR malware detection based on runtime behaviors

• Ricardo P. Pinheiro
• Sidney M. L. Lima
• Wellington P. dos Santos

Therapeutic enzyme engineering using a generative neural network

• Andrew Giessel
• Athanasios Dousis
• Stuart Licht

Identification of genes associated with human-canine communication in canine evolution

• Akiko Tonoike
• Ken-ichi Otaki
• Miho Nagasawa

Breath chemical markers of sexual arousal in humans

• G. Pugliese
• J. Williams

A 5-km-thick reservoir with > 380,000 km 3 of magma within the ancient Earth's crust

• Rais Latypov
• Sofya Chistyakova
• Mauritz van der Merwe

Return of large fin whale feeding aggregations to historical whaling grounds in the Southern Ocean

• Helena Herr
• Sacha Viquerat
• Bettina Meyer

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MIT Technology Review

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Super-efficient solar cells: 10 Breakthrough Technologies 2024

Solar cells that combine traditional silicon with cutting-edge perovskites could push the efficiency of solar panels to new heights.

• Emma Foehringer Merchant archive page

Beyond Silicon, Caelux, First Solar, Hanwha Q Cells, Oxford PV, Swift Solar, Tandem PV

3 to 5 years

In November 2023, a buzzy solar technology broke yet another world record for efficiency. The previous record had existed for only about five months—and it likely won’t be long before it too is obsolete. This astonishing acceleration in efficiency gains comes from a special breed of next-­generation solar technology: perovskite tandem solar cells. These cells layer the traditional silicon with materials that share a unique crystal structure.

In the decade that scientists have been toying with perovskite solar technology , it has continued to best its own efficiency records, which measure how much of the sunlight that hits the cell is converted into electricity. Perovskites absorb different wavelengths of light from those absorbed by silicon cells, which account for 95% of the solar market today. When silicon and perovskites work together in tandem solar cells, they can utilize more of the solar spectrum, producing more electricity per cell. 

Technical efficiency levels for silicon-­based cells top out below 30%, while perovskite-only cells have reached experimental efficiencies of around 26%. But perovskite tandem cells have already exceeded 33% efficiency in the lab. That is the technology’s tantalizing promise: if deployed on a significant scale, perovskite tandem cells could produce more electricity than the legacy solar cells at a lower cost. 

But perovskites have stumbled when it comes to actual deployment. Silicon solar cells can last for decades. Few perovskite tandem panels have even been tested outside. 

The electrochemical makeup of perovskites means they’re sensitive to sucking up water and degrading in heat, though researchers have been working to create better barriers around panels and shifting to more stable perovskite compounds. 

In May, UK-based Oxford PV said it had reached an efficiency of 28.6% for a commercial-size perovskite tandem cell, which is significantly larger than those used to test the materials in the lab, and it plans to deliver its first panels and ramp up manufacturing in 2024. Other companies could unveil products later this decade. 

Climate change and energy

The problem with plug-in hybrids their drivers..

Plug-in hybrids are often sold as a transition to EVs, but new data from Europe shows we’re still underestimating the emissions they produce.

• Casey Crownhart archive page

These artificial snowdrifts protect seal pups from climate change

The human-built habitats shield the pups from predators and the freezing cold, but they’re threatened by global temperature rise.

• Matthew Ponsford archive page

How thermal batteries are heating up energy storage

The systems, which can store clean energy as heat, were chosen by readers as the 11th Breakthrough Technology of 2024.

The hard lessons of Harvard’s failed geoengineering experiment

Some observers argue the end of SCoPEx should mark the end of such proposals. Others say any future experiments should proceed in markedly different ways.

• James Temple archive page

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