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One of the hardest parts of writing a research paper can be just finding a good topic to write about. Fortunately we've done the hard work for you and have compiled a list of 113 interesting research paper topics. They've been organized into ten categories and cover a wide range of subjects so you can easily find the best topic for you.

In addition to the list of good research topics, we've included advice on what makes a good research paper topic and how you can use your topic to start writing a great paper.

What Makes a Good Research Paper Topic?

Not all research paper topics are created equal, and you want to make sure you choose a great topic before you start writing. Below are the three most important factors to consider to make sure you choose the best research paper topics.

#1: It's Something You're Interested In

A paper is always easier to write if you're interested in the topic, and you'll be more motivated to do in-depth research and write a paper that really covers the entire subject. Even if a certain research paper topic is getting a lot of buzz right now or other people seem interested in writing about it, don't feel tempted to make it your topic unless you genuinely have some sort of interest in it as well.

#2: There's Enough Information to Write a Paper

Even if you come up with the absolute best research paper topic and you're so excited to write about it, you won't be able to produce a good paper if there isn't enough research about the topic. This can happen for very specific or specialized topics, as well as topics that are too new to have enough research done on them at the moment. Easy research paper topics will always be topics with enough information to write a full-length paper.

Trying to write a research paper on a topic that doesn't have much research on it is incredibly hard, so before you decide on a topic, do a bit of preliminary searching and make sure you'll have all the information you need to write your paper.

#3: It Fits Your Teacher's Guidelines

Don't get so carried away looking at lists of research paper topics that you forget any requirements or restrictions your teacher may have put on research topic ideas. If you're writing a research paper on a health-related topic, deciding to write about the impact of rap on the music scene probably won't be allowed, but there may be some sort of leeway. For example, if you're really interested in current events but your teacher wants you to write a research paper on a history topic, you may be able to choose a topic that fits both categories, like exploring the relationship between the US and North Korea. No matter what, always get your research paper topic approved by your teacher first before you begin writing.

113 Good Research Paper Topics

Below are 113 good research topics to help you get you started on your paper. We've organized them into ten categories to make it easier to find the type of research paper topics you're looking for.

Arts/Culture

• Discuss the main differences in art from the Italian Renaissance and the Northern Renaissance .
• Analyze the impact a famous artist had on the world.
• How is sexism portrayed in different types of media (music, film, video games, etc.)? Has the amount/type of sexism changed over the years?
• How has the music of slaves brought over from Africa shaped modern American music?
• How has rap music evolved in the past decade?
• How has the portrayal of minorities in the media changed?

Current Events

• What have been the impacts of China's one child policy?
• How have the goals of feminists changed over the decades?
• How has the Trump presidency changed international relations?
• Analyze the history of the relationship between the United States and North Korea.
• What factors contributed to the current decline in the rate of unemployment?
• What have been the impacts of states which have increased their minimum wage?
• How do US immigration laws compare to immigration laws of other countries?
• How have the US's immigration laws changed in the past few years/decades?
• How has the Black Lives Matter movement affected discussions and view about racism in the US?
• What impact has the Affordable Care Act had on healthcare in the US?
• What factors contributed to the UK deciding to leave the EU (Brexit)?
• What factors contributed to China becoming an economic power?
• Discuss the history of Bitcoin or other cryptocurrencies  (some of which tokenize the S&P 500 Index on the blockchain) .
• Do students in schools that eliminate grades do better in college and their careers?
• Do students from wealthier backgrounds score higher on standardized tests?
• Do students who receive free meals at school get higher grades compared to when they weren't receiving a free meal?
• Do students who attend charter schools score higher on standardized tests than students in public schools?
• Do students learn better in same-sex classrooms?
• How does giving each student access to an iPad or laptop affect their studies?
• What are the benefits and drawbacks of the Montessori Method ?
• Do children who attend preschool do better in school later on?
• What was the impact of the No Child Left Behind act?
• How does the US education system compare to education systems in other countries?
• What impact does mandatory physical education classes have on students' health?
• Which methods are most effective at reducing bullying in schools?
• Do homeschoolers who attend college do as well as students who attended traditional schools?
• Does offering tenure increase or decrease quality of teaching?
• How does college debt affect future life choices of students?
• Should graduate students be able to form unions?

• What are different ways to lower gun-related deaths in the US?
• How and why have divorce rates changed over time?
• Is affirmative action still necessary in education and/or the workplace?
• Should physician-assisted suicide be legal?
• How has stem cell research impacted the medical field?
• How can human trafficking be reduced in the United States/world?
• Should people be able to donate organs in exchange for money?
• Which types of juvenile punishment have proven most effective at preventing future crimes?
• Has the increase in US airport security made passengers safer?
• Analyze the immigration policies of certain countries and how they are similar and different from one another.
• Several states have legalized recreational marijuana. What positive and negative impacts have they experienced as a result?
• Do tariffs increase the number of domestic jobs?
• Which prison reforms have proven most effective?
• Should governments be able to censor certain information on the internet?
• Which methods/programs have been most effective at reducing teen pregnancy?
• What are the benefits and drawbacks of the Keto diet?
• How effective are different exercise regimes for losing weight and maintaining weight loss?
• How do the healthcare plans of various countries differ from each other?
• What are the most effective ways to treat depression ?
• What are the pros and cons of genetically modified foods?
• Which methods are most effective for improving memory?
• What can be done to lower healthcare costs in the US?
• What factors contributed to the current opioid crisis?
• Analyze the history and impact of the HIV/AIDS epidemic .
• Are low-carbohydrate or low-fat diets more effective for weight loss?
• How much exercise should the average adult be getting each week?
• Which methods are most effective to get parents to vaccinate their children?
• What are the pros and cons of clean needle programs?
• How does stress affect the body?
• Discuss the history of the conflict between Israel and the Palestinians.
• What were the causes and effects of the Salem Witch Trials?
• Who was responsible for the Iran-Contra situation?
• How has New Orleans and the government's response to natural disasters changed since Hurricane Katrina?
• What events led to the fall of the Roman Empire?
• What were the impacts of British rule in India ?
• Was the atomic bombing of Hiroshima and Nagasaki necessary?
• What were the successes and failures of the women's suffrage movement in the United States?
• What were the causes of the Civil War?
• How did Abraham Lincoln's assassination impact the country and reconstruction after the Civil War?
• Which factors contributed to the colonies winning the American Revolution?
• What caused Hitler's rise to power?
• Discuss how a specific invention impacted history.
• What led to Cleopatra's fall as ruler of Egypt?
• How has Japan changed and evolved over the centuries?
• What were the causes of the Rwandan genocide ?

• Why did Martin Luther decide to split with the Catholic Church?
• Analyze the history and impact of a well-known cult (Jonestown, Manson family, etc.)
• How did the sexual abuse scandal impact how people view the Catholic Church?
• How has the Catholic church's power changed over the past decades/centuries?
• What are the causes behind the rise in atheism/ agnosticism in the United States?
• What were the influences in Siddhartha's life resulted in him becoming the Buddha?
• How has media portrayal of Islam/Muslims changed since September 11th?

Science/Environment

• How has the earth's climate changed in the past few decades?
• How has the use and elimination of DDT affected bird populations in the US?
• Analyze how the number and severity of natural disasters have increased in the past few decades.
• Analyze deforestation rates in a certain area or globally over a period of time.
• How have past oil spills changed regulations and cleanup methods?
• How has the Flint water crisis changed water regulation safety?
• What are the pros and cons of fracking?
• What impact has the Paris Climate Agreement had so far?
• What have NASA's biggest successes and failures been?
• How can we improve access to clean water around the world?
• Does ecotourism actually have a positive impact on the environment?
• Should the US rely on nuclear energy more?
• What can be done to save amphibian species currently at risk of extinction?
• What impact has climate change had on coral reefs?
• How are black holes created?
• Are teens who spend more time on social media more likely to suffer anxiety and/or depression?
• How will the loss of net neutrality affect internet users?
• Analyze the history and progress of self-driving vehicles.
• How has the use of drones changed surveillance and warfare methods?
• Has social media made people more or less connected?
• What progress has currently been made with artificial intelligence ?
• Do smartphones increase or decrease workplace productivity?
• What are the most effective ways to use technology in the classroom?
• How is Google search affecting our intelligence?
• When is the best age for a child to begin owning a smartphone?
• Has frequent texting reduced teen literacy rates?

How to Write a Great Research Paper

Even great research paper topics won't give you a great research paper if you don't hone your topic before and during the writing process. Follow these three tips to turn good research paper topics into great papers.

#1: Figure Out Your Thesis Early

Before you start writing a single word of your paper, you first need to know what your thesis will be. Your thesis is a statement that explains what you intend to prove/show in your paper. Every sentence in your research paper will relate back to your thesis, so you don't want to start writing without it!

As some examples, if you're writing a research paper on if students learn better in same-sex classrooms, your thesis might be "Research has shown that elementary-age students in same-sex classrooms score higher on standardized tests and report feeling more comfortable in the classroom."

If you're writing a paper on the causes of the Civil War, your thesis might be "While the dispute between the North and South over slavery is the most well-known cause of the Civil War, other key causes include differences in the economies of the North and South, states' rights, and territorial expansion."

#2: Back Every Statement Up With Research

Remember, this is a research paper you're writing, so you'll need to use lots of research to make your points. Every statement you give must be backed up with research, properly cited the way your teacher requested. You're allowed to include opinions of your own, but they must also be supported by the research you give.

#3: Do Your Research Before You Begin Writing

You don't want to start writing your research paper and then learn that there isn't enough research to back up the points you're making, or, even worse, that the research contradicts the points you're trying to make!

Get most of your research on your good research topics done before you begin writing. Then use the research you've collected to create a rough outline of what your paper will cover and the key points you're going to make. This will help keep your paper clear and organized, and it'll ensure you have enough research to produce a strong paper.

What's Next?

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These recommendations are based solely on our knowledge and experience. If you purchase an item through one of our links, PrepScholar may receive a commission.

Christine graduated from Michigan State University with degrees in Environmental Biology and Geography and received her Master's from Duke University. In high school she scored in the 99th percentile on the SAT and was named a National Merit Finalist. She has taught English and biology in several countries.

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• USC Libraries
• Research Guides

Organizing Your Social Sciences Research Paper

• 1. Choosing a Research Problem
• Purpose of Guide
• Design Flaws to Avoid
• Independent and Dependent Variables
• Glossary of Research Terms
• Reading Research Effectively
• Narrowing a Topic Idea
• Broadening a Topic Idea
• Extending the Timeliness of a Topic Idea
• Academic Writing Style
• Applying Critical Thinking
• Choosing a Title
• Making an Outline
• Paragraph Development
• Research Process Video Series
• Executive Summary
• The C.A.R.S. Model
• Background Information
• The Research Problem/Question
• Theoretical Framework
• Citation Tracking
• Content Alert Services
• Evaluating Sources
• Primary Sources
• Secondary Sources
• Tiertiary Sources
• Scholarly vs. Popular Publications
• Qualitative Methods
• Quantitative Methods
• Insiderness
• Using Non-Textual Elements
• Limitations of the Study
• Common Grammar Mistakes
• Writing Concisely
• Avoiding Plagiarism
• Footnotes or Endnotes?
• Further Readings
• Generative AI and Writing
• USC Libraries Tutorials and Other Guides
• Bibliography

In the social and behavioral sciences, the subject of analysis is most often framed as a problem that must be researched in order to obtain a greater understanding, formulate a set of solutions or recommended courses of action, and/or develop a better approach to practice. The research problem, therefore, is the main organizing principle guiding the analysis of your research. The problem under investigation establishes an occasion for writing and a focus that governs what you want to say. It represents the core subject matter of scholarly communication and the means by which scholars arrive at other topics of conversation and the discovery of new knowledge and understanding.

Alvesson, Mats and Jörgen Sandberg. Constructing Research Questions: Doing Interesting Research . London: Sage, 2013; Jacobs, Ronald L. “Developing a Dissertation Research Problem: A Guide for Doctoral Students in Human Resource Development and Adult Education.” New Horizons in Adult Education and Human Resource Development 25 (Summer 2013): 103-117; Chapter 1: Research and the Research Problem. Nicholas Walliman . Your Research Project: Designing and Planning Your Work . 3rd edition. Thousand Oaks, CA: Sage Publications, 2011.

Choosing a Research Problem / How to Begin

Do not assume that identifying a research problem to investigate will be a quick and easy task! You should be thinking about it during the beginning of the course. There are generally three ways you are asked to write about a research problem : 1) your professor provides you with a general topic from which you study a particular aspect; 2) your professor provides you with a list of possible topics to study and you choose a topic from that list; or, 3) your professor leaves it up to you to choose a topic and you only have to obtain permission to write about it before beginning your investigation. Here are some strategies for getting started for each scenario.

I.  How To Begin:  You are given the topic to write about

Step 1 : Identify concepts and terms that make up the topic statement . For example, your professor wants the class to focus on the following research problem: “Is the European Union a credible security actor with the capacity to contribute to confronting global terrorism?" The main concepts in this problem are: European Union, security, global terrorism, credibility [ hint : focus on identifying proper nouns, nouns or noun phrases, and action verbs in the assignment description]. Step 2 : Review related literature to help refine how you will approach examining the topic and finding a way to analyze it . You can begin by doing any or all of the following: reading through background information from materials listed in your course syllabus; searching the USC Libraries Catalog to find a recent book on the topic and, if appropriate, more specialized works about the topic; conducting a preliminary review of the research literature using multidisciplinary databases such as ProQuest or subject-specific databases from the " By Subject Area " drop down menu located above the list of databases.

Choose the advanced search option in the database and enter into each search box the main concept terms you developed in Step 1. Also consider using their synonyms to retrieve additional relevant records. This will help you refine and frame the scope of the research problem. You will likely need to do this several times before you can finalize how to approach writing about the topic. NOTE : Always review the references from your most relevant research results cited by the authors in footnotes, endnotes, or a bibliography to locate related research on your topic. This is a good strategy for identifying important prior research about the topic because titles that are repeatedly cited indicate their significance in laying a foundation for understanding the problem. However, if you’re having trouble at this point locating relevant research literature, ask a librarian for help!

ANOTHER NOTE :  If you find an article from a database that's particularly helpful, paste it into Google Scholar , placing the title of the article in quotes. If the article record appears, look for a "cited by" reference followed by a number [e.g., C ited by 37] just below the record. This link indicates how many times other scholars have subsequently cited that article in their own research since it was first published. This is an effective strategy for identifying more current, related research on your topic. Finding additional cited by references from your original list of cited by references helps you navigate through the literature and, by so doing, understand the evolution of thought around a particular research problem. Step 3 : Since social science research papers are generally designed to encourage you to develop your own ideas and arguments, look for sources that can help broaden, modify, or strengthen your initial thoughts and arguments. For example, if you decide to argue that the European Union is inadequately prepared to take on responsibilities for broader global security because of the debt crisis in many EU countries, then focus on identifying sources that support as well as refute this position. From the advanced search option in ProQuest , a sample search would use "European Union" in one search box, "global security" in the second search box, and adding a third search box to include "debt crisis."

There are least four appropriate roles your related literature plays in helping you formulate how to begin your analysis :

• Sources of criticism -- frequently, you'll find yourself reading materials that are relevant to your chosen topic, but you disagree with the author's position. Therefore, one way that you can use a source is to describe the counter-argument, provide evidence from your own review of the literature as to why the prevailing argument is unsatisfactory, and to discuss how your approach is more appropriate based upon your interpretation of the evidence.
• Sources of new ideas -- while a general goal in writing college research papers in the social sciences is to examine a research problem with some basic idea of what position you'd like to take and on what basis you'd like to defend your position, it is certainly acceptable [and often encouraged] to read the literature and extend, modify, and refine your own position in light of the ideas proposed by others. Just make sure that you cite the sources !
• Sources for historical context -- another role your related literature plays in formulating how to begin your analysis is to place issues and events in proper historical context. This can help to demonstrate familiarity with developments in relevant scholarship about your topic, provide a means of comparing historical versus contemporary issues and events, and identifying key people, places, and events that had an important role related to the research problem. Given its archival journal coverage, a good multidisciplnary database to use in this case is JSTOR .
• Sources of interdisciplinary insight -- an advantage of using databases like ProQuest to begin exploring your topic is that it covers publications from a variety of different disciplines. Another way to formulate how to study the topic is to look at it from different disciplinary perspectives. If the topic concerns immigration reform, for example, ask yourself, how do studies from sociological journals found by searching ProQuest vary in their analysis from those in political science journals. A goal in reviewing related literature is to provide a means of approaching a topic from multiple perspectives rather than the perspective offered from just one discipline.

NOTE : Remember to keep careful notes at every stage or utilize a citation management system like EndNotes or RefWorks . You may think you'll remember what you have searched and where you found things, but it’s easy to forget or get confused. Most databases have a search history feature that allows you to go back and see what searches you conducted previously as long as you haven't closed your session. If you start over, that history could be deleted.

Step 4 : Assuming you have done an effective job of synthesizing and thinking about the results of your initial search for related literature, you're ready to prepare a detailed outline for your paper that lays the foundation for a more in-depth and focused review of relevant research literature [after consulting with a librarian, if needed!]. How will you know you haven't done an effective job of synthesizing and thinking about the results of our initial search for related literature? A good indication is that you start composing the outline and gaps appear in how you want to approach the study. This indicates the need to gather further background information and analysis about the research problem.

II.  How To Begin:  You are provided a list of possible topics to choose from Step 1 : I know what you’re thinking--which topic on this list will be the easiest to find the most information on? An effective instructor would never include a topic that is so obscure or complex that no research is available to examine and from which to design an effective study. Therefore, don't approach a list of possible topics to study from the perspective of trying to identify the path of least resistance; choose a topic that you find interesting in some way, that is controversial and that you have a strong opinion about, that has some personal meaning for you, or relates to your major or a minor. You're going to be working on the topic for quite some time, so choose one that you find interesting and engaging or that motivates you to take a position. Embrace the opportunity to learn something new! Once you’ve settled on a topic of interest from the list provided by your professor, follow Steps 1 - 4 listed above to further develop it into a research paper.

NOTE : It’s ok to review related literature to help refine how you will approach analyzing a topic, and then discover that the topic isn’t all that interesting to you. In that case, choose a different topic from the list. Just don’t wait too long to make a switch and, of course, be sure to inform your professor that you are changing your topic.

III.  How To Begin:  Your professor leaves it up to you to choose a topic

Step 1 : Under this scenario, the key process is turning an idea or general thought into a topic that can be configured into a research problem. When given an assignment where you choose the topic, don't begin by thinking about what to write about, but rather, ask yourself the question, "What do I want to understand or learn about?" Treat an open-ended research assignment as an opportunity to gain new knowledge about something that's important or exciting to you in the context of the overall subject of the course.

Step 2 : If you lack ideas, or wish to gain focus, try any or all of the following strategies:

• Review your course readings, particularly the suggested readings, for topic ideas. Don't just review what you've already read, but jump ahead in the syllabus to readings that have not been covered yet.
• Search the USC Libraries Catalog for a recently published book and, if appropriate, more specialized works related to the discipline area of the course [e.g., for the course SOCI 335: Society and Population, search for books on "population and society" or "population and social impact"]. Reviewing the contents of a book about your area of interest can give you insight into what conversations scholars are having about the topic and, thus, how you might want to contribute your own ideas to these conversations through the research paper you write for the class.
• Browse through some current scholarly [a.k.a., academic, peer reviewed] journals in your subject discipline. Even if most of the articles are not relevant, you can skim through the contents quickly. You only need one to be the spark that begins the process of wanting to learn more about a topic. Consult with a librarian and/or your professor about what constitutes the core journals within the subject area of the writing assignment.
• Think about essays you have written for other courses you have taken or academic lectures and programs you have attended outside of class. Thinking back, ask yourself why did you want to take this class or attend this event? What interested you the most? What would you like to know more about? Place this question in the context of the current course assignment. Note that this strategy also applies to anything you've watched on TV or has been shared on social media.
• Search online news media sources, such as CNN , the Los Angeles Times , Huffington Post , MSNBC , Fox News , or Newsweek , to see if your idea has been covered by the media. Use this coverage to refine your idea into something that you'd like to investigate further, but in a more deliberate, scholarly way in relation to a particular problem that needs to be researched.

Step 3 : To build upon your initial idea, use the suggestions under this tab to help narrow , broaden , or increase the timeliness of your idea so you can write it out as a research problem.

Once you are comfortable with having turned your idea into a research problem, follow Steps 1 - 4 listed in Part I above to further develop it into an outline for a research paper.

Alderman, Jim. "Choosing a Research Topic." Beginning Library and Information Systems Strategies. Paper 17. Jacksonville, FL: University of North Florida Digital Commons, 2014; Alvesson, Mats and Jörgen Sandberg. Constructing Research Questions: Doing Interesting Research . London: Sage, 2013; Chapter 2: Choosing a Research Topic. Adrian R. Eley. Becoming a Successful Early Career Researcher . New York: Routledge, 2012; Answering the Question. Academic Skills Centre. University of Canberra; Brainstorming. Department of English Writing Guide. George Mason University; Brainstorming. The Writing Center. University of North Carolina; Chapter 1: Research and the Research Problem. Nicholas Walliman . Your Research Project: Designing and Planning Your Work . 3rd edition. Thousand Oaks, CA: Sage Publications, 2011; Choosing a Topic. The Writing Lab and The OWL. Purdue University;  Mullaney, Thomas S. and Christopher Rea. Where Research Begins: Choosing a Research Project That Matters to You (and the World) . Chicago, IL: University of Chicago Press, 2022; Coming Up With Your Topic. Institute for Writing Rhetoric. Dartmouth College; How To Write a Thesis Statement. Writing Tutorial Services, Center for Innovative Teaching and Learning. Indiana University; Identify Your Question. Start Your Research. University Library, University of California, Santa Cruz; The Process of Writing a Research Paper. Department of History. Trent University; Trochim, William M.K. Problem Formulation. Research Methods Knowledge Base. 2006.

Resources for Identifying a Topic

Resources for Identifying a Research Problem

If you are having difficulty identifying a topic to study or need basic background information, the following web resources and databases can be useful:

• CQ Researcher -- a collection of single-themed public policy reports that provide an overview of an issue. Each report includes background information, an assessment of the current policy situation, statistical tables and maps, pro/con statements from representatives of opposing positions, and a bibliography of key sources.
• New York Times Topics -- each topic page collects news articles, reference and archival information, photos, graphics, audio and video files. Content is available without charge on articles going back to 1981.
• Opposing Viewpoints In Context -- an online resource covering a wide range of social issues from a variety of perspectives. The database contains a media-rich collection of materials, including pro/con viewpoint essays, topic overviews, primary source materials, biographies of social activists and reformers, journal articles, statistical tables, charts and graphs, images, videos, and podcasts.
• Policy Commons -- platform for objective, fact-based research from the world’s leading policy experts, nonpartisan think tanks, and intergovernmental and non-governmental organizations. The database provides advanced searching across millions of pages of books, articles, working papers, reports, policy briefs, data sets, tables, charts, media, case studies, and statistical publications, including archived reports from more than 200 defunct think tanks. Coverage is international in scope.

Descriptions of resources are adapted or quoted from vendor websites.

Writing Tip

Not Finding Anything on Your Topic? Ask a Librarian!

Don't assume or jump to the conclusion that your topic is too narrowly defined or obscure just because your initial search has failed to identify relevant research. Librarians are experts in locating and critically assessing information and how it is organized. This knowledge will help you develop strategies for analyzing existing knowledge in new ways. Therefore, always consult with a librarian before you consider giving up on finding information about the topic you want to investigate. If there isn't a lot of information about your topic, a librarian can help you identify a closely related topic that you can study. Use the Ask-A-Librarian link above to identify a librarian in your subject area.

Another Writing Tip

Don't be a Martyr!

In thinking about what to study, don't adopt the mindset of pursuing an esoteric or overly complicated topic just to impress your professor but that, in reality, does not have any real interest to you. Choose a topic that is challenging but that has at least some interest to you or that you care about. Obviously, this is easier for courses within your major, but even for those nasty prerequisite classes that you must take in order to graduate [and that provide an additional tuition revenue for the university], try to apply issues associated with your major to the general topic given to you. For example, if you are an international relations major taking a GE philosophy class where the assignment asks you to apply the question of "what is truth" to some aspect of life, you could choose to study how government leaders attempt to shape truth through the use of nationalistic propaganda.

Still Another Writing Tip

A Research Problem is Not a Thesis Statement

A thesis statement and a research problem are two different parts of the introduction section of your paper. The thesis statement succinctly describes in one or two sentences, usually in the last paragraph of the introduction, what position you have reached about a topic. It includes an assertion that requires evidence and support along with your opinion or argument about what you are researching. There are three general types of thesis statements: analytical statements that break down and evaluate the topic; argumentative statements that make a claim about the topic and defend that claim; and, expository statements that present facts and research about the topic. Each are intended to set forth a claim that you will seek to validate through the research you describe in your paper.

Before the thesis statement, your introduction must include a description of a problem that describes either a key area of concern, a condition to be improved upon, a difficulty to be eliminated, or a troubling issue that exists . The research problem describes something that can be empirically verified and measured; it is often followed by a set of questions that underpin how you plan to approach investigating that problem. In short, the thesis statement states your opinion or argument about the research problem and summarizes how you plan to address it.

Tips and Examples for Writing Thesis Statements. The Writing Lab and The OWL. Purdue University; Write a Strong Thesis Statement! The Writing Center, University of Evansville; Thesis Statements. The Writing Center. University of North Carolina; Tutorial #26: Thesis Statements and Topic Sentences. Writing Center, College of San Mateo; Creswell,  John W. and J. David Creswell. Research Design: Qualitative, Quantitative, and Mixed Methods Approaches . 5th edition. Thousand Oaks, CA: SAGE Publications, 2017.

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45 Research Problem Examples & Inspiration

A research problem is an issue of concern that is the catalyst for your research. It demonstrates why the research problem needs to take place in the first place.

Generally, you will write your research problem as a clear, concise, and focused statement that identifies an issue or gap in current knowledge that requires investigation.

The problem will likely also guide the direction and purpose of a study. Depending on the problem, you will identify a suitable methodology that will help address the problem and bring solutions to light.

Research Problem Examples

In the following examples, I’ll present some problems worth addressing, and some suggested theoretical frameworks and research methodologies that might fit with the study. Note, however, that these aren’t the only ways to approach the problems. Keep an open mind and consult with your dissertation supervisor!

Psychology Problems

1. Social Media and Self-Esteem: “How does prolonged exposure to social media platforms influence the self-esteem of adolescents?”

• Theoretical Framework : Social Comparison Theory
• Methodology : Longitudinal study tracking adolescents’ social media usage and self-esteem measures over time, combined with qualitative interviews.

2. Sleep and Cognitive Performance: “How does sleep quality and duration impact cognitive performance in adults?”

• Theoretical Framework : Cognitive Psychology
• Methodology : Experimental design with controlled sleep conditions, followed by cognitive tests. Participant sleep patterns can also be monitored using actigraphy.

3. Childhood Trauma and Adult Relationships: “How does unresolved childhood trauma influence attachment styles and relationship dynamics in adulthood?

• Theoretical Framework : Attachment Theory
• Methodology : Mixed methods, combining quantitative measures of attachment styles with qualitative in-depth interviews exploring past trauma and current relationship dynamics.

4. Mindfulness and Stress Reduction: “How effective is mindfulness meditation in reducing perceived stress and physiological markers of stress in working professionals?”

• Theoretical Framework : Humanist Psychology
• Methodology : Randomized controlled trial comparing a group practicing mindfulness meditation to a control group, measuring both self-reported stress and physiological markers (e.g., cortisol levels).

5. Implicit Bias and Decision Making: “To what extent do implicit biases influence decision-making processes in hiring practices?

• Theoretical Framework : Cognitive Dissonance Theory
• Methodology : Experimental design using Implicit Association Tests (IAT) to measure implicit biases, followed by simulated hiring tasks to observe decision-making behaviors.

6. Emotional Regulation and Academic Performance: “How does the ability to regulate emotions impact academic performance in college students?”

• Theoretical Framework : Cognitive Theory of Emotion
• Methodology : Quantitative surveys measuring emotional regulation strategies, combined with academic performance metrics (e.g., GPA).

7. Nature Exposure and Mental Well-being: “Does regular exposure to natural environments improve mental well-being and reduce symptoms of anxiety and depression?”

• Theoretical Framework : Biophilia Hypothesis
• Methodology : Longitudinal study comparing mental health measures of individuals with regular nature exposure to those without, possibly using ecological momentary assessment for real-time data collection.

8. Video Games and Cognitive Skills: “How do action video games influence cognitive skills such as attention, spatial reasoning, and problem-solving?”

• Theoretical Framework : Cognitive Load Theory
• Methodology : Experimental design with pre- and post-tests, comparing cognitive skills of participants before and after a period of action video game play.

9. Parenting Styles and Child Resilience: “How do different parenting styles influence the development of resilience in children facing adversities?”

• Theoretical Framework : Baumrind’s Parenting Styles Inventory
• Methodology : Mixed methods, combining quantitative measures of resilience and parenting styles with qualitative interviews exploring children’s experiences and perceptions.

10. Memory and Aging: “How does the aging process impact episodic memory , and what strategies can mitigate age-related memory decline?

• Theoretical Framework : Information Processing Theory
• Methodology : Cross-sectional study comparing episodic memory performance across different age groups, combined with interventions like memory training or mnemonic strategies to assess potential improvements.

Education Problems

11. Equity and Access : “How do socioeconomic factors influence students’ access to quality education, and what interventions can bridge the gap?

• Theoretical Framework : Critical Pedagogy
• Methodology : Mixed methods, combining quantitative data on student outcomes with qualitative interviews and focus groups with students, parents, and educators.

12. Digital Divide : How does the lack of access to technology and the internet affect remote learning outcomes, and how can this divide be addressed?

• Theoretical Framework : Social Construction of Technology Theory
• Methodology : Survey research to gather data on access to technology, followed by case studies in selected areas.

13. Teacher Efficacy : “What factors contribute to teacher self-efficacy, and how does it impact student achievement?”

• Theoretical Framework : Bandura’s Self-Efficacy Theory
• Methodology : Quantitative surveys to measure teacher self-efficacy, combined with qualitative interviews to explore factors affecting it.

14. Curriculum Relevance : “How can curricula be made more relevant to diverse student populations, incorporating cultural and local contexts?”

• Theoretical Framework : Sociocultural Theory
• Methodology : Content analysis of curricula, combined with focus groups with students and teachers.

15. Special Education : “What are the most effective instructional strategies for students with specific learning disabilities?

• Theoretical Framework : Social Learning Theory
• Methodology : Experimental design comparing different instructional strategies, with pre- and post-tests to measure student achievement.

16. Dropout Rates : “What factors contribute to high school dropout rates, and what interventions can help retain students?”

• Methodology : Longitudinal study tracking students over time, combined with interviews with dropouts.

17. Bilingual Education : “How does bilingual education impact cognitive development and academic achievement?

• Methodology : Comparative study of students in bilingual vs. monolingual programs, using standardized tests and qualitative interviews.

18. Classroom Management: “What reward strategies are most effective in managing diverse classrooms and promoting a positive learning environment?

• Theoretical Framework : Behaviorism (e.g., Skinner’s Operant Conditioning)
• Methodology : Observational research in classrooms , combined with teacher interviews.

19. Standardized Testing : “How do standardized tests affect student motivation, learning, and curriculum design?”

• Theoretical Framework : Critical Theory
• Methodology : Quantitative analysis of test scores and student outcomes, combined with qualitative interviews with educators and students.

20. STEM Education : “What methods can be employed to increase interest and proficiency in STEM (Science, Technology, Engineering, and Mathematics) fields among underrepresented student groups?”

• Theoretical Framework : Constructivist Learning Theory
• Methodology : Experimental design comparing different instructional methods, with pre- and post-tests.

21. Social-Emotional Learning : “How can social-emotional learning be effectively integrated into the curriculum, and what are its impacts on student well-being and academic outcomes?”

• Theoretical Framework : Goleman’s Emotional Intelligence Theory
• Methodology : Mixed methods, combining quantitative measures of student well-being with qualitative interviews.

22. Parental Involvement : “How does parental involvement influence student achievement, and what strategies can schools use to increase it?”

• Theoretical Framework : Reggio Emilia’s Model (Community Engagement Focus)
• Methodology : Survey research with parents and teachers, combined with case studies in selected schools.

23. Early Childhood Education : “What are the long-term impacts of quality early childhood education on academic and life outcomes?”

• Theoretical Framework : Erikson’s Stages of Psychosocial Development
• Methodology : Longitudinal study comparing students with and without early childhood education, combined with observational research.

24. Teacher Training and Professional Development : “How can teacher training programs be improved to address the evolving needs of the 21st-century classroom?”

• Theoretical Framework : Adult Learning Theory (Andragogy)
• Methodology : Pre- and post-assessments of teacher competencies, combined with focus groups.

25. Educational Technology : “How can technology be effectively integrated into the classroom to enhance learning, and what are the potential drawbacks or challenges?”

• Theoretical Framework : Technological Pedagogical Content Knowledge (TPACK)
• Methodology : Experimental design comparing classrooms with and without specific technologies, combined with teacher and student interviews.

Sociology Problems

26. Urbanization and Social Ties: “How does rapid urbanization impact the strength and nature of social ties in communities?”

• Theoretical Framework : Structural Functionalism
• Methodology : Mixed methods, combining quantitative surveys on social ties with qualitative interviews in urbanizing areas.

27. Gender Roles in Modern Families: “How have traditional gender roles evolved in families with dual-income households?”

• Theoretical Framework : Gender Schema Theory
• Methodology : Qualitative interviews with dual-income families, combined with historical data analysis.

28. Social Media and Collective Behavior: “How does social media influence collective behaviors and the formation of social movements?”

• Theoretical Framework : Emergent Norm Theory
• Methodology : Content analysis of social media platforms, combined with quantitative surveys on participation in social movements.

29. Education and Social Mobility: “To what extent does access to quality education influence social mobility in socioeconomically diverse settings?”

• Methodology : Longitudinal study tracking educational access and subsequent socioeconomic status, combined with qualitative interviews.

30. Religion and Social Cohesion: “How do religious beliefs and practices contribute to social cohesion in multicultural societies?”

• Methodology : Quantitative surveys on religious beliefs and perceptions of social cohesion, combined with ethnographic studies.

31. Consumer Culture and Identity Formation: “How does consumer culture influence individual identity formation and personal values?”

• Theoretical Framework : Social Identity Theory
• Methodology : Mixed methods, combining content analysis of advertising with qualitative interviews on identity and values.

32. Migration and Cultural Assimilation: “How do migrants negotiate cultural assimilation and preservation of their original cultural identities in their host countries?”

• Theoretical Framework : Post-Structuralism
• Methodology : Qualitative interviews with migrants, combined with observational studies in multicultural communities.

33. Social Networks and Mental Health: “How do social networks, both online and offline, impact mental health and well-being?”

• Theoretical Framework : Social Network Theory
• Methodology : Quantitative surveys assessing social network characteristics and mental health metrics, combined with qualitative interviews.

34. Crime, Deviance, and Social Control: “How do societal norms and values shape definitions of crime and deviance, and how are these definitions enforced?”

• Theoretical Framework : Labeling Theory
• Methodology : Content analysis of legal documents and media, combined with ethnographic studies in diverse communities.

35. Technology and Social Interaction: “How has the proliferation of digital technology influenced face-to-face social interactions and community building?”

• Theoretical Framework : Technological Determinism
• Methodology : Mixed methods, combining quantitative surveys on technology use with qualitative observations of social interactions in various settings.

Nursing Problems

36. Patient Communication and Recovery: “How does effective nurse-patient communication influence patient recovery rates and overall satisfaction with care?”

• Methodology : Quantitative surveys assessing patient satisfaction and recovery metrics, combined with observational studies on nurse-patient interactions.

37. Stress Management in Nursing: “What are the primary sources of occupational stress for nurses, and how can they be effectively managed to prevent burnout?”

• Methodology : Mixed methods, combining quantitative measures of stress and burnout with qualitative interviews exploring personal experiences and coping mechanisms.

38. Hand Hygiene Compliance: “How effective are different interventions in improving hand hygiene compliance among nursing staff, and what are the barriers to consistent hand hygiene?”

• Methodology : Experimental design comparing hand hygiene rates before and after specific interventions, combined with focus groups to understand barriers.

39. Nurse-Patient Ratios and Patient Outcomes: “How do nurse-patient ratios impact patient outcomes, including recovery rates, complications, and hospital readmissions?”

• Methodology : Quantitative study analyzing patient outcomes in relation to staffing levels, possibly using retrospective chart reviews.

40. Continuing Education and Clinical Competence: “How does regular continuing education influence clinical competence and confidence among nurses?”

• Methodology : Longitudinal study tracking nurses’ clinical skills and confidence over time as they engage in continuing education, combined with patient outcome measures to assess potential impacts on care quality.

Communication Studies Problems

41. Media Representation and Public Perception: “How does media representation of minority groups influence public perceptions and biases?”

• Theoretical Framework : Cultivation Theory
• Methodology : Content analysis of media representations combined with quantitative surveys assessing public perceptions and attitudes.

42. Digital Communication and Relationship Building: “How has the rise of digital communication platforms impacted the way individuals build and maintain personal relationships?”

• Theoretical Framework : Social Penetration Theory
• Methodology : Mixed methods, combining quantitative surveys on digital communication habits with qualitative interviews exploring personal relationship dynamics.

43. Crisis Communication Effectiveness: “What strategies are most effective in managing public relations during organizational crises, and how do they influence public trust?”

• Theoretical Framework : Situational Crisis Communication Theory (SCCT)
• Methodology : Case study analysis of past organizational crises, assessing communication strategies used and subsequent public trust metrics.

44. Nonverbal Cues in Virtual Communication: “How do nonverbal cues, such as facial expressions and gestures, influence message interpretation in virtual communication platforms?”

• Theoretical Framework : Social Semiotics
• Methodology : Experimental design using video conferencing tools, analyzing participants’ interpretations of messages with varying nonverbal cues.

45. Influence of Social Media on Political Engagement: “How does exposure to political content on social media platforms influence individuals’ political engagement and activism?”

• Theoretical Framework : Uses and Gratifications Theory
• Methodology : Quantitative surveys assessing social media habits and political engagement levels, combined with content analysis of political posts on popular platforms.

Before you Go: Tips and Tricks for Writing a Research Problem

This is an incredibly stressful time for research students. The research problem is going to lock you into a specific line of inquiry for the rest of your studies.

So, here’s what I tend to suggest to my students:

• Start with something you find intellectually stimulating – Too many students choose projects because they think it hasn’t been studies or they’ve found a research gap. Don’t over-estimate the importance of finding a research gap. There are gaps in every line of inquiry. For now, just find a topic you think you can really sink your teeth into and will enjoy learning about.
• Take 5 ideas to your supervisor – Approach your research supervisor, professor, lecturer, TA, our course leader with 5 research problem ideas and run each by them. The supervisor will have valuable insights that you didn’t consider that will help you narrow-down and refine your problem even more.
• Trust your supervisor – The supervisor-student relationship is often very strained and stressful. While of course this is your project, your supervisor knows the internal politics and conventions of academic research. The depth of knowledge about how to navigate academia and get you out the other end with your degree is invaluable. Don’t underestimate their advice.

I’ve got a full article on all my tips and tricks for doing research projects right here – I recommend reading it:

• 9 Tips on How to Choose a Dissertation Topic

Chris Drew (PhD)

Dr. Chris Drew is the founder of the Helpful Professor. He holds a PhD in education and has published over 20 articles in scholarly journals. He is the former editor of the Journal of Learning Development in Higher Education. [Image Descriptor: Photo of Chris]

• Chris Drew (PhD) https://helpfulprofessor.com/author/chris-drew-phd/ Social-Emotional Learning (Definition, Examples, Pros & Cons)
• Chris Drew (PhD) https://helpfulprofessor.com/author/chris-drew-phd/ What is Educational Psychology?
• Chris Drew (PhD) https://helpfulprofessor.com/author/chris-drew-phd/ What is IQ? (Intelligence Quotient)
• Chris Drew (PhD) https://helpfulprofessor.com/author/chris-drew-phd/ 5 Top Tips for Succeeding at University

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Research Problem – Definition, Steps & Tips

Published by Jamie Walker at August 12th, 2021 , Revised On October 3, 2023

Once you have chosen a research topic, the next stage is to explain the research problem: the detailed issue, ambiguity of the research, gap analysis, or gaps in knowledge and findings that you will discuss.

Here, in this article, we explore a research problem in a dissertation or an essay with some research problem examples to help you better understand how and when you should write a research problem.

“A research problem is a specific statement relating to an area of concern and is contingent on the type of research. Some research studies focus on theoretical and practical problems, while some focus on only one.”

The problem statement in the dissertation, essay, research paper, and other academic papers should be clearly stated and intended to expand information, knowledge, and contribution to change.

This article will assist in identifying and elaborating a research problem if you are unsure how to define your research problem. The most notable challenge in the research process is to formulate and identify a research problem. Formulating a problem statement and research questions while finalizing the research proposal or introduction for your dissertation or thesis is necessary.

Why is Research Problem Critical?

An interesting research topic is only the first step. The real challenge of the research process is to develop a well-rounded research problem.

A well-formulated research problem helps understand the research procedure; without it, your research will appear unforeseeable and awkward.

Research is a procedure based on a sequence and a research problem aids in following and completing the research in a sequence. Repetition of existing literature is something that should be avoided in research.

Therefore research problem in a dissertation or an essay needs to be well thought out and presented with a clear purpose. Hence, your research work contributes more value to existing knowledge. You need to be well aware of the problem so you can present logical solutions.

Formulating a research problem is the first step of conducting research, whether you are writing an essay, research paper,   dissertation , or  research proposal .

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Step 1: Identifying Problem Area – What is Research Problem

The most significant step in any research is to look for  unexplored areas, topics, and controversies . You aim to find gaps that your work will fill. Here are some research problem examples for you to better understand the concept.

Practical Research Problems

To conduct practical research, you will need practical research problems that are typically identified by analysing reports, previous research studies, and interactions with the experienced personals of pertinent disciplines. You might search for:

• Problems with performance or competence in an organization
• Institutional practices that could be enhanced
• Practitioners of relevant fields and their areas of concern
• Problems confronted by specific groups of people within your area of study

If your research work relates to an internship or a job, then it will be critical for you to identify a research problem that addresses certain issues faced by the firm the job or internship pertains to.

Examples of Practical Research Problems

Decreased voter participation in county A, as compared to the rest of the country.

The high employee turnover rate of department X of company Y influenced efficiency and team performance.

A charity institution, Y, suffers a lack of funding resulting in budget cuts for its programmes.

Theoretical Research Problems

Theoretical research relates to predicting, explaining, and understanding various phenomena. It also expands and challenges existing information and knowledge.

Identification of a research problem in theoretical research is achieved by analysing theories and fresh research literature relating to a broad area of research. This practice helps to find gaps in the research done by others and endorse the argument of your topic.

Here are some questions that you should bear in mind.

• A case or framework that has not been deeply analysed
• An ambiguity between more than one viewpoints
• An unstudied condition or relationships
• A problematic issue that needs to be addressed

Theoretical issues often contain practical implications, but immediate issues are often not resolved by these results. If that is the case, you might want to adopt a different research approach  to achieve the desired outcomes.

Examples of Theoretical Research Problems

Long-term Vitamin D deficiency affects cardiac patients are not well researched.

The relationship between races, sex, and income imbalances needs to be studied with reference to the economy of a specific country or region.

The disagreement among historians of Scottish nationalism regarding the contributions of Imperial Britain in the creation of the national identity for Scotland.

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Step 2: Understanding the Research Problem

The researcher further investigates the selected area of research to find knowledge and information relating to the research problem to address the findings in the research.

Background and Rationale

• Population influenced by the problem?
• Is it a persistent problem, or is it recently revealed?
• Research that has already been conducted on this problem?
• Any proposed solution to the problem?
• Recent arguments concerning the problem, what are the gaps in the problem?

How to Write a First Class Dissertation Proposal or Research Proposal

Particularity and Suitability

• What specific place, time, and/or people will be focused on?
• Any aspects of research that you may not be able to deal with?
• What will be the concerns if the problem remains unresolved?
• What are the benefices of the problem resolution (e.g. future researcher or organisation’s management)?

Example of a Specific Research Problem

A non-profit institution X has been examined on their existing support base retention, but the existing research does not incorporate an understanding of how to effectively target new donors. To continue their work, the institution needs more research and find strategies for effective fundraising.

Once the problem is narrowed down, the next stage is to propose a problem statement and hypothesis or research questions.

If you are unsure about what a research problem is and how to define the research problem, then you might want to take advantage of our dissertation proposal writing service. You may also want to take a look at our essay writing service if you need help with identifying a research problem for your essay.

Frequently Asked Questions

What is research problem with example.

A research problem is a specific challenge that requires investigation. Example: “What is the impact of social media on mental health among adolescents?” This problem drives research to analyse the relationship between social media use and mental well-being in young people.

How many types of research problems do we have?

• Descriptive: Describing phenomena as they exist.
• Explanatory: Understanding causes and effects.
• Exploratory: Investigating little-understood phenomena.
• Predictive: Forecasting future outcomes.
• Prescriptive: Recommending actions.
• Normative: Describing what ought to be.

What are the principles of the research problem?

• Relevance: Addresses a significant issue.
• Re searchability: Amenable to empirical investigation.
• Clarity: Clearly defined without ambiguity.
• Specificity: Narrowly framed, avoiding vagueness.
• Feasibility: Realistic to conduct with available resources.
• Novelty: Offers new insights or challenges existing knowledge.
• Ethical considerations: Respect rights, dignity, and safety.

Why is research problem important?

A research problem is crucial because it identifies knowledge gaps, directs the inquiry’s focus, and forms the foundation for generating hypotheses or questions. It drives the methodology and determination of study relevance, ensuring that research contributes meaningfully to academic discourse and potentially addresses real-world challenges.

How do you write a research problem?

To write a research problem, identify a knowledge gap or an unresolved issue in your field. Start with a broad topic, then narrow it down. Clearly articulate the problem in a concise statement, ensuring it’s researchable, significant, and relevant. Ground it in the existing literature to highlight its importance and context.

How can we solve research problem?

To solve a research problem, start by conducting a thorough literature review. Formulate hypotheses or research questions. Choose an appropriate research methodology. Collect and analyse data systematically. Interpret findings in the context of existing knowledge. Ensure validity and reliability, and discuss implications, limitations, and potential future research directions.

You May Also Like

Repository of ten perfect research question examples will provide you a better perspective about how to create research questions.

How to write a hypothesis for dissertation,? A hypothesis is a statement that can be tested with the help of experimental or theoretical research.

Penning your dissertation proposal can be a rather daunting task. Here are comprehensive guidelines on how to write a dissertation proposal.

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Research Topic Ideas

• Picking a Topic
• Area & Interdisciplinary Studies
• Behavioral & Social Sciences
• Business, Economics, & Management

Not Sure Which Topic to Choose?

Controversial issues and current events, flint water crisis.

• Education & Social Work
• Health Sciences
• Natural and Physical Sciences

Look at the "Picking a Topic" tab on this guide for help brainstorming your topic. Also, our Research Process guide can help you throughout your research process.

• Research Process by Liz Svoboda Last Updated Apr 26, 2024 7864 views this year
• Affirmative Action
• Affordable Care Act
• Alternative medicine
• America's global influence
• Artificial intelligence
• Assisted suicide
• Bilingual education
• Black Lives Matter
• Border security
• Capital punishment
• Charter schools
• Childhood obesity
• Civil rights
• Climate change
• Concussions in football
• COVID restrictions
• Cryptocurrency
• Cyber bullying
• Cybersecurity
• Drug legalization
• Early voting
• Eating disorders
• Equal Rights Amendment
• Executive order
• Factory farming
• Foreign aid
• Freedom of speech
• General Data Protection Regulation
• Genetic engineering
• Gerrymandering
• Green New Deal
• Hate speech
• Health insurance
• Human trafficking
• Immigration
• Israel-Palestine relations
• Judicial activism
• Labor unions
• Land acknowledgments
• #MeToo movement
• Minimum wage
• Misinformation
• Net neutrality
• Nuclear energy
• Offshore drilling
• Online anonymity
• Organic food
• Outsourcing
• Police reform
• Political activism
• Prescription drug addiction
• Racial profiling
• Reparations
• Russian hacking
• Sanctuary city
• Screen addiction
• Self-driving cars
• Sex education
• Smart speakers
• Social Security reform
• Standardized testing
• Stimulus packages
• Supreme Court confirmation
• Syrian civil war
• Title IX enforcement
• Trade tariffs
• Transgender rights
• Ukraine and Russia
• Urban agriculture
• Vaccination mandates
• Violence in the media
• Voter ID laws
• Voting fraud and security
• White nationalism
• Women's rights
• Zero tolerance policies

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Research Topics & Ideas: Healthcare

100+ Healthcare Research Topic Ideas To Fast-Track Your Project

Finding and choosing a strong research topic is the critical first step when it comes to crafting a high-quality dissertation, thesis or research project. If you’ve landed on this post, chances are you’re looking for a healthcare-related research topic , but aren’t sure where to start. Here, we’ll explore a variety of healthcare-related research ideas and topic thought-starters across a range of healthcare fields, including allopathic and alternative medicine, dentistry, physical therapy, optometry, pharmacology and public health.

NB – This is just the start…

The topic ideation and evaluation process has multiple steps . In this post, we’ll kickstart the process by sharing some research topic ideas within the healthcare domain. This is the starting point, but to develop a well-defined research topic, you’ll need to identify a clear and convincing research gap , along with a well-justified plan of action to fill that gap.

If you’re new to the oftentimes perplexing world of research, or if this is your first time undertaking a formal academic research project, be sure to check out our free dissertation mini-course. In it, we cover the process of writing a dissertation or thesis from start to end. Be sure to also sign up for our free webinar that explores how to find a high-quality research topic.

Overview: Healthcare Research Topics

• Allopathic medicine
• Alternative /complementary medicine
• Veterinary medicine
• Physical therapy/ rehab
• Optometry and ophthalmology
• Pharmacy and pharmacology
• Public health
• Examples of healthcare-related dissertations

Allopathic (Conventional) Medicine

• The effectiveness of telemedicine in remote elderly patient care
• The impact of stress on the immune system of cancer patients
• The effects of a plant-based diet on chronic diseases such as diabetes
• The use of AI in early cancer diagnosis and treatment
• The role of the gut microbiome in mental health conditions such as depression and anxiety
• The efficacy of mindfulness meditation in reducing chronic pain: A systematic review
• The benefits and drawbacks of electronic health records in a developing country
• The effects of environmental pollution on breast milk quality
• The use of personalized medicine in treating genetic disorders
• The impact of social determinants of health on chronic diseases in Asia
• The role of high-intensity interval training in improving cardiovascular health
• The efficacy of using probiotics for gut health in pregnant women
• The impact of poor sleep on the treatment of chronic illnesses
• The role of inflammation in the development of chronic diseases such as lupus
• The effectiveness of physiotherapy in pain control post-surgery

Topics & Ideas: Alternative Medicine

• The benefits of herbal medicine in treating young asthma patients
• The use of acupuncture in treating infertility in women over 40 years of age
• The effectiveness of homoeopathy in treating mental health disorders: A systematic review
• The role of aromatherapy in reducing stress and anxiety post-surgery
• The impact of mindfulness meditation on reducing high blood pressure
• The use of chiropractic therapy in treating back pain of pregnant women
• The efficacy of traditional Chinese medicine such as Shun-Qi-Tong-Xie (SQTX) in treating digestive disorders in China
• The impact of yoga on physical and mental health in adolescents
• The benefits of hydrotherapy in treating musculoskeletal disorders such as tendinitis
• The role of Reiki in promoting healing and relaxation post birth
• The effectiveness of naturopathy in treating skin conditions such as eczema
• The use of deep tissue massage therapy in reducing chronic pain in amputees
• The impact of tai chi on the treatment of anxiety and depression
• The benefits of reflexology in treating stress, anxiety and chronic fatigue
• The role of acupuncture in the prophylactic management of headaches and migraines

Topics & Ideas: Dentistry

• The impact of sugar consumption on the oral health of infants
• The use of digital dentistry in improving patient care: A systematic review
• The efficacy of orthodontic treatments in correcting bite problems in adults
• The role of dental hygiene in preventing gum disease in patients with dental bridges
• The impact of smoking on oral health and tobacco cessation support from UK dentists
• The benefits of dental implants in restoring missing teeth in adolescents
• The use of lasers in dental procedures such as root canals
• The efficacy of root canal treatment using high-frequency electric pulses in saving infected teeth
• The role of fluoride in promoting remineralization and slowing down demineralization
• The impact of stress-induced reflux on oral health
• The benefits of dental crowns in restoring damaged teeth in elderly patients
• The use of sedation dentistry in managing dental anxiety in children
• The efficacy of teeth whitening treatments in improving dental aesthetics in patients with braces
• The role of orthodontic appliances in improving well-being
• The impact of periodontal disease on overall health and chronic illnesses

Tops & Ideas: Veterinary Medicine

• The impact of nutrition on broiler chicken production
• The role of vaccines in disease prevention in horses
• The importance of parasite control in animal health in piggeries
• The impact of animal behaviour on welfare in the dairy industry
• The effects of environmental pollution on the health of cattle
• The role of veterinary technology such as MRI in animal care
• The importance of pain management in post-surgery health outcomes
• The impact of genetics on animal health and disease in layer chickens
• The effectiveness of alternative therapies in veterinary medicine: A systematic review
• The role of veterinary medicine in public health: A case study of the COVID-19 pandemic
• The impact of climate change on animal health and infectious diseases in animals
• The importance of animal welfare in veterinary medicine and sustainable agriculture
• The effects of the human-animal bond on canine health
• The role of veterinary medicine in conservation efforts: A case study of Rhinoceros poaching in Africa
• The impact of veterinary research of new vaccines on animal health

Topics & Ideas: Physical Therapy/Rehab

• The efficacy of aquatic therapy in improving joint mobility and strength in polio patients
• The impact of telerehabilitation on patient outcomes in Germany
• The effect of kinesiotaping on reducing knee pain and improving function in individuals with chronic pain
• A comparison of manual therapy and yoga exercise therapy in the management of low back pain
• The use of wearable technology in physical rehabilitation and the impact on patient adherence to a rehabilitation plan
• The impact of mindfulness-based interventions in physical therapy in adolescents
• The effects of resistance training on individuals with Parkinson’s disease
• The role of hydrotherapy in the management of fibromyalgia
• The impact of cognitive-behavioural therapy in physical rehabilitation for individuals with chronic pain
• The use of virtual reality in physical rehabilitation of sports injuries
• The effects of electrical stimulation on muscle function and strength in athletes
• The role of physical therapy in the management of stroke recovery: A systematic review
• The impact of pilates on mental health in individuals with depression
• The use of thermal modalities in physical therapy and its effectiveness in reducing pain and inflammation
• The effect of strength training on balance and gait in elderly patients

Topics & Ideas: Optometry & Opthalmology

• The impact of screen time on the vision and ocular health of children under the age of 5
• The effects of blue light exposure from digital devices on ocular health
• The role of dietary interventions, such as the intake of whole grains, in the management of age-related macular degeneration
• The use of telemedicine in optometry and ophthalmology in the UK
• The impact of myopia control interventions on African American children’s vision
• The use of contact lenses in the management of dry eye syndrome: different treatment options
• The effects of visual rehabilitation in individuals with traumatic brain injury
• The role of low vision rehabilitation in individuals with age-related vision loss: challenges and solutions
• The impact of environmental air pollution on ocular health
• The effectiveness of orthokeratology in myopia control compared to contact lenses
• The role of dietary supplements, such as omega-3 fatty acids, in ocular health
• The effects of ultraviolet radiation exposure from tanning beds on ocular health
• The impact of computer vision syndrome on long-term visual function
• The use of novel diagnostic tools in optometry and ophthalmology in developing countries
• The effects of virtual reality on visual perception and ocular health: an examination of dry eye syndrome and neurologic symptoms

Topics & Ideas: Pharmacy & Pharmacology

• The impact of medication adherence on patient outcomes in cystic fibrosis
• The use of personalized medicine in the management of chronic diseases such as Alzheimer’s disease
• The effects of pharmacogenomics on drug response and toxicity in cancer patients
• The role of pharmacists in the management of chronic pain in primary care
• The impact of drug-drug interactions on patient mental health outcomes
• The use of telepharmacy in healthcare: Present status and future potential
• The effects of herbal and dietary supplements on drug efficacy and toxicity
• The role of pharmacists in the management of type 1 diabetes
• The impact of medication errors on patient outcomes and satisfaction
• The use of technology in medication management in the USA
• The effects of smoking on drug metabolism and pharmacokinetics: A case study of clozapine
• Leveraging the role of pharmacists in preventing and managing opioid use disorder
• The impact of the opioid epidemic on public health in a developing country
• The use of biosimilars in the management of the skin condition psoriasis
• The effects of the Affordable Care Act on medication utilization and patient outcomes in African Americans

Topics & Ideas: Public Health

• The impact of the built environment and urbanisation on physical activity and obesity
• The effects of food insecurity on health outcomes in Zimbabwe
• The role of community-based participatory research in addressing health disparities
• The impact of social determinants of health, such as racism, on population health
• The effects of heat waves on public health
• The role of telehealth in addressing healthcare access and equity in South America
• The impact of gun violence on public health in South Africa
• The effects of chlorofluorocarbons air pollution on respiratory health
• The role of public health interventions in reducing health disparities in the USA
• The impact of the United States Affordable Care Act on access to healthcare and health outcomes
• The effects of water insecurity on health outcomes in the Middle East
• The role of community health workers in addressing healthcare access and equity in low-income countries
• The impact of mass incarceration on public health and behavioural health of a community
• The effects of floods on public health and healthcare systems
• The role of social media in public health communication and behaviour change in adolescents

Examples: Healthcare Dissertation & Theses

While the ideas we’ve presented above are a decent starting point for finding a healthcare-related research topic, they are fairly generic and non-specific. So, it helps to look at actual dissertations and theses to see how this all comes together.

Below, we’ve included a selection of research projects from various healthcare-related degree programs to help refine your thinking. These are actual dissertations and theses, written as part of Master’s and PhD-level programs, so they can provide some useful insight as to what a research topic looks like in practice.

• Improving Follow-Up Care for Homeless Populations in North County San Diego (Sanchez, 2021)
• On the Incentives of Medicare’s Hospital Reimbursement and an Examination of Exchangeability (Elzinga, 2016)
• Managing the healthcare crisis: the career narratives of nurses (Krueger, 2021)
• Methods for preventing central line-associated bloodstream infection in pediatric haematology-oncology patients: A systematic literature review (Balkan, 2020)
• Farms in Healthcare: Enhancing Knowledge, Sharing, and Collaboration (Garramone, 2019)
• When machine learning meets healthcare: towards knowledge incorporation in multimodal healthcare analytics (Yuan, 2020)
• Integrated behavioural healthcare: The future of rural mental health (Fox, 2019)
• Healthcare service use patterns among autistic adults: A systematic review with narrative synthesis (Gilmore, 2021)
• Mindfulness-Based Interventions: Combatting Burnout and Compassionate Fatigue among Mental Health Caregivers (Lundquist, 2022)
• Transgender and gender-diverse people’s perceptions of gender-inclusive healthcare access and associated hope for the future (Wille, 2021)
• Efficient Neural Network Synthesis and Its Application in Smart Healthcare (Hassantabar, 2022)
• The Experience of Female Veterans and Health-Seeking Behaviors (Switzer, 2022)
• Machine learning applications towards risk prediction and cost forecasting in healthcare (Singh, 2022)
• Does Variation in the Nursing Home Inspection Process Explain Disparity in Regulatory Outcomes? (Fox, 2020)

Looking at these titles, you can probably pick up that the research topics here are quite specific and narrowly-focused , compared to the generic ones presented earlier. This is an important thing to keep in mind as you develop your own research topic. That is to say, to create a top-notch research topic, you must be precise and target a specific context with specific variables of interest . In other words, you need to identify a clear, well-justified research gap.

Need more help?

If you’re still feeling a bit unsure about how to find a research topic for your healthcare dissertation or thesis, check out Topic Kickstarter service below.

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15 Comments

I need topics that will match the Msc program am running in healthcare research please

Hello Mabel,

I can help you with a good topic, kindly provide your email let’s have a good discussion on this.

Can you provide some research topics and ideas on Immunology?

Thank you to create new knowledge on research problem verse research topic

Help on problem statement on teen pregnancy

This post might be useful: https://gradcoach.com/research-problem-statement/

can you provide me with a research topic on healthcare related topics to a qqi level 5 student

Please can someone help me with research topics in public health ?

Hello I have requirement of Health related latest research issue/topics for my social media speeches. If possible pls share health issues , diagnosis, treatment.

I would like a topic thought around first-line support for Gender-Based Violence for survivors or one related to prevention of Gender-Based Violence

Please can I be helped with a master’s research topic in either chemical pathology or hematology or immunology? thanks

Can u please provide me with a research topic on occupational health and safety at the health sector

Good day kindly help provide me with Ph.D. Public health topics on Reproductive and Maternal Health, interventional studies on Health Education

may you assist me with a good easy healthcare administration study topic

May you assist me in finding a research topic on nutrition,physical activity and obesity. On the impact on children

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Organizing Your Social Sciences Research Paper: The Research Problem/Question

• Purpose of Guide
• Writing a Research Proposal
• Design Flaws to Avoid
• Independent and Dependent Variables
• Narrowing a Topic Idea
• Broadening a Topic Idea
• The Research Problem/Question
• Academic Writing Style
• Choosing a Title
• Making an Outline
• Paragraph Development
• The C.A.R.S. Model
• Background Information
• Theoretical Framework
• Citation Tracking
• Evaluating Sources
• Reading Research Effectively
• Primary Sources
• Secondary Sources
• What Is Scholarly vs. Popular?
• Is it Peer-Reviewed?
• Qualitative Methods
• Quantitative Methods
• Common Grammar Mistakes
• Writing Concisely
• Avoiding Plagiarism [linked guide]
• Annotated Bibliography
• Grading Someone Else's Paper

A research problem is a definite or clear expression [statement] about an area of concern, a condition to be improved upon, a difficulty to be eliminated, or a troubling question that exists in scholarly literature, in theory, or within existing practice that points to a need for meaningful understanding and deliberate investigation. A research problem does not state how to do something, offer a vague or broad proposition, or present a value question.

Bryman, Alan. “The Research Question in Social Research: What is its Role?” International Journal of Social Research Methodology 10 (2007): 5-20; Guba, Egon G., and Yvonna S. Lincoln. “Competing Paradigms in Qualitative Research.” In Handbook of Qualitative Research . Norman K. Denzin and Yvonna S. Lincoln, editors. (Thousand Oaks, CA: Sage, 1994), pp. 105-117.

Importance of...

The purpose of a problem statement is to:

• Introduce the reader to the importance of the topic being studied . The reader is oriented to the significance of the study.
• Anchors the research questions, hypotheses, or assumptions to follow . It offers a concise statement about the purpose of your paper.
• Place the topic into a particular context that defines the parameters of what is to be investigated.
• Provide the framework for reporting the results and indicates what is probably necessary to conduct the study and explain how the findings will present this information.

In the social sciences, the research problem establishes the means by which you must answer the "So What?" question. This question refers to a research problem surviving the relevancy test [the quality of a measurement procedure that provides repeatability and accuracy]. Note that answering the "So What?" question requires a commitment on your part to not only show that you have reviewed the literature, but that you have thoroughly considered its significance and its implications applied to obtaining new knowledge or understanding.

To survive the "So What" question, problem statements should possess the following attributes:

• Clarity and precision [a well-written statement does not make sweeping generalizations and irresponsible pronouncements; it also does include unspecific determinates like "very" or "giant"],
• Demonstrate a researchable topic or issue [i.e., feasibility of conducting the study is based upon access to information that can be effectively acquired, gathered, interpreted, synthesized, and understood],
• Identification of what would be studied, while avoiding the use of value-laden words and terms,
• Identification of an overarching question or small set of questions accompanied by key factors or variables,
• Identification of key concepts and terms,
• Articulation of the study's boundaries or parameters or limitations,
• Some generalizability in regards to applicability and bringing results into general use,
• Conveyance of the study's importance, benefits, and justification [i.e., regardless of the type of research, it is important to demonstrate that the research is not trivial],
• Does not have unnecessary jargon or overly complex sentence constructions; and,
• Conveyance of more than the mere gathering of descriptive data providing only a snapshot of the issue or phenomenon under investigation.

Bryman, Alan. “The Research Question in Social Research: What is its Role?” International Journal of Social Research Methodology 10 (2007): 5-20; Castellanos, Susie. Critical Writing and Thinking . The Writing Center. Dean of the College. Brown University; Ellis, Timothy J. and Yair Levy Nova Framework of Problem-Based Research: A Guide for Novice Researchers on the Development of a Research-Worthy Problem. Informing Science: the International Journal of an Emerging Transdiscipline 11 (2008); Thesis and Purpose Statements . The Writer’s Handbook. Writing Center. University of Wisconsin, Madison; Thesis Statements . The Writing Center. University of North Carolina; Tips and Examples for Writing Thesis Statements . The Writing Lab and The OWL. Purdue University.  

Structure and Writing Style

 Sources of Problems for Investigation

The identification of a problem to study can be challenging, not because there's a lack of issues that could be investigated, but due to the challenge of formulating an academically relevant and researchable problem which is unique and does not simply duplicate the work of others. To facilitate how you might select a problem from which to build a research study, consider these sources of inspiration:

Deductions from Theory This relates to deductions made from social philosophy or generalizations embodied in life and in society that the researcher is familiar with. These deductions from human behavior are then placed within an empirical frame of reference through research. From a theory, the researcher can formulate a research problem or hypothesis stating the expected findings in certain empirical situations. The research asks the question: “What relationship between variables will be observed if theory aptly summarizes the state of affairs?” One can then design and carry out a systematic investigation to assess whether empirical data confirm or reject the hypothesis, and hence, the theory.

Interdisciplinary Perspectives Identifying a problem that forms the basis for a research study can come from academic movements and scholarship originating in disciplines outside of your primary area of study. This can be an intellectually stimulating exercise. A review of pertinent literature should include examining research from related disciplines that can reveal new avenues of exploration and analysis. An interdisciplinary approach to selecting a research problem offers an opportunity to construct a more comprehensive understanding of a very complex issue that any single discipline may be able to provide.

Interviewing Practitioners The identification of research problems about particular topics can arise from formal interviews or informal discussions with practitioners who provide insight into new directions for future research and how to make research findings more relevant to practice. Discussions with experts in the field, such as, teachers, social workers, health care providers, lawyers, business leaders, etc., offers the chance to identify practical, “real world” problems that may be understudied or ignored within academic circles. This approach also provides some practical knowledge which may help in the process of designing and conducting your study.

Personal Experience Don't undervalue your everyday experiences or encounters as worthwhile problems for investigation. Think critically about your own experiences and/or frustrations with an issue facing society, your community, your neighborhood, your family, or your personal life. This can be derived, for example, from deliberate observations of certain relationships for which there is no clear explanation or witnessing an event that appears harmful to a person or group or that is out of the ordinary.

Relevant Literature The selection of a research problem can be derived from a thorough review of pertinent research associated with your overall area of interest. This may reveal where gaps exist in understanding a topic or where an issue has been understudied. Research may be conducted to: 1) fill such gaps in knowledge; 2) evaluate if the methodologies employed in prior studies can be adapted to solve other problems; or, 3) determine if a similar study could be conducted in a different subject area or applied in a different context or to different study sample [i.e., different setting or different group of people].Also, authors frequently conclude their studies by noting implications for further research; read the conclusion of pertinent studies because statements about further research can be a valuable source for identifying new problems to investigate. The fact that a researcher has identified a topic worthy of further exploration validates the fact it is worth pursuing.

What Makes a Good Research Statement?

A good problem statement begins by introducing the broad area in which your research is centered, gradually leading the reader to the more specific issues you are investigating. The statement need not be lengthy, but a good research problem should incorporate the following features:

1.  Compelling Topic The problem chosen should be one that motivates you to address it but simple curiosity is not a good enough reason to pursue a research study because this does not indicate significance. The problem that you choose to explore must be important to you, but it must also be viewed as important by your readers and to a the larger academic and/or social community that could be impacted by the results of your study. 2.  Supports Multiple Perspectives The problem must be phrased in a way that avoids dichotomies and instead supports the generation and exploration of multiple perspectives. A general rule of thumb in the social sciences is that a good research problem is one that would generate a variety of viewpoints from a composite audience made up of reasonable people. 3.  Researchability This isn't a real word but it represents an important aspect of creating a good research statement. It seems a bit obvious, but you don't want to find yourself in the midst of investigating a complex research project and realize that you don't have enough prior research to draw from for your analysis. There's nothing inherently wrong with original research, but you must choose research problems that can be supported, in some way, by the resources available to you. If you are not sure if something is researchable, don't assume that it isn't if you don't find information right away--seek help from a librarian !

NOTE:   Do not confuse a research problem with a research topic. A topic is something to read and obtain information about, whereas a problem is something to be solved or framed as a question raised for inquiry, consideration, or solution, or explained as a source of perplexity, distress, or vexation. In short, a research topic is something to be understood; a research problem is something that needs to be investigated.

Asking Analytical Questions about the Research Problem

Research problems in the social and behavioral sciences are often analyzed around critical questions that must be investigated. These questions can be explicitly listed in the introduction [i.e., "This study addresses three research questions about women's psychological recovery from domestic abuse in multi-generational home settings..."], or, the questions are implied in the text as specific areas of study related to the research problem. Explicitly listing your research questions at the end of your introduction can help in designing a clear roadmap of what you plan to address in your study, whereas, implicitly integrating them into the text of the introduction allows you to create a more compelling narrative around the key issues under investigation. Either approach is appropriate.

The number of questions you attempt to address should be based on the complexity of the problem you are investigating and what areas of inquiry you find most critical to study. Practical considerations, such as, the length of the paper you are writing or the availability of resources to analyze the issue can also factor in how many questions to ask. In general, however, there should be no more than four research questions underpinning a single research problem.

Given this, well-developed analytical questions can focus on any of the following:

• Highlights a genuine dilemma, area of ambiguity, or point of confusion about a topic open to interpretation by your readers;
• Yields an answer that is unexpected and not obvious rather than inevitable and self-evident;
• Provokes meaningful thought or discussion;
• Raises the visibility of the key ideas or concepts that may be understudied or hidden;
• Suggests the need for complex analysis or argument rather than a basic description or summary; and,
• Offers a specific path of inquiry that avoids eliciting generalizations about the problem.

NOTE:   Questions of how and why concerning a research problem often require more analysis than questions about who, what, where, and when. You should still ask yourself these latter questions, however. Thinking introspectively about the who, what, where, and when of a research problem can help ensure that you have thoroughly considered all aspects of the problem under investigation and help define the scope of the study in relation to the problem.

Mistakes to Avoid

Beware of circular reasoning! Do not state that the research problem as simply the absence of the thing you are suggesting. For example, if you propose the following, "The problem in this community is that there is no hospital," this only leads to a research problem where:

• The need is for a hospital
• The objective is to create a hospital
• The method is to plan for building a hospital, and
• The evaluation is to measure if there is a hospital or not.

This is an example of a research problem that fails the "So What?" test . In this example, the problem does not reveal the relevance of why you are investigating the fact there is no hospital in the community [e.g., there's a hospital in the community ten miles away]; it does not elucidate the significance of why one should study the fact there is no hospital in the community [e.g., that hospital in the community ten miles away has no emergency room]; the research problem does not offer an intellectual pathway towards adding new knowledge or clarifying prior knowledge [e.g., the county in which there is no hospital already conducted a study about the need for a hospital]; and, the problem does not offer meaningful outcomes that lead to recommendations that can be generalized for other situations or that could suggest areas for further research [e.g., the challenges of building a new hospital serves as a case study for other communities].

Alvesson, Mats and Jörgen Sandberg. “Generating Research Questions Through Problematization.” Academy of Management Review 36 (April 2011): 247-271 ; Choosing and Refining Topics . Writing@CSU. Colorado State University; Ellis, Timothy J. and Yair Levy Nova. "Framework of Problem-Based Research: A Guide for Novice Researchers on the Development of a Research-Worthy Problem." Informing Science: the International Journal of an Emerging Transdiscipline 11 (2008); How to Write a Research Question . The Writing Center. George Mason University; Invention: Developing a Thesis Statement . The Reading/Writing Center. Hunter College; Problem Statements PowerPoint Presentation . The Writing Lab and The OWL. Purdue University; Procter, Margaret. Using Thesis Statements . University College Writing Centre. University of Toronto; Trochim, William M.K. Problem Formulation . Research Methods Knowledge Base. 2006; Thesis and Purpose Statements . The Writer’s Handbook. Writing Center. University of Wisconsin, Madison; Thesis Statements . The Writing Center. University of North Carolina; Tips and Examples for Writing Thesis Statements . The Writing Lab and The OWL. Purdue University; Walk, Kerry. Asking an Analytical Question . [Class handout or worksheet]. Princeton University; White, Patrick. Developing Research Questions: A Guide for Social Scientists . New York: Palgrave McMillan, 2009.

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• How to Define a Research Problem | Ideas & Examples

How to Define a Research Problem | Ideas & Examples

Published on 8 November 2022 by Shona McCombes and Tegan George.

A research problem is a specific issue or gap in existing knowledge that you aim to address in your research. You may choose to look for practical problems aimed at contributing to change, or theoretical problems aimed at expanding knowledge.

Some research will do both of these things, but usually the research problem focuses on one or the other. The type of research problem you choose depends on your broad topic of interest and the type of research you think will fit best.

This article helps you identify and refine a research problem. When writing your research proposal or introduction , formulate it as a problem statement and/or research questions .

Table of contents

Why is the research problem important, step 1: identify a broad problem area, step 2: learn more about the problem, frequently asked questions about research problems.

Having an interesting topic isn’t a strong enough basis for academic research. Without a well-defined research problem, you are likely to end up with an unfocused and unmanageable project.

You might end up repeating what other people have already said, trying to say too much, or doing research without a clear purpose and justification. You need a clear problem in order to do research that contributes new and relevant insights.

Whether you’re planning your thesis , starting a research paper , or writing a research proposal , the research problem is the first step towards knowing exactly what you’ll do and why.

Prevent plagiarism, run a free check.

As you read about your topic, look for under-explored aspects or areas of concern, conflict, or controversy. Your goal is to find a gap that your research project can fill.

Practical research problems

If you are doing practical research, you can identify a problem by reading reports, following up on previous research, or talking to people who work in the relevant field or organisation. You might look for:

• Issues with performance or efficiency
• Processes that could be improved
• Areas of concern among practitioners
• Difficulties faced by specific groups of people

Examples of practical research problems

Voter turnout in New England has been decreasing, in contrast to the rest of the country.

The HR department of a local chain of restaurants has a high staff turnover rate.

A non-profit organisation faces a funding gap that means some of its programs will have to be cut.

Theoretical research problems

If you are doing theoretical research, you can identify a research problem by reading existing research, theory, and debates on your topic to find a gap in what is currently known about it. You might look for:

• A phenomenon or context that has not been closely studied
• A contradiction between two or more perspectives
• A situation or relationship that is not well understood
• A troubling question that has yet to be resolved

Examples of theoretical research problems

The effects of long-term Vitamin D deficiency on cardiovascular health are not well understood.

The relationship between gender, race, and income inequality has yet to be closely studied in the context of the millennial gig economy.

Historians of Scottish nationalism disagree about the role of the British Empire in the development of Scotland’s national identity.

Next, you have to find out what is already known about the problem, and pinpoint the exact aspect that your research will address.

Context and background

• Who does the problem affect?
• Is it a newly-discovered problem, or a well-established one?
• What research has already been done?
• What, if any, solutions have been proposed?
• What are the current debates about the problem? What is missing from these debates?

Specificity and relevance

• What particular place, time, and/or group of people will you focus on?
• What aspects will you not be able to tackle?
• What will the consequences be if the problem is not resolved?

Example of a specific research problem

A local non-profit organisation focused on alleviating food insecurity has always fundraised from its existing support base. It lacks understanding of how best to target potential new donors. To be able to continue its work, the organisation requires research into more effective fundraising strategies.

Once you have narrowed down your research problem, the next step is to formulate a problem statement , as well as your research questions or hypotheses .

Once you’ve decided on your research objectives , you need to explain them in your paper, at the end of your problem statement.

Keep your research objectives clear and concise, and use appropriate verbs to accurately convey the work that you will carry out for each one.

I will compare …

The way you present your research problem in your introduction varies depending on the nature of your research paper . A research paper that presents a sustained argument will usually encapsulate this argument in a thesis statement .

A research paper designed to present the results of empirical research tends to present a research question that it seeks to answer. It may also include a hypothesis – a prediction that will be confirmed or disproved by your research.

Research objectives describe what you intend your research project to accomplish.

They summarise the approach and purpose of the project and help to focus your research.

Your objectives should appear in the introduction of your research paper , at the end of your problem statement .

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5 Sources of a Research Problem: The Complete Guide

by  Antony W

February 20, 2022

In this guide, you will learn about the best sources of a research problem for your next project. 

The term research problem refers to a clear expression of an area of concern that requires a clear understanding and deliberate investigation. While it offers a broad proposition and a valuable question, a research problem doesn’t demonstrate how to do something.

It’s worth looking at a research problem for a number of reasons. It introduces a reader to the topic under investigation and orients to the importance of the study.

Besides allowing you to define the most important parameter to investigate in your paper, a research problem offers you a concise guide to come up with research questions , make relevant assumptions, and formulate a proposition .

More importantly, a research problem gives you a more comprehensive framework to conduct extensive studies and explain your findings.

Need help with your research paper, dissertation, or thesis but you have no idea where to start? Hire Help for Assessment for Assistance.

Type of Research Problems

There are four types of research problems that you need to know before we look at the sources of a research problem.

These are casuist, difference, descriptive and relational research problems.

1. Relational Research Problem

A relational research problem suggests the need to investigate the correlation between two or more variables.

It’s the researcher’s responsibility to investigate a number of precise characteristics and identify the relationship between them.

2. Casuist Research Problem

Casuist research problem has something to do with the determination of what’s right and what’s wrong.

It questions human conduct by looking closely at the moral dilemmas by means of careful differentiation of cases as well as the application of general rules.

3. Descriptive Research Problem

In this case, a researcher looks forward to investigating a “what is” kind of issue.

The goal of examining a descriptive research problem is to determine the underlying significance of an event or the existence of a situation.

It’s with the descriptive research problem that a researcher can discover understudied or hidden issues.

5. Difference Research Problem

A difference research problem focuses on the distinction between two or more groups.  More often than not, researchers use this type of problem to compare and contrast more than one phenomenon.

What are the Sources of Research Problems?

Now that you know the types of possible research problems that you can focus on in a term paper , let’s look at the sources that you can use to identify research problems.

From a research perspective, the kind of research problem that you wish to investigate should meet two conditions.

First, the problem has to be unique and not something other researchers have already looked into exhaustively. Second, the problem has to be concise enough to raise specific issues that you can address in a research paper .

With that said, below are five sources of a research problem:

1. Interviews

Interviews sessions can be significant sources of research problems. The method gives you an opportunity to have formal discussions and informal interactions with individuals who can provide useful insights into research and make findings more relevant to future research. 

Consider having discussions with experts in the field you wish to investigate. These professionals mat be healthcare service providers, business leaders, teachers, social workers, attorneys, and accountants to mention but a few examples.

By interacting with these experts, you’re able to identify real-world problems that researchers have either ignored or understudied in the academic space.

Moreover, interview sessions give you the opportunity to get some practical knowledge that can help you to design and conduct your studies.

2. Personal Experiences

Your everyday experiences are a good source of research problem.

You have to think critically about your personal experiences with an issue that affects your family, your personal life, or your community.

A research problem derived from personal experience can spring from any issue and from anywhere.

For example, you can construct a research problem from events that appear to be out of the ordinary or from community relationships that don’t have clear explanations.

3. Deductions from Theory

A deduction from theory refers to inferences a researcher makes from the generalizations of life in a society that a researcher knows very well.

A researcher takes the deduction, places them in an empirical frame, and then, based on a theory, they come up with a research problem and a hypothesis that suggests some findings based on given empirical results.

The research accounts for the relationship to observe if a theory summarizes the state of an affair.

A systematic investigation, which evaluates if the empirical information affirms or rejects the hypothesis , comes next.

4. Interdisciplinary Perspective

If you consider interdisciplinary perspective to identify a problem for a research study, you’ll have to look at scholarship and academic movements from outside your main area of investigation.

It’s an intellectually involving process, one that requires reviewing pertinent literature to discover unique avenues of exploration an analysis.

The benefit of using this approach to identify a research problem for your research paper assignment is that it presents an opportunity for you to understand complex issues with ease.

5. Relevant Literature

To generate a research problem from relevant literature, you first have to review research related to your area of interest.

Doing so allows you to find gaps on the topic, making it easy for you to understand just how much understudied your area of interest is.

Data collected from relevant literature is relevant because it helps to:

• Fill existing gaps in knowledge based on a specific research
• Determine if current studies can have implications on further research on the same issue
• See if it’s possible to conduct a similar study in a different area or apply the same in a different context
• Determine if the methods used in previous studies can be effective in solving future problems

We can’t stress enough on the value of existing literature. The results should point you towards an outstanding issue, give suggestion for future gaps, and make it possible to delineate gaps in existing knowledge.

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Research Topics

Five research topics exploring the science of mental health.

Mental wellbeing is increasingly recognized as an essential aspect of our overall health. It supports our ability to handle challenges, build strong relationships, and live more fulfilling lives. The World Health Organization (WHO) emphasizes the importance of mental health by acknowledging it as a fundamental human right.

This Mental Health Awareness Week, we highlight the remarkable work of scientists driving open research that helps everyone achieve better mental health.

Here are five Research Topics that study themes including how we adapt to a changing world, the impact of loneliness on our wellbeing, and the connection between our diet and mental health.

All articles are openly available to view and download.

1 | Community Series in Mental Health Promotion and Protection, volume II

40.300 views | 16 articles

There is no health without mental health. Thus, this Research Topic collects ideas and research related to strategies that promote mental health across all disciplines. The goal is to raise awareness about mental health promotion and protection to ensure its incorporation in national mental health policies.

This topic is of relevance given the mental health crisis being experienced across the world right now. A reality that has prompted the WHO to declare that health is a state of complete physical, mental, and social wellbeing.

View Research Topic

2 | Dietary and Metabolic Approaches for Mental Health Conditions

176.800 views | 11 articles

There is increased recognition that mental health disorders are, at least in part, a form of diet-related disease. For this reason, we focus attention on a Research Topic that examines the mechanistic interplay between dietary patterns and mental health conditions.

There is a clear consensus that the quality, quantity, and even timing of our human feeding patterns directly impact how brains function. But despite the epidemiological and mechanistic links between mental health and diet-related diseases, these two are often perceived as separate medical issues.

Even more urgent, public health messaging and clinical treatments for mental health conditions place relatively little emphasis on formulating nutrition to ease the underlying drivers of mental health conditions.

3 | Comparing Mental Health Cross-Culturally

94.000 views | 15 articles

Although mental health has been widely discussed in later years, how mental health is perceived across different cultures remains to be examined. This Research Topic addresses this gap and deepens our knowledge of mental health by comparing positive and negative psychological constructs cross-culturally.

The definition and understanding of mental health remain to be refined, partially because of a lack of cross-cultural perspectives on mental health. Also, due to the rapid internationalization taking place in the world today, a culturally aware understanding of, and interventions for mental health problems are essential.

4 | Adaption to Change and Coping Strategies: New Resources for Mental Health

85.000 views | 29 articles

In this Research Topic, scientists study a wider range of variables involved in change and adaptation. They examine changes of any type or magnitude whenever the lack of adaptive response diminishes our development and well-being.

Today’s society is characterized by change, and sometimes, the constant changes are difficult to assimilate. This may be why feelings of frustration and defenselessness appear in the face of the impossibility of responding adequately to the requirements of a changing society.

Therefore, society must develop an updated notion of the processes inherent to changing developmental environments, personal skills, resources, and strategies. This know-how is crucial for achieving and maintaining balanced mental health.

5 | Mental Health Equity

29.900 views | 10 articles

The goal of this Research Topic is to move beyond a synthesis of what is already known about mental health in the context of health equity. Rather, the focus here is on transformative solutions, recommendations, and applied research that have real world implications on policy, practice, and future scholarship.

Attention in the field to upstream factors and the role of social and structural determinants of health in influencing health outcomes, combined with an influx of innovation –particularly the digitalization of healthcare—presents a unique opportunity to solve pressing issues in mental health through a health equity lens.

The topic is opportune because factors such as structural racism and climate change have disproportionately negatively impacted marginalized communities across the world, including Black, Indigenous, People of Color (BIPOC), LGBTQ+, people with disabilities, and transition-age youth and young adults. As a result, existing disparities in mental health have exacerbated.

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List of 40 Social Issues Topics for College Students

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• Free education for everyone: shall it be implemented?
• National identity versus globalization
• Women rights and trans people rights
• Obesity as an obstacle in social life. Fatshaming
• Civil rights: shall they be expanded?
• Abuse and neglect in asylums, orphanages, and care homes
• Church and state: shall they remain separate?
• The problem of bigotry in modern society
• Immigration and resocialization of the immigrants
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• Legalizing drugs: basic rights to choose or a danger to society?
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How Do Psychologists Decide What to Study?

Personal perspective: psychological research is sometimes, but not always, “me-search.".

Posted May 14, 2024 | Reviewed by Ray Parker

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• It is sometimes assumed that the personal concerns of the researcher guide psychological research.
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• Connecting new research to existing bodies of research is essential.

There is an old saying among psychological scientists that “Research is me-search.” This means, of course, that people, including psychologists, are drawn to topics that have deep relevance to issues in their own lives.

This old saying certainly rings true as I watch my undergraduate students select topics for their capstone senior research projects: The too-thin young woman who wants to study eating disorders, the student of color who is interested in racism , the child of divorce who desperately wishes to understand how a marriage ending in divorce affects children.

Given that I am best known for my work on creepiness and gossip, this old truism about “me-search” stalks and haunts me whenever I do a media interview about my research on either of these topics. The interviewer always wants to know what it is, exactly, that enticed me to devote years of my life to studying such a thing. There seems to be an assumption that I have a personal story to tell about a lifetime of being plagued by gossip or about my fear that I am chronically creeping other people out.

I will let the discerning reader draw their own conclusions about my interest in creepiness, but my interest in gossip does have an identifiable point of origin that is a bit more mundane than one might expect.

Research Ideas Can Be Inspired by Everyday Life

One day, about 25 years ago, I was standing in a long, slow-moving line at a grocery store. As it happened, my progress was stalled right next to a magazine rack rife with tabloids full of scandalous stories about movie stars, politicians, and assorted other celebrities.

For the first time in my life, I really looked at these publications and found myself wondering how they all stayed in business. Who reads all of this stuff? Why do we care so much about the private lives of individuals who we will never meet? I pondered this during my drive to the office after I left the store. I remember posing questions about the allure of these magazines to the first psychologist colleague I encountered when I got to work, and our ensuing conversation fanned the flames of my interest even further.

Being a good academic, my first impulse was to turn to the scientific literature to see what experts on gossip had been able to uncover. I was stunned by what I found, or more accurately, by what I did not find. There were a few studies in which anthropologists hung out in villages in random cultures and reported on what they heard people talking about when they gossiped and some intriguing anthropological theories about the origin of gossip.

However, I was unable to find anything in the way of actual experiments done by social psychologists on how gossip works. This is extraordinary: Until the dawn of the 21 st century, a universal human activity that lies at the heart of social life had been largely ignored by scientists whose stated mission was to understand human social interaction.

As an experimental social psychologist, I found the implied challenge irresistible. And so, with the help of some of my students, I embarked on a series of experiments on the psychology of gossip. I am proud to say that an interest in gossip spread like wildfire throughout the research community and that the study of gossip is now a thriving enterprise in the field of social psychology and related social sciences.

Thus, some research ideas do indeed spring directly from questions that arise through observing everyday life or from personal concerns faced by the researcher. However, this is not the only way in which research questions are formulated, and I will explore this in another post.

Frank McAndrew, Ph.D., is the Cornelia H. Dudley Professor of Psychology at Knox College.

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Environmental Changes Are Fueling Human, Animal and Plant Diseases, Study Finds

Biodiversity loss, global warming, pollution and the spread of invasive species are making infectious diseases more dangerous to organisms around the world.

By Emily Anthes

Several large-scale, human-driven changes to the planet — including climate change, the loss of biodiversity and the spread of invasive species — are making infectious diseases more dangerous to people, animals and plants, according to a new study.

Scientists have documented these effects before in more targeted studies that have focused on specific diseases and ecosystems. For instance, they have found that a warming climate may be helping malaria expand in Africa and that a decline in wildlife diversity may be boosting Lyme disease cases in North America.

But the new research, a meta-analysis of nearly 1,000 previous studies, suggests that these patterns are relatively consistent around the globe and across the tree of life.

“It’s a big step forward in the science,” said Colin Carlson, a biologist at Georgetown University, who was not an author of the new analysis. “This paper is one of the strongest pieces of evidence that I think has been published that shows how important it is health systems start getting ready to exist in a world with climate change, with biodiversity loss.”

In what is likely to come as a more surprising finding, the researchers also found that urbanization decreased the risk of infectious disease.

The new analysis, which was published in Nature on Wednesday, focused on five “global change drivers” that are altering ecosystems across the planet: biodiversity change, climate change, chemical pollution, the introduction of nonnative species and habitat loss or change.

The researchers compiled data from scientific papers that examined how at least one of these factors affected various infectious-disease outcomes, such as severity or prevalence. The final data set included nearly 3,000 observations on disease risks for humans, animals and plants on every continent except for Antarctica.

The researchers found that, across the board, four of the five trends they studied — biodiversity change, the introduction of new species, climate change and chemical pollution — tended to increase disease risk.

“It means that we’re likely picking up general biological patterns,” said Jason Rohr, an infectious disease ecologist at the University of Notre Dame and senior author of the study. “It suggests that there are similar sorts of mechanisms and processes that are likely occurring in plants, animals and humans.”

The loss of biodiversity played an especially large role in driving up disease risk, the researchers found. Many scientists have posited that biodiversity can protect against disease through a phenomenon known as the dilution effect.

The theory holds that parasites and pathogens, which rely on having abundant hosts in order to survive, will evolve to favor species that are common, rather than those that are rare, Dr. Rohr said. And as biodiversity declines, rare species tend to disappear first. “That means that the species that remain are the competent ones, the ones that are really good at transmitting disease,” he said.

Lyme disease is one oft-cited example. White-footed mice, which are the primary reservoir for the disease, have become more dominant on the landscape, as other rarer mammals have disappeared, Dr. Rohr said. That shift may partly explain why Lyme disease rates have risen in the United States. (The extent to which the dilution effect contributes to Lyme disease risk has been the subject of debate, and other factors, including climate change, are likely to be at play as well.)

Other environmental changes could amplify disease risks in a wide variety of ways. For instance, introduced species can bring new pathogens with them, and chemical pollution can stress organisms’ immune systems. Climate change can alter animal movements and habitats, bringing new species into contact and allowing them to swap pathogens .

Notably, the fifth global environmental change that the researchers studied — habitat loss or change — appeared to reduce disease risk. At first glance, the findings might appear to be at odds with previous studies, which have shown that deforestation can increase the risk of diseases ranging from malaria to Ebola. But the overall trend toward reduced risk was driven by one specific type of habitat change: increasing urbanization.

The reason may be that urban areas often have better sanitation and public health infrastructure than rural ones — or simply because there are fewer plants and animals to serve as disease hosts in urban areas. The lack of plant and animal life is “not a good thing,” Dr. Carlson said. “And it also doesn’t mean that the animals that are in the cities are healthier.”

And the new study does not negate the idea that forest loss can fuel disease; instead, deforestation increases risk in some circumstances and reduces it in others, Dr. Rohr said.

Indeed, although this kind of meta-analysis is valuable for revealing broad patterns, it can obscure some of the nuances and exceptions that are important for managing specific diseases and ecosystems, Dr. Carlson noted.

Moreover, most of the studies included in the analysis examined just a single global change drive. But, in the real world, organisms are contending with many of these stressors simultaneously. “The next step is to better understand the connections among them,” Dr. Rohr said.

Emily Anthes is a science reporter, writing primarily about animal health and science. She also covered the coronavirus pandemic. More about Emily Anthes

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Scientists say they have found an “alphabet” in the songs of sperm whales , raising the possibility that the animals are communicating in a complex language.

Indigenous rangers in Australia’s Western Desert got a rare close-up with the northern marsupial mole , which is tiny, light-colored and blind, and almost never comes to the surface.

For the first time, scientists observed a primate in the wild treating a wound  with a plant that has medicinal properties.

A new study resets the timing for the emergence of bioluminescence back to millions  of years earlier than previously thought.

Scientists are making computer models to better understand how cicadas  emerge collectively after more than a decade underground .

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• A Majority of Latinas Feel Pressure To Support Their Families or To Succeed at Work

1. Daily life experiences of Latinas

Table of contents.

• The impact of gender, Hispanic identity and skin color on the lives of Latinas
• 2. Pressures Latinas face in their lives
• 3. Life satisfaction and sources of joy for Latinas
• Acknowledgments
• The American Trends Panel survey methodology

About four-in-ten Hispanic women say that being female or Hispanic impacts their daily lives. In fact, Hispanic women are more likely than Hispanic men to say sexism is a problem in the workplace, schools and the media.

Differences by gender disappear in other areas. Similar shares of Hispanic women and Hispanic men say they have been treated as if they’re not smart.

This chapter explores Latinas’ views of sexism and their experiences with harassment and discrimination.

Substantial shares of Hispanic women say gender (43%), Hispanic identity (40%) and skin color (35%) shape their daily life experiences a great deal or a fair amount. Overall, 54% say at least one of these shapes their daily life.

By comparison, Hispanic men are somewhat less likely than Hispanic women to say gender (38%), Hispanic identity (36%) and skin color (30%) impact their daily lives a great deal or a fair amount.

Does gender shape daily life for Latinas?

Latinas’ opinions on how much gender shapes their lives can vary by age, education, nativity and political party:

• Age: About half (53%) of Latinas ages 18 to 29 say gender shapes their life, while 30% of Latinas 65 and older say so.
• Education: A majority of Latinas (57%) with a bachelor’s degree or higher say gender shapes their daily life experiences. By comparison, 34% of Latinas with a high school diploma or less say the same.
• Party identification: About half of Latinas (49%) who identify as Democrats or lean toward the Democratic Party say gender shapes their daily life, compared with 35% of Latinas who identify as Republicans or lean Republican.
• Nativity: Nearly half (48%) of Latinas born in the United States say gender shapes their daily life, compared with 38% of Latina immigrants.

How do views of sexism differ by gender?

Hispanic women are more likely than Hispanic men to say sexism against women is at least a somewhat big problem in media, the workplace, schools and families.

• 52% of Hispanic women say sexism against women in the workplace is at least a somewhat big problem, compared with 44% of Hispanic men.
• 48% of Hispanic women say sexism against women in schools is at least a somewhat big problem, while 37% of Hispanic men say this.
• Half of Hispanic women say sexism against women in English-language music is a problem, versus 40% of Hispanic men. 4
• 46% of Hispanic women say sexism against women in Spanish-language music is a problem, compared with 38% of Hispanic men. 5

How do different groups of Latinas view sexism in the workplace?

Latinas who are young adults, college graduates, U.S. born, Democrats or don’t have children are more likely to say that sexism against women at work is at least a somewhat big problem:

• Age: 63% of Latinas ages 18 to 29 say sexism in the workplace is at least a somewhat big problem, compared with 44% of those 65 and older.
• Education: 65% of Latinas who are college graduates say sexism in the workplace is at least a somewhat big problem, versus 47% of those with a high school diploma or less.
• Immigrant generation: 59% of Latinas who are U.S. born and have at least one immigrant parent (second-generation Hispanics) say this is at least a somewhat big problem, compared with 48% of Latina immigrants.
• Party affiliation: 60% of Latinas who identify as or lean Democratic say workplace sexism is at least a somewhat big problem, compared with 43% of Republican and Republican-leaning Latinas.

What experiences do Latinas have with harassment and discrimination?

Over four-in-ten Hispanic women (44%) say that in the past 12 months people have acted as if they were not smart, the most common of five negative experiences asked about in our survey. Meanwhile, 38% of Hispanic men say they experienced the same thing.

About a third (31%) of Hispanic women say they have feared for their personal safety in the past year. The same share say a stranger made a comment about their appearance that made them feel uncomfortable during this time. By contrast, Hispanic men are less likelyto say these experiences have happened to them.

Overall, a majority of Hispanic women (62%) and about half of Hispanic men (52%) say at least one of these five negative experiences has happened to them in the past year.

By immigrant generation and age

Among Hispanic women, those who are second generation (71%) are more likely than immigrants (59%) to say they have had at least one of the five negative experiences happen to them.

Notable differences exist between the youngest and oldest age groups of Latinas:

• 50% of Latinas ages 18 to 29 say people have acted as if they were not smart in the past year, compared with 21% of those 65 and older.
• 43% of Latina adults under 30 say they have feared for their personal safety in the past year, versus 16% of those 65 and older.
• 42% of Latinas 18 to 29 say a stranger commented on their appearance and made them feel uncomfortable, compared with 12% of those in the oldest age group.

Overall, 72% of Latinas ages 18 to 29 say they havehad at least one of the survey’s five negative experiences happen to them in the past year, compared with 36% of those 65 and older.

• Asked only of those who say they can carry on a conversation in English at least “a little.” ↩
• Asked only of those who say they can carry on a conversation in Spanish at least “a little.” ↩

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Bitter makes the stomach acidic, but how?

How bitter food constituents influence gastric acid production.

In the stomach, so-called parietal cells are responsible for acid production. They react not only to the body's own messenger molecules, but also to bitter-tasting food constituents such as caffeine. A research team from the Leibniz Institute for Food Systems Biology at the Technical University of Munich has now carried out a study on a human gastric cell line. Their results help to clarify the molecular regulatory mechanisms by which bitter substances influence gastric acid production.

It is known that taste receptors for bitter substances are not only found on the tongue, but also on the surface of other tissues and cells. These include the parietal cells of the stomach, which secrete protons into the stomach -- i.e. produce gastric acid. Recent studies have already shown that the bitter taste receptors found in parietal cells are involved in the regulation of gastric acid release. However, the underlying molecular signaling pathways are not yet fully understood.

Gastric cells as a test system

To further clarify the molecular interaction between bitter substances, bitter taste receptors, and gastric acid production, a research team led by Veronika Somoza, Director of the Leibniz Institute in Freising, has carried out a study on a cellular test system. This involves human parietal HGT-1 cells, which are able to secrete protons and, like taste cells, have bitter taste receptors.

Veronika Somoza's team initially developed a working hypothesis based on the results of previous studies and the findings on signal transduction pathways in taste cells. According to this hypothesis, bitter tasting food constituents stimulate bitter taste receptors that are embedded in the cell membrane. This releases calcium ions inside the cells, leading to ion channel opening. This, in turn, allows sodium ions to flow into the gastric cells from the outside, ultimately contributing to the release of protons.

Hypothesis confirmed

First author Phil Richter explains: "We have successfully tested this mechanism with the two bitter substances caffeine and l-arginine. As expected from previous results, both food constituents were shown to stimulate gastric cell proton secretion in our test system." The PhD student adds: "For the first time, we were able to demonstrate that the transient receptor potential channelsM4 and M5 are involved in the signaling cascade not only in taste cells but also in gastric cells and ensure an influx of sodium ions into the cells."

Senior Scientist Gaby Andersen says: "By using knock-out experiments, in which we specifically switched off one type of bitter taste receptor in the cells, we were also able to show for the first time that there is a link between bitter taste receptors and the activation of the ion channels." The scientist emphasizes that the results not only contribute to a better understanding of the role of taste receptors in the stomach but would also show that HGT-1 cells could be suitable as a replacement model for taste cells.

The research team agrees that the results will provide new insights into the regulation of gastric acid production and thus lead to innovative approaches in treating gastric diseases in the long term. However, further studies are needed to deepen knowledge of the molecular regulatory mechanisms and intracellular signaling pathways.

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Materials provided by Leibniz-Institut für Lebensmittel-Systembiologie an der TU München . Note: Content may be edited for style and length.

Journal Reference :

• Phil Richter, Gaby Andersen, Kristin Kahlenberg, Alina Ulrike Mueller, Philip Pirkwieser, Valerie Boger, Veronika Somoza. Sodium-Permeable Ion Channels TRPM4 and TRPM5 are Functional in Human Gastric Parietal Cells in Culture and Modulate the Cellular Response to Bitter-Tasting Food Constituents . Journal of Agricultural and Food Chemistry , 2024; 72 (9): 4906 DOI: 10.1021/acs.jafc.3c09085

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