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Research in Disability and Community Inclusion (RDCI) is a website to share the research of academic staff working in Disability and Community Inclusion at Flinders University.

Working in partnership with people with disability and a wide range of government, community services, and advocacy organisations, our research aims to:

Promote human rights

Privilege the experiences and priorities of people with disability

Develop understanding about how we can jointly promote social inclusion and challenge marginalisation of people with disability

Generate knowledge useful for policy and practice

Interested in studying with us? 

We offer a wide range of undergraduate and postgraduate study programs. You can find out more about these here.  

Our research is conducted with and for a wide range of partners across government and non-government sectors and in community organisations. We work closely with people with disability and their organisations in our research.

These include:

Association of Frontotemporal Degeneration (USA)

Australia's National Research Organisation for Women's Safety

Australian Association of Gerontology

Australian Research Council

Channel 7 Children’s Research Foundation

Charles Perkins Centre Active Ageing Research Node, University of Sydney

Commonwealth Department of Health 

Department of Social Services

National Alliance of Capacity Building Organisations

National Disability Research Partnership

National Health and Medical Research Council

NDIS Quality and Safeguards Commission

NSW Council for Intellectual Disability

Our Voice SA

Purple Orange

Queensland Department of Child Safety, Youth and Women

Royal Commission into Violence, Abuse, Neglect and Exploitation of People with Disability

SA Council for Intellectual Disability

UNSW Social Policy Research Centre

Researchers in Disability and Community Inclusion are members of the Caring Futures Institute at Flinders University. 

Sphingosine kinase and sphingosine-1-phosphate receptor signaling pathway in inflammatory gastrointestinal disease and cancers: A novel therapeutic target

Affiliations.

• 1 Discipline of Health Sciences, College of Nursing and Health Sciences, Flinders University, Bedford Park, South Australia 5042, Australia.
• 2 Department of Surgery, Samuel Oschin Cancer Center Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
• 3 Advanced Medical and Dental Institute, University Sains 13200 Kepala Batas, Pulau Pinang, Malaysia.
• 4 Institute of Clinical Chemistry and Laboratory Medicine, University Hospital `Carl Gustav Carus`, Technical University of Dresden, Dresden 01307, Germany.
• 5 Sechenov First Moscow State Medical University (Sechenov University), Moscow 119991, Russia.
• 6 Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka 142432, Russia.
• 7 Discipline of Clinical Pharmacology, College of Medicine and Public Health, Flinders University and Flinders Medical Centre, Bedford Park, South Australia 5042, Australia.
• 8 Sechenov First Moscow State Medical University (Sechenov University), Moscow 119991, Russia; Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka 142432, Russia; GALLY International Research Institute, San Antonio, TX 78229, USA; Research Institute of Human Morphology, Moscow 117418, Russia.
• 9 Lake Erie College of Osteopathic Medicine, Bradenton, FL 34211, USA. Electronic address: [email protected].
• PMID: 31863815
• DOI: 10.1016/j.pharmthera.2019.107464

Inflammatory gastrointestinal (GI) diseases and malignancies are associated with growing morbidity and cancer-related mortality worldwide. GI tumor and inflammatory cells contain activated sphingolipid-metabolizing enzymes, including sphingosine kinase 1 (SphK1) and SphK2, that generate sphingosine-1-phosphate (S1P), a highly bioactive compound. Many inflammatory responses, including lymphocyte trafficking, are directed by circulatory S1P, present in high concentrations in both the plasma and the lymph of cancer patients. High fat and sugar diet, disbalanced intestinal flora, and obesity have recently been linked to activation of inflammation and SphK/S1P/S1P receptor (S1PR) signaling in various GI pathologies, including cancer. SphK1 overexpression and activation facilitate and enhance the development and progression of esophageal, gastric, and colon cancers. SphK/S1P axis, a mediator of inflammation in the tumor microenvironment, has recently been defined as a target for the treatment of GI disease states, including inflammatory bowel disease and colitis. Several SphK1 inhibitors and S1PR antagonists have been developed as novel anti-inflammatory and anticancer agents. In this review, we analyze the mechanisms of SphK/S1P signaling in GI tissues and critically appraise recent studies on the role of SphK/S1P/S1PR in inflammatory GI disorders and cancers. The potential role of SphK/S1PR inhibitors in the prevention and treatment of inflammation-mediated GI diseases, including GI cancer, is also evaluated.

Keywords: Colitis; Colon cancer; Esophageal cancer; Fingolimod; Gastric cancer; Inflammatory bowel disease; Microbiome; Sphingosine kinase; Sphingosine-1-phosphate; Sphingosine-1-phosphate receptor.

Copyright © 2019 Elsevier Inc. All rights reserved.

Publication types

• Research Support, Non-U.S. Gov't
• Gastrointestinal Diseases / drug therapy*
• Gastrointestinal Diseases / metabolism
• Inflammation / drug therapy*
• Inflammation / metabolism
• Neoplasms / drug therapy*
• Neoplasms / metabolism
• Phosphotransferases (Alcohol Group Acceptor) / antagonists & inhibitors*
• Phosphotransferases (Alcohol Group Acceptor) / metabolism
• Signal Transduction
• Sphingolipids / metabolism
• Sphingosine-1-Phosphate Receptors / antagonists & inhibitors*
• Sphingosine-1-Phosphate Receptors / metabolism
• Sphingolipids
• Sphingosine-1-Phosphate Receptors
• Phosphotransferases (Alcohol Group Acceptor)
• sphingosine kinase

Clusters of alcohol abstainers and dr inkers incorporating motives against drinking: a random survey of 18 to 34 year olds in four cities in four different continents

Research output : Contribution to journal › Article › peer-review

Objective: The aim of this analysis was to identify alcohol consumption clusters for adolescents and early adults according to attitudes to drinking, motivations against drinking and perceptions associated with alcohol. Method: Interviews were undertaken with people aged 18–34 years old living in four cities in different regions of the world. Multistage random sampling was consistent across the four cities (Ilorin (Nigeria), Wuhan (China), Montevideo (Uruguay) and Moscow (Russia)). The questionnaire was forward and back translated into relevant languages and face-to-face interviewing undertaken. The data were weighted to the population of each city. In total 6235 structured interviews were undertaken (1391 in Ilorin, 1600 in Montevideo, 1604 in Moscow and 1640 in Wuhan). Questions regarding motivation against alcohol consumption (14 items), assessing perceptions (3 items) and attitudes to drinking in certain situations (8 items) were asked of all respondents including abstainers. Factor analysis was initially undertaken to identify highly related correlated variables. Results: Cluster analysis provided a variety of clusters (Ilorin (3 clusters), Montevideo (5), Moscow (4) and Wuhan (4)). At least one cluster in each city was dominated by abstainers and another by heavy episodic drinkers. Variations by city and alcohol consumption patterns existed in regards to variables included. Conclusion: This analysis detailed the city specific motivations against drinking alcohol, and the attitudes towards alcohol consumption. Differences highlight the influence of country/city specific culture, customs, laws, societal norms and traditions.

• motivations
• perceptions

Access to Document

• 10.3934/publichealth.2019.1.15 Licence: CC BY
• Published version Final published version, 671 KB Licence: CC BY

Other files and links

• Link to publication in Scopus

Fingerprint

• Urban Areas Social Sciences 100%
• Surveys Social Sciences 100%
• Alcohol Psychology 100%
• Alcohol Consumption Social Sciences 50%
• Analysis Social Sciences 25%
• Alcohol Abuse Psychology 16%
• Cluster Analysis Psychology 16%
• Structured Interview Psychology 16%

T1 - Clusters of alcohol abstainers and dr inkers incorporating motives against drinking

T2 - a random survey of 18 to 34 year olds in four cities in four different continents

AU - Winifred Taylor, Anne

AU - Bewick, Bridgette M.

AU - Ling, Qing

AU - Kirzhanova, Valentina

AU - Alterwain, Paulo

AU - Dal Grande, Eleonora

AU - Tucker, Graeme

AU - Makanjuola, Alfred B.

PY - 2019/1/17

Y1 - 2019/1/17

N2 - Objective: The aim of this analysis was to identify alcohol consumption clusters for adolescents and early adults according to attitudes to drinking, motivations against drinking and perceptions associated with alcohol. Method: Interviews were undertaken with people aged 18–34 years old living in four cities in different regions of the world. Multistage random sampling was consistent across the four cities (Ilorin (Nigeria), Wuhan (China), Montevideo (Uruguay) and Moscow (Russia)). The questionnaire was forward and back translated into relevant languages and face-to-face interviewing undertaken. The data were weighted to the population of each city. In total 6235 structured interviews were undertaken (1391 in Ilorin, 1600 in Montevideo, 1604 in Moscow and 1640 in Wuhan). Questions regarding motivation against alcohol consumption (14 items), assessing perceptions (3 items) and attitudes to drinking in certain situations (8 items) were asked of all respondents including abstainers. Factor analysis was initially undertaken to identify highly related correlated variables. Results: Cluster analysis provided a variety of clusters (Ilorin (3 clusters), Montevideo (5), Moscow (4) and Wuhan (4)). At least one cluster in each city was dominated by abstainers and another by heavy episodic drinkers. Variations by city and alcohol consumption patterns existed in regards to variables included. Conclusion: This analysis detailed the city specific motivations against drinking alcohol, and the attitudes towards alcohol consumption. Differences highlight the influence of country/city specific culture, customs, laws, societal norms and traditions.

AB - Objective: The aim of this analysis was to identify alcohol consumption clusters for adolescents and early adults according to attitudes to drinking, motivations against drinking and perceptions associated with alcohol. Method: Interviews were undertaken with people aged 18–34 years old living in four cities in different regions of the world. Multistage random sampling was consistent across the four cities (Ilorin (Nigeria), Wuhan (China), Montevideo (Uruguay) and Moscow (Russia)). The questionnaire was forward and back translated into relevant languages and face-to-face interviewing undertaken. The data were weighted to the population of each city. In total 6235 structured interviews were undertaken (1391 in Ilorin, 1600 in Montevideo, 1604 in Moscow and 1640 in Wuhan). Questions regarding motivation against alcohol consumption (14 items), assessing perceptions (3 items) and attitudes to drinking in certain situations (8 items) were asked of all respondents including abstainers. Factor analysis was initially undertaken to identify highly related correlated variables. Results: Cluster analysis provided a variety of clusters (Ilorin (3 clusters), Montevideo (5), Moscow (4) and Wuhan (4)). At least one cluster in each city was dominated by abstainers and another by heavy episodic drinkers. Variations by city and alcohol consumption patterns existed in regards to variables included. Conclusion: This analysis detailed the city specific motivations against drinking alcohol, and the attitudes towards alcohol consumption. Differences highlight the influence of country/city specific culture, customs, laws, societal norms and traditions.

KW - Ilorin

KW - Montevideo

KW - Moscow

KW - adolescent

KW - alcohol

KW - motivations

KW - perceptions

KW - survey

UR - http://www.scopus.com/inward/record.url?scp=85087358026&partnerID=8YFLogxK

U2 - 10.3934/publichealth.2019.1.15

DO - 10.3934/publichealth.2019.1.15

M3 - Article

SN - 2327-8994

JO - AIMS Public Health

JF - AIMS Public Health

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Bachelor of Criminology (Strategy and Analysis)

Study criminology (strategy and analysis) at flinders.

Learn how to increase your positive social impact and develop a strategic mindset to address existing and emerging challenges related to the criminal justice system.

Push the boundaries and see the criminal justice system through a courageous new lens.    With a focus on strategy and analysis, this Criminology specialisation provides a comprehensive understanding of crime and social harm, preparing you for careers in intelligence, research, and policy.     By undertaking a selection of topics from business, public policy and social work you will cultivate a strategic mindset that will allow you to recognise and act on opportunities.    Learn how to apply your knowledge and skills in a dynamic context, and future-proof your career in an ever-changing work landscape.

What you will study 

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How to apply 

Certificate IV or above

245171 (Bedford Park) 284911 (City)

• – Bedford Park
• – City

3 years full-time (or part-time equivalent) Deferrable: Yes

• 2025: $19,922
• – March
• – July

Student and ATAR profile 

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3 years full-time Deferrable: Yes

• 2025: $33,900

Entry requirements by country 

Apply via SATAC

245171 (Bedford Park)

284911 (City)

Why study Criminology (Strategy and Analysis) at Flinders

Learn from South Australia’s largest and most experienced Criminology team

Develop a strategic mindset that will set you apart in a fast-changing world

Intelligence and policy analyst jobs are set to grow by 20% in the ten years to May 2033 (Source: Jobs and Skills Australia 2024)

Complete an Industry Placement and connect with leaders: our powerful industry partnerships span government bodies, public and private organisations. 

Your career

This degree will prepare you for a career addressing the challenges of the future in the criminal justice system and beyond, and provide a comprehensive understanding of crime and social harm, preparing you specifically for policy and research roles. 

Potential occupations include:

• Strategy and impact advisor
• Senior policy officer
• Program manager
• Intelligence analyst
• Cybercrime analyst
• Ministerial advisor
• Business analyst

Potential employers include:

What you will study.

View study program

View study program (City)

Practical experience

Immerse yourself in Industry Placements with not for profits or government departments that address issues relating to criminology. 

You will gain comprehensive experience with industry partners you work for. If undertaking a project, you will conduct research and develop strategic insights and recommendations for your client, which could have real-world impact.

Study abroad

Flinders has a series of international exchange links that give you a chance to study part of your degree overseas, from a short-term three-week study tour to a yearlong exchange at any one of 80 partner universities around the world.

ATAR and Student Profile Information

Atar and selection rank profile.

The ATAR and Selection Rank profile shows data for students offered a place wholly or partly on the basis of ATAR who commenced the course in the previous admission year. As this course is new there is currently no ATAR and Selection Rank data available.

Student Profile

The Student Profile gives an indication of the likely peer cohort for new students in a particular course. It provides data on students who commenced the course in the previous admission year. As this course is new there is currently no Student Profile data available

Add Innovation and Enterprise to your degree

At Flinders University, we recognise that careers are evolving and the workplace of the future will look very different from today.

Whatever undergraduate course you are studying at Flinders, you can add innovation and enterprise electives to your degree to gain new, adaptable and transferrable skills that will equip you for the careers of tomorrow.

How to apply

Choose your preferred course.

Check the entry requirements and admission pathways available to you.

Choose other courses to include in your preferences.

Visit SATAC and submit your application online.

284921 (City)

Flinders students can apply to transfer to this course internally. Visit: www.flinders.edu.au/internaltransfer for more information.

Applicants can apply for this course using Year 12 qualifications, previous higher education study, TAFE/VET qualifications, or through adult entry (STAT/Foundation Studies/tertiary preparation course). Find the entry path that’s right for you.

Explore our pathways

After completing the one-year Flinders University Diploma in Criminology, applicants have guaranteed entry into second year of the Bachelor of Criminology.

Explore the Diploma in Criminology

When choosing your preferences through SATAC, another Flinders degree you might want to include in your list are:

• Bachelor of Criminology
• Bachelor of Criminology (People and Community)

Select your course.

Check entry requirements.

Check your eligibility for credit .

Apply online

Obtain certified documents.

Submit your application and documents.

View further details

If you don’t meet our English language entry requirements and need to improve your English language proficiency, you can do so through Flinders University Academy – or our approved English Language Instruction Course for Overseas Students (ELICOS) providers.

This means that you can attend the required English language tuition at approved ELICOS providers and gain direct entry into university without an IELTS or TOEFL test.

Find out more

If you don’t meet our academic entry requirements, you can still gain entry to Flinders University through Flinders University Academy. With a range of diplomas, foundation and English language courses, students can find a direct pathway into the destination degree of their choice. 

Course enquiries

Want more information about studying at Flinders University? Contact us to find out more – we’d love to help you decide if Flinders University is the right choice for you.

For all course enquiries phone or email us or complete the course enquiry form.

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