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PROJECT PROPOSAL CERVICAL CANCER SCREENING T VENGESAI

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To report the results of a pilot study for a service for cervical cancer screening and diagnosis in north-western Tanzania. The pilot study was launched in 2012 after a community-level information campaign. Women aged 15-64 years were encouraged to attend the district health centres. Attendees were offered a conventional Pap smear and a visual inspection of the cervix with acetic acid (VIA). The first 2500 women were evaluated. A total of 164 women (detection rate 70.0/1000) were diagnosed with high-grade cervical intraepithelial neoplasia and invasive cervical cancer. The performance of VIA was comparable to that of Pap smear. The district of residence, a history of untreated sexually transmitted disease, an HIV-negative status (inverse association), and parity were independently associated with the detected prevalence of disease. The probability of invasive versus preinvasive disease was lower in HIV-positive women and in women practicing breast self-examination. The diagnostic pr...

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Women living with Human Immunodeficiency Virus (WLHIV) have a higher risk of developing cervical cancer due to their immune-compromised state. Cervical cancer screening leads to early detection and treatment. The aim of the study was to determine the knowledge, attitude, and practices of cervical cancer screening among women infected with HIV in Kasenengwa District, Eastern Province, Zambia. A descriptive cross-sectional study design using a semi-structured questionnaire was used to collect data from 266 WLHIV. Basic descriptive statistics were done using SPSS version 23.0. Almost two-thirds (62.7%) of the 266 WLHIV in the study had adequate knowledge about cervical cancer screening. Almost three-fifths of the respondents (57.1%) had a negative attitude toward cervical cancer screening. The majority (78.2%) had been counselled by healthcare workers on cervical cancer screening with good emotional support from family members (72.9%). About twothirds (68.4%) of the respondents had been screened for cervical cancer. Most women indicated that they didn't have access to cervical cancer screening services because they did not know where to go (61.5%) and distant screening sites (56.3%) WLHIV in the study had adequate knowledge, but unfavorable attitude towards cervical cancer screening, while two-thirds had been screened for cervical cancer. Accessibility to screening sites was poor. More education and sensitization are needed in the district to eliminate misconceptions about cervical cancer screening, which may influence uptake.

Marianne Calnan

Determinants of Cervical Cancer Screening in HIV-Positive Young Women in Swaziland by Marianne Calnan MPH, Manchester University, 2012 MMed Internal Medicine, Makerere University, 2005 MBCHB, Mbarara University of Science and Technology, 1998 Doctoral Study Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Public Health Walden University February 2019 Abstract In Swaziland, cases of cervical cancer among Human Immunodeficiency Virus (HIV)positive adolescent girls and young women (AGYW) are increasing, but there is low uptake of cervical cancer screening. This study was conducted using the systems thinking theory to explore the relationships between the uptake of cervical cancer screening among HIVpositive AGYW in Swaziland and the availability of trained health providers, cervical screening services, and the provision of referrals for cervical screening. The study also investigated any differences in uptake of cervical screening based on age group. For...

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Applications due April 25

This is a joint competition for VU and VUMC investigators. All investigators should follow these instructions .

Vanderbilt (VU and VUMC, collaboratively) may choose one nominee for the Pediatric Cancer Research Grant Program. The single nominee may apply in either the V Scholar or the Translational program type for support.

Note that internal competitions for the V Foundation awards (V Scholar, Translational) focused on adult cancers have already closed for 2024.

  • Translational projects should move a novel strategy from the laboratory into a human clinical trial or use specimens from a clinical trial to develop biomarkers or mechanisms.  The research should apply in some direct way to human beings within the time frame of less than 3 years from the end of the grant.  If biomarker research is undertaken, a validation set or independent clinical trial is essential.  A plan for biomarker validation, if applicable, must be included in any proposal. The endpoint of the project should be the planning or initiation of a new clinical trial.
  • This award is specifically for pediatric cancer research that falls into preclinical/translational research as described above. Please note that research areas not included in this scope are epidemiology, behavioral science, and health services research.
  • This award is specifically for pediatric cancer research. Please note that research areas not included in this scope are epidemiology, behavioral science, and health services research.

Eligibility

  • Exceptions may be made for non-tenure track faculty holding Assistant, Associate, or Full Professor positions. Please reach out to [email protected] if you are interested in applying but are not tenure-track.
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  • The V Scholar award is intended to support research to leverage these larger awards; so, the nominee should not have already received such awards.
  • View the 2024 V Scholar Eligibility: Are they Eligible handout for additional guidance.

Internal Application Process

Anyone interested in being considered as Vanderbilt’s nominee for either of the Pediatric Awards above must submit the following (in PDF format) to [email protected]   by 11:59 p.m. on April 25, 202 4. Late applications will not be considered.

  • Brief (2 page maximum) research plan including summary budget;
  • V Scholar award does not allow indirect costs. V Scholar letters must acknowledge that this grant does not allow indirect costs. This statement can be used/modified within the letter: “The Department recognizes that this grant does not allow indirect costs and will commit to covering any associated indirect costs per applicable institutional/school policy.” Consult [email protected] for further guidance.
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A short nomination package for Vanderbilt’s selected candidate will be submitted to the V Foundation by May 10, 2024. The candidate will then receive an invitation to submit a full application, due June 17, 2024.

Email [email protected] if you have any questions about the program, foundation or internal review process.

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Limited Submission Opportunity: 2024 V Foundation Women Scientists Innovation Award for Cancer Research

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Limited Submission Opportunity: 2024 Pediatric Cancer Research Foundation Grants

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Final Rule to Strengthen Standards for Synthetic Organic Chemical Plants and Polymers and Resins Plants

April 9, 2024, the U.S. Environmental Protection Agency (EPA) announced a set of final rules that will significantly reduce emissions of toxic air pollution from chemical plants, including the potent air toxics ethylene oxide (EtO) and chloroprene. The reductions dramatically reduce the number of people with elevated air toxics-related cancer risks in communities surrounding the plants that use those two chemicals, especially communities historically overburdened by air toxics pollution.

Regulatory Documents

  • Final Rule (prepublication version) (pdf) (5 MB)
  • Regulatory Impact Analysis for the Final Rule (pdf) (1.3 MB)

Fact Sheets, Infographic and Presentation

  • Fact Sheet: Overview of the Final Rule (pdf) (287.6 KB)
  • Fact Sheet: Key Things to Know About the Final Rule (pdf) (192.9 KB)
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  • Proposed Rule  
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Synthetic Organic Chemical Manufacturing Industry: Organic National Emission Standards for Hazardous Air Pollutants (NESHAP) - 40 CFR 63 Subparts F,G,H,I

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