RESEARCH ON AGING - WoS Journal Info

Research On Aging impact factor, indexing, ranking (2024)

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Aim and Scope

The Research On Aging is a research journal that publishes research related to Medicine; Psychology; Social Sciences . This journal is published by the SAGE Publications Inc.. The ISSN of this journal is 01640275, 15527573 . Based on the Scopus data, the SCImago Journal Rank (SJR) of research on aging is 0.965 .

Research On Aging Ranking

The latest Impact Factor list (JCR) is released in June 2024.

The Impact Factor of Research On Aging is 1.8.

The impact factor (IF) is a measure of the frequency with which the average article in a journal has been cited in a particular year. It is used to measure the importance or rank of a journal by calculating the times its articles are cited.

The impact factor was devised by Eugene Garfield, the founder of the Institute for Scientific Information (ISI) in Philadelphia. Impact factors began to be calculated yearly starting from 1975 for journals listed in the Journal Citation Reports (JCR). ISI was acquired by Thomson Scientific & Healthcare in 1992, and became known as Thomson ISI. In 2018, Thomson-Reuters spun off and sold ISI to Onex Corporation and Baring Private Equity Asia. They founded a new corporation, Clarivate , which is now the publisher of the JCR.

Important Metrics

Research on Aging
SAGE Publications Inc.
01640275, 15527573
journal
Medicine; Psychology; Social Sciences
United States
71
0.965
Health (social science) (Q1); Social Psychology (Q1); Geriatrics and Gerontology (Q2)

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The Web of Science Core Collection includes the Science Citation Index Expanded (SCIE), Social Sciences Citation Index (SSCI), Arts & Humanities Citation Index (AHCI), and Emerging Sources Citation Index (ESCI).

Research On Aging Impact Factor 2024

The latest impact factor of research on aging is 1.8 which is recently updated in June, 2024.

The impact factor (IF) is a measure of the frequency with which the average article in a journal has been cited in a particular year. It is used to measure the importance or rank of a journal by calculating the times it's articles are cited.

Note: Every year, The Clarivate releases the Journal Citation Report (JCR). The JCR provides information about academic journals including impact factor. The latest JCR was released in June, 2023. The JCR 2024 will be released in the June 2024.

The latest Quartile of research on aging is Q1 .

Each subject category of journals is divided into four quartiles: Q1, Q2, Q3, Q4. Q1 is occupied by the top 25% of journals in the list; Q2 is occupied by journals in the 25 to 50% group; Q3 is occupied by journals in the 50 to 75% group and Q4 is occupied by journals in the 75 to 100% group.

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Final summary.

  • The impact factor of research on aging is 1.8.
  • The research on aging is a reputed research journal.
  • It is published by SAGE Publications Inc. .
  • The journal is indexed in UGC CARE, Scopus, SSCI, PubMed .
  • The (SJR) SCImago Journal Rank is 0.965 .

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Aging in Russia

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Olga Strizhitskaya, Aging in Russia, The Gerontologist , Volume 56, Issue 5, October 2016, Pages 795–799, https://doi.org/10.1093/geront/gnw007

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Russia has always been at an intersection of Western and Eastern cultures, with its dozens of ethnic groups and different religions. The federal structure of the country also encompasses a variety of differences in socioeconomic status across its regions. This diversity yields complexity in aging research; aging people in Russia differ in terms of nationality, religion, political beliefs, social and economic status, access to health care, income, living conditions, etc. Thus, it is difficult to control for all these factors or to draw a picture of an “average” Russian older adult. Nevertheless, there is a great deal of research on aging in Russia, mainly focusing on biomedical and social aspects of aging. Most such research is based in the Central and Western regions, whereas the Siberian and Far East regions are underrepresented. There is also a lack of secondary databases and representative nationwide studies. Social policy and legislation address the needs of older adults by providing social services, support, and protection. The retirement system in Russia enables adults to retire at relatively young ages—55 and 60 years for women and men, respectively—but also to maintain the option of continuing their professional career or re-establishing a career after a “vocation” period. Though in recent years the government has faced a range of political issues, affecting the country’s economy in general, budget funds for support of aging people have been maintained.

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Assessing the Efficacy and Mechanisms of Pycnogenol ® on Cognitive Aging From In Vitro Animal and Human Studies

Tamara simpson, christina kure.

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Edited by: Luc Pieters, University of Antwerp, Belgium

Reviewed by: Petra Högger, Julius-Maximilians-Universität Würzburg, Germany; Zdenka Ďuračková, Comenius University, Slovakia

*Correspondence: Tamara Simpson, [email protected]

This article was submitted to Ethnopharmacology, a section of the journal Frontiers in Pharmacology

Received 2018 Dec 19; Accepted 2019 May 28; Collection date 2019.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Brain aging is a complex and multifactorial process broadly involving changes in the brain’s structure, neuronal activity, and biochemical profile. These changes in brain function have also been linked to age-associated variations in cognitive function. Recent research has suggested a role of increased oxidative stress and reduced cognition in older people. Therefore, studies that examine the effects of antioxidants on cognitive performance are important, particularly in the context of an increase in elderly populations in most Western countries. One such antioxidant, Pycnogenol, is a standardized plant-based extract obtained from the bark of the French maritime pine and has a long historical use to treat inflammation and improve health. More recently, Pycnogenol has been subjected to more than 100 research trials. In vitro and animal studies using the standardized extract have indicated a multimodal action of Pycnogenol, and several human studies have shown improvements in cognitive function after chronic administration. In this paper, we review these studies in the context of understanding both biological and cognitive changes due to Pycnogenol and evaluate possibilities of Pycnogenol to improve neurocognitive function.

Keywords: Pycnogenol®, aging, cognition, memory, RCT—randomized controlled trial

Introduction

The purpose of this paper is to present mechanistic and efficacy studies relating to the antioxidative properties of the patented French maritime pine bark extract, trading under the name Pycnogenol ® (PYC; Pinus pinaster ssp. atlantica , Pinaceae: Horphag Research Ltd., UK, Geneva, Switzerland) and how these mechanisms support cognitive function in aging. PYC is utilized as a nutritional supplement and as a bioactive remedy for several chronic diseases. Human clinical trials have demonstrated that PYC enhances domains of cognitive ability, and in vitro and in vivo animal and human studies have assessed its mechanisms of action, particularly its strong antioxidative properties as well as anti-inflammatory and vascular functions. Cost-effective interventions with therapeutic potential to sustain and maintain an individual’s cognitive ability and to alter the biochemical profile and symptom severity in different disease states have stimulated interest within the scientific community and are important targets, particularly for older populations.

What is Pycnogenol?

PYC is a plant-based extract derived from the bark of the French maritime pine. It grows along the coastal southwest of France. Pine bark extracts have been used traditionally and date back at least to Hippocrates (inflammation) around 400 bc and Hans Minner around 1479 to treat wounds ( Drehsen, 1999 ). The standardized extract is composed of phenolic compounds, divided between monomers (catechin, epicatechin, and taxifolin), condensed flavonoids (classed as procyanidins/proanthocyanidins) and phenolic acids (cinnamic acids and other glycosides) ( Petrassi et al., 2000 ; Rohdewald, 2005 ; refer to Figure 1 ). After being ingested, these phenolic compounds undergo biotransformation and are broken down in the colon by microbial enzymes yielding smaller, bioavailable molecules that can then be absorbed by the colon into the bloodstream and transported to tissues and organs ( Trebatická and Ďuračková, 2015 ). The nutritional preparation is extracted from crushed bark, followed by a patented extraction process ( Rohdewald, 2002 ). The quality and purity of the raw bark are assessed by a French independent regulatory and control body, The French Association of Norms Association Française des Normes, AFNOR (Association Française des Normes, AFNOR: Packer et al., 1999 ) and conforms to the monograph “Maritime pine extract” in the United States Pharmacopeia (USP). PYC is available in most countries as an over-the-counter product, in tablet or capsule form in doses varying from 20 to 100 mg ( Rohdewald, 2002 ), and has demonstrated good tolerability with very few side effects and a high level of safety ( Rohdewald, 2005 ). Based on a recent update by the American Botanical Council of the Scientific and Clinical Monograph for Pycnogenol ( The American Botanical Council, 2019 ), it is stated that an independent panel of toxicology experts has classified PYC as generally recognized as safe (GRAS) based on clinical safety and preclinical toxicology data. Additionally, while there are no known contraindications for PYC, it is recommended that children under 6 years of age should not use PYC, and PYC should not be taken during the first 3 months of pregnancy as a precaution. The data of 91 human clinical studies (6,849 people) have informed the safety PYC whereby the frequency of adverse events (AEs) is 2.4%; and in healthy participants, the global AE rate is 0.1%. Furthermore, the AEs reported in the clinical trials were unrelated to the duration of use or dose of PYC. The most commonly reported AE was gastrointestinal discomfort; it is therefore recommended that PYC is taken with food. Other reported AEs are dizziness, headache, and nausea.

Figure 1

Structural representation of a procyanidin molecule consisting of catechin and epicatechin subunits which are the main constituents of Pycnogenol (PYC). The catechin and epicatechin units can be linked by different bonds, the main being C4-C8 bonds and C4-C6 bonds as well as C4-C8 bonds with different chain lengths up to dodecamers.

Because of its composition of multiple constituents, PYC has several actions that give rise to its reported multiple health benefits. PYC has been widely studied and has shown to have promising effects in improving conditions including diabetes ( Spadea and Balestrazzi, 2001 ; Liu et al., 2004a ; Liu et al., 2004b ), cardiovascular health ( Fitzpatrick et al., 1998 ; Liu et al., 2000 ; Valls et al., 2016 ), asthma ( Hosseini et al., 2001 ; Lau et al., 2004 ; Shin et al., 2013 ), osteoarthritis ( Farid et al., 2007 ; Belcaro et al., 2008a ; Belcaro et al., 2008b ), sexual disorders ( Stanislavov and Nikolova, 2003 ; Aoki et al., 2012 ; Kobori, 2015 ), venous insufficiency ( Petrassi et al., 2000 ; Cesarone et al., 2010 ; Gulati, 2014 ), and neurological disorders including attention-deficit hyperactivity disorder ( Chovanová et al., 2006 ; Dvořáková et al., 2006 ; Trebatická et al., 2006 ) and cognitive impairment ( Maimoona et al., 2011 ). For the purposes of this review, we characterize the antioxidative activity of PYC, how this activity relates to aging, and how these mechanisms support cognitive function.

Cognitive Function and Oxidative Stress in the Aging Brain

Cognition is a collective term generally referring to mental processes requiring the ability to remember and recall information and use information logically as well as abstractly and tasks that require sustained attention ( Budson and Price, 2005 ). While cognitive impairment or deterioration is a hallmark of advancing age, the outcomes are more insidious where there are functional losses that impact an individual’s potential to lead an active, productive, and healthy lifestyle. Alterations in brain structure, neural activity, and biochemical profile are believed to contribute to the associated functional losses of reduced cognitive ability ( Sohal and Orr, 2012 ). Particularly, an increase in oxidative stress, elevated inflammation, and damage to the vasculature all play a role in age-associated cognitive decline ( Teunissen et al., 2003 ; Ansari and Scheff, 2010 ; Jomova et al., 2010 ; Waldstein and Elias, 2015 ). Oxidative stress is an imbalance in the production of free radicals [reactive oxygen species (ROS)] and the antioxidant system. In the elderly, age-related oxidative stress is multifactorial, marked by increased production of free radicals, reduced activities of antioxidant enzymes, diminished antioxidant levels, and weakened repair of oxidative damage ( Rybka et al., 2011 ). During aging, the presence of persistent oxidative stress and lack of antioxidant support increases the production of amyloid-β plaques in the brain, increasing the risk of developing neurodegenerative disease, mild cognitive impairment, and Alzheimer’s disease (AD) ( Smith et al., 2002 ; Mariani et al., 2005 ).

Aging impacts the brain’s capacity to scavenge free radicals such as ROS because of reduced antioxidant defenses, making oxidative stress a significant feature of general aging and age-related neurodegenerative disorders like AD ( Cadenas and Davies, 2000 ; Valko et al., 2007 ). Increased production of ROS with or without decreased antioxidant defenses leads to damage of macromolecules, impaired organ function, and disease development ( Finkel and Holbrook, 2000 ). The human brain is highly susceptible to oxidative damage. This is due to several factors, particularly because of its 1) high oxygen metabolic activity. The human brain consumes 20% of the body’s oxygen metabolism, providing energy for neuronal activity ( Raichle et al., 2001 ). This dynamic metabolic exchange must be stable for normal brain function. Dysfunctional oxygen metabolism is the hallmark of neurodegenerative disorders associated with cognitive decline ( Watts et al., 2018 ); 2) high concentration of polyunsaturated fatty acids (PUFAs). The biochemical process of excessive free radical-mediated peroxidation of PUFA causes destruction to cell membranes, structure, and function ( Syslová et al., 2014 ); 3) cytotoxic action of the excitatory amino acid glutamate. Glutamate receptors are found on the surface of cells and therefore can only exert its excitatory function through extracellular fluid ( Zhou and Danbolt, 2014 ). If glutamate receptors are excessively activated, the increased glutamate can overstimulate nerve cells, depolarizing them (known as excitotoxicity) and eventually leading to cell death ( Kritis et al., 2015 ); 4) compared with other organs of the human body, the brain has reduced antioxidant mechanisms due to lower glutathione peroxidase (GPx) and catalase (CAT) ( Packer, 1992 ). Both GPx and CAT reduce hydrogen peroxide into water and oxygen to assist in maintaining beneficial levels of ROS to prevent damage to molecular bonds, cell membranes, and DNA ( Basu, 2010 ).

Additionally, essential biometals such as copper, iron, and zinc are involved in several biological processes and are essential for the survival of living organisms. These biometals, particularly iron and copper, act by increasing the speed of chemical reactions due to their oxidizing and reducing powers (redox potential) ( Greenough et al., 2013 ). It is because of this process, where oxygen is transported and/or metabolized, that free radical formation (superoxide and hydroxyl radicals) and other ROS, formed via the Fenton reaction, increases the risk of oxidative stress in the brain ( Winterbourn, 1995 ; Jomova and Valko, 2011 ). This breakdown or dyshomeostasis of biometals whereby antioxidant protection is overwhelmed in favor of elevated concentration of metals leads to a state of neurotoxicity with damaging interaction to proteins, lipid peroxidation, and DNA, all evidence of increased oxidative stress in the AD affected brain ( Jomova et al., 2010 ; Jomova and Valko, 2011 ). Oxidative stress has been suggested to be not only an early feature of AD but also the mechanism that leads to the disease state ( Ansari and Scheff, 2010 ). The cognitive impairments experienced by those with AD severely impact the individual’s ability to function on a daily basis. They are unable to remember new information and perform complex tasks, have problems with language functions as well as visuospatial abilities, and lose the ability to make good judgments ( McKhann et al., 2011 ).

Due to these mechanisms of aging and hallmarks of neurodegenerative diseases, it may be beneficial for older individuals to consume dietary interventions with antioxidant properties to maintain cognitive function and reduce the risk of increased oxidative stress ( Simpson et al., 2015 ). In light of this, the antioxidant mechanisms of PYC are discussed below.

Antioxidative Activity of Pycnogenol

Due to its antioxidant and various biomodulating effects, PYC has potential benefits in improving cognitive function because it acts as a regulator and protects cells against oxidative stress by 1) being a potent free radical scavenger; 2) protecting DNA from damage; 3) increasing the synthesis of antioxidant enzymes; and 4) protecting other endogenous antioxidants (vitamin C, vitamin E, and glutathione) from oxidative damage ( Packer et al., 1999 ; Rohdewald, 2002 ). Demonstrating its antioxidant actions, PYC had been shown to decrease oxidative damage to DNA in children with attention deficit hyperactivity disorder ( Chovanová et al., 2006 ). In a group of patients suffering from erectile dysfunction, plasma antioxidant activity significantly increased total cholesterol, and low-density lipoprotein cholesterol decreased in response to PYC intervention ( Ďuračková et al., 2003 ). Experiments on cultured neuroblastoma cells exposed to oxidative stress toxicity (acrolein induced) have showed that pre-treatment with PYC significantly diminished the ensuing cytotoxicity, protein damage, lipid peroxidation, and cell death ( Ansari et al., 2008 ). Furthermore, in animal models of dementia, PYC and vitamin E mitigated cognitive deficits and oxidative damage in the cerebral cortex and hippocampus ( Ishrat et al., 2009 ). Clinical studies have demonstrated the antioxidant function of PYC. For example, a 6-week PYC intervention (150 mg/day) in healthy adults resulted in a significant increase in plasma oxygen radical absorbance capacity (ORAC), a biomarker of antioxidant activity ( Devaraj et al., 2002 ). Additionally, in smokers who largely have higher oxidative stress than non-smokers, PYC supplementation (50 mg/day) reduced plasma levels of reactive oxidative species (derivatives of the reactive oxygen metabolites test) and increased antioxidant potential (biological antioxidant potential test) ( Belcaro et al., 2013 ).

Researchers have also revealed additional pharmacological actions that may benefit conditions associated with cognitive impairments. One study showed that PYC not only exerts antioxidant activity but also increases plasma high-density lipoprotein and decreases serum low-density lipoprotein, indicating additional benefits on the lipid profile ( Stough et al., 2012b ). A study of erythrocyte membrane fluidity found increased membrane surface fluidity in response to PYC as well as a further outcome of protection against lipid peroxidation either from chelating metal ions or quenching free radicals, or both ( Sivonová et al., 2004 ). As it is known that lipoproteins are associated with cognitive impairments in the elderly ( Van Exel et al., 2002 ), this mechanism may also be important in improving cognition. PYC has also demonstrated a potential role in protecting genetic damage through its antimutagenic effects ( Križková et al., 2008 ). Attenuation of DNA cleavage has been seen in beta-amyloid-induced apoptosis in rodent models ( Peng et al., 2002 ). However, since research into the genetic effects of PYC is in its infancy, these findings need to be further explored to determine the clinical use of these genetic mechanisms. Findings from these studies further support the multiple roles PYC may have as a potential cognitive enhancer ( Liu et al., 2000 ).

Mechanistically, PYC targets free radicals derived from both oxygen and nitrogen. While at higher concentrations nitric oxide (NO) is detrimental and contributes to neuroinflammation and neurodegeneration, at normal physiological levels, the role of NO is integral within the brain for neurotransmission (modulates serotonin, dopamine, and norepinephrine), neuromodulation, and synaptic plasticity ( Dvořáková et al., 2006 ). The balance of NO production within the brain is therefore integral to cognitive health. Animal experiments have demonstrated that learning and memory increase NO production within the brain ( Paul and Ekambaram, 2011 ). PYC either inhibits or increases vasodilation by assisting in the regulation of endothelial cell production of NO, which increases blood flow as well as oxygenation and transport of nutrients around the body to all organs including the brain ( Fitzpatrick et al., 1998 ; Finkel and Holbrook, 2000 ). This action of relaxing blood vessels and making them more flexible not just benefits the brain but also reduces demand on the cardiovascular system and entire body due to better circulation.

The effects of PYC on stimulated macrophage cell cultures to mimic the immune response identified that the most active metabolite of PYC, M1 (δ-(3,4-dihydroxyphenyl)-γ-valerolactone), mediated anti-inflammatory effects by impeding nitric oxide generation and inducible nitric oxide synthase (iNOS) upregulation production ( Uhlenhut and Högger, 2012 ). Furthermore, M1 has been identified to accumulate in erythrocytes, monocytes, and endothelial cells with this cellular uptake and has the ability to cross the blood–brain barrier (BBB) possibly via the GLUT-1-type glucose transporter ( Uhlenhut and Högger, 2012 ; Kurlbaum et al., 2013 ). The M1 metabolite is a by-product of PYC consumption formed in the gut from catechins ( Kurlbaum et al., 2013 ). An in vitro study utilizing cultured B16 melanoma cells found that while PYC suppressed reactive species in their assays, glutathione was enhanced ( Kim et al., 2008 ). The most important intracellular antioxidant in the human body is glutathione (GSH). GSH is a unique tripeptide made from glutamate, cysteine, and glycine found predominantly in the cytosol, mitochondria, and cell nucleus ( Berk et al., 2008 ). GSH has many roles; for example, it acts as a detoxifier, and the ratio of reduced to oxidized glutathione (GSH:GSSG) forms a marker of intracellular antioxidant redox potential to regulate drug detoxification and elimination; second, GSH’s antioxidant properties protect proteins, lipids, and nucleic acids from free radicals, peroxides, and toxins ( Wu and Batist, 2013 ). Interestingly, the facilitated uptake of M1 into cells involves further metabolism by conjugation with GSH in erythrocytes ( Kurlbaum et al., 2013 ). Therefore, the antioxidative properties of PYC make it particularly novel in reducing oxidative stress in the brain than do other endogenous antioxidants, which are unable to cross the BBB ( Iuga et al., 2011 ).

Several studies discussed confirm PYC’s antioxidant and free radical scavenging effects and potential use in improving cognitive function (see Figure 2 ). Future studies are required to investigate the modulation of GSH metabolism in response to PYC administration and further elucidate the role of M1 and GSH. Interestingly, neuroimaging studies have not yet been performed as a method to investigate GSH metabolism and cognitive effects in relation to PYC administration. Given that oxidative stress is known to affect neuroplasticity, attempts to normalize such impairments are of great therapeutic value in aging and cognition research. Neuroimaging is a non-invasive modality that may assist in answering structural, functional, and mechanistic questions, complementary to the in vivo animal, histological, and hematological studies and human clinical trials that have been discussed in response to PYC intervention. We now review studies that have investigated the efficacy of PYC as a cognitive enhancer in humans.

Figure 2

Proposed mechanism of action of PYC as a targeted therapy for preventing cognitive decline. With increasing age, inflammation-reduced antioxidant metabolism leading to increased oxidative stress and damage to fatty acids are common mechanisms that over time can impact on the brain causing structural and functional changes culminating in the outcome of age-associated cognitive decline, cognitive impairment, and/or dementia. PYC potentially inhibits these mechanisms as represented by the x in the diagram due to its scavenging ability to free radicals and protection of proteins (biomolecules) against oxidative damage ( Packer et al., 1999 ; Rohdewald, 2002 ; Ansari et al., 2008 ), neuron protection from β amyloid-induced apoptonis ( Peng et al., 2002 ; Gulati, 2014 ), anti-inflammatory effects ( Lau et al., 2004 ), and reduction of fatty acids ( Sivonová et al., 2004 ).

Pycnogenol as a Cognitive Enhancer

Preliminary findings from clinical trials show promising cognitive-enhancing effects of PYC in healthy adults. Luzzi et al. (2011) found that in a group of young healthy university students, an 8-week PYC intervention (100 mg/day) when taken in conjunction with a standardized health plan resulted in improvements in sustained attention, memory, and executive functioning. Students in this study who were taking PYC also showed improvements on mood parameters (alertness, contentedness, and reduced anxiety) and performed significantly better on actual university exams than did the control group. In a similar study, Belcaro and colleagues (2014) examined the effects of a 12-week intervention comprising PYC (150 mg/day) and a healthy lifestyle plan (controlled diet and lifestyle suggestions) in young healthy professionals (aged 33 and 55 years) who had elevated oxidative stress at baseline. These authors found significant improvements in those who were taking PYC on mood (alertness and attention) and cognitive parameters (episodic memory and spatial working memory) and a 30.4% reduction in the oxidative stress marker, with no changes seen in controls. Furthermore, a 3-month daily PYC intervention (150 mg/day) resulted in improvements in working memory, but not in concentration or psychomotor abilities, in healthy, elderly individuals and concomitant decreases in plasma levels of the oxidative stress marker F2-isoprostanes ( Ryan et al., 2008 ). Findings from these studies are promising, and trials with larger sample sizes are currently being conducted to confirm these potential benefits of PYC in preventing cognitive decline ( Stough et al., 2012b ).

Conclusions

Converging evidence suggests that the biomodulating effects of PYC improve several mechanisms that may underpin cognition including vascular, anti-inflammatory, neuroprotective, and antioxidant processes. Research into PYC for improving cognitive function is growing with preliminary clinical studies indicating benefits on several cognitive domains including attention, memory, and executive functioning. Future clinical studies using PYC in larger sample sizes and over longer treatment conditions are needed to further support its use as a treatment for improving cognitive function and to further elucidate the antioxidant mechanisms supporting cognitive health and/or improvement ( Stough et al., 2012a ). Research investigating the role of M1 in relation to GSH as well as the effect of PYC on brain metabolites (e.g., Simpson et al., 2019 ) is an area of study that shows promise in elucidating the in vivo brain effects and mechanisms of PYC. Furthermore, neuroimaging techniques to investigate brain structure, function, and metabolism in response to PYC is warranted.

Author Contributions

TS, CK, and CS all contributed to the design, writing, and editing of the manuscript.

The authors thank the Australian Research Council Discovery Grant (DP1093825) to CS, with additional funding from Horphag and philanthropic grants from Doug Mitchell and Roderic O’Connor, while working on this manuscript. TS received an Australian Government Research Training Program Scholarship.

Conflict of Interest Statement

The authors conduct studies using Pycnogenol ® that are funded by Horphag. Horphag had no role in the preparation of the manuscript or decision to publish.

  • Ansari M. A., Keller J. N., Scheff S. W. (2008). Protective effect of Pycnogenol in human neuroblastoma SH-SY5Y cells following acrolein-induced cytotoxicity. Free. Radic. Biol. Med. 45 (11), 1510–1519. 10.1016/j.freeradbiomed.2008.08.025 [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]
  • Ansari M. A., Scheff S. W. (2010). Oxidative stress in the progression of Alzheimer disease in the frontal cortex. J. Neuropathol. Exp. Neurol. 69 (2), 155–167. 10.1097/NEN.0b013e3181cb5af4 [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]
  • Aoki H., Nagao J., Ueda T., Strong J. M., Schonlau F., Yu-Jing S., et al. (2012). Clinical assessment of a supplement of Pycnogenol ® and l-arginine in Japanese patients with mild to moderate erectile dysfunction. Phytother. Res. 26 (2), 204–207. 10.1002/ptr.3462 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Basu S. (2010). Fatty acid oxidation and isoprostanes: oxidative strain and oxidative stress. Prostaglandins Leukot. Essent. Fatty Acids 82 (4–6), 219–225. 10.1016/j.plefa.2010.02.031 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Belcaro G., Cesarone M. R., Errichi S., Zulli C., Errichi B. M., Vinciguerra G., et al. (2008. a). Variations in C-reactive protein, plasma free radicals and fibrinogen values in patients with osteoarthritis treated with Pycnogenol ® . Redox Rep. 13 (6), 271–276. 10.1179/135100008X309019 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Belcaro G., Cesarone M. R., Errichi S., Zulli C., Errichi B. M., Vinciguerra G., et al. (2008. b). Treatment of osteoarthritis with Pycnogenol ® . Phytother. Res. 22 (4), 518–523. 10.1002/ptr.2376 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Belcaro G., Hu S., Cesarone M. R., Dugall M. (2013). A controlled study shows daily intake of 50 mg of French pine bark extract (Pycnogenol ® ) lowers plasma reactive oxygen metabolites in healthy smokers. Minerva Med. 104 (4), 439–446. [ PubMed ] [ Google Scholar ]
  • Belcaro G., Luzzi R., Dugall M., Ippolito E., Saggino A. (2014). Pycnogenol ® improves cognitive function, attention, mental performance and specific professional skills in healthy professionals aged 35-55. J. Neurosurg. Sci. 58 (4), 239–248. [ PubMed ] [ Google Scholar ]
  • Berk M., Copolov D., Dean O., Lu K., Jeavons S., Schapkaitz I., et al. (2008). N-Acetyl cysteine as a glutathione precursor for schizophrenia—a double-blind, randomized, placebo-controlled trial. Biol. Psychiatry. 64 (5), 361–368. 10.1016/j.biopsych.2008.03.004 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Budson A. E., Price B. H. (2005). Memory dysfunction. N. Engl. J. Med. 352 (7), 692–699. 10.1056/NEJMra041071 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Cadenas E., Davies K. J. A. (2000). Mitochondrial free radical generation, oxidative stress, and aging. Free Radic. Biol. Med. 29 (3–4), 222–230. 10.1016/S0891-5849(00)00317-8 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Cesarone M. R., Belcaro G., Rohdewald P., Pellegrini L., Ledda A., Vinciguerra G., et al. (2010). Improvement of signs and symptoms of chronic venous insufficiency and microangiopathy with Pycnogenol ® : a prospective, controlled study. Phytomedicine 17 (11), 835–839. 10.1016/j.phymed.2010.04.009 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Chovanová Z., Muchová J., Sivoňová M., Dvořáková M., Žitňanová I., Waczulíková I., et al. (2006). Effect of polyphenolic extract, Pycnogenol ® , on the level of 8-oxoguanine in children suffering from attention deficit/hyperactivity disorder. Free Radic. Res. 40 (9), 1003–1010. 10.1080/10715760600824902 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Devaraj S., Vega-Lopez S., Kaul N., Schonlau F., Rohdewald P., Jialal I. (2002). Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37 (10), 931–934. 10.1007/s11745-006-0982-3 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Drehsen G. (1999). “20-From ancient pine bark uses to Pycnogenol” in Antioxidant food supplements in human health. Eds. Packer L., Hiramatsu M., Yoshikawa T. (San Diego: Academic Press; ), 311–322. [ Google Scholar ]
  • Ďuračková Z., Trebatický B., Novotný V., Žitňanová I., Breza J. (2003). Lipid metabolism and erectile function improvement by Pycnogenol ® , extract from the bark of Pinus pinaster in patients suffering from erectile dysfunction—a pilot study. Nutr. Res. 23 (9), 1189–1198. 10.1016/S0271-5317(03)00126-X [ DOI ] [ Google Scholar ]
  • Dvořáková M., Sivoňová M., Trebatická J., Škodáček I., Waczuliková I., Muchová J., et al. (2006). The effect of polyphenolic extract from pine bark, Pycnogenol ® on the level of glutathione in children suffering from attention deficit hyperactivity disorder (ADHD). Redox Rep. 11 (4), 163–172. 10.1179/135100006X116664 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Farid R., Mirfeizi Z., Mirheidari M., Rezaieyazdi Z., Mansouri H., Esmaelli H., et al. (2007). Pycnogenol supplementation reduces pain and stiffness and improves physical function in adults with knee osteoarthritis. Nutr. Res. 27 (11), 692–697. 10.1016/j.nutres.2007.09.007 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Finkel T., Holbrook N. J. (2000). Oxidants, oxidative stress and the biology of ageing. Nature 408 (6809), 239–247. 10.1038/35041687 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Fitzpatrick D. F., Bing B., Rohdewald P. (1998). Endothelium-dependent vascular effects of Pycnogenol. J. Cardiovasc. Pharmacol. Ther. 32 (4), 509–515. 10.1097/00005344-199810000-00001 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Greenough M. A., Camakaris J., Bush A. I. (2013). Metal dyshomeostasis and oxidative stress in Alzheimer’s disease. Neurochem. Int. 62 (5), 540–555. 10.1016/j.neuint.2012.08.014 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Gulati O. P. (2014). Pycnogenol ® in chronic venous insufficiency and related venous disorders. Phytother. Res. 28 (3), 348–362. 10.1002/ptr.5019 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Hosseini S., Pishnamazi S., Sadrzadeh S. M. H., Farid F., Farid R., Watson R. R. (2001). Pycnogenol ® in the management of asthma. J. Med. Food 4 (4), 201–209. 10.1089/10966200152744472 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Ishrat T., Parveen K., Hoda M. N., Khan M. B., Yousuf S., Ansari M. A., et al. (2009). Effects of Pycnogenol and vitamin E on cognitive deficits and oxidative damage induced by intracerebroventricular streptozotocin in rats. Behav Pharmacol. 20 (7), 567–575. 10.1097/FBP.0b013e32832c7125 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Iuga C., Alvarez-Idaboy J. R., Vivier-Bunge A. (2011). ROS initiated oxidation of dopamine under oxidative stress conditions in aqueous and lipidic environments. J. Phys. Chem. 115 (42), 12234–12246. 10.1021/jp206347u [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]
  • Jomova K., Valko M. (2011). Advances in metal-induced oxidative stress and human disease. Toxicology 283 (2), 65–87. 10.1016/j.tox.2011.03.001 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Jomova K., Vondrakova D., Lawson M., Valko M. (2010). Metals, oxidative stress and neurodegenerative disorders. Mol. Cell. Biochem. 345 (1-2), 91–104. 10.1007/s11010-010-0563-x [ DOI ] [ PubMed ] [ Google Scholar ]
  • Kim Y. J., Kang K. S., Yokozawa T. (2008). The anti-melanogenic effect of Pycnogenol by its anti-oxidative actions. Food Cosmet. Toxicol. 46 (7), 2466–2471. 10.1016/j.fct.2008.04.002 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Kobori Y., Suzuki K., Iwahata T., Shin T., Sadaoka Y., Sato R., et al. (2015). Improvement of seminal quality and sexual function of men with oligoasthenoteratozoospermia syndrome following supplementation with l-arginine and Pycnogenol ® . Arch. Ital. Urol. Androl. 87 (3), 190–193. 10.4081/aiua.2015.3.190 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Kritis A. A., Stamoula E. G., Paniskaki K. A., Vavilis T. D. (2015). Researching glutamate-induced cytotoxicity in different cell lines: a comparative/collective analysis/study. Front. Cell. Neurosci. 9, 91–91. 10.3389/fncel.2015.00091 [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]
  • Križková L., Chovanová Z., Ďuračková Z., Krajčovič J. (2008). Antimutagenic in vitro activity of plant polyphenols: Pycnogenol ® and Ginkgo biloba extract (EGb 761). Phytother. Res. 22 (3), 384–388. 10.1002/ptr.2331 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Kurlbaum M., Mülek M., Högger P. (2013). Facilitated uptake of a bioactive metabolite of maritime pine bark extract (Pycnogenol) into human erythrocytes. PLoS ONE 8 (4), e63197. 10.1371/journal.pone.0063197 [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]
  • Lau B. H. S., Riesen S. K., Truong K. P., Lau E. W., Rohdewald P., Barreta R. A. (2004). Pycnogenol ® as an adjunct in the management of childhood asthma. J. Asthma 41 (8), 825–832. 10.1081/JAS-200038433 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Liu F., Lau B. H., Peng Q., Shah V. (2000). Pycnogenol protects vascular endothelial cells from beta-amyloid-induced injury. Biol. Pharm. Bull. 23 (6), 735–737. 10.1248/bpb.23.735 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Liu X., Wei J., Tan F., Zhou S., Würthwein G., Rohdewald P. (2004. a). Antidiabetic effect of Pycnogenol ® French maritime pine bark extract in patients with diabetes type II. Life Sci. 75 (21), 2505–2513. 10.1016/j.lfs.2003.10.043 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Liu X., Zhou H.-J., Rohdewald P. (2004. b). French maritime pine bark extract Pycnogenol dose-dependently lowers glucose in type 2 diabetic patients. Diabetes Care 27 (3), 839. 10.2337/diacare.27.3.839 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Luzzi R., Belcaro G., Zulli C., Cesarone M. R., Cornelli U., Dugall M., et al. (2011). Pycnogenol ® supplementation improves cognitive function, attention and mental performance in students. Panminerva Med. 53 ( Suppl 1), 75–82. [ PubMed ] [ Google Scholar ]
  • Maimoona A., Naeem I., Saddiqe Z., Jameel K. (2011). A review on biological, nutraceutical and clinical aspects of French maritime pine bark extract. J. Ethnopharmacol. 133 (2), 261–277. 10.1016/j.jep.2010.10.041 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Mariani E., Polidori M. C., Cherubini A., Mecocci P. (2005). Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview. J. Chromatogr. B 827, 65–75. 10.1016/j.jchromb.2005.04.023 [ DOI ] [ PubMed ] [ Google Scholar ]
  • McKhann G. M., Knopman D. S., Chertkow H., Hyman B. T., Jack C. R., Jr., Kawas C. H., et al. (2011). The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging–Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 7 (3), 263–269. 10.1016/j.jalz.2011.03.005 [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]
  • Packer L. (1992). “Free radical scavengers and antioxidants in prophylaxy and treatment of brain diseases” in Free radicals in the brain. Eds. Packer L., Prilipko L., Christensen Y. (Berlin, Heidelberg: Springer; ), 1–20. [ Google Scholar ]
  • Packer L., Rimbach G., Virgili F. (1999). Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, Pycnogenol. Free Radic. Biol. Med. 27 (5-6), 704–724. 10.1016/S0891-5849(99)00090-8 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Paul V., Ekambaram P. (2011). Involvement of nitric oxide in learning & memory processes. Indian J. Med. Res. 133 (5), 471–478. [ PMC free article ] [ PubMed ] [ Google Scholar ]
  • Peng Q. L., Buz’Zard A. R., Lau B. H. (2002). Pycnogenol protects neurons from amyloid-beta peptide-induced apoptosis. Brain Res. Mol. Brain Res 104 (1), 55–65. 10.1016/S0169-328X(02)00263-2 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Petrassi C., Mastromarino A., Spartera C. (2000). Pycnogenol ® in chronic venous insufficiency. Phytomedicine 7 (5), 383–388. 10.1016/S0944-7113(00)80059-8 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Raichle M. E., MacLeod A. M., Snyder A. Z., Powers W. J., Gusnard D. A., Shulman G. L. (2001). A default mode of brain function. Proc. Natl. Acad. Sci. U.S.A. 98 (2), 676–682. 10.1073/pnas.98.2.676 [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]
  • Rohdewald P. (2002). A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology. Int. J. Clin. Pharmacol. Ther. 40 (4), 158–168. 10.5414/CPP40158 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Rohdewald P. (2005). “Pycnogenol ® , French maritime pine bark extract,” in Encyclopedia of dietary supplements. Eds. Coates P., Blackman M., Cragg G., Levine M., Moss J., White J. (New York: Marcel Dekker; ), 545–553. 10.1201/b13959-57 [ DOI ] [ Google Scholar ]
  • Ryan J., Croft K., Mori T., Wesnes K., Spong J., Downey L., et al. (2008). An examination of the effects of the antioxidant Pycnogenol ® on cognitive performance, serum lipid profile, endocrinological and oxidative stress biomarkers in an elderly population. J. Psychopharmacol. 22 (5), 553–562. 10.1177/0269881108091584 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Rybka J., Kupczyk D., Kędziora-Kornatowska K., Pawluk H., Czuczejko J., Szewczyk-Golec K., et al. (2011). Age-related changes in an antioxidant defense system in elderly patients with essential hypertension compared with healthy controls. Redox Rep. 16 (2), 71–77. 10.1179/174329211X13002357050897 [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]
  • Shin I.-S., Shin N.-R., Jeon C.-M., Hong J.-M., Kwon O.-K., Kim J.-C., et al. (2013). Inhibitory effects of Pycnogenol ® (French maritime pine bark extract) on airway inflammation in ovalbumin-induced allergic asthma. Food Cosmet. Toxicol. 62, 681–686. 10.1016/j.fct.2013.09.032 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Simpson T., Deleuil S., Echeverria N., Komanduri M., Macpherson H., Suo C., et al. (2019). The Australian Research Council Longevity Intervention (ARCLI) study protocol (ANZCTR12611000487910) addendum: neuroimaging and gut microbiota protocol. Nutr. J. 18 (1), 1. 10.1186/s12937-018-0428-9 [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]
  • Simpson T., Pase M., Stough C. (2015). Bacopa monnieri as an antioxidant therapy to reduce oxidative stress in the aging brain. Evid Based Complement. Alternat. Med. 2015, 615384. 10.1155/2015/615384 [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]
  • Sivonová M., Waczulíková I., Kilanczyk E., Hrnciarová M., Bryszewska M., Klajnert B., et al. (2004). The effect of Pycnogenol on the erythrocyte membrane fluidity. Gen. Physiol. Biophys. 23 (1), 39–51. [ PubMed ] [ Google Scholar ]
  • Smith M. A., Casadesus G., Joseph J. A., Perry G. (2002). Amyloid-β and τ serve antioxidant functions in the aging and Alzheimer brain. Free Radic. Biol. Med. 33 (9), 1194–1199. 10.1016/S0891-5849(02)01021-3 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Sohal R. S., Orr W. C. (2012). The redox stress hypothesis of aging. Free Radic. Biol. Med. 52, 539–555. 10.1016/j.freeradbiomed.2011.10.445 [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]
  • Spadea L., Balestrazzi E. (2001). Treatment of vascular retinopathies with Pycnogenol ® . Phytother. Res. 15 (3), 219–223. 10.1002/ptr.853 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Stanislavov R., Nikolova V. (2003). Treatment of erectile dysfunction with Pycnogenol and l-arginine. J. Sex. Marital. Ther. 29 (3), 207–213. 10.1080/00926230390155104 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Stough C., Pase M., Cropley V., Myers S., Nolidin K., King R., et al. (2012. a). A randomized controlled trial investigating the effect of Pycnogenol and Bacopa CDRI08 herbal medicines on cognitive, cardiovascular, and biochemical functioning in cognitively healthy elderly people: the Australian Research Council Longevity Intervention (ARCLI) study protocol (ANZCTR12611000487910). Nutr. J. 11 (1), 11. 10.1186/1475-2891-11-11 [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]
  • Stough C. K., Pase M. P., Cropley V., Myers S., Nolidin K., King R., et al. (2012. b). A randomized controlled trial investigating the effect of Pycnogenol and Bacopa CDRI08 herbal medicines on cognitive, cardiovascular, and biochemical functioning in cognitively healthy elderly people: the Australian Research Council Longevity Intervention (ARCLI) study protocol (ANZCTR12611000487910). Nutr J. 11, 11. 10.1186/1475-2891-11-11 [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]
  • Syslová K., Böhmová A., Mikoška M., Kuzma M., Pelclová D., Kačer P. (2014). Multimarker screening of oxidative stress in aging. Oxid. Med. Cell. Longev. 2014, 14. 10.1155/2014/562860 [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]
  • Teunissen C. E., van Boxtel M. P. J., Bosma H., Bosmans E., Delanghe J., De Bruijn C., et al. (2003). Inflammation markers in relation to cognition in a healthy aging population. J. Neuroimmunol. 134 (1–2), 142–150. 10.1016/S0165-5728(02)00398-3 [ DOI ] [ PubMed ] [ Google Scholar ]
  • The American Botanical Council (2019). Scientific and clinical monograph for Pycnogenol (French maritime pine bark extract) Pinus pinaster Aiton subsp. atlantica [Fam. Pinaceae]. 2019 Update).
  • Trebatická J., Ďuračková Z. (2015). Psychiatric disorders and polyphenols: can they be helpful in therapy? Oxid. Med. Cell. Longev. 2015, 248529. 10.1155/2015/248529 [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]
  • Trebatická J., Kopasová S., Hradecná Z., Cinovsky K., Skodácek I., Suba J., et al. (2006). Treatment of ADHD with French maritime pine bark extract, Pycnogenol. Eur. Child. Adolesc. Psychiatry 15 (6), 329–335. 10.1007/s00787-006-0538-3 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Uhlenhut K., Högger P. (2012). Facilitated cellular uptake and suppression of inducible nitric oxide synthase by a metabolite of maritime pine bark extract (Pycnogenol). Free Radic. Biol. Med. 53 (2), 305–313. 10.1016/j.freeradbiomed.2012.04.013 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Valko M., Leibfritz D., Moncol J., Cronin M. T. D., Mazur M., Telser J. (2007). Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell Biol. 39, 44–84. 10.1016/j.biocel.2006.07.001 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Valls R.-M., Llauradó E., Fernández-Castillejo S., Puiggrós F., Solà R., Arola L., et al. (2016). Effects of low molecular weight procyanidin rich extract from French maritime pine bark on cardiovascular disease risk factors in stage-1 hypertensive subjects: randomized, double-blind, crossover, placebo-controlled intervention trial. Phytomedicine 23 (12), 1451–1461. 10.1016/j.phymed.2016.08.007 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Van Exel E., de Craen A. J. M., Gussekloo J., Houx P., Bootsma-van der Wiel A., Macfarlane P. W., et al. (2002). Association between high-density lipoprotein and cognitive impairment in the oldest old. Ann. Neurol. 51 (6), 716–721. 10.1002/ana.10220 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Waldstein S. R., Elias M. F. (2015). Neuropsychology of cardiovascular disease. New York: Routledge, Taylor & Francis. 10.4324/9781315851877 [ DOI ] [ Google Scholar ]
  • Watts M. E., Pocock R., Claudianos C. (2018). Brain energy and oxygen metabolism: emerging role in normal function and disease. Front Mol. Neurosci. 11, 216–216. 10.3389/fnmol.2018.00216 [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]
  • Winterbourn C. C. (1995). Toxicity of iron and hydrogen peroxide: the Fenton reaction. Toxicol. Lett. 82-83, 969–974. 10.1016/0378-4274(95)03532-X [ DOI ] [ PubMed ] [ Google Scholar ]
  • Wu J. H., Batist G. (2013). Glutathione and glutathione analogues; therapeutic potentials. Biochim. Biophys. Acta. Gen. Subj. 1830 (5), 3350–3353. 10.1016/j.bbagen.2012.11.016 [ DOI ] [ PubMed ] [ Google Scholar ]
  • Zhou Y., Danbolt N. C. (2014). Glutamate as a neurotransmitter in the healthy brain. J. Neural. Transm. (Vienna, Austria: 1996) 121 (8), 799–817. .org/ 10.1007/s00702-014-1180-8 [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]
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Innovative UB center opens at The Brothers of Mercy Wellness Campus to find out the secret to resilient aging

research news

Nikhil Satchidanand in an exercise room.

UB faculty member Nikhil Satchidanand stands in the UB Aging and Resilience Research Cente with equipment including programmable exercise bikes and a SMARTFit system — an innovative, multisensory exergaming platform that engages the brain and body using game technology. The center also features tools for assessing the aerobic fitness of participants, as well as their level of cognition. Photo: Sandra Kicman

By ELLEN GOLDBAUM

Published October 21, 2024

Why do some people remain highly energetic and able to maintain their normal routine well into their 90s while others seem to begin an age-related decline in their 70s or earlier?

To find out, UB has established the UB Aging and Resilience Research Center.

The new health facility on The Brothers of Mercy Wellness Campus in Clarence, which opened on Oct. 16 in in the Russell J. Salvatore Health Center, is dedicated to identifying the factors that contribute to healthy, resilient aging and developing interventions so that more people can benefit from them. Funding for the UB center was provided by the Mother Cabrini Foundation to The Brothers of Mercy.

“The UB Aging and Resilience Research Center is a prime example of how the Jacobs School works directly with community partners to improve the health of Western New Yorkers,” says Allison Brashear, vice president for health sciences and dean of the Jacobs School of Medicine and Biomedical Sciences. “Healthy aging is one of the Jacobs School’s key research priorities, so we are pleased that The Brothers of Mercy is making it possible for us to bring this research and the results it generates directly to the people who will most benefit from it.” 

Novel partnership

Nikhil Satchidanand, assistant professor of medicine at the Jacobs School and the center’s founder and director, asserts that this is a novel partnership between a senior living community and an academic research center.

“The Brothers of Mercy definitely has an innovative vision in its commitment to host and support our center,” he says. “Our goal is to conduct real-world, relevant research to develop novel strategies to improve recovery capacity and reduce frailty in older adults. We believe that situating the center here, on The Brothers of Mercy campus, will allow us to gain a perspective on aging that is more holistic than what is possible in a traditional research setting. We see older adults as our partners in understanding how we can best support them as they age healthfully, on their own terms.”

Participants will be recruited from among residents at The Brothers of Mercy and from the local community. Satchidanand stressed that the center is a nonclinical setting that will not provide health-related services; the goal is to gather data about how people can age well.

“Our residents will be able to participate and benefit from having the University at Buffalo Aging and Resiliency Research Center as part of the new Russell J. Salvatore Health Center on the campus,” says Peter Eimer, CEO of The Brothers of Mercy Wellness Campus. “This research fits nicely into our mission and our rehabilitation services, and the health center includes other services for the campus and community. We are continuing to be open to other medical organizations moving into the facility.”

Rack of medicine balls.

Exercises that participants will do may involve the lifting and carrying of medicine balls, sometimes through a maze of cones. Photo: Sandra Kicman

Variable outcomes

Satchidanand is especially interested in how much outcomes among older adults can vary after an injury and surgery.

“As an exercise physiologist, I’m interested in exploring the intersection between established markers of physical fitness and resilience in aging,” he explains. “Does higher aerobic capacity or muscular strength predict a more favorable recovery from illness or injury? There’s a great deal of variability in aging. You can compare two older adults, both suffering a hip fracture: One person bounces back quite quickly after surgery and rehab, while for the other one, the injury becomes that trigger of decline, leading to loss of independence.”

The research could, for example, lead to development of prescreening tools to identify people who are more at risk for a sharp decline in health and function, and permanent loss of independence.

COMMENTS

  1. Research on Aging

    Research on Aging is an interdisciplinary journal designed to reflect the expanding role of research in the field of social gerontology. Research on Aging exists to provide for publication of research in the broad range of disciplines concerned with aging. ... The users of Scimago Journal & Country Rank have the possibility to dialogue through ...

  2. Journal Rankings on Aging

    SCImago Journal Country & Rank SCImago Institutions Rankings SCImago Media Rankings SCImago Iber SCImago Research Centers Ranking SCImago Graphica Ediciones Profesionales de la Información. Scimago Journal & Country Rank ... International Journal of Aging and Human Development: journal: 0.821 Q3: 70: 70: 161: 3101: 427: 159: 2.42: 44.30: 61.13 ...

  3. Journal Rankings on Geriatrics and Gerontology

    SCImago Journal Country & Rank SCImago Institutions Rankings SCImago Media Rankings SCImago Iber SCImago Research Centers Ranking SCImago Graphica Ediciones Profesionales de la Información. Scimago Journal & Country Rank. ... International Journal of Aging and Human Development: journal: 0.821 Q2: 70: 70: 161: 3101: 427: 159: 2.42: 44.30: 61 ...

  4. Journal of Aging and Health: Sage Journals

    Journal of Aging and Health (JAH) explores the complex and dynamic relationship between gerontology and health. Peer-reviewed and published 10 times per year, scholars present views and perspectives from a wide variety of disciplines, including Allied Health, Psychology, Public Health, Social Policy and Work, Epidemiology, Health Services Research, Sociology, and Nursing.

  5. Journal of Aging Studies

    The Journal of Aging Studies features scholarly articles offering theoretically engaged interpretations that challenge existing theory and empirical work. Articles need not deal with the field of aging as a whole, but with any defensibly relevant topic pertinent to the aging experience and related to the broad concerns and subject matter of the social and behavioral sciences and the humanities.

  6. Journal of Aging Research

    Journal of Aging Research is a peer-reviewed, open access journal that publishes original research articles, review articles and clinical studies on all aspects of gerontology and geriatric medicine. As part of Wiley's Forward Series, this journal offers a streamlined, faster publication experience with a strong emphasis on integrity.

  7. Research on Aging

    Abstract. The current study shifts the focus of research on media's role in facilitating and inhibiting self-stereotyping among the members of stigmatized groups. More specifically, this study proposes and tests a conceptual model explaining (un)intentional effects ... Open AccessResearch articleFirst published April 24, 2024pp. 480-491.

  8. Aging (journal)

    Aging is a bimonthly peer-reviewed open access bio-medical journal covering research on all aspects of gerontology. The journal was established in 2009 and is published by Impact Journals. ... According to Scopus/Scimago Journal Rank (2015), Aging is ranked number 3 on Cites/Docs (2 years) in the Aging category. [5] The journal has a 2021 ...

  9. Journal Rankings on Aging

    SCImago Journal Country & Rank SCImago Institutions Rankings SCImago Media Rankings SCImago Iber SCImago Research Centers Ranking SCImago Graphica Ediciones Profesionales de la Información. Scimago Journal & Country Rank. ... International Journal of Aging and Human Development: journal: 0.592 Q3: 70: 57: 131: 2663: 232: 127: 1.83: 46.72: 63 ...

  10. RESEARCH ON AGING

    Check with SCIMAGO » ... » RESEARCH ON AGING. Abbreviation: RES AGING ISSN: 0164-0275 eISSN: 1552-7573 Category / Quartile: GERONTOLOGY - SSCI(Q3) WoS Core Citation Indexes: SSCI - Social Sciences Citation Index. Impact Factor (IF): 2.6

  11. Research On Aging impact factor, indexing, ranking (2024)

    Aim and Scope. The Research On Aging is a research journal that publishes research related to Medicine; Psychology; Social Sciences.This journal is published by the SAGE Publications Inc.. The ISSN of this journal is 01640275, 15527573.Based on the Scopus data, the SCImago Journal Rank (SJR) of research on aging is 0.965.. Also, please check the following important details about research on ...

  12. Vera Gorbunova, PhD

    Gorbunova pioneered comparative biology approach to study aging and identified rules that control evolution of tumor suppressor mechanisms depending on the species lifespan and body mass. Her work received awards of from the Ellison Medical Foundation, the Glenn Foundation, American Federation for Aging Research, and from the National ...

  13. Olga Strizhitskaya

    The research featured the effect of experienced and daily hassles on self-actualization and psychological wellbeing in adolescents. The study involved 360 people: 126 men and 234 women aged 20 ...

  14. Development of the "Construction of aging strategies" questionnaire

    The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium conducted a meta-analysis of GWAS data for longevity, defined as survival to age 90 years or older, that identified ...

  15. Journal of Aging Research

    Scope. Journal of Aging Research is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies on all aspects of gerontology and geriatric medicine. Articles on mental and physical geriatric health will be considered, as well epidemiological studies relevant to the aging population.

  16. Aging in Russia

    Life expectancy is another challenge affecting aging research in Russia. In 2014, life expectancy was 79 years for women and 64 years for men. Although the general pattern—a huge difference in life expectancy between men and women—remains, from a longer perspective, it increased from 74 years for women and 59 years for men in 2010, just 4 ...

  17. Aging Cell

    Aging Cell facilitates discussions on Cell biology, Internal medicine, Endocrinology, Senescence and Genetics. While the journal focused on Cell biology, it was also able to explore topics like Oxidative stress and Transcription factor. The work tackled in Aging Cell goes beyond the discipline of Oxidative stress as it also encompasses Reactive ...

  18. Age and Ageing

    Age and Ageing is an international journal publishing refereed original articles and commissioned reviews on geriatric medicine and gerontology. Its range includes research on ageing and clinical, epidemiological, and psychological aspects of later life. Join the conversation about this journal. Quartiles. 1999 2001 2003 2005 2007 2009 2011 ...

  19. Assessing the Efficacy and Mechanisms of Pycnogenol® on Cognitive Aging

    Proposed mechanism of action of PYC as a targeted therapy for preventing cognitive decline. With increasing age, inflammation-reduced antioxidant metabolism leading to increased oxidative stress and damage to fatty acids are common mechanisms that over time can impact on the brain causing structural and functional changes culminating in the outcome of age-associated cognitive decline ...

  20. Aging

    The SJR is a size-independent prestige indicator that ranks journals by their 'average prestige per article'. It is based on the idea that 'all citations are not created equal'. SJR is a measure of scientific influence of journals that accounts for both the number of citations received by a journal and the importance or prestige of the journals ...

  21. What's the secret to resilient aging?

    To find out, UB has established the UB Aging and Resilience Research Center. The new health facility on The Brothers of Mercy Wellness Campus in Clarence, which opened on Oct. 16 in in the Russell J. Salvatore Health Center, is dedicated to identifying the factors that contribute to healthy, resilient aging and developing interventions so that ...

  22. SJR

    SCImago Journal Country & Rank SCImago Institutions Rankings SCImago Media Rankings SCImago Iber SCImago Research Centers Ranking SCImago Graphica Ediciones Profesionales de la Información. Scimago Journal & Country Rank. menu. Home; Journal Rankings; Country Rankings; Viz Tools; Help; About Us; 1 - 3 of 3. Aging Cell United Kingdom Wiley ...