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Little Girl Lost
A Case Study on Defective Cellular Organelles
By Tracie Y. Hudson
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This case study introduces students to the structure and function of cellular organelles and seeks to show their importance by discussing diseases and disorders that can result when an organelle does not function as it should. The storyline follows a family whose joy at bringing home a new baby is soon altered by their child's sudden illness, which is eventually diagnosed as Leigh Disease. This disease occurs when defective mitochondria fail to produce energy needed by the cell, particularly affecting cells with high-energy needs like those in the brain, muscle, and gastrointestinal tract. The narrative also discusses some of the ways in which Leigh disease is inherited, treatment options, and the typical prognosis. The case was designed for an introductory non-majors biology course, but could also be used in other science or health related courses. Instructors also have the option of running the case in a "flipped classroom" in which students watch three recommended videos outside of class as a way of preparing for working on the case in class.
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Date Posted
- Define the term organelle .
- List the key organelles found in animal cells.
- Describe the functions of animal cell organelles.
- Map other disorders and syndromes to the appropriate defective organelles.
- Describe Leigh Syndrome as well as other disorders and syndromes linked to defective cellular organelles.
- Compare and contrast cellular structure and function to that of a factory.
- Create analogies to aid in understanding and remembering the function of cellular organelles.
Organelles; cellular structure; inheritance; plant cells; animal cells; failure to thrive; Leigh Disease; mitochondria; mitochondrial disease; autosomal recessive mutation
Subject Headings
EDUCATIONAL LEVEL
High school, Undergraduate lower division, General public & informal education
TOPICAL AREAS
TYPE/METHODS
Teaching Notes & Answer Key
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Materials & Media
Supplemental materials.
- Through the Virtual Cell This video provides an overview of many cellular organelles and also discusses transcription and translation. Running time: 6:47 min. Produced by NDSU Virtual Cell Animations Project, 2009.
- Faces of Mitochondrial Disease—The Swinns Emily Swinn and her family discuss what life is like for Emily, who suffers from a mitochondrial disease. Running time: 2:58 min. Produced by the United Mitochondrial Disease Foundation. Uploaded to YouTube October 29, 2000.
- Cellular Respiration and the Mighty Mitochondria This video provides a general overview of mitochondria, ATP, and cellular respiration. Running time: 7:48 min. Produced by the Amoeba Sisters, 2014.
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Strict restrictions apply to your use of this answer key. Only registered NCCSTS password account holders are permitted to view this material, and they are only allowed (1) to view it on their local machines (as temporarily stored in a cache), and (2) to print out one hard copy for their personal use.
View Answer Key for "Little Girl Lost" - Case Study Collection - National Center for Case Study Teaching from BIOLOGY 102 at Compton College. 9/14/2020 Answer Key for "Little Girl Lost" - Case
Abstract. This case study introduces students to the structure and function of cellular organelles and seeks to show their importance by discussing diseases and disorders that can result when an organelle does not function as it should. The storyline follows a family whose joy at bringing home a new baby is soon altered by their child's sudden ...
"Little Girl Lost" by Tracie Y. Hudson Page 1 NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE Part II - The Diagnosis "Given the results of the metabolic screen, the multiple organ system involvement, and the telltale lesions in the brain, it appears that Nicole has Leigh Syndrome (LS)," reported the ER doctor.
Study with Quizlet and memorize flashcards containing terms like Failure to Thrive, First baby died at 12 mos old, Leigh Syndrome and more. ... little girl lost case. 35 terms. tlopezpacheco01. Preview. chapter 29. 21 terms. katieeex20. Preview. PKU. 17 terms. Daliah_Gonzalez. Preview.
Symptoms of ALD. Build up fatty acids in the brain and spinal cord; lethargic, weak, dizzy; loss of limb control. Affected organelle in ALD. Peroxisomes. Pompe Symptoms. Build up of excess glycogen within muscle cells; extreme muscle weakness and a "floppy" appearance; breathing difficulties, trouble feeding.
Chloroplast. site of photosynthesis in a plant (only found in plants). Vacuole. storage vesicleS (found in both plants and animals) large vacuole. fills with water to provide rigidity (only found in plants) Study with Quizlet and memorize flashcards containing terms like Nucleus, Nucleolus, Cytoplasm and more.
Little Girl Lost: A Case Study Defective Cellular Organelles. After many years of trying to get pregnant again, Kenneth and Vicki Johnson were thrilled at the birth of their baby Nicole. T eir frst child had died mysteriously at 12 months of age, and it had taken fve years for Vicki to become pregnant again.
breathing problems, serious sinus, ear, and/or lung infections; infertility. Thiamine. helps make genetic material; helps makes new genes for nicole because she is experiencing cell death. Study with Quizlet and memorize flashcards containing terms like What organelle does Leigh Syndrome affect?, What are some treatments for Leigh Syndrome ...
Answer Key for "Little Girl Lost" - Case Study Collection - National Center for Case Study Teaching . Solutions Available. Compton College. ... View Little Girl Lost Case Study.updated.docx from SCIENCE MISC at South Carolina State... Related Textbook Solutions See more. Biology: The Unity and Diversity of Life ...
Little Girl Lost A Case Study on Defective Cellular Organelles. Course. General Biology 101 (BI101) 18 Documents. Students shared 18 documents in this course. ... Chapter 8 Key terms and questions MC and short answer; Baby case study on nicole and FTT; Questions for Coffee togo; Related documents. Section A Notes - Bio;
View Little Girl Lost_ A Case Study on Defective Cellular Organelles.pdf from SCIENCE 101 at Buckhorn High School. Little Girl Lost: A Case Study on Defective Cellular Organelles Part I - Bringing ... Copy_of_LIttle_Girl_Lost_Answer_Sheet. Solutions Available. Cranston High School West. ... Draw a flow chart for the order of processes involved ...
NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE "Little Girl Lost" by Tracie Y. Hudson Page 2 Part II - The Diagnosis "Given the results of the metabolic screen, the multiple organ system involvement, and the telltale lesions in the brain, it appears that Nicole has Leigh Syndrome (LS)," reported the ER doctor.
1.2 Ultrastructure of Cells. 28 terms. SuryAm504. Preview. Exam 2 Chapter 5. 43 terms. phall1232. Preview. Study with Quizlet and memorize flashcards containing terms like What does the phrase failure to thrive mean?, Reasons some newborn babies fail to thrive, Leigh syndrome and more.
Little Girl Lost - A Case Study in Defective Organelles by Tracie Y. Hudson Department of Biology Malcolm X College, Chicago, Illinois In this activity you will be following Kenneth and Vicki Johnson, a couple who has had a negative history with the survival of their children. For each of the 5 sections, you will have some sort of text/background information given to you that will help you ...
Mitochondrial diseasesevere neurological disorderdegeneration of the nervous systemnuclear mutation of the SURF1 genefatal within a couple years. Start studying Little Girl Lost case study. Learn vocabulary, terms, and more with flashcards, games, and other study tools.
Question: Little Girl Lost" Case Study Forum66 66 unread replies. 79 79 replies.Read through the "Little Girl Lost" Case Study and complete the associated tables in the document - Little Girl Lost Case Study Download Little Girl Lost Case StudyTo begin, compose a substantive post addressing the following question - "Which disease/affected organelle from Table 2
View Copy_of_Little_Girl_Lost_Questions from APB 12019-1 at Millbrook High School. Name:_ Case Study: Little Girl Lost As you read through the story above, answer the following questions
severe neurological disorder that usually becomes apparent in the first year of life. This condition is characterized by progressive loss of mental and movement abilities (psychomotor regression) and typically results in death within two to three years, usually due to respiratory failure. Click the card to flip 👆. 1 / 35.
Little Girl Lost: A Case Study on Defective Cellular Organelles Part I - Bringing Home Baby After many years of trying to get pregnant again, Kenneth and Vicki Johnson were thrilled at the birth of their baby Nicole. Their first child had died mysteriously at 12 months of age, and it had taken five years for Vicki to become pregnant again. "Kenneth, she's so beautiful!