The Soil's Secrets: A Microbial 'Stress Vaccine' Revolutionizing Mental Health
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Hygiene hypothesis and treatments for Type I reactions
From the Hygiene Hypothesis to Bacterial Dysbiosis
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The Hygiene Hypothesis and New Perspectives—Current Challenges Meeting
Keywords: hygiene hypothesis, allergy, asthma, non-communicable inflammatory diseases, chronic inflammation. Go to: Throughout its history, the Hygiene Hypothesis has shown itself to be adaptable and flexible whenever it has been challenged by innovation in science ( 1 ). A number of new findings need to be considered in this ongoing revisiting ...
Is the Hygiene Hypothesis True?
You mentioned the hygiene hypothesis, which was postulated back in the '80s. German scientists noticed that families with fewer children tended to have more allergic disease. This was interpreted [to mean] that allergic disease was linked to experiencing fewer infections. I have explored this idea in my research for a couple of decades now.
Frontiers
The Hygiene Hypothesis and New Perspectives—Current Challenges Meeting an Old Postulate. Holger Garn 1,2* Daniel Piotr Potaczek 1 Petra Ina Pfefferle 2,3,4. 1 Translational Inflammation Research Division & Core Facility for Single Cell Multiomics, Medical Faculty, Biochemical Pharmacological Center (BPC), Philipps University of Marburg ...
The hygiene hypothesis in autoimmunity: the role of pathogens and
The initial application of the hygiene hypothesis for autoimmune diseases proposed in the early 2000s has been confirmed and consolidated by a wealth of published data in both animal models and ...
The hygiene hypothesis: current perspectives and future therapies
The "hygiene hypothesis", proposed by Strachan in 1989, aimed to explain this peculiar generational rise in immune dysregulation. However, research over the past 10 years provides evidence connecting the commensal and symbiotic microbes (intestinal microbiota) and parasitic helminths with immune development, expanding the hygiene hypothesis ...
The hygiene hypothesis, the COVID pandemic, and consequences for the
The original hygiene hypothesis, first framed by David Strachan , has evolved into new, ... Hence, examining the variable effects of COVID-19 mobility restrictions on human microbiomes is an important research question, but depends, in part, on implementation and experiences of these restrictions. Implementation of these measures has varied ...
The Ecoimmunology of Health and Disease: The Hygiene Hypothesis and
The original hygiene hypothesis proposed that certain diseases derive from low levels of early-life microbial exposure. Since then, the hypothesis has been applied to numerous inflammatory, autoimmune, and allergic conditions. The changes in hygiene linked to these diseases include numerous changes in biotic exposure and lifestyle. To this end, some scholars have called for abandonment of the ...
Cleaning up the hygiene hypothesis
They decided the name has to go (15). "Thetroubleis,assoonasyouusethewords 'hygiene hypothesis,' the word hygiene prejudges what the cause is," says Bloomfield. To the public, "hygiene" is inter- preted as personal cleanliness: washing hands, keeping food clean and fresh, sanitizing the home.
Can It Be Bad to Be Too Clean?: The Hygiene Hypothesis
Barnes: So, the hygiene hypothesis, I guess, simply stated is this notion that as human society has morphed from developing environment, or what we consider a developing world environment, into ...
The Hygiene Hypothesis
Postulated by Strachan more than 30 years ago, the Hygiene Hypothesis has undergone many revisions and adaptations. This review journeys back to the beginnings of the Hygiene Hypothesis and describes the most important landmarks in its development considering the many aspects that have refined and generalized the Hygiene Hypothesis over time.
Frontiers
Postulated by Strachan more than 30 years ago, the Hygiene Hypothesis has undergone many revisions and adaptations. This review journeys back to the beginnings of the Hygiene Hypothesis and describes the most important landmarks in its development considering the many aspects that have refined and generalized the Hygiene Hypothesis over time.
The hygiene hypothesis at a glance: Early exposures, immune mechanism
The hygiene hypothesis was proposed almost three decades ago. Nevertheless, its mechanism still remains with relevant controversies. Some studies defend that early exposures during childhood to microbes and parasites are key determinants to prevent allergies and autoimmune diseases; however, other studies demonstrated that these early exposures can even potentiate the clinical scenario of the ...
The Hygiene Hypothesis in the Age of the Microbiome
The hygiene hypothesis emerged as a tentative explanation to a massive shift in the human disease spectrum from infections to allergies ().It borrowed its name from a hypothesis originally proposed in the 1980s to explain the appendicitis epidemic of the early 20th century by an immune system not adequately trained for infections ().Against the then prevailing idea that viruses triggered ...
'Hygiene Hypothesis' Gets a Gut Check
One of the best-supported theories to explain this peculiar public health pattern has been dubbed the "hygiene hypothesis.". The theory is based on the premise that exposure to pathogens early in life is actually beneficial to the education and development of the human immune system and that the sanitary conditions in westernized countries ...
The hygiene hypothesis: Current perspectives and future therapies
The "h ygiene h ypothesis", proposed by Strachan in 1 989, aimed to explain this peculiar genera. tional rise in immune dysre gulation. Ho wev er, research o ver the past 1 0 years provides ...
The hygiene hypothesis: current perspectives and future therapies
This review aims to provide readers with the historical and current perspectives of the hygiene hypothesis and to elabo-rate on the modern scientific and medical applications of this theory. We also discuss the increasing evidence connecting the hygiene hypothesis to the development of atopic disease and immune-mediated disorders, in addition ...
'hygiene hypothesis' for autoimmune and allergic diseases: an update
Proof of principle of the hygiene hypothesis is brought by animal models and to a lesser degree by intervention trials in humans. Underlying mechanisms are multiple and complex. They include decreased consumption of homeostatic factors and immunoregulation, involving various regulatory T cell subsets and Toll-like receptor stimulation.
Hygiene Hypothesis and its Immunological Implications
Last year we celebrated the 30th anniversary of the Hygiene Hypothesis. Starting with the simple observation that frequent microbes or parasites infections in childhood are inversely associated with allergic diseases, this theory postulates that minor hygiene conditions are responsible for this phenomenon. Based on this assumption the more specific "Old Friends-Hypothesis" lines out that ...
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Keywords: hygiene hypothesis, allergy, asthma, non-communicable inflammatory diseases, chronic inflammation. Go to: Throughout its history, the Hygiene Hypothesis has shown itself to be adaptable and flexible whenever it has been challenged by innovation in science ( 1 ). A number of new findings need to be considered in this ongoing revisiting ...
You mentioned the hygiene hypothesis, which was postulated back in the '80s. German scientists noticed that families with fewer children tended to have more allergic disease. This was interpreted [to mean] that allergic disease was linked to experiencing fewer infections. I have explored this idea in my research for a couple of decades now.
The Hygiene Hypothesis and New Perspectives—Current Challenges Meeting an Old Postulate. Holger Garn 1,2* Daniel Piotr Potaczek 1 Petra Ina Pfefferle 2,3,4. 1 Translational Inflammation Research Division & Core Facility for Single Cell Multiomics, Medical Faculty, Biochemical Pharmacological Center (BPC), Philipps University of Marburg ...
The initial application of the hygiene hypothesis for autoimmune diseases proposed in the early 2000s has been confirmed and consolidated by a wealth of published data in both animal models and ...
The "hygiene hypothesis", proposed by Strachan in 1989, aimed to explain this peculiar generational rise in immune dysregulation. However, research over the past 10 years provides evidence connecting the commensal and symbiotic microbes (intestinal microbiota) and parasitic helminths with immune development, expanding the hygiene hypothesis ...
The original hygiene hypothesis, first framed by David Strachan , has evolved into new, ... Hence, examining the variable effects of COVID-19 mobility restrictions on human microbiomes is an important research question, but depends, in part, on implementation and experiences of these restrictions. Implementation of these measures has varied ...
The original hygiene hypothesis proposed that certain diseases derive from low levels of early-life microbial exposure. Since then, the hypothesis has been applied to numerous inflammatory, autoimmune, and allergic conditions. The changes in hygiene linked to these diseases include numerous changes in biotic exposure and lifestyle. To this end, some scholars have called for abandonment of the ...
They decided the name has to go (15). "Thetroubleis,assoonasyouusethewords 'hygiene hypothesis,' the word hygiene prejudges what the cause is," says Bloomfield. To the public, "hygiene" is inter- preted as personal cleanliness: washing hands, keeping food clean and fresh, sanitizing the home.
Barnes: So, the hygiene hypothesis, I guess, simply stated is this notion that as human society has morphed from developing environment, or what we consider a developing world environment, into ...
Postulated by Strachan more than 30 years ago, the Hygiene Hypothesis has undergone many revisions and adaptations. This review journeys back to the beginnings of the Hygiene Hypothesis and describes the most important landmarks in its development considering the many aspects that have refined and generalized the Hygiene Hypothesis over time.
Postulated by Strachan more than 30 years ago, the Hygiene Hypothesis has undergone many revisions and adaptations. This review journeys back to the beginnings of the Hygiene Hypothesis and describes the most important landmarks in its development considering the many aspects that have refined and generalized the Hygiene Hypothesis over time.
The hygiene hypothesis was proposed almost three decades ago. Nevertheless, its mechanism still remains with relevant controversies. Some studies defend that early exposures during childhood to microbes and parasites are key determinants to prevent allergies and autoimmune diseases; however, other studies demonstrated that these early exposures can even potentiate the clinical scenario of the ...
The hygiene hypothesis emerged as a tentative explanation to a massive shift in the human disease spectrum from infections to allergies ().It borrowed its name from a hypothesis originally proposed in the 1980s to explain the appendicitis epidemic of the early 20th century by an immune system not adequately trained for infections ().Against the then prevailing idea that viruses triggered ...
One of the best-supported theories to explain this peculiar public health pattern has been dubbed the "hygiene hypothesis.". The theory is based on the premise that exposure to pathogens early in life is actually beneficial to the education and development of the human immune system and that the sanitary conditions in westernized countries ...
The "h ygiene h ypothesis", proposed by Strachan in 1 989, aimed to explain this peculiar genera. tional rise in immune dysre gulation. Ho wev er, research o ver the past 1 0 years provides ...
This review aims to provide readers with the historical and current perspectives of the hygiene hypothesis and to elabo-rate on the modern scientific and medical applications of this theory. We also discuss the increasing evidence connecting the hygiene hypothesis to the development of atopic disease and immune-mediated disorders, in addition ...
Proof of principle of the hygiene hypothesis is brought by animal models and to a lesser degree by intervention trials in humans. Underlying mechanisms are multiple and complex. They include decreased consumption of homeostatic factors and immunoregulation, involving various regulatory T cell subsets and Toll-like receptor stimulation.
Last year we celebrated the 30th anniversary of the Hygiene Hypothesis. Starting with the simple observation that frequent microbes or parasites infections in childhood are inversely associated with allergic diseases, this theory postulates that minor hygiene conditions are responsible for this phenomenon. Based on this assumption the more specific "Old Friends-Hypothesis" lines out that ...