topics for dissertation medicine

Research Topics & Ideas: Healthcare

100+ Healthcare Research Topic Ideas To Fast-Track Your Project

Finding and choosing a strong research topic is the critical first step when it comes to crafting a high-quality dissertation, thesis or research project. If you’ve landed on this post, chances are you’re looking for a healthcare-related research topic , but aren’t sure where to start. Here, we’ll explore a variety of healthcare-related research ideas and topic thought-starters across a range of healthcare fields, including allopathic and alternative medicine, dentistry, physical therapy, optometry, pharmacology and public health.

NB – This is just the start…

The topic ideation and evaluation process has multiple steps . In this post, we’ll kickstart the process by sharing some research topic ideas within the healthcare domain. This is the starting point, but to develop a well-defined research topic, you’ll need to identify a clear and convincing research gap , along with a well-justified plan of action to fill that gap.

If you’re new to the oftentimes perplexing world of research, or if this is your first time undertaking a formal academic research project, be sure to check out our free dissertation mini-course. In it, we cover the process of writing a dissertation or thesis from start to end. Be sure to also sign up for our free webinar that explores how to find a high-quality research topic.

Overview: Healthcare Research Topics

• Allopathic medicine
• Alternative /complementary medicine
• Veterinary medicine
• Physical therapy/ rehab
• Optometry and ophthalmology
• Pharmacy and pharmacology
• Public health
• Examples of healthcare-related dissertations

Allopathic (Conventional) Medicine

• The effectiveness of telemedicine in remote elderly patient care
• The impact of stress on the immune system of cancer patients
• The effects of a plant-based diet on chronic diseases such as diabetes
• The use of AI in early cancer diagnosis and treatment
• The role of the gut microbiome in mental health conditions such as depression and anxiety
• The efficacy of mindfulness meditation in reducing chronic pain: A systematic review
• The benefits and drawbacks of electronic health records in a developing country
• The effects of environmental pollution on breast milk quality
• The use of personalized medicine in treating genetic disorders
• The impact of social determinants of health on chronic diseases in Asia
• The role of high-intensity interval training in improving cardiovascular health
• The efficacy of using probiotics for gut health in pregnant women
• The impact of poor sleep on the treatment of chronic illnesses
• The role of inflammation in the development of chronic diseases such as lupus
• The effectiveness of physiotherapy in pain control post-surgery

Topics & Ideas: Alternative Medicine

• The benefits of herbal medicine in treating young asthma patients
• The use of acupuncture in treating infertility in women over 40 years of age
• The effectiveness of homoeopathy in treating mental health disorders: A systematic review
• The role of aromatherapy in reducing stress and anxiety post-surgery
• The impact of mindfulness meditation on reducing high blood pressure
• The use of chiropractic therapy in treating back pain of pregnant women
• The efficacy of traditional Chinese medicine such as Shun-Qi-Tong-Xie (SQTX) in treating digestive disorders in China
• The impact of yoga on physical and mental health in adolescents
• The benefits of hydrotherapy in treating musculoskeletal disorders such as tendinitis
• The role of Reiki in promoting healing and relaxation post birth
• The effectiveness of naturopathy in treating skin conditions such as eczema
• The use of deep tissue massage therapy in reducing chronic pain in amputees
• The impact of tai chi on the treatment of anxiety and depression
• The benefits of reflexology in treating stress, anxiety and chronic fatigue
• The role of acupuncture in the prophylactic management of headaches and migraines

Topics & Ideas: Dentistry

• The impact of sugar consumption on the oral health of infants
• The use of digital dentistry in improving patient care: A systematic review
• The efficacy of orthodontic treatments in correcting bite problems in adults
• The role of dental hygiene in preventing gum disease in patients with dental bridges
• The impact of smoking on oral health and tobacco cessation support from UK dentists
• The benefits of dental implants in restoring missing teeth in adolescents
• The use of lasers in dental procedures such as root canals
• The efficacy of root canal treatment using high-frequency electric pulses in saving infected teeth
• The role of fluoride in promoting remineralization and slowing down demineralization
• The impact of stress-induced reflux on oral health
• The benefits of dental crowns in restoring damaged teeth in elderly patients
• The use of sedation dentistry in managing dental anxiety in children
• The efficacy of teeth whitening treatments in improving dental aesthetics in patients with braces
• The role of orthodontic appliances in improving well-being
• The impact of periodontal disease on overall health and chronic illnesses

Tops & Ideas: Veterinary Medicine

• The impact of nutrition on broiler chicken production
• The role of vaccines in disease prevention in horses
• The importance of parasite control in animal health in piggeries
• The impact of animal behaviour on welfare in the dairy industry
• The effects of environmental pollution on the health of cattle
• The role of veterinary technology such as MRI in animal care
• The importance of pain management in post-surgery health outcomes
• The impact of genetics on animal health and disease in layer chickens
• The effectiveness of alternative therapies in veterinary medicine: A systematic review
• The role of veterinary medicine in public health: A case study of the COVID-19 pandemic
• The impact of climate change on animal health and infectious diseases in animals
• The importance of animal welfare in veterinary medicine and sustainable agriculture
• The effects of the human-animal bond on canine health
• The role of veterinary medicine in conservation efforts: A case study of Rhinoceros poaching in Africa
• The impact of veterinary research of new vaccines on animal health

Topics & Ideas: Physical Therapy/Rehab

• The efficacy of aquatic therapy in improving joint mobility and strength in polio patients
• The impact of telerehabilitation on patient outcomes in Germany
• The effect of kinesiotaping on reducing knee pain and improving function in individuals with chronic pain
• A comparison of manual therapy and yoga exercise therapy in the management of low back pain
• The use of wearable technology in physical rehabilitation and the impact on patient adherence to a rehabilitation plan
• The impact of mindfulness-based interventions in physical therapy in adolescents
• The effects of resistance training on individuals with Parkinson’s disease
• The role of hydrotherapy in the management of fibromyalgia
• The impact of cognitive-behavioural therapy in physical rehabilitation for individuals with chronic pain
• The use of virtual reality in physical rehabilitation of sports injuries
• The effects of electrical stimulation on muscle function and strength in athletes
• The role of physical therapy in the management of stroke recovery: A systematic review
• The impact of pilates on mental health in individuals with depression
• The use of thermal modalities in physical therapy and its effectiveness in reducing pain and inflammation
• The effect of strength training on balance and gait in elderly patients

Topics & Ideas: Optometry & Opthalmology

• The impact of screen time on the vision and ocular health of children under the age of 5
• The effects of blue light exposure from digital devices on ocular health
• The role of dietary interventions, such as the intake of whole grains, in the management of age-related macular degeneration
• The use of telemedicine in optometry and ophthalmology in the UK
• The impact of myopia control interventions on African American children’s vision
• The use of contact lenses in the management of dry eye syndrome: different treatment options
• The effects of visual rehabilitation in individuals with traumatic brain injury
• The role of low vision rehabilitation in individuals with age-related vision loss: challenges and solutions
• The impact of environmental air pollution on ocular health
• The effectiveness of orthokeratology in myopia control compared to contact lenses
• The role of dietary supplements, such as omega-3 fatty acids, in ocular health
• The effects of ultraviolet radiation exposure from tanning beds on ocular health
• The impact of computer vision syndrome on long-term visual function
• The use of novel diagnostic tools in optometry and ophthalmology in developing countries
• The effects of virtual reality on visual perception and ocular health: an examination of dry eye syndrome and neurologic symptoms

Topics & Ideas: Pharmacy & Pharmacology

• The impact of medication adherence on patient outcomes in cystic fibrosis
• The use of personalized medicine in the management of chronic diseases such as Alzheimer’s disease
• The effects of pharmacogenomics on drug response and toxicity in cancer patients
• The role of pharmacists in the management of chronic pain in primary care
• The impact of drug-drug interactions on patient mental health outcomes
• The use of telepharmacy in healthcare: Present status and future potential
• The effects of herbal and dietary supplements on drug efficacy and toxicity
• The role of pharmacists in the management of type 1 diabetes
• The impact of medication errors on patient outcomes and satisfaction
• The use of technology in medication management in the USA
• The effects of smoking on drug metabolism and pharmacokinetics: A case study of clozapine
• Leveraging the role of pharmacists in preventing and managing opioid use disorder
• The impact of the opioid epidemic on public health in a developing country
• The use of biosimilars in the management of the skin condition psoriasis
• The effects of the Affordable Care Act on medication utilization and patient outcomes in African Americans

Topics & Ideas: Public Health

• The impact of the built environment and urbanisation on physical activity and obesity
• The effects of food insecurity on health outcomes in Zimbabwe
• The role of community-based participatory research in addressing health disparities
• The impact of social determinants of health, such as racism, on population health
• The effects of heat waves on public health
• The role of telehealth in addressing healthcare access and equity in South America
• The impact of gun violence on public health in South Africa
• The effects of chlorofluorocarbons air pollution on respiratory health
• The role of public health interventions in reducing health disparities in the USA
• The impact of the United States Affordable Care Act on access to healthcare and health outcomes
• The effects of water insecurity on health outcomes in the Middle East
• The role of community health workers in addressing healthcare access and equity in low-income countries
• The impact of mass incarceration on public health and behavioural health of a community
• The effects of floods on public health and healthcare systems
• The role of social media in public health communication and behaviour change in adolescents

Examples: Healthcare Dissertation & Theses

While the ideas we’ve presented above are a decent starting point for finding a healthcare-related research topic, they are fairly generic and non-specific. So, it helps to look at actual dissertations and theses to see how this all comes together.

Below, we’ve included a selection of research projects from various healthcare-related degree programs to help refine your thinking. These are actual dissertations and theses, written as part of Master’s and PhD-level programs, so they can provide some useful insight as to what a research topic looks like in practice.

• Improving Follow-Up Care for Homeless Populations in North County San Diego (Sanchez, 2021)
• On the Incentives of Medicare’s Hospital Reimbursement and an Examination of Exchangeability (Elzinga, 2016)
• Managing the healthcare crisis: the career narratives of nurses (Krueger, 2021)
• Methods for preventing central line-associated bloodstream infection in pediatric haematology-oncology patients: A systematic literature review (Balkan, 2020)
• Farms in Healthcare: Enhancing Knowledge, Sharing, and Collaboration (Garramone, 2019)
• When machine learning meets healthcare: towards knowledge incorporation in multimodal healthcare analytics (Yuan, 2020)
• Integrated behavioural healthcare: The future of rural mental health (Fox, 2019)
• Healthcare service use patterns among autistic adults: A systematic review with narrative synthesis (Gilmore, 2021)
• Mindfulness-Based Interventions: Combatting Burnout and Compassionate Fatigue among Mental Health Caregivers (Lundquist, 2022)
• Transgender and gender-diverse people’s perceptions of gender-inclusive healthcare access and associated hope for the future (Wille, 2021)
• Efficient Neural Network Synthesis and Its Application in Smart Healthcare (Hassantabar, 2022)
• The Experience of Female Veterans and Health-Seeking Behaviors (Switzer, 2022)
• Machine learning applications towards risk prediction and cost forecasting in healthcare (Singh, 2022)
• Does Variation in the Nursing Home Inspection Process Explain Disparity in Regulatory Outcomes? (Fox, 2020)

Looking at these titles, you can probably pick up that the research topics here are quite specific and narrowly-focused , compared to the generic ones presented earlier. This is an important thing to keep in mind as you develop your own research topic. That is to say, to create a top-notch research topic, you must be precise and target a specific context with specific variables of interest . In other words, you need to identify a clear, well-justified research gap.

Need more help?

If you’re still feeling a bit unsure about how to find a research topic for your healthcare dissertation or thesis, check out Topic Kickstarter service below.

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15 Comments

I need topics that will match the Msc program am running in healthcare research please

Hello Mabel,

I can help you with a good topic, kindly provide your email let’s have a good discussion on this.

Can you provide some research topics and ideas on Immunology?

Thank you to create new knowledge on research problem verse research topic

Help on problem statement on teen pregnancy

This post might be useful: https://gradcoach.com/research-problem-statement/

can you provide me with a research topic on healthcare related topics to a qqi level 5 student

Please can someone help me with research topics in public health ?

Hello I have requirement of Health related latest research issue/topics for my social media speeches. If possible pls share health issues , diagnosis, treatment.

I would like a topic thought around first-line support for Gender-Based Violence for survivors or one related to prevention of Gender-Based Violence

Please can I be helped with a master’s research topic in either chemical pathology or hematology or immunology? thanks

Can u please provide me with a research topic on occupational health and safety at the health sector

Good day kindly help provide me with Ph.D. Public health topics on Reproductive and Maternal Health, interventional studies on Health Education

may you assist me with a good easy healthcare administration study topic

May you assist me in finding a research topic on nutrition,physical activity and obesity. On the impact on children

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Explore the Best Medical and Health Research Topics Ideas

Table of contents

• 1 How to Choose Medical Research Paper Topics
• 2 New Medical Research Paper Topics
• 3 Medical Research Topics for College Students
• 4 Controversial Medical Topics for Research Paper
• 5 Health Research Topics
• 6 Medicine Research Topics
• 7 Healthcare Research Topics
• 8 Public Health Research Topics
• 9 Mental Health Research Paper Topics
• 10 Anatomy Research Topics
• 11 Biomedical Research Topics
• 12 Bioethics Research Topics
• 13 Cancer Research Topics
• 14 Clinical Research Topics
• 15 Critical Care Research Topics
• 16 Pediatric Research Topics
• 17 Dental Research Topics Ideas
• 18 Dermatology Research Topics
• 19 Primary Care Research Topics
• 20 Pharmaceutical Research Topics
• 21 Medical Anthropology Research Topics
• 22 Paramedic Research Paper Topics
• 23 Surgery Research Topics
• 24 Radiology Research Paper Topics
• 25 Anatomy and Physiology Research Paper Topics
• 26 Healthcare Management Research Paper Topics
• 27 Medical Ethics Research Paper Topics
• 28 Environmental Health and Pollution Research Paper Topics
• 29 Conclusion

In such a complex and broad field as medicine, writing an original and compelling research paper is a daunting task. From investigating public care concerns to cancer treatment studies, each student decides where his interests lie. Our goal is to help students find new angles to study and focus on relevant topics. With our resources, you can write an engaging and rigorous paper.

How to Choose Medical Research Paper Topics

Choosing good research paper topics is often more challenging than the writing process itself. You need to select a captivating subject matter that will grab the reader’s attention, showcase your knowledge of a specific field, help you progress in your studies, and perhaps even inspire future research.

To accomplish that, you need to start with brainstorming, followed by thorough research. Here are some great tips to follow:

• Pick an interesting topic – The key is to pick something that you find interesting, and yet make sure it’s not too general or too narrow. It should allow you to delve deep into the subject matter and show that you’re a professional who is ready to take on a challenge when it comes to your chosen field of medicine.
• Narrow down your focus – Once you have a list of potential topics, sift through recent medical research papers to get up-to-date with the latest trends, developments, and issues in medicine and healthcare. Check out textbooks, news articles, and other relevant sources for more information related to your potential topics. If a particular condition or disease interests you (perhaps something that drew you to a career in medicine), there’s your cue for narrowing down your topic.
• Pinpoint the “why,” “how,” and “what” – Whether you are looking into nutrition research paper topics , controversial medical topics, nursing research topics, or anything in-between, ask yourself why each of them is important. How could they contribute to the available medical studies, if any? What new information could they bring to improve the future of medicine? Asking these questions will help you pick the right medical research paper topic that suits you and helps you move forward and reach your aspirations.

To help you on that quest, we’ve compiled a list of topics that you could use or that might inspire you to come up with something unique. Let’s dive in.

New Medical Research Paper Topics

Are you interested in the newest and most interesting developments in medicine? We put hours of effort into identifying the current trends in health research so we could provide you with these examples of topics. Whether you hire a research paper writing service for students or write a paper by yourself, you need an appealing topic to focus on.

• Epidemics versus pandemics
• Child health care
• Medical humanitarian missions in the developing world
• Effectiveness of mobile health clinics in rural Africa
• Homeopathic medicines – the placebo effect
• Comparative study of the efficacy of homeopathic treatments and conventional medicine in managing chronic pain
• Virus infections – causes and treatment
• Trends in COVID-19 vaccine uptake
• Advancements in the treatment of influenza
• Is medical research on animals ethical
• Vaccination – dangers versus benefits
• Artificial tissues and organs
• Rare genetic diseases
• Brain injuries
• Long-Term Effects of COVID-19
• Social behavior shifts due to COVID-19

Medical Research Topics for College Students

You don’t know where to start with your medical research paper? There are so many things you could write about that the greatest challenge is to narrow them down. This is why we decided to help.

• Antibiotics treatments
• Efficacy of mRNA vaccines against viral diseases
• Viability and function of 3D printed tissues
• Chronic diseases
• Palliative treatment
• Battling Alzheimer’s disease
• How modern lifestyle affects public health
• Professional diseases
• Sleep disorders
• Changes in physical and mental health due to aging
• Eating disorders
• Terminal diseases

Controversial Medical Topics for Research Paper

In healthcare, new discoveries can change people’s lives in the blink of an eye. This is also the reason why there are so many controversial topics in medicine, which involve anything from religion to ethics or social responsibility. Read on to discover our top controversial research topics.

• Ethical debates on artificial tissue engineering
• Public opinions on vaccination safety
• Implementing food standards
• Telehealth’s Role in Chronic Illness Management
• Gluten allergy
• Assisted suicide for terminal patients
• Testing vaccines on animals – ethical concerns
• Moral responsibilities regarding cloning
• Marijuana legalization for medical purposes
• Abortion – medical approaches
• Vegan diets – benefits and dangers
• Increased life expectancy: a burden on the healthcare system?
• Circumcision effects

Health Research Topics

Students conducting health research struggle with finding good ideas related to their medical interests. If you want to write interesting college papers, you can select a good topic for our list.

• Impact of location, ethnicity, or age on vaccination rates
• Uses of biomaterials in vaccination technology
• Deafness: communication disorders
• Household air pollution
• Diabetes – a public danger
• Coronaviruses
• Oral health assessment
• Tobacco and alcohol control
• Diseases caused by lack of physical exercise
• How urban pollution affects respiratory diseases
• Healthy diets

Medicine Research Topics

Regardless of the requirements in your research assignment, you can write about something that is both engaging and useful in your future career. Choose a topic from below.

• Causes for the increasing cancer cases
• Insulin resistance
• How terrorism affects mental health
• AIDS/HIV – latest developments
• Treating pregnant women versus non-pregnant women
• Latest innovations in medical instruments
• Genetic engineering
• Successful treatment of mental diseases
• Is autism a disease
• Natural coma versus artificial coma
• Treatments for sleep disorders and their effectiveness
• Role of melatonin supplements in sleep quality

Healthcare Research Topics

Healthcare research includes political and social aspects, besides medical. For college students who want to explore how medicine is affected by society’s values or principles, we provide examples of topics for papers. Select yours from the list below.

• Government investment in healthcare services in the EU versus the USA
• Inequalities in healthcare assistance and services
• Electronic health records systems – pros and cons
• Can asylums treat mental issues
• Health care for prison inmates
• Equipment for improving the treatment of AIDS
• Correlation between economic development and health care services across countries
• Impact of smoking on organs
• Heart attacks – causes and effects
• Breast cancer – recent developments
• Materials used in artificial tissue and their impacts

Public Health Research Topics

For current examples of public health topics, browse our list. We provide only original, researchable examples for which you can easily find supporting data and evidence.

• Public versus private hospitals
• Health Disparities in Diabetes Management Across Different Socioeconomic Groups
• Health care professionals – management principles
• Surgery failures – who is responsible
• What legal responsibilities has the hospital administration
• Patient service quality in public versus private hospitals
• What benefits do national health care systems have
• Estimated costs of cancer treatments
• Public health in developing countries
• Banning tobacco ads – importance for public health
• Government solutions to the anti-vaccine’s movement
• How the COVID-19 pandemic has changed public health regulations

Mental Health Research Paper Topics

Mental health is one of the most complex areas of medicine, where things are never as clear as with other medical issues. This increases the research potential of the field with plenty of topics left for debate.

• Mental Health Impact of Social Media on American Teenagers
• Causes of anxiety disorders
• Bulimia versus anorexia
• Childhood trauma
• Mental health public policies
• Impact of Lifestyle Factors on the Progression of Dementia in the Elderly Population
• Postpartum Depression
• Posttraumatic Stress Disorder
• Seasonal Affective Disorder
• Schizophrenia
• Stress and its effects on sleep quality
• Insomnia and its relation to mental health disorders

Anatomy Research Topics

Anatomy covers everything about the human body and how it works. If you find that intriguing and want to pay for medical research paper, start by selecting a topic.

• Causes and treatments of virus infections
• Chemotherapy: how it affects the body
• Thyroid glands – functions in the body
• Human endocrine system
• Preventative Measures and Treatments for Common Liver Diseases
• Heart diseases
• How does the human muscular system develop
• Lymphatic system – importance
• Investigating genetic diseases
• Digestive system
• Role of the Spleen in the Human Immune System and Related Disorders

Biomedical Research Topics

Biology and medicine often work together. For the newest changes in the biomedical field, check our topics.

• Comparative Efficacy of Alternative Medicine Practices in Chronic Pain Management
• Alzheimer’s disease – paths for treatment
• Vaccines and drug development in the treatment of Ebola
• Antibiotic resistance
• Biological effects caused by aging
• Air pollution effects on health
• Infectious disease past versus present
• Regenerative medicine
• Biomedical diagnostics
• Biomedical technology
• Advanced biomaterials for vaccine delivery

Bioethics Research Topics

A controversial area of medicine, bioethics is where you get the chance to add personal input to a research topic and come up with new insights. You could consider these subjects.

• Organ donation
• Alternative or complementary medicine
• Assisted suicide or the right to die
• Artificial insemination or surrogacy
• Chemical and biological warfare
• Contraception
• Environmental bioethics
• In Vitro Fertilization
• Ethical considerations in medical research on animals

Cancer Research Topics

Are you writing a paper related to cancer causes, diagnosis, treatment or effects? Look below for a hot topic that it’s easy to research and important for medical advance.

• The ability of immune system cells to fight cancer
• Computational oncology
• Metastasis affected by drug resistance
• Stem cells – applications for cancer treatment
• Tumor microenvironment
• Obesity and age in cancer occurrence
• Early cancer detection – benefits
• Artificial intelligence predicting cancer
• Hematologic malignancies
• Pathogen-related cancers
• Impact of COVID-19 on cancer treatment studies

Clinical Research Topics

Learn more about clinical medicine by conducting more in-depth research. We prepared for you a list of relevant issues to touch upon.

• Ethical concerns regarding research on human subjects
• Subject recruitment
• Budget preparation
• Human subject protection
• Clinical trials – financial support
• Clinical practices for health professionals
• Using vulnerable populations in clinical research
• Quality assurance in clinical research
• Academic clinical trials versus clinical trials units
• Data collection and management
• Evolution of clinical symptoms in COVID-19 patients

Critical Care Research Topics

Critical care is a key area in medical studies. Explore these topics in your research paper to gain more valuable knowledge in this field. You can also get in contact with nursing research paper writers .

• Obesity and asthma – clinical manifestations
• Chronic obstructive pulmonary disease
• Rhythm analysis for cardiac arrest
• Traumatic brain injury – fluid resuscitation
• Hydrocortisone for multiple trauma patients
• Care and nutrition for critically ill adults
• Diagnosis of hypersensitivity pneumonitis
• Coma and sedation scales
• Artificial airways suctioning
• Arterial puncture and arterial line
• Long-term cardiac and respiratory effects of COVID-19

Pediatric Research Topics

Any topic that refers to health care for children, pregnant women, mothers, and adolescents goes under pediatric care.

• Early Intervention Methods for Children Diagnosed with Autism Spectrum Disorder
• Preventive healthcare strategies for children
• Impact of early childhood nutrition on long-term health
• Attention deficit hyperactivity disorder (ADHD)
• Congenital heart disease in newborns
• Adolescent medicine
• Neonatal medicine
• Rare diseases in children and teenagers
• Obesity and weight fluctuations
• Behavioral sleep problems in children
• Children with anemia
• Child healthcare enhancements and innovations

Dental Research Topics Ideas

Choose a topic on oral health or dental care from this list of the most interesting topics in the field.

• How smoking affects oral health
• Children’s risk for dental caries
• Causes of Dental Anxiety and Effective Interventions for Reducing Fear in Patients
• Types of dental materials – new advances
• Bad breath bacteria
• How diabetes affects oral health
• Oral cancer
• Dental pain – types, causes
• Dental implants
• Oral health-related quality of life
• Advancements in treatments for virus infections

Dermatology Research Topics

Find the best research topic for your dermatology paper among our examples.

• Atopic dermatitis
• Contact dermatitis
• Epidemiology behind uncommon skin disorders
• Cutaneous aging
• Risk factors of melanoma skin cancer
• Acne versus rosacea
• Genetic testing for skin conditions
• Effects of cosmetic agents on skin health
• Improving skin barrier with pharmaceutical agents
• Skin manifestations of autoimmune disorders
• Study of virus effects on skin health

Primary Care Research Topics

Write a primary care paper that can demonstrate your research skills and interest in powerful scientific findings.

• Primary care for vulnerable/uninsured populations
• Interpersonal continuity in care treatment
• How primary care contributes to health systems
• Primary care delivery models
• Developments in family medicine
• Occupational/environmental health
• Pharmacotherapy approaches
• Formal allergy testing
• Oral contraception side effects
• Dietary or behavioral interventions for obesity management

Pharmaceutical Research Topics

Pharma students who need paper topics can use one from our list. We include all things related to pharmacy life.

• Drugs that can treat cancer
• Drug excretion
• Elimination rate constant
• Inflammatory stress drug treatment
• Aspirin poising
• Ibuprofen – dangers versus benefits
• Toxicodynamics
• Opioid use disorder
• Pharmacotherapy for schizophrenia
• Ketamine in depression treatment

Medical Anthropology Research Topics

Medical anthropology unites different areas of human knowledge. Find powerful ideas for a paper below.

• Cultural contexts regarding reproductive health
• Women sexuality
• Anthropological aspects of health care
• Contributions of social sciences to public health
• Euthanasia and medical ethics across cultures
• Health-related behavior in adults across cultures
• Transcultural nursing
• Forensic psychiatry
• Symptoms of Celiac Disease – a disease with no symptoms
• Nursing ethics

Paramedic Research Paper Topics

Topics for paramedic research must be based on evidence, data, statistics, or practical experience. Just like ours.

• Trends and statistics in EMS
• Disaster medicine
• Mass casualties
• Pandemics and epidemics
• Infection control
• Basic versus advanced life support
• Scene safety in EMS
• Shock management
• Motor vehicle accidents
• Challenges in medical humanitarian missions during pandemics

Surgery Research Topics

Discover all the intricacies of surgeries that save lives by writing about our topics.

• Medical malpractice and legal issues
• Methicillin-resistant Staphylococcus aureus
• Early Detection and Management Strategies for Sepsis in Hospital Settings
• Pain management
• Perioperative nursing
• Wound management
• Colorectal cancer surgery
• Breast cancer surgery
• Minimally invasive surgeries
• Vascular disease
• Changes in surgical practices during pandemics

Radiology Research Paper Topics

Find a radiology topic related to your academic interests to write a successful paper.

• Using MRI to diagnose hepatic focal lesions
• Multidetector computer tomography
• Ultrasound elastography in breast cancer
• Assessing traumatic spinal cord injuries with MRI diffusion tensor imaging
• Sonographic imaging to detect male infertility
• Role of tomography in diagnosing cancer
• Brain tumor surgery with magnetic resonance imaging
• Bacterial meningitis imaging
• Advanced imaging techniques for virus infection detection

Anatomy and Physiology Research Paper Topics

Any ideas for a medical research paper? We have included the most important topics for an anatomy and physiology paper.

• What role has the endocrine system
• Staphylococcus aureus
• Environmental factors that affect development of human muscular system
• What role has the lymphatic system
• An investigation of genetic diseases
• Explaining the aging process
• The digestive tract
• Effects of stress on cells and muscles
• Evolution of the human nervous system
• What role has the cardiovascular system
• Impact of viruses on respiratory health in urban settings

Healthcare Management Research Paper Topics

There are numerous topics you could write about when it comes to healthcare management. There’s a wide range of options to pick, from infrastructure, staff, and financial management to HR and patient management. Here are some of the top healthcare management research paper options.

Medical Ethics Research Paper Topics

Medical ethics is a field that opens the door to numerous compelling topics for research papers. Here are some of the most appealing ones you could tackle.

• Clinical research on humans
• Vaccines and immunization
• Religious beliefs in healthcare
• Euthanasia and physician-assisted suicide
• Ethical issues across cultures
• Amniocentesis or prenatal birth defect testing
• Medical malpractice and going back to work
• Racial and ethnic preferences and perceptions in organ donations
• Racial and ethnic disparities in healthcare
• Ethical concerns of AI in healthcare
• Debates on animal ethics in medical research
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Environmental Health and Pollution Research Paper Topics

• Environmental Pollutants and Respiratory Health in Urban Areas of the USA
• How environmental changes affect human health
• Long-Term Impact of PM2.5 Exposure on Lung, Heart, and Brain Function
• Health Risks of Air Pollution Across Different Life Stages
• Hospital Admissions and Air Quality in the USA
• Risk Reduction Strategies for Indoor Air Pollution from Gas Stoves
• Impact of Air Pollution on Cognitive Development and Socioeconomic Achievements
• Long-Term Health Effects of Early Childhood Exposure to Air Pollution
• Impact of Traffic Noise on Cardiovascular Health

If you need further assistance with your medical research paper, PapersOwl is here for you. Our expert writers can provide you with top-notch research and help you write an impressive paper. Contact us anytime, pick your writer, tell them more about your topic, and get a unique, plagiarism-free research paper with impeccable grammar and formatting.

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100+ Medical Research Paper Topics for Students

The medical field is vast and rich, so choosing a medical topic for a research paper is easy. However, the abundance of medical topics to research can also make choosing the “best” one a daunting task. Medical research topics are about drugs and their interactions and those expounding on the root causes of diseases. There are a variety of topics in medicine to discuss, spanning the different angles of the field, including medical social issues research topics .

Tips for Choosing the Best Research Topics in Medicine

Best topics for medical research paper, great research health topics on genetics for an a+ paper, interesting healthcare research topics, research topics in healthcare: pediatric medicine, anatomical research topics for healthcare to write on, amazing health care topics to write about, top medical research paper topics today, medical research papers topics on public health, audience attention-grabbing medical topics for research paper, interesting medical topics to research on, interesting medical topics for presentation, healthcare research topics for college students.

If you find it difficult to choose a medical research topic for your paper, that is to be expected. This article will give you 100+ medical research topics to work on, spanning different aspects of medicine. However, before that, we will show you how to select the best-med research topics. Whether you’re looking for argumentative essay topics or anatomy research paper topics , there is no dearth of medical research topics.

Choosing a research topic, even if it’s an interesting thesis statement about social media , is often more challenging than the actual writing. To be able to do justice to these medical research topics, you need to choose topics that inspire you. Below are our A+ tips for choosing the best medical topics to write about:

• Choose medicine research topics you are interested in; whether you’re working on economics research paper topics or biochemistry topics , personal interest is vital.
• Choose a few med research topics first; then, sift through scholarly articles to get updated with the latest medical developments and issues.
• Understand the why, how, and what of your research; how will it contribute to the existing knowledge body?
• Choose healthcare research topics that are neither general nor too narrow; there should be sufficient research scope.
• Choose a significant medical research topic for you and your chosen career path.

You’re close to a breakthrough now that you know what factors to consider when choosing health topics to research. There are many places to get inspiration, including research topics on medicine. Below, we have compiled some of the best research topics in health.

• The genetics of epilepsy
• Clinical genetic research malpractice
• The concept of reverse genetics in creating vaccines
• GNE myopathy: therapies
• Brain imaging
• Genes behind juvenile idiopathic arthritis
• How screenings help gynecologic cancer prevention
• Drug addiction: the genetics
• Parkinson’s and Alzheimer’s disease: exploring the genetic similarities
• Genetic factors in HIV
• Telehealth: meaning and benefits
• Eating disorders
• Staying healthy while studying
• Health fraud
• Occupation diseases: how are they classified?
• Effective measures to help reduce sports injuries
• Safe use of medical devices
• Is mental disorder curable?
• Causative diseases of B vitamins deficiency
• Regular exercise and heart health
• Non-therapeutic ADHD medication use in children
• Type 1 diabetes in children: effective management
• Movement disorders in children
• Secondhand smoking: its effect on children
• Sudden infant death syndrome (SIDS)
• Children exposed to meningitis
• Autism in children
• How exposure to air pollution affects prenatal
• Diagnosis and management of childhood asthma
• Prevention strategies for obesity in children
• Human microbial ecology: the latest discoveries
• How to attenuate arthritic bone tissue destruction
• Brain changes in stroke survivors
• Cancer effect on bone marrow
• Effective diagnostic methods of endometriosis
• Photoperiodic changes and their effect on brainstem volume
• The crystal structure of human enamel
• Measuring musculoskeletal and neuromuscular function
• Extensor hallucis longus in hallux pathology
• Obesity and knee osteoarthritis
• Pandemic vs. epidemic
• The placebo effect of homeopathic medicine
• Causes and treatment for virus infection
• Brain injuries
• Chronic diseases
• Alzheimer’s
• Effects of circumcision
• Medical approaches to abortion
• Legalization of marijuana for medicine
• Effect of environmental changes on human health
• Urban pollution and respiratory diseases: exploring the relationship
• Communication disorders
• Why are cancer cases increasing?
• Latest developments in HIV/AIDs
• Medical tools and instruments: latest innovations
• Effect of terrorism on mental health
• Insulin resistance
• Genetic engineering
• Adverse effects of smoking on vital organs
• Developments in breast cancer research
• Management principle of healthcare professionals
• Private hospitals vs. public hospitals
• Who should be held responsible for surgery failures?
• The anti-vaccine movement
• Cancer treatments: estimated costs
• Hospital administration and their legal responsibilities
• The upside to national healthcare systems
• Anxiety disorders: causes and treatment
• Public policies on mental health
• Treatment of childhood trauma in public healthcare systems
• Schizophrenia
• Anorexia vs. Bulimia
• Postpartum depression
• The mental health of rape victims
• Side effects of chemotherapy
• Child vaccination programs: benefits and limitations
• Medical internships: the benefits
• Use of AI in medicine
• Doctors’ roles vs. nurses’ roles
• Poor sanitation: management in developing countries
• Sleep paralysis
• Vaccination: benefits and side effects
• Eating disorders: causes and remedies
• Sexual organ transplantation
• Challenges in biomedical research
• The importance of the lymphatic system
• Functions of thyroid glands on the body
• The digestive system
• The developmental stages of the human muscular system
• Antibiotic resistance
• Effects of air pollution on health
• Aging: biological effects
• Contraception
• Surrogacy vs. artificial insemination
• Causative diseases for hair loss
• Effect or non-effect of alcohol on the bone marrow
• Tongue disorders
• Understanding when chest pain becomes severe
• The relationship between diabetes and eye problems
• Alternative medicine and complementary medicine: is one better than the other?
• The reversal potentials of diabetic nerve damage
• Thrombocytopenia: do they cause bleeding disorders?
• Does one’s ethnic group influence one’s susceptibility to metabolic syndrome?
• Mandating flu vaccination for health workers

There are thousands of ideas and angles to explore in the medical field. With the 100+ interesting medical topics for the research papers that we have provided, you have options to work with. The tips for choosing a topic can also help you sift through research topics for STEM students , among others, to choose the best.

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Selecting a thesis topic: A postgraduate’s dilemma

Rajiv k. saini.

Department of Psychiatry, Command Hospital (EC) Kolkata, West Bengal, India

Mohan Issac

1 Department of Psychiatry, The University of Western Australia, Perth, Australia

K. J. D. Kumar

2 Department of Psychiatry, Military Hospital, Pathankot, Punjab, India

Suprakash Chaudhury

3 Department of Psychiatry, D. Y. Patil Medical College, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune, Maharashtra, India

Rachit Sharma

4 Department of Psychiatry, Armed Forces Medical College, Pune, Maharashtra, India

Ankit Dangi

5 Department of Psychiatry, Command Hospital, Panchkula, Haryana, India

It is said that well begun is half done. Choosing a thesis topic and submitting a research protocol is an essential step in the life cycle of a postgraduate resident. National Medical Commission of India mandates that all postgraduate trainees must submit at least one original research work (dissertation), one oral paper, one poster, and one publication to be eligible for final year examination. It is the duty of the faculty to ensure that trainees take active interest and submit their theses on time. However, their journey is often marred by multiple challenges and hurdles. The literature was searched from year 2000 onwards till 2011 using Pubmed, ResearchGate, MEDLINE, and the Education Resources Information Centre databases with terms related to residency training, selecting thesis topic, challenges or hurdles, and conversion of thesis into journal article. Existing literature on the subject matter is sparse. Current article advocates promotion of ethical and original research during postgraduation and proposes a checklist for residents before submission of their proposals.

INTRODUCTION

Residency is an extremely important period in the life cycle of a modern medical graduate. During this period, a resident learns to practice and acquire proficiency in a subject under guidance of a teacher. Along with acquiring new skills, it is also expected that they learn to critically analyze clinical scenarios and reach a rational conclusion. They are also expected to formulate and conduct original research which is submitted in form of a dissertation or thesis. Research work by a postgraduate should eventually translate into a scientific publication in a peer-reviewed medical journal, which helps in dissemination of thesis findings to the community and scientists. It is essential toward furthering medical knowledge, clinical practice, and the progression of science.[ 1 ] The National Medical Commission has stated the aims of completing this task as “Writing the thesis is aimed at contributing to the development of a spirit of inquiry, besides exposing the candidate to the techniques of research, critical analysis, acquaintance with the latest advances in medical science and the manner of identifying and consulting available literature.”[ 2 ]

CHOOSING THE TOPIC

The most intriguing question while conducting research is “How do I choose the right topic and will I be able to find the right answer?” Starting off with fire in the belly gives the best chance of seeing one’s work through. So, it is important to choose something that entices one’s mind and promises a gratifying result. Existing literature on the topic suggests that the journey of choosing the right topic is often marred by multiple challenges and dilemmas at various stages of this tumultuous journey. There are constraints of time, availability of resources, and support network.[ 3 ]

Therefore, students must remain open to suggestions from within and outside their minds. It is also important to allow the research area to simmer inside their mind for some time so that they can analyze various facets of the chosen area. It is at deeper layer of learning where higher order thinking skills such as analysis, synthesis, and evaluation reside. This then justifies the longer period it takes to arrive at a meaningful thesis title as it represents the highest order of cognitive reasoning referred to as “create” stage.[ 2 ] Short of this, novice researchers operate at lower order and remain “copy-paste” type of researchers.[ 4 ]

Lord “Dhanwantri” also known Physician of Gods brought “ Amrit ” elixir of life after “Samudra Manthan,” which was the result of intensive deliberations.[ 5 ] A systematic stepwise approach for answering any research question offers the best chance of finding the right answer. Succeeding paragraphs in this article shall delve into an enriching scientific journey toward zeroing onto a suitable thesis title.

Area of interest

A journey into an area of one’s interest is bound to be fulfilling. It is a good idea to review one’s past works and experiences, which may be intriguing. A frank and one-to-one discussion with the guide further helps in unravelling novel ideas. Starting with an open and fertile mind promises novel ideas and helps to sustain long-term interest and enthusiasm.[ 6 ] Tendency to merely replicate similar studies should be avoided as they fail to ignite the zest for newer information.[ 7 ] Think about why you got into your field of study. Consider what you like to read about in your free time, especially things related to your field.

From general to specific

A dissertation topic in medicine needs to be captivating and must intrigue the reader to look closer into the research work.[ 8 ] At the outset, it is a good strategy to just define a broad area and a dissertation topic need not be very specific or restrictive. The defined general area must be studied thoroughly and all its facets analyzed in detail. Look for gaps in knowledge which offer an avenue for research. For example, while studying factors responsible for relapse in alcohol dependence, doing a research on employment status of the spouse may be a good idea as it may not have been studied as extensively as other factors. It is needless to say that the student must first be familiar with the disease and all the variables which define its long-term trajectory. Medical science is an evolving field . There are factors of significance that can crop up during course of the study. Therefore, some scope for minor modifications must be kept for unexpected spinoffs. Most of the institutional review board permit minor revision of the protocols though they adhere to their own standards to safeguard interests of the patients. Authors conducted a survey and found that out of 184 submitted, 96 (52%) received requests for minor revision of research protocols. The acceptance resulted in further refinements in research methodology and outcomes.[ 9 ] Therefore, while submitting any protocol, some scope for minor change with probable reasons must be endorsed so that there are no complications while submitting final draft. After discussion with the guide, a suitable title can be given to the research proposal. Selection of the title should be such that it reflects the gist of the whole research and must attract attention of the reader. The title has a long shelf life and may be the first (and many a times, also the only) part of an article that readers see or read. Based on their understanding of the title, readers decide if the article is relevant to them or not.[ 8 ]

Do not bite more than you can chew

The average time allotted for completion of the MD/MS/DNB thesis is 2 years. It may be further reduced due to administrative delays like allotment of thesis guides and selection of topic. It is safe to assume that it takes around 1 month to finalize and submit the protocol and 2 months to write, print, and submit the complete thesis. That leaves just around year and nine months for actual and adequate data collection. All these facts must be kept in mind to ensure genuineness of data.[ 10 ]

A bird in hand is worth two in the bush

Modern medical science thrives on multispecialty approach, and it is not uncommon that students may end up with a research topic involving more than one department or more than one facility of the institution. Studies conducted during Covid pandemic are perfect examples owing to multiple facets of the illness in terms of prevention, pathophysiology, and long-term sequele.[ 11 ] A realistic check for the available resources in terms of infrastructure, availability of study materials, and support from affiliated departments must be done before finalizing the research topic. It is highly unlikely that your thesis is the first or the last research work in a particular area. Negotiating with other department/institution to regularly avail their facilities is often challenging. It is because of the difference in timing, priorities, work culture, and administrative barriers. One way to deal with it is to have a co-guide from that facility/institution. Dissertation reviewers have noticed that students often select topics that become unmanageable during course of their study. It can lead to development of stress and uncertainty about findings at the time of analysis. It was found that institutional support in terms of guidance, access to other departments, and statistical guidance improved overall performance of students and led to timely submission of thesis for publication in journals.[ 12 ]

Avoid controversy

Getting into controversy during initial years of residency is bound to raise stress levels and may dissuade the worker from continuing the research work. Field of medicine is fast evolving on the wheels of technology. Moral and ethical boundaries are slowly getting blurred. Many a times, laws are not revised and many laws are land specific. Therefore, it is a sound practice to familiarize oneself with existing laws and to take care that they are not violated. Central Drug Standard and Control Organization is the regulatory authority responsible for clinical trial oversight, approval, and inspections in India. It functions under Director General of Health Servicesand part of Ministry of Health and Family Welfare. The information is available online on their website and it is updated regularly. It is a good idea to visit the website and familiarize oneself about the existing laws before undertaking any research work. The website also gives information about National Ethical Guidelines for biomedical and health research involving human participants. Similarly, informed consent needs to be spelt out quite clearly and should be devoid of incomplete information or concealment of vital health related information. It is now mandatory that all research proposals be vetted by institutional ethical committee prior to submission to the university.[ 13 - 15 ]

Conformation with national health policy

Young medical professionals can contribute immensely by their research designs and valuable inputs in ratifying existing health-related measures or to suggest further refinements. This concept must always be kept in mind while formulating any research designs. Researchers of today are planners for tomorrow and their work is reflection of their goal toward health of the nation. In a comprehensive report, it was found that merely 0.5% of the 4230 thesis citations were quoted in policy decision.[ 16 ] The figures may be even lower for this country. The figures are abysmal compared to the magnitude of the research undertaken in centers of higher learning. The success of National Iodine Deficiency Disorder Control Program in India owes credit to sound scientific inquiries beginning in 1956. Despite stiff opposition and cultural bias, the program gained strength and helped in significantly reducing burden of iodine deficiency disorders.[ 17 ] The findings led to significant policy change and legislation supporting sale of only iodized salt in the country.

Scope for publication

Any research work is considered futile if it does not reach the stage of publication in a reputed journal. A genuine research must eventually translate into a research article. It has become increasingly difficult to translate thesis into a scientific publication in an indexed journal due to stringent standards and peer review. In a retrospective analysis of 85 theses, it was found that the conversion rate to peer-reviewed publication was 32.5%. The most common reasons for not publishing were a lack of originality and poor design. The authors further encouraged publication of full length articles as it helped residents in long term.[ 18 ] Originality of research, sound methodology, and analysis of data besides cogency in manuscript writing have been defining factors that promote acceptance of an article in a reputed journal.[ 19 ] Lure of quick publishing in a predatory journal can be damaging in the long run. Young and inexperienced authors publishing in a predatory journal must be aware of the damage of their reputation, of inadequate peer-review processes and that these journals might get closed any time for variety of reasons. Such publishing harms the scientific community in the long run, and hence such an approach is best avoided.[ 20 ] It is prudent practice to check whether an intended journal is predatory or not from the https://predatoryjournals.com/journals/or Beall’s list (https://beallslist.net/). Similarly, increasing the score by “salami” publication is unethical and should be avoided.

Familiarization with research methodology

Imagine you are gifted a do-it-yourself kit to build a plane which can fly. It is meant for an age group of 18 years or more and should take 1 h to assemble. It has all the wheels, gears, levers, motors, wires, motherboard, etc., required to assemble it into a functioning plane. The kit also has a manual. How long should it take to assemble? 60 min? Now imagine trying to assemble without the manual. It may be extremely difficult if not impossible to assemble the plane and is surely bound to take much longer. Research methodology is exactly like a manual for research. A major confounding factor in medical research is student’s conceptual understanding and comfort level with research methodology.[ 21 ] Findings indicate that there were noticeable differences in perspectives regarding what constitutes research methodology and its utility at least during the first year of residency.[ 21 ] Familiarizing with basic research methods is now mandated for all the medical postgraduates before they submit their research proposals, and free certificate online courses are available on their website. Writing a thesis during MD/MS and DNB courses, without having a correct research methodology planning, is practically impossible. Some of the prominent causes of rejection of submitted manuscripts are poor methodology, small sample size, and poor statistical analysis.[ 22 ] Furthermore, postgraduate students choose research methodology based on a number of factors such as familiarity with a method, methodological orientation of the primary supervisor, the domain of study, and the nature of research problems pursued. Participants reported key challenges that they faced in understanding research methodology include framing research questions, understanding the theory or literature and its role in shaping research outcomes, and difficulties in performing data analysis.[ 23 ]

Motivation level of the researcher

Dr APJ Abdul Kalam, former president of India, quoted that “Dream is not that you see in sleep but it is something that doesn’t let you sleep.” No research work will reach its logical conclusion till the time a researcher has strong motivation to pursue it. Another factor that defines sustained interest in thesis topic is motivation. As described by David Langford, there exists a continuum from extrinsic to intrinsic motivation.[ 24 ] Extrinsic motivation basically refers to a situation wherein the students are ordered (to study). As we move along this continuum, the quality of learning improves consistently with the maturing of the relationship between teacher and student. The culmination of the relationship occurs when the teacher becomes an enabler while the student becomes an active self-learner (intrinsic motivation). The process involves a definitive element of mentorship. In traditional Indian context, Gurukul envisages a firm and enduring relationship between “Guru” (teacher) and “Shishya” (student). Vedas in ancient times were combined with prepared commentaries in the form of “Upanisads.” The term upanisad refers to “Sitting down near a teacher in order to learn.” Though many students have inherent intrinsic motivation, a dynamic “Guru” can really shape the “Shishya.” Though the concept is old, it still remains relevant in modern times because learning medical practice is both art and science and best habits are still passed on to the next generation by trained and experienced teachers.[ 25 ]

WHAT CAN HELP POSTGRADUATE THESIS SELECTION?

The authors of this article put their minds together to devise a questionnaire that can act as a checklist for the residents before they actually submit their draft proposal for submission [ Table 1 ]. The checklist contains 10 questions and the responses can be marked from strongly disagree to strongly agree on a five-point likert scale. The checklist can be self-administered and the responses will give an insight into the lacunae. The residents can gradually work on these lacunae so that they feel at ease during the fantastic journey of scientific research and publication.

Postgraduate thesis topic selection questionnaire

Note: Rate your responses after regular intervals while preparing your research proposal and work on areas that feel difficult

Choosing thesis topic and submitting the protocols is an important milestone in the career of a postgraduate resident. However, its importance cannot be undermined from the fact that it is usually the first scientific pursuit of a medical graduate. Challenges and hurdles are expected but can be overcome with sustained and systematic effort. The authors of this article reviewed the literature concerning this topic and found some key areas which a resident must familiarize with before finalizing their research topic. The postgraduate thesis selection questionnaire can further act as a checklist to facilitate the process.

Financial support and sponsorship

Minds United for Health Sciences & Humanity Trust, IToP STEPS program grant.

Conflicts of interest

There are no conflicts of interest.

Acknowledgment

Minds United for Health Sciences & Humanity Trust, IToP STEPS program grant for financial support and motivation.

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INFORMATION FOR

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Student Research Resources

Resources and forms to help you navigate student research opportunities!

Required Formatting and Components of the MD Thesis

Examples for reference section formatting, avoiding the risk of copyright violation and liability when submitting your md thesis, instructions for submitting a thesis to the yale medicine thesis digital library, thesis depositors declaration form, evaluations of advisor.

In general, one topic is appropriate for the thesis, but it is recognized that some students may have performed several projects in parallel under the supervision of their mentor. If the student elects to include more than one study in the thesis, it is recommended that an attempt be made to integrate the topics into one coherent presentation. In rare cases where this goal cannot be achieved, it may be acceptable to divide the results section into different portions (or “chapters”). However, to be consistent with Yale formatting requirements, a thesis may not contain more than one abstract, introduction, statement of purpose, methods, results, and discussion section. It is not acceptable to submit a published or submitted manuscript in lieu of the thesis requirement. The formal thesis is presented as a digital document (PDF) during the graduation year. It must adhere to the following formatting and content requirements. These aspects of research are critical in making the work sound, error-free, and impactful for communities of interest. Recognizing that students may have uncertainly regarding how these guidelines relate to their thesis, OSR will be happy to answer any questions that may arise. Additionally, students may find it useful to consult the Equator reporting guidelines to enhance the quality and transparency of their theses. The Yale MD Thesis is a doctoral thesis that assesses research competencies as the basis for the conferring of a doctoral degree. Therefore, a minimum requirement of 30 pages (exclusive of title page, abstract, acknowledgements, table of contents, figure legends, references) is considered the minimum acceptable length.

• Font: 10-12-point font should be used.
• Line spacing: Body paragraphs and tables should consist of double-spaced text. Single spaced text may be used within block quotations, footnotes, and bibliography.
• Margins: 1.5-inch margins on the left with one-inch margins on the remaining three sides. These margins apply to text, full-page images and illustrations, and tables.
• Figures: Illustrative information, schematics, and representative data should be included as figures. Each panel in a figure should be labeled. Legends should describe each panel in detail in a 9-point font or greater and positioned below the figure to which they refer. Figure legends do not count towards the 30-page minimum.
• Page Numbers: Each page in the thesis should be numbered except the title page, abstract, acknowledgements, and table of contents. The numbering should start at page 1 of the first page of the instruction be placed either at the top or bottom center, or at the top or bottom right-hand corner, at least 1/2 inches from any edge.
• Minimal page requirement: Most Yale MD theses average 40-80 pages of text. A minimum of 30 pages of text excluding title page, abstract, acknowledgements, table of contents, figures, legends, and references is required. Tables may count towards the minimum page requirement.

Required Components

• Title page: Title should not exceed 100 characters including spaces between words. The title page is not included in the 30-page minimum.
• Abstract page: As described below. The abstract is not included in the 30-page minimum.
• Acknowledgements: Personal and faculty acknowledgements, grant support, departmental support, etc. The acknowledgements page is not included in the 30 page minimum.
• Table of Contents: with page numbers for each section. The table of contents is not included in the 30-page minimum.
• Introduction: A thorough, complete, detailed, critical review of the literature that contextualizes and cites the work of previous investigators. This section should describe the state of the existing knowledge, provide rationale for the study, identify knowledge gaps, and frame the contribution of the thesis to medicine. The introduction is included in the 30-page minimum.
• Statement of purpose: Specific hypothesis if appropriate, and specific aims of the thesis. The statement of purpose is included in the towards the 30-page minimum.
• Student Contributions: Describe in detail exactly which procedures, methods and experiments were conducted by you and which procedures, methods and experiments, generation of data, or production of reagents, were performed by other members of the study team. It is not sufficient to state that this information may be mentioned elsewhere. It must be summarized here. It is recognized that students may often be completing a portion of a larger work. A statement detailing precisely what was done by the student and what was done by others does not detract from the thesis but is necessary for academic honesty.
• Ethics Statement: Include information regarding the ethical and responsible conduct of research.
• Human Subjects Research: If relevant, include explicit information regarding Institutional Review Board approval and informed consent. If the study had a waiver of consent, this exception must be clearly stated. Information regarding inclusion of historically vulnerable populations as research participants should be included here.
• Laboratory Animals: For studies involving laboratory animals, include an explicit statement regarding study approval from the Institutional Animal Care and Use Committee. Include information regarding the species, strain, sex, and age of laboratory animals in this section as well.
• Methods Description: Provide information regarding the materials and methods used in the study. Each method should consist of its subheading and paragraph and be described in detail that is sufficient to allow its replication by an investigator who did not participate in the study.
• Statistical Methods: The last paragraph in this section should present the methods used to derive results. As needed, describe any data preprocessing such as transformation and normalization. Describe how outliers were defined and handled and present descriptive statistics as appropriate. The number of sampled units (ie, “n”) and significance (ie, “P”) should be reported for each statistical comparison. Continuous variables that are normally distributed may be presented as mean + standard deviation. Continuous variables that are asymmetrically distributed should be presented as median + interquartile range. All statistical tests should be clearly described and include information regarding testing level (alpha) and one- or two-sided comparisons. Corrections for multiple testing should be addressed and reported. Any novel or complex data algorithms should be clearly described and appropriately referenced.
• Transparent reporting of results: All primary data related to the thesis topic should be presented. Important data should be enumerated in figures or tables. For ease of review, it is preferred that figures and tables be included in proximity to their callout in the text. Alternately, tables and figures can be presented separately after the discussion but, if possible, it is advantageous to the reader to include these components in the body of the results section, as occurs in research publications. The results section is included in the 30-page minimum.
• Discussion: This section presents thorough and detailed interpretation and analysis of data, conclusions drawn, and framing of observations with the larger scientific literature. Limitations should be addressed, as should alternate interpretations and how the thesis may inform future studies in the field. Whenever relevant, a discussion of how the thesis may or already has meaningfully impact(ed) communities of interest should be included here. The discussion section is included in the 30-page minimum.
• Challenges & Limitations : A brief discussion of methodologic, operational, and other challenges relevant to the research presented in the thesis. Please also include a brief discussion of how these challenges were addressed. Recognizing that all research projects have important limitations that readers should consider in interpreting the results, please include a brief discussion of the limitations relevant for your research. This section is included in the 30-page minimum.
• Dissemination: Please include efforts made to share findings with the scientific community (through oral presentation, peer-reviewed publications, and other venues) and the larger community including patients. This section is included in the 30-page minimum.
• Figure References and Legends: Figures must be cited sequentially in the text using Arabic numerals (for example, “Fig. 7”). Provide a short title (in the legend, not on the figure itself), explanation in sufficient detail to make the figure intelligible without reference to the text, and a key to any symbols used. Figures and legends are not included in the 30-page minimum.
• Tables: All tables should be double-spaced, self-contained, and self-explanatory. Provide brief titles and use superscript capital letters starting from A and continuing in alphabetical order for footnotes. Tables and their legends are included in the 30-page minimum.
• References: We strongly recommend the use of bibliography software such as Endnote for managing the references. References should be formatted according to New England Journal of Medicine Style. References are not included in the 30-page minimum.

It is acknowledged that theses in the area of medical humanities, ethics, history, and related fields may not obviously adhere to the above requirements. In this case, the thesis will likely replace the “hypothesis” with a “claim” based on evidence gleaned through literary, historical, and ethical research. The first paragraph of the Methods should still contain information about the student’s contribution. The subsequent paragraphs should describe the artistic, literary, or historical databases and methods used to gather the “evidence” presented in support of and contrary to the central claim. The discussion and remaining sections are the same and the 30-page minimum applies. If you have questions about how to best frame your thesis, please contact OSR.

Abstract Page

Standardized format for the abstract of each MD thesis is required. This format must be followed for all abstracts published in the Yale Medicine Thesis Digital Library. These abstracts will not be reviewed for content. It is the responsibility of the student investigator and the faculty advisor to prepare the abstract. Faculty sponsors provide approval of the abstract when they approve the final version of the thesis. These abstract instructions are to be used for the digital library submission.

• Abstracts should be formatted with 1.5-inch margins on the left and 1-inch margins on the remaining three sides. All text, including title page, must be double-spaced.
• Abstracts may be no more than 800 words in length, not including title and author information.
• Titles should be brief, clear, and carefully chosen. The title should not exceed 100 characters including spaces between words. Capitalize the entire title, using no abbreviations.
• Authors’ names are to be written in full, omitting degrees. The student author's name shall be first. If the faculty sponsor also qualifies as an author, their name should be last. If the faculty member has been only a sponsor, his or her name should appear in parentheses after the name(s) of other authors as follows: "(Sponsored by...)". Other collaborators should be listed after the student's name and before the faculty sponsor's name. Immediately following the faculty sponsor's name, designate section (if any), departmental affiliation, institution, city, and state (Yale University School of Medicine, New Haven, CT) (see examples in the Thesis Guide ).
• For thesis work performed at another institution, designate the senior author's departmental and institutional affiliation. In parenthesis, indicate the Yale faculty sponsor and institutional affiliation with the phrase: "Sponsored by..." (see examples).
• A statement of the hypothesis or goals and specific aims of the study.
• A statement of the methods used.
• A summary of the results presented in sufficient detail to support the conclusions. Include actual values with statistics, if appropriate.
• A statement of the conclusions reached.
• Do not use subtitles, e.g., methods, results.
• Do not include graphs, references to other publications, or acknowledgement of any research grant support. A single short table of results can be used if appropriate.
• Abbreviations may be used in text only if defined initially by placing them in parentheses after the full word (or phrase) first appears in the text. Abbreviations may not be introduced in the title.
• Non-proprietary (generic) names are required the first time a drug is mentioned, written in small letters. Proprietary names are always capitalized, e.g., acetazolamide (Diamox).
• Completed abstracts must be approved by faculty advisor.

Thesis Assessment

The thesis assessment will assess student performance on the following domains using a 1-5 Likert Scale.

• Significance
• Rigor of Prior Research
• Methodologic Rigor
• Responsible Conduct of Research
• Organization and Clarity of Text
• Presentation of Data
• Interpretation of Data
• Student Effort
• Dissemination to Communities of Interest

Likert Scale:

• Not Acceptable

The vast majority of YSM students receive scores of 2-3 across these domains. Scores of 1 are considered truly outstanding. Scores of 5 are highly unusual and indicate the presence of critical deficiencies. Students receiving a score of “5” in any domain will be referred to OSR and the Progress Committee for remediation in order that they may stay on track to graduate.

Journal Articles

1. Yalow, R.S., and Berson, S.A. 1960. Immunoassay of endogenous plasma insulin in man. J. Clin. Invest. 39:1157-1175.

2. Gardner, W., and Schultz, H.D. 1990. Prostaglandins regulate the synthesis and secretion of the atrial natriuretic peptide. J. Clin. Invest. In press.

Complete Books

3. Myant, N.B. 1981. The Biology of Cholesterol and Related Steroids. London: Heinemann Medical Books. 882 pp.

Articles in Books

4. Innerarity, T.L., Hui, D.Y., and Mahley, R.W. 1982. Hepatic apoprotein E (remnant) receptor. In Lipoproteins and Coronary Atherosclerosis. G. Noseda, S. Fragiacomo, R. Fumagalli, and R. Paoletti, editors. Amsterdam: Elsevier/North Holland. 173-181.

5. Standardized format for the abstract of each MD thesis is required. This format must be followed for all abstracts published in the Yale Medicine Thesis Digital Library. These abstracts will not be reviewed for content. It is the responsibility of the student investigator and the faculty advisor to prepare the abstract. Faculty sponsors provide approval of the abstract when they approve the final version of the thesis. These abstract instructions are to be used for the digital library submission.

Your MD Thesis represents an academic milestone. The protection of your thesis copyright exists from the time your work was created in digital form. Every article, book, or web page you used in conducting research and writing your thesis is also protected by copyright. When you download a single personal copy of a research article or cite a short passage, this scholarship is protected by the legal concept of fair use. A basic understanding of copyright protections and fair use is found at www.copyright.gov . Yale University also provides a guide to copyright protection and fair use: http://ogc.yale.edu/legal_reference/copyright.html .

Section 107 of the U.S. Copyright Law describes how to determine if a particular use of copyrighted material is fair. However, the distinction between what is fair use and what is infringement is not always clear or easily defined. Copying an image from an academic e-journal and citing the source does not substitute for obtaining permission to reproduce the image. Many publishers use www.copyright.com to grant reproduction rights of their articles to authors.

ProQuest/UMI and the Yale Medicine Thesis Digital Library may elect not to distribute your thesis in the absence of evidence that permission or reproduction rights have been secured. Providing evidence of permission or reproduction rights is a student author responsibility. Examples encountered in MD Thesis research that require documentation of reproduction rights include but are not limited to:

• Sections of published survey instruments or questionnaires.
• Complete journal articles or other complete scholarly works [Note: The publisher Elsevier does allow graduate student authors of a journal article prior to graduation to reproduce their article in a thesis].
• Image, graphic, or pictorial works from publications where the author has transferred copyright to the publisher, a common occurrence.

The safest course to avoid a delay in thesis is to avoid using published images without obtaining permission. It is almost always possible to cite a source and expect that readers can find the figure, chart, or image in the published version of the referenced work. Research faculty who transfer copyright to a publisher of their article are no longer the copyright holder and are unable to grant permission for reproduction. To circumvent this issue, the student or mentor may be able to offer unpublished images from their group’s image collection.

When it is impracticable or prohibitively expensive to obtain permission through the publisher or the Copyright Clearance Center (www.copyright.com), students should avoid using that the material, unless they have obtained a written legal opinion that fair use would apply to the situation. Neither the Office of Student Research nor the Yale Library can supply legal advice on copyright and fair use. If there is any doubt, it is advisable to consult the Yale University Office of the Vice President and General Counsel at 432-4949. If a student is unable to obtain permission to use their previously published work in their MD thesis, they may place a permanent embargo on their thesis at the time it is uploaded into the Yale Medicine Digital Thesis Library (see below).

Upon receiving notification that the MD thesis has been approved as meeting graduation requirements, students should upload the thesis to the Yale Medicine Digital Thesis Library.

Yale Medicine Digital Thesis Library:

Starting with the YSM class of 2002, the Cushing/Whitney Medical Library and OSR have collaborated on the Yale Medicine Digital Thesis Library (YMTDL) project, publishing the digitized full text of medical student theses as a durable product of Yale student research efforts. Digital publication of theses ensures access for all scientists to a summary of such work, provides students with a formal citation for their thesis, and demonstrates the exceptional quality of student research and student-faculty cooperation at Yale. In 2006, the digital copy became a graduation requirement. Starting in 2012, alumni of the Yale School of Medicine were invited to participate in the YMTDL project by granting scanning and hosting permission to the Cushing/Whitney Medical Library, which digitized the Library’s print copy of their thesis or dissertation.

The Office of Student Research and Yale School of Medicine require that the MD thesis be submitted to the YMTDL. This submission should be accompanied by a completed “ Yale School of Medicine Digital Thesis Depositor’s Declaration Form. ”

Submitting a thesis via the ProQuest website:

Detailed instructions on how to submit a thesis via the ProQuest website will be provided to students at the time they receive notification of formal YSM thesis approval and feedback from the Office of Student Research.

The electronic thesis submission process in ProQuest is organized into three major categories: Publishing information, About my dissertation/thesis, and Submission & payment. The system will walk you through the submission process step-by-step.

A few things to note: the ETD Administrator software is a 3rd party product that YSM licenses from ProQuest. Because this vendor is unaffiliated with Yale, OSR and Yale University Libraries do not have control over its policies or processes. The ProQuest Dissertations and Theses Global database is a subscription resource that collects dissertations and theses from multiple countries and a range of academic specialties. This collection is then made available to subscribers. When students choose to make their thesis publicly available, the full-text will appear in this database and users will be able to read, save, and download the text.

EliScholar is a digital platform for scholarly publishing provided by the Yale University Library (YUL). While it is supported by third party software, EliScholar is maintained by YUL and offers more flexibility in uploading and managing theses. The option selected for thesis release in the ETD Administrator system will apply to both ProQuest Dissertations and Theses Global and EliScholar. All theses are available to the Yale community (individuals with a NetID and password and users physically present at a library facility on campus) upon publication. A limited release of approved theses to the awarding institution’s user community is common practice.

YSM requires a Thesis Publishing Agreement Form, previously known as a Thesis Deposit Declaration Form, to be submitted in conjunction with your final thesis to ProQuest. For reference, you can find a copy of the form at this link .

We urge your participation in evaluating your experience with your thesis advisor at this Qualtrics link . The results will be kept anonymous, and any feedback to the individual faculty member will be made over a three- to four-year interval and will be a summarized statement, not involving reproduction or direct quotes from this form.

We will file these evaluations for future use by first and second year students who are looking for a project and research advisor. These evaluations have been immensely valuable to students initiating thesis projects. Thank you for your cooperation in this effort.

Contact us if you have questions or need accessibility assistance with the documents on this page.

• [email protected]

Research Guide for Students

Thesis publishing agreement form, student evaluation of thesis advisor.

Thesis Helpers

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201 Stellar Medical Researches Topics For Any Taste

If you are in a medical college, you probably understand the struggle students face in finding medical research topics. On top of having to view corpses during practical sessions, there is another scary part of looking for best-rated medical research topic ideas.

What Is A Medical Research Paper?

It refers to an academic paper designed to test medical students’ understanding of medicine’s various aspects. These include nursing, psychotherapy, surgery, diseases, and many more.

Finding great medical research paper topics is not as hard as most students perceive it to be. It is only the fear that turns down most students, preventing them from unleashing their potential. However, here are some of the readily available sources that will give you medical topics for research papers:

Reputable medicine-related websites such as the WHO’s Known books and scholarly journals in medicine A credible online writing site (such as ours)

Through this paper’s help, you will know how to write top-rated medical research papers topics in an easy-to-understand manner.

Medical Research Topics For College Students

• Discuss why doctors use a snake in their logo
• Why is the field of medicine not preferred by most students?
• Evaluate the effectiveness of using simulations instead of natural bodies in a medical class
• The role of therapy in advancing the economic and political status of a country
• Why schools should incorporate First Aid skills as part of their curriculum
• Are the medical internships too long for students?
• Assess the possibility of paying doctors more than any other workers
• Should all the staff in a medical facility have a background in medicine?
• Discuss the impact of technological advancements on medicine
• Do movies depict the unfair practice of medicine?
• The perception of students towards medicine: A case study of middle school students
• What is the greatest challenge facing doctors and clinicians?
• Does the medical curriculum cover every aspect of medicine
• Discuss the impact of online learning on medical students
• Should doctors down their tools in case of a disagreement with their employers?
• How often should one go for a dental check-up?
• Analyze the number of medical colleges in the US
• Should doctors undergo a psychological check-up after every three months?
• What is the role of the government in ensuring a sustainable healthcare program?
• The impact of long shifts to the mental state of a doctor

Med Research Topics in Nursing

• Analyze the factors affecting elderly nursing care programs
• Discuss why memory loss is associated with advancement in age
• Should first responders to an accident scene dress the wounds of the victims?
• Why is the field of nursing not a favorite for men?
• Compare and contrast the roles of a doctor versus those of a nurse
• Evaluate the effectiveness of nursing shifts in case of a pandemic
• Why is the uniform of most nurses white in color?
• Analyze the different ethical challenges associated with the nursing profession
• What is the motivation story behind most of the nurses in work?
• The impact of domestic violence on the effectiveness of a nurse
• How nurses manage to stay sober despite the horrific scenes they encounter daily
• Are nurses born or made: A case study of nurses at a hospital of your choice
• The role of nurses in caring for those in Acoma
• The impact of the nursing profession on one’s social interactions
• Compare and contrast nursing in developing countries versus developed countries
• Describe the effect of negligence on the part of the nurses to patients
• Are nurses compensated enough for their labor?
• Describe what constitutes a typical day of a nurse
• Is stereotyping a leading cause for the dominance of females in the nursing profession
• Conduct a critical analysis of the role of nurses in a surgery room

Interesting Medical Topics on Health

• The impact of global warming on the behavior of disease-causing micro-organisms
• Dealing with the problem of poor sanitation in developing countries
• Why are the whites primarily susceptible to malaria attacks
• Discuss why vaccines can only be effective if made within one year
• Conduct a comparative analysis of the effectiveness of syringes versus tablets
• What is the impact of taking a dose and not completing it?
• Evaluate why sourcing doctors from outside may not be effective
• Are the research papers on health conclusive enough?
• Why governments need to invest more in the health systems of a nation
• Barriers to affordable medical care among low-income families
• What are the considerations for an effective universal healthcare program?
• Analyze the various factors that impede the productivity of healthcare workers
• The effectiveness of counseling and psychology before a surgery
• Is it possible to achieve a healthy world with the ravaging effects of greenhouse gases?
• The impact of private health firms on the existing public one
• How to regulate the sale of medical products
• Discuss why most people opt for advanced medical procedures overseas
• Analyze the challenges encountered in maternity wards
• The role of religious persons in a medical facility
• Should the government tax medical products?

Medical Research Topics For High School Students

• Discuss why HIV/AIDS has not found a cure to date
• What is the impact of alternative medicine in promoting healthcare services?
• The role of exercises and fitness in leading a healthy lifestyle
• Why is there a need for health care reform measures
• The part of fast-food restaurants in deteriorating the health of a country
• Evaluate the impact of dietary supplements on one’s health
• Reasons why Over-the-Counter prescription drugs are killing many
• Considerations before going for a weight loss surgery
• What are the medical reasons behind vegetarianism?
• The impact of organic foods on the health of a person
• Why depression is the leading cause of health complications among teens
• Discuss drug abuse in the line of health impacts
• Practical ways of helping a smoking addict to reform
• Discuss the relationship between fat diets and obesity
• Why do people who work in offices predominantly suffer from obesity?
• Compare and contrast between cycling and jogging: Which is advisable?
• Why do some people prefer injections while others opt for syrups?
• Should medicine as a course be introduced at the high school level?
• What are the physical traits and qualities of a person aspiring to do the treatment?
• Evaluate the time taken to complete a medical course: is it long or short?

COVID-19 Medical Topics To Write About

• Why is the world experiencing second and third waves of COVID-19?
• Assess the viability and effectiveness of the coronavirus vaccines?
• How does washing hands prevent one from contracting COVID-19?
• Compare and contrast the point of a surgical mask and one made of cloth
• Discuss why there are more COVID-19 related deaths in European countries than African countries
• The impact of quarantines on the mental state of a person
• What is the maximum number of nasal swabs that a person should take?
• Discuss the science behind social distancing in curbing the spread of the virus
• Why coronavirus cases are still on the rise despite the availability of vaccines
• What determines the immunity of a person against coronavirus?
• Evaluate the chances of contracting coronavirus from handling a corpse
• Is it possible to eliminate coronavirus?
• How effective are the COVID-19 certificates for travelers?
• Is it possible to curb the spread of coronavirus in kindergartens?
• Critically evaluate COVID-19 treatment and containment measures in developed and developing countries
• The role of researchers in providing medical information during the COVID-19 pandemic
• What are the differences between coronavirus and the Spanish flu?
• Impact of economic recessions on the containment of the virus
• Analyze the roles of various stakeholders in containing coronavirus
• Discuss the mutation of the coronavirus

Top Topics For Medical Research Paper

• Discuss the differences between epidemic and pandemics
• Analyze the critical considerations for a child health care program
• The role of humanitarian medical missions in reaching the developing nations
• Why are most people suffering from heart diseases of late?
• Discuss the dangers and benefits of vaccination
• Critically analyze the ethical considerations of conducting medical research on animals
• The impact of rare genetic disorders on the stability of families
• What are the effects of surgeries on organs and artificial tissues
• Discuss why brain surgeries are always a matter between life and death
• Evaluate the various causes and treatments of virus infections
• Are antibiotics treatments effective for complex diseases?
• Discuss the ethical considerations in ending the life of a person with a terminal illness
• The causes and remedies of eating disorders
• How age affects mental health and physical development
• Analyze the shortcomings of palliative treatment
• The impact of modern lifestyles on people’s health
• How technology is helping patients battling with Alzheimer’s disease
• Considerations before being part of a blood donation exercise
• How to care for cancer patients in their critical stages
• Are professional conditions only for specific careers?

Controversial Medical Topics For Research Paper

• Do doctors have the right to conduct abortions when it is a matter between life and death?
• The ethical underlining of artificial insemination in man
• Discuss why most surrogate parents are not considered
• Is it right to use birth control pills for school-going children?
• Discuss the impact of stem cell research on a society’s morals
• Is plastic surgery, for whatever case, unethical?
• Should male doctors attend to female patients?
• Is it possible to achieve confidentiality in a hospital set-up?
• Why do most male patients prefer being treated by female nurses?
• Discuss the ethical implications behind sperm and egg donation
• Is donating blood unethical? A case study of selected religious sects
• Should families pay for medical bills after their death of their beloved one?
• Discuss the implication of LGBTQ on medical care
• Is it ethical to sell body organs before or after death?
• Critically discuss the impact of transplanting a sexual organ
• Discuss how to deal with teen pregnancy
• How do religion, culture, and tradition differ from the field of medicine?
• Are health insurance companies to cover all healthcare costs?
• Discuss the impact of taxing on medical supplies
• Who should be paid more between doctors and nurses?

Researchable Medical Research Topics Examples

• Discuss the medical implications of male circumcision
• The impact of political action on the effectiveness of health care systems
• The role of international collaborations in improving medical care
• Evaluate the challenges faced in the regulation of biomedical research
• A survey of the different attitudes towards psychiatry in the United States
• Evaluate the occupational safety concerns of medical laboratories
• Discuss the considerations of a controlled clinical trial
• Challenges during mass medical reparations: A case study of terrorist attacks
• The essence of introducing research training in psychiatry
• Evaluate the effectiveness of the courses offered in the medical colleges
• Discuss the impact of the US-African medical partnerships
• Why scientists need to collaborate in the case of a pandemic
• Are vaccines the best way to prevent one from contracting a disease?
• The impact of community-based participatory approaches in improving hygiene standards
• The vital role of pharmacy workers in a medical profession
• The critical place of knowledge and experience in the field of medicine
• The role of stakeholders in developing better health care policies
• The impact of demoralization of HIV/AIDS
• Discuss the process of production and distribution of medical products
• Analyze the critical aspect of globalization in medical research

Hot Medical Research Paper Topics For College Students

• The role of medicine in setting and implementing food standards
• What are the critical causes of gluten allergy
• Is it ethical to conduct assisted suicide for terminal patients?
• Ethical concerns of charging fees for patients who die in the process of treatment
• The ethical considerations when conducting a postmortem
• How is virtual reality transforming medicine?
• An analysis of the myths and misconceptions surrounding medicine?
• Why many people are against cloning
• Is it legal to use marijuana as a medical product?
• Evaluate the benefits and dangers of immunization at a tender age
• Is increased life expectancy a burden on the healthcare system?
• Analyze the health effects of female genital mutilation
• The impact of the environment on human health
• How to deal with deafness as a communication disorder
• Discuss air pollution in the context of a household
• Alcohol control practices
• The public danger of diabetes
• Urban population and respiratory diseases
• Effectiveness of oral health assessments
• Unhealthy diets

Unbeatable Research Topics in Medical Field

• Factors leading to increased cancer cases
• Resistance to insulin
• Treating autism
• Genetic engineering
• Latest developments in cancer
• Terrorism and mental health
• Dealing with coma
• Treating mental diseases
• Inequalities in healthcare
• Effects of smoking on body organs
• Healthcare considerations for prison inmates
• Economic development and healthcare
• The role of infrastructure in healthcare systems
• Recent developments in coronavirus
• Genetic mutations
• Benefits of banning tobacco ads
• Dealing with anti-vaccine movements
• How to deal with childhood trauma
• Effects of posttraumatic stress disorder
• Importance of the lymphatic system
• How to care for the liver

From the marvelous medical research topics ideas above, we hope you find one that suits your task. If not, you can still opt for our quality research paper writing help.

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Healthcare Dissertation Topics

Choosing an appropriate dissertation topic is the first step in implementing an appropriate, effective, and specialised research strategy that in turn allows students to facilitate their own academic and professional development.

The ability to explore a given subject in depth and to use the appropriate research tools to answer a dissertation question is often regarded as one of the most essential processes that indicates and demonstrates students’ capacities as future researchers. Therefore, it is important for students to have clear knowledge of the current trends pertaining to their discipline, thus allowing them to make informed decision regarding their own professional future.

To help students prepare for this process this article highlights several healthcare dissertation topics that healthcare students can base their project on; these are divided into five categories: Global health policies, healthcare management, evidence-based healthcare, mental healthcare, and technological advancements (technology takeover).

Global health policies dissertation topics

Healthcare management, evidence-based practice, mental health care dissertation topics, technology takeover.

In general, global health policies pertain to the decisions and the decision-making processes that translate evidence-based practice and healthcare into effective public interventions. The COVID-19 pandemic has dominated our lives but has also highlighted the importance of public health policies. As such, the following topics revolve around this field of healthcare.

• Lessons from the COVID-19 pandemic: How can the World Health Organisation prevent and respond to major pandemic crises?
• What is the effect of recent public health policies on reducing or controlling childhood obesity? A UK-based case study.
• What are the current trends, attitudes, and causes that facilitate and establish vaccine hesitancy in British HCPs and what are the barriers towards mitigating this phenomenon?
• The European Union demonstrated a very inefficient response in terms of securing an adequate number of vaccines in the recent COVID-19 pandemic. What are the underlying reasons for this response to the COVID-19 outbreak?
• Models and policies of supervision used as a support method for therapists.
• It has been one year since the beginning of the COVID-19 pandemic. How has Brexit affected Britain’s response to this outbreak?

Healthcare management involves the administration of care systems and institutions and the means with which these processes can optimise healthcare treatment, delivery, and the quality of healthcare services provided. Therefore, healthcare management is also intertwined with patient satisfaction and patient outcomes.

• What are the ramifications of increasing patient numbers in emergency care settings?
• What are the socioeconomic and intrinsic healthcare barriers that prevent vaccine equity?
• Investigating the factors that undermine childhood vaccine coverage in the UK.
• Ethical and legal matters regarding patients refusing treatment: a deontological approach.
• What are the best healthcare management practices in follow-up procedures following medical-related errors?
• What is the difference and the effectiveness of horizontal and vertical healthcare strategies?

Evidence-based practise or EBP is an interdisciplinary approach in which current scientific evidence is used to formulate and define the underlying decision-making processes regarding patient care and treatment. Therefore, this term underlines the importance of integrating clinical experience with the best and most appropriate clinical evidence stemming from systematic research. Dissertation topics related to evidence-based practice intend to investigate the most effective care available and whose implementation is bound to improve patient outcomes and satisfaction rates.

• A Systematic review on the effectiveness of single and multi-tablet regimes for treating HIV in patients.
• What are the determinants for success in apical surgery? A systematic review.
• Can chronic stress increase the risk of atherosclerosis?
• Can stigmatisation help change or shape individual health behaviours?
• What is the efficiency of physical activity in terms of reducing excessive weight during pregnancy?
• Child poverty and healthcare access: A case study for the UK.
• Diabetes: The efficiency of associated lifestyle interventions in tackling this major public health issue.

Mental health care refers to the services, policies, and processes that focus on the treatment of mental illnesses and disorders. Therefore, the main purpose of this healthcare field involves the improvement of mental health in patients suffering from dementia, anxiety disorders, depression, personality disorders, etc. by enhancing their quality of life through consultation, support, and innovative therapeutic approaches.

• What is the psychological and mental aftermath of the COVID-19 outbreak in children?
• Mapping of the pathophysiology related to the diagnosis of a person experiencing complex healthcare needs such as vascular dementia.
• Evaluating the risk of suicidal intent in individual who survive overdoses via routine screening for depression and alcohol abuse.
• Assessing and understanding the mental health needs of individuals who have suffered sexual and physical abuse.
• What is the relationship between mental health and physical health: A systematic review.
• Providing support and consultation to families who care for elderly patients with dementia. A focus on modern technology.
• Non-medical strategies to assist patients suffering from depression in the UK. A qualitative study.

Undoubtedly, the recent technological advancements have transformed healthcare, and this trend is expected not only to continue but also to become significantly more prevalent in the coming years. Elements such as artificial intelligence, machine learning, telemedicine, and healthcare cryptocurrencies are destined to change healthcare delivery and management. However, these advancements have also introduced essential challenges related to data privacy and cybersecurity.

• How does telemedicine and comprehensive remote work affect healthcare efficiency?
• What is the effect of healthcare cryptocurrencies with respect to long-term therapeutic efficiency?
• Data privacy and cybersecurity in care settings: the case of Palantir Foundry in the NHS.
• What is the effect of 5G technologies in care delivery and remote medical care consultation?
• What is the effectiveness and related challenges of e-learning in healthcare settings?
• Deep learning has been identified as one of the most promising and feasible diagnostic processes of artificial intelligence. How can deep learning be used to diagnose diseases in patients?
• Technology has shaped healthcare in irreversible ways. However, has it also facilitated a distinct exacerbation in malpractice claims?

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EliScholar > Medicine > Medicine Thesis Digital Library

Yale Medicine Thesis Digital Library

Starting with the Yale School of Medicine (YSM) graduating class of 2002, the Cushing/Whitney Medical Library and YSM Office of Student Research have collaborated on the Yale Medicine Thesis Digital Library (YMTDL) project, publishing the digitized full text of medical student theses on the web as a valuable byproduct of Yale student research efforts. The digital thesis deposit has been a graduation requirement since 2006. Starting in 2012, alumni of the Yale School of Medicine were invited to participate in the YMTDL project by granting scanning and hosting permission to the Cushing/Whitney Medical Library, which digitized the Library’s print copy of their thesis or dissertation. A grant from the Arcadia Fund in 2017 provided the means for digitizing over 1,000 additional theses. IF YOU ARE A MEMBER OF THE YALE COMMUNITY AND NEED ACCESS TO A THESIS RESTRICTED TO THE YALE NETWORK, PLEASE MAKE SURE YOUR VPN (VIRTUAL PRIVATE NETWORK) IS ON.

Theses/Dissertations from 2024 2024

Refractory Neurogenic Cough Management: The Non-Inferiority Of Soluble Steroids To Particulate Suspensions For Superior Laryngeal Nerve Blocks , Hisham Abdou

Percutaneous Management Of Pelvic Fluid Collections: A 10-Year Series , Chidumebi Alim

Behavioral Outcomes In Patients With Metopic Craniosynostosis: Relationship With Radiographic Severity , Mariana Almeida

Ventilator Weaning Parameters Revisited: A Traditional Analysis And A Test Of Artificial Intelligence To Predict Successful Extubation , John James Andrews

Developing Precision Genome Editors: Peptide Nucleic Acids Modulate Crispr Cas9 To Treat Autosomal Dominant Disease , Jem Atillasoy

Radiology Education For U.s. Medical Students In 2024: A State-Of-The-Art Analysis , Ryan Bahar

Out-Of-Pocket Spending On Medications For Diabetes In The United States , Baylee Bakkila

Imaging Markers Of Microstructural Development In Neonatal Brains And The Impact Of Postnatal Pathologies , Pratheek Sai Bobba

A Needs Assessment For Rural Health Education In United States Medical Schools , Kailey Carlson

Racial Disparities In Behavioral Crisis Care: Investigating Restraint Patterns In Emergency Departments , Erika Chang-Sing

Social Determinants Of Health & Barriers To Care In Diabetic Retinopathy Patients Lost To Follow-Up , Thomas Chang

Association Between Fine Particulate Matter And Eczema: A Cross-Sectional Study Of The All Of Us Research Program And The Center For Air, Climate, And Energy Solutions , Gloria Chen

Predictors Of Adverse Outcomes Following Surgical Intervention For Cervical Spondylotic Myelopathy , Samuel Craft

Genetic Contributions To Thoracic Aortic Disease , Ellelan Arega Degife

Actigraphy And Symptom Changes With A Social Rhythm Intervention In Young Persons With Mood Disorders , Gabriela De Queiroz Campos

Incidence Of Pathologic Nodal Disease In Clinically Node Negative, Microinvasive/t1a Breast Cancers , Pranammya Dey

Spinal Infections: Pathophysiology, Diagnosis, Prevention, And Management , Meera Madhav Dhodapkar

Childen's Reentry To School After Psychiatric Hospitalization: A Qualitative Study , Madeline Digiovanni

Bringing Large Language Models To Ophthalmology: Domain-Specific Ontologies And Evidence Attribution , Aidan Gilson

Surgical Personalities: A Cultural History Of Early 20th Century American Plastic Surgery , Joshua Zev Glahn

Implications Of Acute Brain Injury Following Transcatheter Aortic Valve Replacement , Daniel Grubman

Latent Health Status Trajectory Modelling In Patients With Symptomatic Peripheral Artery Disease , Scott Grubman

The Human Claustrum Tracks Slow Waves During Sleep , Brett Gu

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Nursing Dissertation Topics Ideas & Examples

Published by Alvin Nicolas at January 10th, 2023 , Revised On May 8, 2024

Choosing an appropriate nursing dissertation topic is an extremely important step toward producing an exciting and manageable research study. This post aims to help medicine and nursing students select the most appropriate dissertation title according to their research interests.

It should be noted that the subject of nursing encompasses various areas of knowledge, including but not limited to general nursing, community nursing, public health , environmental health, mental health, clinical management, health organization, and occupational health and safety.

So there is plenty to whet your appetite here. Nursing dissertations can be based on either primary research or secondary research. Primary data nursing dissertations incorporate the collection and analysis of data obtained through questionnaires and surveys. Secondary data nursing dissertations, on the other hand, make use of existing literature to test the  research hypothesis .

To help you get started with brainstorming for medicine and nursing topic ideas, we have developed a list of the latest nursing dissertation topics that can be used for writing your dissertation.

These topics have been developed by PhD-qualified writers of our team , so you can trust to use these topics for drafting your dissertation.

You may also want to start your dissertation by requesting  a brief research proposal  from our writers on any of these topics, which includes an  introduction  to the problem,  research questions , aim and objectives ,  literature review  along with the proposed  methodology  of research to be conducted.  Let us know  if you need any help in getting started.

Check our  example dissertations  to get an idea of  how to structure your dissertation .

You can review step by step guide on how to write your dissertation  here.

View our free dissertation topics database.

• Evidence-based Practice Nursing Dissertation Topics
• Child Health Nursing Dissertation Topics
• Adult Nursing Dissertation Topics
• Critical Care Nursing Dissertation Topics
• Dementia Nursing Dissertation Topics

Midwifery Dissertation Topics

• Palliative Care Nursing Dissertation Topics
• Mental Health Nursing Dissertation Topics
• Coronavirus (COVID-19) Nursing Dissertation Topics

2024 Nursing Dissertation Topics

Topic 1: assessing the parental perceptions and attitude towards the adoption of healthy behaviour patterns to control obesity and overweight concerns in young children..

Research Aim: This study aims to analyse the parent’s perceptions and attitudes in relation to healthy behaviours practises to control obesity and overweight disorders in young children. It will also focus on the obstacles parents or caregivers experience when it comes to obesity control in young children.

Topic 2: Investigating the importance of community nursing for the care of Old People suffering from Dementia- A case study of the UK.

Research Aim: This study aims to find the usefulness of nursing practise for the care of people suffering from dementia. This will also focus on how trained nurses are very professional in providing information and support to the people suffering from dementia so that they can prepare themselves to live their life well with dementia. This study will conduct a systematic review of published literature to find the potential roles of nurses in taking care of people living with dementia. Furthermore, it will also look at various characteristics and effectiveness of nurse interventions.

Topic 3: Assessing the role of midwives in providing medical services to pregnant women in low-income countries.

Research Aim: Midwives are health professionals who are specialised in taking care of pregnant women and newborn health. Women living In low-income countries are far less to get midwifery care, and it is very challenging for them to face this situation. The aim of this study is to find the role of midwives in providing medical services to pregnant women in low-income countries. Furthermore, this study will also look at the challenges and factors in getting midwifery care for women faced with low income.

Topic 4: Examining the mental health of nurses working in ICU.

Research Aim: Nurses working in critical care had significantly higher rates of emotional discomfort and poor health than other nurses, which has a negative impact on their mental health. However, it is unknown how intensive care nurses’ physical health impacts the frequency of medical mistakes. This study will examine the mental health of nurses working in ICU and how it affects their work and causes medical errors. Furthermore, it will also analyse the perception of nurses working in ICU.

Topic 5: Examing nursing practices during the stages of newborn development – A comparative study between the UK and US.

Research Aim: This study’s primary goal is to compare nursing staff practises during the stages of newborn development in the US and UK. This study will compare the effects of nurses’ care practises and will look at the challenges that occur during this process and how they handle these challenges.

Covid-19 Medicine and Nursing Research Topics

Topic 1: research to identify the training resources of nurses to combat the covid-19 pandemic.

Research Aim: Nursing staff plays a vital role in treating and recovering patients from illness. This study will identify the training programs and resources designed for nursing staff to combat the Coronavirus pandemic.

Topic 2: Research to find whether robotic nurses will be a long-lasting solution to treat the patients of Coronavirus.

Research Aim: Medical teams across the globe have been on their toes to combat coronavirus, and substantial human resources have also been invested in overcoming this crisis. This study will focus on collecting information about the idea of using robotic nurses to treat patients of Covid-19. It will reveal the advantages and disadvantages of using robotic nurses.

Topic 3: Research to analyse the risk of nurses getting affected while treating Covid-19 patients

Research Aim: This study will focus on analysing the risks faced by nurses and the medical team. It will discuss the safety measures adopted to protect the medical staff, the challenges they face, and appropriate solutions to minimise them.

Topic 4: Research to identify the impacts of Coronavirus on pharmaceutical industries

Research Aim: This study will focus on identifying the impacts of coronavirus on pharmaceutical industries, production, and supply of medicines. It will discuss the possible ways to combat COVID-19.

Topic 5: Research to know the contributions of pharmaceutical industries to combat Covid-19

Research Aim: This study will focus on identifying the contributions of pharmaceutical industries to combat Covid-19. Did COVID-19 increase the business of pharmaceutical sectors?

More Coronavirus and Nursing Dissertation Topics

• Coronavirus research: Keys to diagnosis, treatment, and prevention of SARS.
• Investigating the nurses in Australia issue plea to stop violence, theft of sanitizer and masks.
• To study and analyse the emergency Coronavirus guidelines for nurses and medical staff across the globe with a particular focus on the USA and the UK.
• Coronavirus in nursing homes: ‘We are going to see deaths’ – A case study of the UK nursing homes
• Why are nursing homes at risk during the Coronavirus pandemic? – Case study of any European state
• How nurses and medical staff can help parents and children cope with the mental issues and uncertainly in the midst of coronavirus crisis
• To devise strategies to combat testing and prevention kits in hard-hit nursing homes.
• How coronavirus has the potential to lead shortage of nurses and doctors across the globe?

Nursing and Medicine Dissertation Topics for 2023

Topic 1: impact of coronavirus on the pharmaceutical industry.

Research Aim: This research aims to identify the impact of Coronavirus on the pharmaceutical industry.

Topic 2: The role and impact of occupational safety and health in medical clinics

Research Aim: This research aims to measure the impact of occupational safety and health in medical clinics.

Topic 3: Increasing work pressure and occupational health concerns

Research Aim: This research aims to address increasing work pressure and occupational health concerns during a pandemic.

Topic 4: How researchers’ nurses may enhance the operation of clinical research?

Research Aim: The quality improvement of the performance of health care includes scientific study. The research team from the place where there was a shortage of research has established a steadily growing spectrum of testing within the Bradford Teaching Hospitals Foundation Trust. In this research, the main emphasis would be on the key role of research nurses.

Topic 15: Developing effective nursing strategies for dealing with patients possessing acute and chronic pain: A case study of NHS

Research Aim: The concept of nursing has evolved since recent times. Many health care institutions have developed effective strategies to increase nursing efficiency. Therefore, the main purpose of the research is to develop effective nursing strategies for dealing with patients possessing acute and chronic pain by analysing the case study of the NHS.

Topic 6: Critical analysis of community nursing and health care needs: A comparative analysis of UK and USA

Research Aim: Nursing and health care needs have a direct and positive relationship. The main purpose of this research is to conduct a critical analysis of community and health care needs. This research will compare the UK and USA nursing practices and provide recommendations to improve the existing strategy.

Topic 7: Analysing the societal acceptance of Marijuana: The case of developing countries

Research Aim: The purpose of this study is to contemplate upon the key benefits that the use of Marijuana, within a medicinal capacity, has. Ideally, in developing countries, the use of marijuana is considered “Taboo” or unacceptable by the members of the community/society. Hence, the study intends to analyze the societal acceptance of Marijuana within developing countries.

Topic 8: Developing effective nursing strategies for dealing with patients suffering Coronavirus disease: A case study of NHS

Research Aim: The coronavirus has taken the world by storm, infecting millions in nearly 200 countries. Many health care institutions have developed strategies to increase nursing efficiency. Therefore, the main purpose of the research is to identify effective nursing strategies for dealing with patients possessing coronavirus by analysing the case study of NHS.

Topic 9: Coronavirus research: Keys to diagnosis, treatment, and prevention of SARS

Research Aim: This research will discuss the basic life cycle and replication of the well-studied coronavirus, mouse hepatitis virus (MHV), identifying the unique characteristics of coronavirus biology and highlighting critical points where research has made significant advances, and which might represent targets for antivirals or vaccines. Areas where rapid progress has been made in SCV research, will be described. Finally, areas of need for research in coronavirus replication, genetics, and pathogenesis will be summarised.

Mental Health Dissertation Topics

• Investigating the effectiveness of psychiatric treatment and medicine for patients suffering schizophrenia – A qualitative study based on UK mental health nurses and patients
• Exploring the legal aspects of mental health research in the UK
• To study and determine the causes to increasing number of suicides in the urban youth population in the developing world
• The role of socioeconomic backgrounds on the mental health of individuals
• Investigating the impact of early maternal mental illness on children
• Parents with serious mental health problems from the perspective of professionals who offer support
• Treatment of mental health difficulties by combining psychological and complementary therapies
• To perform an interpretative phenomenological analysis to treat older people with long term mental health difficulties
• To identify the barriers and risks associated with personalization within the context of mental illness
• To explore mental illness by conducting a biographical narrative study
• Deconstructing mental health difficulties: A critical enquiry into the views and opinions of professionals dealing with families, parents, and children

How Can ResearchProspect Help?

ResearchProspect writers can send several custom topic ideas to your email address. Once you have chosen a topic that suits your needs and interests, you can order for our dissertation outline service which will include a brief introduction to the topic, research questions , literature review , methodology , expected results , and conclusion . The dissertation outline will enable you to review the quality of our work before placing the order for our full dissertation writing service!

Occupational Health and Safety Nursing Dissertation Topics

• To investigate occupational health and safety risks in the UK health care sector: Preventive techniques and recommended practices
• A quantitative study to evaluate the understanding and knowledge nurses have of occupational risks in an operating theatre environment
• To investigate the impact of occupational safety and health on the job performance of nurses
• To identify and discuss factors affecting the practice of occupational health nursing in London
• The role and impact of occupational safety and health in medical clinics
• To identify and discuss key occupational safety and health risks, challenges, and concerns in China
• Workplace health management and the role of occupational health nurses
• Increasing work pressure and occupational health concerns
• Occupational safety and health risks and practices among Filipino nurses
• Adopting a multi-climate approach to address patient safety issues in the nursing work environment
• To assess and understand occupational risks and nursing duties from an ergo logical perspective
• The need to realise the increasing importance of occupational safety and health issues in industrialised societies

“ Complete  this short online form  and provide as much information as possible to receive instant quotes from our writers specialising in your area of research . “

Environmental Health Dissertation Topics

• Improving awareness on environmental health issues by encouraging community participation
• To identify and analyse various environmental health concerns in the health care sector
• To determine the possibility of food poisoning and foot-related illness in urban regions from the perspective of environmental health
• Constrained ordinal models with application in occupational and environmental health
• To examine the impact of secondhand smoke on public health with particular focus on the relevant control strategies
• An investigation into the attitudes of bar staff workers to environmental tobacco smoke and the varying provision of smoke-free areas within public houses
• To study and understand the impact of traffic calming procedures on local air quality
• Investigating how reusable cleaning cloths can help to reduce cross-contamination within the food industry
• Analysing older driver behaviour and road safety
• To review public health nurses’ opinions on environmental hazards and health effects
• Disposing toxic wastes from the perspective of environmental health
• Recommended sanitary hygiene practices for developing countries – A quantitative study
• A qualitative study to address arsenic and lead poisoning issues

Related:  Environmental Engineering Dissertation Topics

Also Read This:   Occupational And Environmental Health Thesis And Dissertations

Evidence-Based Practice Dissertation Topics

• To identify and discuss evidence-based practices that enable nurses to provide high-quality care
• Use of evidence and knowledge management in clinical practice
• How the health care needs of elderly cancer patients can be satisfied with evidence-based nursing programme
• Investigating the use of evidence-based medicine for disease management
• To study the effectiveness of evidence-based practice in the health care industry
• To investigate the relationship between evidence-based practice and the research process
• To study the basic principles of evidence-based practice in the UK health care industry
• Why is it critical for nurses to base the foundation of their practices on reliable evidence?
• Barriers to implementing evidence-based practice and the strategies/organisations used to avoid these barriers
• The role of ethics and leadership in evidence-based nursing practice

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Health Organisations Dissertation Topics

• The Highest Attainable Standard: The World Health Organisation, Contentious Politics of Human Rights and the global health governance
• Factors contributing to efficient service delivery – A qualitative study on the implementation of health policies in Argentina
• Integrating technology, process and the people in lean healthcare
• Should World Health Organisation do more to satisfy the health care needs of people in the developing world? – The current programmes and future ambitions
• An investigation in the health care plans and associated costs of countries across the globe
• To study strategic management policies and strategies of World Health Organisation
• Investigating the power, culture, and dynamics of National Health Service in the UK
• Factors influencing the healthcare policies of new health organisations
• The extent of NHS focus on providing services to elderly
• Research trends and directions within the World Health Organisation
• Exploring practices and experiences of midwives in regards to the evaluation of maternal postnatal genital tract health
• Investigating midwifery practice in the third stage of labour
• To study the professional care in midwifery practice with a focus on woman centered-care
• To determine the factors contributing to midwives decision to stay in midwifery
• How do midwives perceive normal birth and how their ability to practice and support normality might be influenced by the professional and organisational culture of a maternity unit?
• A feminist technoscience perspective of the midwife’s role
• To investigate the challenges associated with carrying out a water-birth randomised controlled trial
• To what extend do midwives can facilitate informed choices among pregnant women?
• To identify and discuss the factors influencing the competence of midwives in a clinical setting
• The role of midwifery in relation to health risks to women due to postpartum depression

Community Nursing Dissertation Topics

• The impact of community participation on social inclusion, self-perception, and everyday lives of participants
• Quality of life, good practices, and senior citizens in residential care homes
• To investigate the impact of existing welfare ideologies and policies on the elderly in Leicestershire
• To what extent the community care has met the needs of the elderly with mental health difficulties after being discharged from long-stay psychiatric clinics? – A review of literature from the past 10 years
• Exploring the relationship between ethnicity and community nursing facilities in London
• Obesity awareness and prevention: Can food labelling help to deal with obesity problems in the USA?
• The role of community nursing practice in relation to health promotion
• Recommended practices and policies to ensure high-quality community nursing services to pregnant women
• Health care needs of children and the community nursing service in Leicestershire
• Factors affecting the quality of life of older people – A review of community nursing practices and challenges

Children Health Nursing Dissertation Topics

• Improving, recording, and perceiving school children’s health from the perspective of school health nursing
• Critical evaluation of child health nursing through education and practice
• Identifying challenges and support processes of child health nursing in developing countries
• To investigate the skills and abilities required to promote and sustain the emerging practice of child health nursing
• Leadership and intellectual skills are needed to be successful in positions of leadership and caring for children
• Caring for young people and children with complicated health needs
• To explore the effects of child patient death on nursing staff in a clinical setting: A literature review
• To understand children’s perspectives on community nursing
• To identify factors that can help to improve breastfeeding initiation practices among community nurses in the UK
• Children with congenital heart diseases and the role of parents – A literature review

Related:  Top QA on Children Health Nursing

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Clinical Management Dissertation Topics

• Clinical governance strategies and practices at National Health Services
• Hospitalised patients with diabetes and clinical decision support systems
• Developing optimum strategies for management of patients in adult intensive care units
• Clinical management of patients with prostate cancer – The risks and challenges
• Effectively managing elderly patients in a clinical setting
• Optimal management plan for patients with post-traumatic stress issues
• Use of advanced technology tools to improve clinical management efficiency
• To study various management strategies in surgical cases

Important Notes

As a student of medicine and nursing looking to get good grades, it is essential to develop new ideas and experiment with existing medicine and nursing theories – i.e., to add value and interest in the topic of your research.

The field of medicine and nursing is vast and interrelated to so many other academic disciplines like civil engineering ,  construction ,  law ,  healthcare , mental health , artificial intelligence , tourism , physiotherapy , sociology , management , marketing, cryptocurrencies and architecture . That is why it is imperative to create a project management dissertation topic that is articular, sound, and actually solves a practical problem that may be rampant in the field.

We can’t stress how important it is to develop a logical research topic; it is the basis of your entire research. There are several significant downfalls to getting your topic wrong; your supervisor may not be interested in working on it, the topic has no academic creditability, the research may not make logical sense, and there is a possibility that the study is not viable.

This impacts your time and efforts in  writing your dissertation  as you may end up in the cycle of rejection at the very initial stage of the dissertation. That is why we recommend reviewing existing research to develop a topic, taking advice from your supervisor, and even asking for help in this particular stage of your dissertation.

While developing a research topic, keeping our advice in mind will allow you to pick one of the best medicine and nursing dissertation topics that fulfil your requirement of writing a research paper and add to the body of knowledge.

Therefore, it is recommended that when finalizing your dissertation topic, you read recently published literature to identify gaps in the research that you may help fill.

Remember- dissertation topics need to be unique, solve an identified problem, be logical, and be practically implemented. Take a look at some of our sample medicine and nursing dissertation topics to get an idea for your own dissertation.

How to Structure your Dissertation on Medicine and Nursing

A well-structured   dissertation can help students   to achieve a high overall academic grade.

• A Title Page
• Acknowledgements
• Declaration
• Abstract: A summary of the research completed
• Table of Contents
• Introduction : This chapter includes the project rationale, research background, key research aims and objectives, and the research problems to be addressed. An outline of the structure of a dissertation  can also be added to this chapter.
• Literature Review :  This chapter presents relevant theories and frameworks by analysing published and unpublished literature available on the chosen research topic, in light of  research questions  to be addressed. The purpose is to highlight and discuss the relative weaknesses and strengths of the selected research area whilst identifying any research gaps. Break down of the topic, and key terms can have a positive impact on your dissertation and your tutor.
• Methodology:  The  data collection  and  analysis  methods and techniques employed by the researcher are presented in the Methodology chapter which usually includes  research design,  research philosophy, research limitations, code of conduct, ethical consideration, data collection methods and  data analysis strategy .
• Findings and Analysis:  Findings of the research are analysed in detail under the Findings and Analysis chapter. All key findings/results are outlined in this chapter without interpreting the data or drawing any conclusions. It can be useful to include  graphs ,  charts and  tables  to this chapter to identify meaningful trends and relationships.
• Discussion  and  Conclusion: The researcher presents his interpretation of results in this chapter, and states whether the research hypothesis has been verified or not. An essential aspect of this section of the paper is to draw a linkage between the results and evidence from the literature. Recommendations with regards to implications of the findings and directions for the future may also be provided. Finally, a summary of the overall research, along with final judgments, opinions, and comments, must be included in the form of suggestions for improvement.
• References:  This should be completed in accordance with your University’s requirements
• Bibliography
• Appendices:  Any additional information, diagrams, graphs that were used to  complete the  dissertation  but not part of the dissertation should be included in the Appendices chapter. Essentially, the purpose is to expand the information/data.

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• Consult peers and professors.
• Select a topic that aligns with your passion and career aspirations.

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Best Medical Dissertation Topics Ideas | 35 Examples

An Easy Approach towards Selection of  Medical Dissertation Topics that are bound to Get You A-Grade Do you require a sample of a medical dissertation topic? Are you confused as to which topic should be selected? A medical dissertation is a doctoral thesis that is written by medical students in the final year of their […]

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An Easy Approach towards Selection of  Medical Dissertation Topics that are bound to Get You A-Grade

Do you require a sample of a medical dissertation topic, are you confused as to which topic should be selected.

A medical dissertation is a doctoral thesis that is written by medical students in the final year of their degree. The topic is selected as per the specialties of the students. However, the main focus of the dissertation is on the problem areas on which the scientific knowledge is applied and the solutions are found through the obtained results. As the medical dissertation involves the human aspect, every student must follow ethical and professional standards along with the legal requirements.

Medical dissertation topics may use a wide range of areas. Some topics have already been discussed and researched, while other topics are evolving and creating further interest among the students and researchers. Modern medicine tells us that there is so much in the field that every minute many new issues are taking place. Hence the range of the topics is boundless.

Selection from Already Researched Topics:

Sometimes the already-researched topics help in the selection. The efforts done on those researched topics can be redefined from a new perspective and more suggestions can be given.

Help From the Instructors and seniors:

The seniors and the professionals help out students in the selection of the topics. The experiences of these people give a good reason for the selection of a particular topic.

However, apart from these general approaches, the students can opt from a wide variety of available topics. A list of these topics, important for a medical dissertation, is given below.

• The impact of genetics on disease susceptibility
• The use of telemedicine in remote healthcare delivery
• The role of stem cells in regenerative medicine
• The impact of artificial intelligence in medical diagnostics
• The use of 3D printing in medical technology
• The role of the gut microbiome in health and disease
• The impact of environmental factors on human health
• The use of virtual reality in medical education and training
• The role of the immune system in cancer development
• The impact of the social determinants of health on health outcomes
• The use of big data in medical research and personalized medicine
• The role of epigenetics in disease development
• The impact of climate change on public health
• The use of nanotechnology in medical therapeutics
• The role of the gut-brain axis in mental health
• The impact of the opioid epidemic on public health
• The use of precision medicine in cancer treatment
• The role of the microbiome in brain development and function
• The impact of the COVID-19 pandemic on healthcare systems and delivery
• The use of machine learning in medical imaging analysis.
• Diseases evolving due to global warming and changing environment.
• The effects of nuclear radiation on living beings.
• The internal defense system of a person.
• The genetic disorders and their remedies.
• Cancer and its different types.
• Hereditary diseases and their protection.
• Alcoholism and its repercussions.
• Organ transplantation – different views of societies.
• The importance of health care and some ways to keep oneself healthy.
• Cardiovascular diseases and their ramifications.
• Abortion and the moral grounds.
• The role of UNO in promoting health care facilities in third-world countries.
• The genetic questions in science fiction.
• Cloning and its moral grounds.
• A contemporary approach towards mind and body problems.

The medical profession is a critical one, for it is to deals with the most crucial aspects of human life. A dissertation on medical dissertation topics is important, bearing the importance of the profession.

Related posts:

• Medical law dissertation topics and Research Ideas

Custom Medical Dissertation Topics Brief Service from Experts

However, there can be a general approach and a particular approach in the selection of the dissertation topic. So it depends on a student as to which one is selected by him/her. Undoubtedly, these topics cover important sections of the medical field and can be selected as medical dissertation topics. However, if you are still unable to select a topic for your medical dissertation from the given choices, fill out the form below and place a request for a custom topic mini proposal on your requirements.

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1.       Clinical profile of type I and II respiratory failure patients at a teriary care hospital.

2.       Clinical profile of end stage renal disease in patients undergoing haemodialysis.

3.       Clinical profile of cardiac autonomic neuropathy in diagnosed patients of type 2 diabetes mellitus.

4.       A study of lipid profile in newly diagnosed hypertension.

5.    Correlation of serum cholinesterase levels,clinical score at presetation and severity of organaphosphorous poisioning.

6.       Dengue fever-clinical profile and complications.

7.     Comparative clinical study of patients of herat failure in Type 2 daibates mellitus verses heart failure in non diabetic patients.

8.       Study of serum ferritin in metabolic syndrome.

9.       A study of lipid abnormilities in chronic kidney disease and its implication in cardio vascular disease.

10.    Clinical study of patients of delirium hospitalized in medical wards & in medical intensive care unit.

11.    Clinicoradiologic study of cerebral venous sinus thrombosis.

12.    Study of clinical profile of HIV patients in the elderly age group.

13.    Study of different types of arrythmias occuring in hospitalised patients of acute myocardial infarction.

14.    Comparative study of seropositive and seronegative arthritis in adult.

15.    Clinical profile and pattern of non communicable diseases in age more than 40 years.

16.    Acute kidney injury of obstetric origin.

17.    Comparative study of pneumonia severity index and CURB 65 in assesing the severity of community acquired pneumonia.

18.    Diagnostic efficacy of adenosine deaminase levels in cerebrospinal fluid in patients of tubercular meningitis

19.    A comparision with PCR.AFB culture,cytology for mycobacterium tuberculosis.

20.    To study the clinical,serological,biopsy profile of adult onset nephrotic syndrome.

21.    Study of renal involvement in acute gastroenteritis.

22.    Study of cardiac manifestation in patients with HIV infection and there correlation with CD4 count.

23.    A study of clinical profile of dengue fever in a tertiary care in central india.

24.    Clinical profile of pattern of dyslipidemia and ischemic heart disease in type 2 diabetes mellitus patients.

25.    Clinical profile of patients with organophosphorus poisoning in an intensive care unit in a tertiary hospital.

26.    Study of thyroid hormone profile in acute coronary syndrome.

27.    A study of hepatic dysfunction in denuge fever Association between serum uric acid level with presence and severity of coronary artery disease.

28.    A study of clinical profile of critically III obstetrics patients admitted in medicine wards ICU

29.    Correlation between electrocardiography and echocardiography in patient with left ventricular hypertrophy.

30.    To study diagnosis,diurnal,seasonal variation,risk factors and outcome of patients admitted to ICU.

31.    Clinical profile of rheumatic fever and rheumatic heart disease.

32.    Correlation between and electrocardiography in patients with left ventricular hypertrophy.

33.    The study of etiology and outcome of non-traumatic coma patients at tertiary care hospital.

34.    Study of left ventricular hypertrophy with reference to left ventricular mass index in patients with hypertension.

35.    Study of postprandial hypertriglyceridemia and carotid intima-media thickness in type 2 diabetes mellitus.

36.    To study the role of serum uric acid as risk factor in acute ischemic stroke.

37.    Clinical profile and cardiac evaluation in patients of chronic obstructive pulmonary disease.

38.    Study of correlation of body mass index,waist hip ratio and lipid profile in patients with newly diagnosed type-2 diabetes.

39.    To study haematological manifestations of malaria

40.    To study clinical profile of dilated cardiomyopathy.

41.    Study of cardiovascular manifestions of hypothyroidism.

42.    Evaluation of thyroid function status in patients of chronic kidney disease.

43.    A cross sectional study of glycosylated hemoglobin in ischemic stroke and transient ischemic attacks.

44.    Study of delirium in patients admitted in the intensive care.

45.    Cardiovascular manifestations in alcoholism

46.    Study of clinical profile of catheter related thrombosis incidance and risk factor related to patient and devices.

47.    Predictors of successful weaning of patient on mechanical ventilation in icu.

48.    Clinical profile of cerebral venous sinus thrombosis.

49.    Clinical spectrum of extra pulmonary tuberculosis.

50.    Clinical profile of encephalopathy in medical intensive care-unit.

51.    Clinical profile of amitraz poisoning.

52.    Clinical Study on the complications of haart in people living with HIV

53.    Study of lipid profile in stroke patients.

54.    The study of clinical and lab profile of acute febrile illness with thrombcoytopenia.

55.    Prevalence of HIV associated neurocognitive disorders among HIV infected patients in a tertiary care center.

56.    Study of prognostic factors affecting outcome of cardiomyopathy.

57.    Validation of pneumonia severity index score for community acquired pneumonia in elderly.

58.    Study of factors predicting conversion of non invasive ventilation to invasive ventilation in patients of acute respiratory distress syndrome.

59.    Evaluation of oculoinflammatory diseases for systemic association and outcome after treatment.

60.    Clinical Profile and serum gamma glutamyl transferase estimation in case of alcohol withdrawal.

61.    Serum homocysteine level in sickle cell anaemia and its association with vaso occlusive crisis.

62.    Assessment of left ventricular mass in normotensive subjects without any cardiovasculer risk.

63.    Glycaemic variability and mortaliy in critically ill patients.

64.    Cognititve and functional impairment in elderly diabetics.

65.    Cardiovascular autonomic dysfunction in alcoholic cirrhosis of liver

66.    To study the clinical profile of pyrexia of unknown origin.

67.    Study of the clinical laboratory and radiological features in patients with large vessel vasculitis in a tertiary care centre.

68.    To study sympathetic modulation in patients with systemic inflammatory response syndrome (SIRS) and it’s correlation with mortality.

69.    Clinical profile of patients with anti-neutrophil cytoplasmic antibody associated vasculitis in tertiary care centre.

70.    Renal involvement in HIV positive patients on tenofovir or zidovudine Based art regimen at tertiary care hospital.

71.    Corelation of serum magnesium,calcium and potassium levels with outcome in critically ill invasively ventilated patients in MNICU.

72.    To study the prevalence of metabolic syndrome after initiation of anti-retroviral therapy and comparison of zidovudine vs tenofovir based regimens.

73.    Study of genetic and environmental factors determining warfarin toxicity

74.    To study the menstrual abnormalities and gonadal hormonal dysfunction in women with connective tissue disorders on immunosuppression with intravenous cyclosphamide and oral mycophenolate mofetil

75.    Evaluation and assesment of the utility of NT-pro BNP in the emergency diagnosis and in hospital monitoring of patients with dyspnea.

76.    Echocardiographic study of left ventricular diastolic dysfunction in type 2 diabetes mellius

77.    Spectrum of acute renal failure patients requiring haemodialysis at medical college hospital.

78.    A clinical study of acute ischemic stroke with reference to colour doppler sonography of the extra cranial carotid vessels.

79.    Clinical profile and echocardiographic findings of patients with cardiomyopathy at tertiary care hospital.

80.    Assessment of the clinical profile and risk factors associated with myocardial infarction in young adults.

81.    Study of the effects of a low protein diet on nutritional status of patients with chronic kidney disease not on dialysis.

82.    Assessment of thyroid function among the young asymptomatic male members of indian armed forces.

83.    A compareative study of renoprotective property of n-acetylcysteine in cis platinum based chemotherapies.

84.    To study the etiological factors,symptoatology and outcome in case of acute pancreatitis.

85.    Clinico-bacteriological study of urinary tract infectons in catheterized patients in hospital.

86.    Clinico biological profile of dengue and malaria with special reference to inflammatory markers.

87.    Ultrasonographic evaluation of gallbladder

88.    contractility in patients of Type 2 diabetes mellitus with & without autonomic neuropathy.

89.    Clinico-endoscopic predictors of clinical outcome in patients with upper gastro-intestinal bleeding.

90.    Electrocardiographic and echocardiographic assessment in patients with chronic obstructive pulmonary disease.

91.    Clinicopathological profile of patients with pancytopenia.

92.    Nonalcoholic fatty liver disease in type 2 diabetes mellitus and it’s correlation with cardiovascular risk factors.

93.    Study of renal osteodystrophy and serum vitamin D level in cases of chronic kidney disease.

94.    Study of clinical features of patients presenting with dengue viral infection     at tertiary care hospital.

95.    Clinical profile of chronic kidney disease patients at tertiary care hospital.

96.    Study of cardiometabolic risk profile of female patients in tertiary care hospital.

97.    Clinical Study of autonomic dysfunction in patients of type-2 diabetes mellitus in rural hospital.

98.    Clinical profile of megaloblastic amaemia in rural hospital.

99.    study of high sensitivity Creactive protein (hs-CRP) in patients with Ischemic stroke.

100.  Study of clinical profile of acute coronary syndrome with special reference to vitamin D level.

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Choosing the Right Thesis Topics in Medicine

Your thesis or dissertation matters. It's the most important piece of writing you'll ever do as a student, and perhaps your life. The biggest stumbling block is making a start. You need medicine dissertation topics that appeal and energize you. So the secret to a successful paper is to write about something you have a genuine interest in. The way forward, therefore, is to find a subject you're passionate about.

Dissertationexpert.org has extensive lists that provide plenty of great ideas. Perhaps you need topics for general or mental health, midwifery, or occupational health. Whatever your needs, we have all your medicine research paper topics covered.

Extensive Lists of Medical Thesis Topics

Here are just a few of our interesting topics in the general medicine category:

• Study of alcoholic vs non-alcoholic cirrhosis of the liver in developing countries
• Cardiac evaluation of chronic kidney disease (CKD)
• Cardiometabolic risk evaluation in patients with metabolic syndrome
• Relationships between morbid obesity and obstructive sleep apnea (OSA)
• Biomass smoke links with cardiovascular health
• Sequelae and effective diabetes management
• Other thesis topics in medicine

Some of you reading here will become doctors, and your choices can get overwhelming. You may not decide your area of specialty until later on in your studies. Family practice may have appealed to you in your early 20s. But by the time you've researched the plethora of dissertation topics in medicine things can change. Perhaps Emergency medicine or surgery seems more appropriate. Or maybe you'll opt for pediatrics or internal medicine as a few examples.

Some medical students are lucky. They know what area of medicine they want to pursue early on, and then follow through with their dream. Others may flip-flop somewhat before making a final choice.

Specialist Topics in Medicine

• Infant and children: minor head trauma evaluation
• Rapid recognition of septic shock and resuscitation
• Breast cancer sentinel lymph node biopsy overview
• Treatment overview of femoral hernia and inguinal in older patients
• Rapid identification processes of newborns with CCHD
• Surgical treatments and management of obesity in adolescents

Choosing the right dissertation topics in medicine is never easy. Even so, with the help of Dissertationexpert.org it can become much easier. Our advice is that you consider your area with great care. This is, after all, the crowning achievement of your education. It will have a major influence in the direction your career takes in the years after university.

You'll spend more time editing and polishing your dissertation than you took to write it. In essence, it's a major life decision and not one you should make lightly. Use our extensive topics lists as a way to help you make the best informed choices possible.

You can contact us by message or get in touch using our 24/7 live support feature.

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The Potential of Nanoparticle-Mediated Macrophage Polarization for Solid Tumor Therapy: Evidence Synthesis and Temporal Monitoring

Cancer persists as a significant public health challenge despite treatment advances.  Colorectal cancer is especially a concern because its incidence and mortality are increasing in  young individuals. Solid tumors, such as colorectal cancer, are challenging to treat with  immunotherapies due to their immunosuppressive microenvironment preventing T cell infiltration.  Tumor-associated macrophages (TAMs) play a pivotal role in supporting this immunosuppression  by adopting an anti-inflammatory and pro-tumoral phenotype within the tumor microenvironment.  Leveraging nanoparticles to repolarize TAMs towards a proinflammatory and tumoricidal  phenotype holds promise for solid tumor therapy. However, clinical translation of cancer nanomedicines has been slow. This dissertation aims to address this through quantitative review  of the intersection between the colorectal cancer nanomedicine and macrophage polarization,  and by proposing a novel method of temporally tracking macrophage polarization using  bioluminescent reporter cells.  

Using eLDA topic modeling, the dissertation identifies six major topics in the intersection  of cancer medicine and macrophage polarization, providing insights into nanoparticle design  choices and therapeutic strategies across various cancer types. A scoping review and meta analysis of colorectal cancer nanomedicine over two decades reveal evolving nanoparticle design  strategies and their impact on macrophage polarization. We also demonstrate how a  nanoparticle’s ability to increase macrophages’ ratio of M1 to M2 polarization is correlated with  their efficacy at reducing tumor growth and increasing survival. This dissertation also includes a  technology assessment of how evidence synthesis of preclinical studies informs open science  policy.   

To better temporally track macrophage polarization, the dissertation introduces a method  utilizing THP-1 reporter cells with bioluminescently labeled polarization-relevant transcription  factors. We demonstrated how these reporter cells enable time-resolved activation curves for  tumor-associated macrophages, revealing unique NFκB activation profiles dependent on cancer  type that we linked to the tumor microenvironments immunogenicity. Furthermore, monitoring  monocyte to macrophage differentiation with this method highlights the importance of selecting appropriate differentiation protocols for the intended use. These examples demonstrate the  potential use of this bioluminescent platform to monitor macrophage polarization in response to  immunomodulatory treatments, like macrophage-targeted cancer nanomedicine.  

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Kasturba Medical College, Mangalore Theses and Dissertations

Theses/dissertations from 2021 2021.

“The Impact of Self-Stigma of Seeking Help and Perceived Social Support on Burnout among Clinical Psychologists” , Aavrita A

The impact of self-stigma of seeking help &percieved social support on burnout among clinical psychologists. , Aavrita .

Immediate Effects of Novel Hand Rehabilitation Board on Fine Motor Skills in Children with Cerebral Palsy. , Romita Fernandes. Abraham

"COMPARISON OF THREE SCORING CRITERIA TO ASSESS RECOVERY FROM GENERAL ANAESTHESIA IN THE POST-ANAESTHESIA CARE UNIT- A LONGITUDINAL OBSERVATIONAL STUDY " , Shagun Aggarwal

Comparative predictive validity of Alberta Infant Motor Scale and Infant Neurological International Battery in Low Birth Weight Infants- A Prospective Longitudinal Study. , Polisetti Siva Sai Anand

Antagonistic Asynchrony in Muscle Recruitment Pattern of Forward Reach Movement In Children With Cerebral Palsy. , Sanya Anklesaria

Muscle fatigue response of rotator cuff muscles in sitting and standing postures , Lisanne Aranha

Effectiveness of static weight bearing versus modified constraint induced movement therapy on improving hand function in hemiplegic cerebral palsy- A Randomized Clinical Trial. , Ruth Bavighar

How informed are our patients about generic medicines? – A study from coastal South India , Darshan BB

Morphological variants of the human spleen, a cadaveric study , Murlimanju BV

Association between cervical breast cancer and Diabtetes mellitus among women seeking health care in tertiary hospitals od south India: A cross sectional study , Pratik Kumar Chatterjee

Carcinoma Breast in among Women with Diabetes Mellitus: A Case Control Study , Pratik Kumar Chatterjee

Perception of Empathy among medical students: A cross sectional study , Pratik Kumar Chatterjee

CLINICOMYCOLOGICAL PROFILE OF DERMATOPHYTOSIS IN A TERTIARY CARE HOSPITAL IN SOUTH INDIA , Adyashree Dalai

Study of outcome of Ponseti technique of management for idiopathic clubfoot in a tertiary center in south India , Lulu Damsas

Comparative study of emotional labour &burnout on life satisfaction among school teachers across different educational settings , Meghana Dharampalan

“Comparative Study of Emotional Labor and Burnout on Life Satisfaction Among School Teachers Across Different Educational Settings” , Meghana V. Dharmapalan

“Relationship Between Sexual Fantasy, Sexual Communication, Personality Traits and Sexual Satisfaction in Married Individuals” , Rhea Dhir

Comparing the efficacy of USG guided supraclavicular brachial plexus block with or without intercostobrachial nerve block for forearm surgeries – an observational study , DIKSHA D’MELLO

Does Quality of Sitting influence Functional Mobility in Cerebral Palsy? A cross-sectional study , Kaiorisa N. Doctor

Factors effecting gait velocity in osteoarthritis knee-An observational study. , Lisha Gretal D’silva

Effect of Inspiratory Muscle Training on Pulmonary Function, Functional Capacity, Quality Of Life And Length Of Stay in individuals undergoing Cardiac Surgery , Fiona Verdine Dsouza

Relationship of Academic Resilience with Self-Efficacy, and Perceived Social Support; Among Civil Service Aspirants , Neha Eldho

EFFICACY, FEASIBILITY, AND SAFETY OF PERCUTANEOUS IMAGE-GUIDED CATHETER DRAINAGE OF THORACIC, ABDOMINAL, AND PELVIC FLUID COLLECTION , Aishwarya Gadwal

Comparison of efficacy of two different bolus doses of norepinephrine as prophylac-tic to prevent post-spinal hypotension during elective caesarean section , PRANATHI GARAPATI

Trends in Frailty and its Associated factors in Community Dwelling Elderly Indian Population during COVID-19 Pandemic- A Prospective Analytical Study , Karan Gautam

Speech Sound acquisition in some south Indian Dravidian languages: A systematic review , Jesica George

Comparison of Femoral nerve block with Dexmedetomidine and Adductor canal block with Dexmedetomidine for postoperative analgesia for Total Knee Arthroplasty . , NEHA GEORGE

Assessment Of Cardiovascular Risk Factors In Patients With Osteoarthritis Knee , Sagar Goel

Effectiveness of Intermittent Cervical Traction with and without Neural Mobilization in Discogenic Cervical Radiculopathy , Aditi Goyal

Study of maternal and cord blood vitamin B12 levels with anthropometry in term neonates born to normal and malnourished mothers: a hospital based cross sectional study , Sugapradha a. GR

Development of a Questionnaire to Determine the Intervention and Service Delivery Practices of Speech-Language Pathologists for Children with Speech Sound Disorders in India , Shaily Gupta

Relationship between Physical Activity, Objective Sleep Parameters and Circadian Rhythm in Patients with Head and Neck Cancer receiving Chemoradiotherapy- A Longitudinal Study , Rachita Gururaj

“Emotional Contagion, Perceived Stress and Coping Strategies Among Nurses” , Saumya Hariharan

Assessment of knowledge and belief about stuttering among undergraduate medical students , Anushree Harihar

Association of serum lipid levels and other systemic risk factors with retinal hard exudates in diabetic retinopathy patients. , Harshita Mukesh Hiran

Assessment of risk of Diabetes Mellitus by using Indian Diabetes Risk Score among Housekeeping staff , Ramesh Holla

“Emotional Intelligence, Self-compassion, and Life-Satisfaction In Clinical Psychologists” , Vania Jacob

UPPER-CROSSED SYNDROME AND DISABILITY IN SHOULDER ADHESIVE CAPSULITIS. , Aishwarya Jaideep

Study to assess the role of doppler ultrasound in evaluation of arteriovenous hemodialysis fistula and the complications of hemodialysis access , Ishank Jain

Relationship between burnout compassion fatigue, work environment & mindfulness in medical residents , Pranay Javeri

“Relationship Between Burnout, Compassion Fatigue, Work Environment and Mindfulness in Medical Residents” , Pranay Harichandra Javeri

“Dating Anxiety in Emerging Adults” , Jisha V. Jayaprakash

“Relationship Between Tolerance for Disagreement and Mindfulness in Married Males and Married Females” , Jahnavi Jha

Antibiotic usage and susceptibility patterns in Uncomplicated UTI in a Tertiary Hospital in South India , Christy John

Association of bed rise difficulty scale with trunk impairment and functional scales among stroke patients , Leena G. John

Is there a correlation between Pediatric Berg Balance Scale and Centre of Pressure Excursion measured through Dual Axis Static Force Plate™ to assess Balance in Children with Spastic Cerebral Palsy and Typically Developing? , Niharika Joshi

Comparison of Sensory Processing Responses in Cerebral Palsy Subtypes and Typically Developing Children (7-36 months): A Cross Sectional Study. , Archana Antony K

‘A study on the Role of Learned Helplessness, Selfefficacy and Perceived Social Support in Determining Resilience in Parents of Children with Neurodevelopmental Disorders’ , Benaisha Khurshed Katrak

A study of correlation of maternal serum zinc levels with breast milk and cord blood of late preterm neonates , Rashmi Katti

Correlation of histopathology and direct immunofluorescence findings in clinically diagnosed prurigo nodularis , Haritha K

Difference in proximal femur loading due to muscle activity during partial weight bearing and NWB standing- A cross-sectional study. , Smital Kshirsagar

Effect of Sesamol on neurobiochemical changes in diet induced (DIO) obesity model of Zebra fish (Danio rerio) , Rashmii K.S.

Importance of integration of medical ethics with undergraduate medical curriculum- Instructors and student’s perspectives. , Rashmii K.S.

Long-term potentiation (LTP): A simple yet powerful cellular process in learning and memory , Rashmii K.S.

Parkinson's Disease Overview: Alternative Potential Curcumin Treatment, Current Treatment and Prevalence Among Ethnic Groups , Rashmii K.S.

Smart brain of India vs. tricky drugs , Rashmii K.S.

The Role of Professionalism and Ethics Training: Instructor’s and Student’s perspectives in a medical College , Rashmii K.S.

Violence Against Doctors: A Qualitative Study On This Rising Predicament , Rashmii K.S.

Morphometric study of the gracilis muscle and its pedicles , Chettiar Ganesh Kumar

Comparative study of bed side tests to assess difficult airway in paediatric patients , S.Abinandha Kumar

Euphorbia thymifolia (Linn.)- A review on ethno pharmacological properties , Vasavi Kumblekar

COMPARISON OF KNOWLEDGE, ATTITUDE, AND PRACTICE TOWARDS THE USE OF SUNSCREEN IN DAILY LIFE BETWEEN FIRST -AND THIRD -YEAR MEDICAL STUDENTS , Aarushi Lall

‘Feminist Identity, Socio-cultural Attitude Towards Appearance, and Body Images issues in Emerging Adult Women’ , Sheena Lonappan

A novel approach to quantify the Dynamic Windlass Mechanism , Ishita Mahajan

METFORMIN VERSUS INSULIN IN THE MANAGEMENT OF GESTATIONAL DIABETES , Varikuti Manogna

Cognitive abilities among employed and unemployed middle-aged women – a systematic review , Aswini M

‘Emotional Intelligence, Job Satisfaction and Psychological Well-being Among Nurses’ , Chetna M

RELATIONSHIP OF COMPUTER AIDED DESIGN(CAD)-BASED PHOTOGRAMMETRY FOR FACIAL DYSFUNCTION WITH FACIAL GRADING SYSTEMS FOR BELL’S PALSY: A PROSPECTIVE OBSERVATIONAL STUDY , Ankita Mehendale

“Effect of Sensation Seeking and Anxious Traits on Suicidal Ideation Among Adults by Birth Order” , Haripriya G. M

Clinical & radiological assessment of intertrochanteric fractures treated with PFN A2 , Harish M

Effect of a home-based pulmonary rehabilitation programme on respiratory function, functional capacity, and quality of life in patients with chronic obstructive pulmonary disease , Vaibhavi Mhatre

Profiling Communication Characteristics of Individuals with Acquired Neuro-communication Disorder in a Tertiary Care Setup , Nikita Subudhi M

Relationship between weight bearing symmetry, trunk control and fear of fall amongst subjects with stroke: A cross sectional study , VIVIAN NEHAL MONIS

Lower extremity muscle recruitment pattern during sit to stand transfer in children with cerebral palsy as compared to typically developing children- a cross sectional study. , Kiran P. Nadgauda

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Effect Of Yoga On Perceived Stress And Pulmonary Function In High Stressed Postmenopausal Women , Vinodini NA

Refractory errors, blood groups & diabetes mellitus: A corrleative study in south Indian population , Vinodini NA

Comparison of Functional outcomes for displaced extra-articular distal radius fractures managed by Conservative versus Operative methods: A Prospective cohort study , Muhammed Ehsan Nazeer

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Assessment of attitude among public towards stuttering in a coastal city of Southern Karnataka , Prithvi N

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‘Effect of Religiosity on Attitude Towards Euthanasia in Medical Students’ , Sumedha Pawar

Development Of A Questionnaire To Determine The Clinical Assessment Practices Of Speech-Language Pathologists For Children With Speech Sound Disorders In India , Prasila Elsa Philip

Correlation of oxidised LDL with oxidant and antioxidant enzymes in subjects with elevated LDL levels , Pooja p

Association of emotional intelligence of primigravida mothers with breastfeeding self efficacy in the early postpartum period and exclusive breastfeeding rates up to 6 months. , Priyanka Reddy p

Morphometric study of the Sartorius muscle and its vascular pedicles , M.D. Prameela

Comparison of the analgesic duration using ultrasound guided popliteal sciatic nerve block between diabetics with neuropathy and non-diabetics without neuropathy , GANESH PRASAD

Early follicular and Mid-luteal phase associated changes in Lower extremity Muscle strength , length and Agility in amateur female athletes – a Prospective Analytical study , Vishnu Priya

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THERMAL ULTRASOUND, MANIPULATION AND EXERCISE ON PAIN AND MOUTH OPENING IN CHRONIC TEMPOROMANDIBULAR JOINT DISORDER: A CASE REPORT , Suchita S. Rao

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PRELEVANCE OF WORK RELATED DERMATOLOGICAL SYMPTOMS IN HEALTH CARE WORKERS IN COVID-19 ERA , Rana R

COMPARISON OF TWO ROUTINE FACIAL EXERCISE PROTCOLS FOR BELL’S PALSY- A RANDOMIZED CONTROLLED TRIAL , Stephanie Santiago

Profiling selected speech characteristics in individuals with Chronic Cough , Nawal Palakkal Sathar

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Personalized oxygenation could improve outcomes for patients on ventilators

Supplemental oxygen is among the most widely prescribed therapies in the world, with an estimated 13 to 20 million patients worldwide requiring oxygen delivery by mechanical ventilation each year. Mechanical ventilation — a form of life support — is a technology that moves breathable air into and out of the lungs, acting like a bellows. Ventilators have moved far beyond the “iron lung” machines some people might picture; now, apparatuses have progressed to sophisticated, compact digital machines that deliver oxygen through a small plastic tube that goes down the throat.

Despite technological advancements, the correct amount of oxygen to deliver to each patient has remained a guessing game. Clinicians prescribe oxygen levels by using devices that record SpO 2 saturation, which measures the amount of oxygen in a patient’s blood. However, prior research was unable to establish whether a higher or lower SpO 2 target is better for patients.

“The standard of care is to maintain oxygen saturation between 88 and 100; within that range, doctors have had to choose an oxygen level for ventilation without having high-quality data to inform their decision-making,” said Kevin Buell, MBBS, a pulmonary and critical care fellow at the University of Chicago Medicine. “Whether we like it or not, making that decision for each patient exposes them to the potential benefits or harms of the chosen oxygen level.”

To take the guesswork out of ventilation, Buell and a group of other researchers used a machine learning model to study whether the effects of different oxygen levels depend on individual patients’ characteristics. The results, published in JAMA , suggest that personalized oxygenation targets could reduce mortality — which could have far-reaching impacts on critical care.

Previously, some research groups conducted randomized trials to investigate whether higher or lower oxygen levels are better for patients overall, but most produced no clear answer. Buell and his collaborators hypothesized that instead of indicating that oxygen levels don’t affect patient outcomes, the neutral results might indicate that the treatment outcomes for different oxygen levels varied by patient and simply averaged to zero effect in randomized trials.

As personalized medicine continues gaining traction, there is a growing interest in using machine learning to make predictions for individual patients. In the context of mechanical ventilation, these models could potentially use specific patient characteristics to predict an ideal oxygen level for each patient. These characteristics included age, sex, heart rate, body temperature and reason for being admitted to an Intensive Care Unit (ICU).

“We set out to create an evidence-based, personalized prediction of who would benefit from a lower or higher oxygen target when they go on a ventilator,” said Buell, a joint first author on the study.

Those previous randomized trials didn’t go to waste — Buell and his collaborators used data from those studies to design and train their machine learning model. After the model was developed using trial data collected in the U.S., the collaborators applied it to data from patients across the world in Australia and New Zealand. For patients who received oxygenation that fell within the target range the machine learning model predicted to be beneficial for them, mortality could have decreased by 6.4% overall.

It’s impossible to generalize predictions based on a single characteristic — for example, not all patients with brain injuries will benefit from lower oxygen saturation even though the data skew in that direction — which is why clinicians need a tool like the researchers’ machine learning model to piece together the mosaic of each patient’s needs. However, Buell pointed out that although the algorithm itself is complicated, the variables healthcare teams would input are all familiar clinical variables, making it easy for anyone to implement this kind of tool in the future.

At UChicago Medicine, healthcare teams can already use algorithms directly integrated into the electronic health record (EHR) system to inform other areas of clinical decision-making. Buell hopes mechanical ventilation can one day function the same way. For hospitals that might not have the resources to integrate machine learning into an EHR, he even envisions creating a web-based application that would allow clinicians to type in patient characteristics and obtain a prediction that way — like an online calculator. A lot of validation, testing and refinement needs to happen before clinical implementation can become a reality, but the end goal makes that future research well worth the investment.

In an editorial that accompanied the article’s publication, renowned critical care expert Derek Angus, MD, wrote: “If the results are true and generalizable, then the consequences are staggering. If one could instantly assign every patient into their appropriate group of predicted benefit or harm and assign their oxygen target accordingly, the intervention would theoretically yield the greatest single improvement in lives saved from critical illness in the history of the field.”

The study, “ Individualized Treatment Effects of Oxygen Targets in Mechanically Ventilated Critically Ill Adults ,” was published in the Journal of the American Medical Association in March 2024. Co-authors include Kevin G. Buell, Alexandra B. Spicer, Jonathan D. Casey, Kevin P. Seitz, Edward T. Qian, Emma J. Graham Linck, Wesley H. Self, Todd W. Rice, Pratik Sinha, Paul J. Young, Matthew W. Semler and Matthew M. Churpek.

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Year in Cardiovascular Medicine 2023

The 2023 Year in Cardiovascular Medicine series highlights and summarises key topics in cardiology from the past 12 months. Explore the collection, which is available to read for free online and register to receive e-mail alerts from European Heart Journal .

The year in cardiovascular medicine 2023: the top 10 papers in arrhythmias

The year in cardiovascular medicine 2023: the top 10 papers in dyslipidaemias, the year in cardiovascular medicine 2023: the top 10 papers in heart failure and cardiomyopathies, the year in cardiovascular medicine 2023: the top 10 papers in valvular heart disease, the year in cardiovascular medicine 2023: the top 10 papers in interventional cardiology.

The year 2023 brought tremendous innovation in interventional cardiovascular medicine, with numerous publications from long-awaited trials that were designed to provide definitive answers regarding the role of physiology, imaging, novel devices, and novel applications of structural interventions. While the 10 papers presented below admittedly represent an arbitrary choice (Graphical Abstract), there are thousands of other ones equally worthy of mention.

The year in cardiovascular medicine 2023: the top 10 papers in diabetes and metabolic disorders

The year in cardiovascular medicine 2023: the top 10 papers in ischaemic heart disease, the year in cardiovascular medicine 2023: the top 10 papers in thrombosis and antithrombotic treatment.

Preventing thrombosis while minimizing bleeding is paramount in antithrombotic therapy. Recent progress has brought this goal closer. This Viewpoint highlights recent pivotal papers on antithrombotic strategies, with findings summarized in the Graphical Abstract.

The year in cardiovascular medicine 2023: the top 10 papers in cardio-oncology

Over the past year, there have been many outstanding contributions to the field of cardio-oncology, and the scope and depth of them are exemplified herein. The first to mention is the update by the International Late Effects of Childhood Cancer Guideline Harmonization Group on tailored cardiomyopathy surveillance recommendations for healthcare providers and childhood and young adult cancer patients, who are at least 2 years from the completion of cancer therapy, which included anthracyclines and/or radiation therapy (RT) with heart exposure.

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Gene variants foretell the biology of future breast cancers in Stanford Medicine study

In a finding that vastly expands the understanding of tumor evolution, researchers discover genetic biomarkers that can predict the breast cancer subtype a patient is likely to develop.

May 30, 2024 - By Krista Conger

Stanford Medicine researchers found that inherited gene sequences can predict what type of breast cancer a patient is likely to develop, along with how aggressive that cancer may be.   Emily Moskal

A Stanford Medicine study of thousands of breast cancers has found that the gene sequences we inherit at conception are powerful predictors of the breast cancer type we might develop decades later and how deadly it might be.

The study challenges the dogma that most cancers arise as the result of random mutations that accumulate during our lifetimes. Instead, it points to the active involvement of gene sequences we inherit from our parents — what’s known as your germline genome — in determining whether cells bearing potential cancer-causing mutations are recognized and eliminated by the immune system or skitter under the radar to become nascent cancers. 

“Apart from a few highly penetrant genes that confer significant cancer risk, the role of hereditary factors remains poorly understood, and most malignancies are assumed to result from random errors during cell division or bad luck,” said Christina Curtis , PhD, the RZ Cao Professor of Medicine and a professor of genetics and of biomedical data science. “This would imply that tumor initiation is random, but that is not what we observe. Rather, we find that the path to tumor development is constrained by hereditary factors and immunity. This new result unearths a new class of biomarkers to forecast tumor progression and an entirely new way of understanding breast cancer origins.”

Curtis is the senior author of the study, which will be published May 31 in Science . Postdoctoral scholar Kathleen Houlahan , PhD, is the lead author of the research.

“Back in 2015, we had posited that some tumors are ‘born to be bad’ — meaning that their malignant and even metastatic potential is determined early in the disease course,” Curtis said. “We and others have since corroborated this finding across multiple tumors, but these findings cast a whole new light on just how early this happens.”

A new take on cancer’s origin

The study, which gives a nuanced and powerful new understanding of the interplay between newly arisen cancer cells and the immune system, is likely to help researchers and clinicians better predict and combat breast tumors.

Currently, only a few high-profile cancer-associated mutations in genes are regularly used to predict cancers, but these account for a small minority of cases. Those include BRCA1 and BRCA2, which occur in about one of every 500 women and confer an increased risk of breast or ovarian cancer, and rarer mutations in a gene called TP53 that causes a disease called Li Fraumeni syndrome, which predisposes to childhood and adult-onset tumors.

Christina Curtis

The findings suggest there are tens or hundreds of additional gene variants — identifiable in healthy people — that through interactions with the immune system pull the strings that determine why some people remain cancer-free throughout their lives.

“Our findings not only explain which subtype of breast cancer an individual is likely to develop,” Houlahan said, “but they also hint at how aggressive and prone to metastasizing that subtype will be. Beyond that, we speculate that these inherited variants may influence a person’s risk of developing breast cancer. However, future studies will be needed to examine this.”  

The genes we inherit from our parents are known as our germline genome. They’re mirrors of our parents’ genetic makeup, and they can vary among people in small ways that give some of us blue eyes, brown hair or type O blood. Some inherited genes include mutations that confer increased cancer risk from the get-go, such as BRCA1, BRCA2 and TP53.

In contrast, most cancer-associated genes are part of what’s known as our somatic genome. As we live our lives, our cells divide and die in the tens of millions. Each time the DNA in a cell is copied, mistakes happen and mutations can accumulate. DNA in tumors is often compared with the germline genomes in blood or normal tissues in an individual to pinpoint which changes likely led to the cell’s cancerous transformation.

Classifying breast cancers

In 2012, Curtis began a deep dive — assisted by machine learning — into the types of somatic mutations that occur in thousands of breast cancers. She was eventually able to categorize the disease into 11 subtypes with varying prognoses and risk of recurrence, finding that four of the 11 groups were significantly more likely to recur even 10 or 20 years after diagnosis — critical information for clinicians making treatment decisions and discussing long-term prognoses with their patients.

Prior studies had shown that people with inherited BRCA1 mutations tend to develop a subtype of breast cancer known as triple negative breast cancer. This correlation implies some behind-the-scenes shenanigans by the germline genome that affects what subtype of breast cancer someone might develop.

“We wanted to understand how inherited DNA might sculpt how a tumor evolves,” Houlahan said. To do so, they took a close look at the immune system.

It’s a quirk of biology that even healthy cells routinely decorate their outer membranes with small chunks of the proteins they have bobbing in their cytoplasm — an outward display that reflects their inner style.

Kathleen Houlahan

The foundations for this display are what’s known as HLA proteins, and they are highly variable among individuals. Like fashion police, immune cells called T cells prowl the body looking for any suspicious or overly flashy bling (called epitopes) that might signal something is amiss inside the cell. A cell infected with a virus will display bits of viral proteins; a sick or cancerous cell will adorn itself with abnormal proteins. These faux pas trigger the T cells to destroy the offenders.

Houlahan and Curtis decided to focus on oncogenes, normal genes that, when mutated, can free a cell from regulatory pathways meant to keep it on the straight and narrow. Often, these mutations take the form of multiple copies of the normal gene, arranged nose to tail along the DNA — the result of a kind of genomic stutter called amplification. Amplifications in specific oncogenes drive different cancer pathways and were used to differentiate one breast cancer subtype from another in Curtis’ original studies.

The importance of bling

The researchers wondered whether highly recognizable epitopes would be more likely to attract T cells’ attention than other, more modest displays (think golf-ball-sized, dangly turquoise earrings versus a simple silver stud). If so, a cell that had inherited a flashy version of an oncogene might be less able to pull off its amplification without alerting the immune system than a cell with a more modest version of the same gene. (One pair of overly gaudy turquoise earrings can be excused; five pairs might cause a patrolling fashionista T cell to switch from tutting to terminating.)

The researchers studied nearly 6,000 breast tumors spanning various stages of disease to learn whether the subtype of each tumor correlated with the patients’ germline oncogene sequences. They found that people who had inherited an oncogene with a high germline epitope burden (read: lots of bling) — and an HLA type that can display that epitope prominently — were significantly less likely to develop breast cancer subtypes in which that oncogene is amplified.

There was a surprise, though. The researchers found that cancers with a large germline epitope burden that manage to escape the roving immune cells early in their development tended to be more aggressive and have a poorer prognosis than their more subdued peers.

“At the early, pre-invasive stage, a high germline epitope burden is protective against cancer,” Houlahan said. “But once it’s been forced to wrestle with the immune system and come up with mechanisms to overcome it, tumors with high germline epitope burden are more aggressive and prone to metastasis. The pattern flips during tumor progression.”

“Basically, there is a tug of war between tumor and immune cells,” Curtis said. “In the preinvasive setting, the nascent tumor may initially be more susceptible to immune surveillance and destruction. Indeed, many tumors are likely eliminated in this manner and go unnoticed. However, the immune system does not always win. Some tumor cells may not be eliminated and those that persist develop ways to evade immune recognition and destruction. Our findings shed light on this opaque process and may inform the optimal timing of therapeutic intervention, as well as how to make an immunologically cold tumor become hot, rendering it more sensitive to therapy.”

The researchers envision a future when the germline genome is used to further stratify the 11 breast cancer subtypes identified by Curtis to guide treatment decisions and improve prognoses and monitoring for recurrence. The study’s findings may also give additional clues in the hunt for personalized cancer immunotherapies and may enable clinicians to one day predict a healthy person’s risk of developing an invasive breast cancer from a simple blood sample.

“We started with a bold hypothesis,” Curtis said. “The field had not thought about tumor origins and evolution in this way. We’re examining other cancers through this new lens of hereditary and acquired factors and tumor-immune co-evolution.”

The study was funded by the National Institutes of Health (grants DP1-CA238296 and U54CA261719), the Canadian Institutes of Health Research and the Chan Zuckerberg Biohub.

About Stanford Medicine

Stanford Medicine is an integrated academic health system comprising the Stanford School of Medicine and adult and pediatric health care delivery systems. Together, they harness the full potential of biomedicine through collaborative research, education and clinical care for patients. For more information, please visit med.stanford.edu .

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“Rosetta Stone” of cell signaling could expedite precision cancer medicine

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A newly complete database of human protein kinases and their preferred binding sites provides a powerful new platform to investigate cell signaling pathways.

Culminating 25 years of research, MIT, Harvard University, and Yale University scientists and collaborators have unveiled a comprehensive atlas of human tyrosine kinases — enzymes that regulate a wide variety of cellular activities — and their binding sites.

The addition of tyrosine kinases to a previously published dataset from the same group now completes a free, publicly available atlas of all human kinases and their specific binding sites on proteins, which together orchestrate fundamental cell processes such as growth, cell division, and metabolism.

Now, researchers can use data from mass spectrometry, a common laboratory technique, to identify the kinases involved in normal and dysregulated cell signaling in human tissue, such as during inflammation or cancer progression.

“I am most excited about being able to apply this to individual patients’ tumors and learn about the signaling states of cancer and heterogeneity of that signaling,” says Michael Yaffe, who is the David H. Koch Professor of Science at MIT, the director of the MIT Center for Precision Cancer Medicine, a member of MIT’s Koch Institute for Integrative Cancer Research, and a senior author of the new study. “This could reveal new druggable targets or novel combination therapies.”

The study, published in Nature , is the product of a long-standing collaboration with senior authors Lewis Cantley at Harvard Medical School and Dana-Farber Cancer Institute, Benjamin Turk at Yale School of Medicine, and Jared Johnson at Weill Cornell Medical College.

The paper’s lead authors are Tomer Yaron-Barir at Columbia University Irving Medical Center, and MIT’s Brian Joughin, with contributions from Kontstantin Krismer, Mina Takegami, and Pau Creixell.

Kinase kingdom

Human cells are governed by a network of diverse protein kinases that alter the properties of other proteins by adding or removing chemical compounds called phosphate groups. Phosphate groups are small but powerful: When attached to proteins, they can turn proteins on or off, or even dramatically change their function. Identifying which of the almost 400 human kinases phosphorylate a specific protein at a particular site on the protein was traditionally a lengthy, laborious process.

Beginning in the mid 1990s, the Cantley laboratory developed a method using a library of small peptides to identify the optimal amino acid sequence — called a motif, similar to a scannable barcode — that a kinase targets on its substrate proteins for the addition of a phosphate group. Over the ensuing years, Yaffe, Turk, and Johnson, all of whom spent time as postdocs in the Cantley lab, made seminal advancements in the technique, increasing its throughput, accuracy, and utility.

Johnson led a massive experimental effort exposing batches of kinases to these peptide libraries and observed which kinases phosphorylated which subsets of peptides. In a corresponding Nature  paper published in January 2023, the team mapped more than 300 serine/threonine kinases, the other main type of protein kinase, to their motifs. In the current paper, they complete the human “kinome” by successfully mapping 93 tyrosine kinases to their corresponding motifs.

Next, by creating and using advanced computational tools, Yaron-Barir, Krismer, Joughin, Takegami, and Yaffe tested whether the results were predictive of real proteins, and whether the results might reveal unknown signaling events in normal and cancer cells. By analyzing phosphoproteomic data from mass spectrometry to reveal phosphorylation patterns in cells, their atlas accurately predicted tyrosine kinase activity in previously studied cell signaling pathways.

For example, using recently published phosphoproteomic data of human lung cancer cells treated with two targeted drugs, the atlas identified that treatment with erlotinib, a known inhibitor of the protein EGFR, downregulated sites matching a motif for EGFR. Treatment with afatinib, a known HER2 inhibitor, downregulated sites matching the HER2 motif. Unexpectedly, afatinib treatment also upregulated the motif for the tyrosine kinase MET, a finding that helps explain patient data linking MET activity to afatinib drug resistance.

Actionable results

There are two key ways researchers can use the new atlas. First, for a protein of interest that is being phosphorylated, the atlas can be used to narrow down hundreds of kinases to a short list of candidates likely to be involved. “The predictions that come from using this will still need to be validated experimentally, but it’s a huge step forward in making clear predictions that can be tested,” says Yaffe.

Second, the atlas makes phosphoproteomic data more useful and actionable. In the past, researchers might gather phosphoproteomic data from a tissue sample, but it was difficult to know what that data was saying or how to best use it to guide next steps in research. Now, that data can be used to predict which kinases are upregulated or downregulated and therefore which cellular signaling pathways are active or not.

“We now have a new tool now to interpret those large datasets, a Rosetta Stone for phosphoproteomics,” says Yaffe. “It is going to be particularly helpful for turning this type of disease data into actionable items.”

In the context of cancer, phosophoproteomic data from a patient’s tumor biopsy could be used to help doctors quickly identify which kinases and cell signaling pathways are involved in cancer expansion or drug resistance, then use that knowledge to target those pathways with appropriate drug therapy or combination therapy.

Yaffe’s lab and their colleagues at the National Institutes of Health are now using the atlas to seek out new insights into difficult cancers, including appendiceal cancer and neuroendocrine tumors. While many cancers have been shown to have a strong genetic component, such as the genes BRCA1 and BRCA2 in breast cancer, other cancers are not associated with any known genetic cause. “We’re using this atlas to interrogate these tumors that don’t seem to have a clear genetic driver to see if we can identify kinases that are driving cancer progression,” he says.

Biological insights

In addition to completing the human kinase atlas, the team made two biological discoveries in their recent study. First, they identified three main classes of phosphorylation motifs, or barcodes, for tyrosine kinases. The first class is motifs that map to multiple kinases, suggesting that numerous signaling pathways converge to phosphorylate a protein boasting that motif. The second class is motifs with a one-to-one match between motif and kinase, in which only a specific kinase will activate a protein with that motif. This came as a partial surprise, as tyrosine kinases have been thought to have minimal specificity by some in the field.

The final class includes motifs for which there is no clear match to one of the 78 classical tyrosine kinases. This class includes motifs that match to 15 atypical tyrosine kinases known to also phosphorylate serine or threonine residues. “This means that there’s a subset of kinases that we didn’t recognize that are actually playing an important role,” says Yaffe. It also indicates there may be other mechanisms besides motifs alone that affect how a kinase interacts with a protein.

The team also discovered that tyrosine kinase motifs are tightly conserved between humans and the worm species C. elegans,  despite the species being separated by more than 600 million years of evolution. In other words, a worm kinase and its human homologue are phosphorylating essentially the same motif. That sequence preservation suggests that tyrosine kinases are highly critical to signaling pathways in all multicellular organisms, and any small change would be harmful to an organism.

The research was funded by the Charles and Marjorie Holloway Foundation, the MIT Center for Precision Cancer Medicine, the Koch Institute Frontier Research Program via L. Scott Ritterbush, the Leukemia and Lymphoma Society, the National Institutes of Health, Cancer Research UK, the Brain Tumour Charity, and the Koch Institute Support (core) grant from the National Cancer Institute.

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10 Things to Know about CDER’s Pharmaceutical Quality Functions

Pharmaceutical quality provides the confidence that a patient’s next dose of medicine is safe, effective, and available when it’s needed. When CDER receives a prescription drug application for approval, we evaluate whether the drug can be made to consistently meet quality standards. Pharmaceutical quality is about more than just the quality of the drug itself. It includes the manufacturing facilities and the processes used to manufacture the drug. Some of CDER’s pharmaceutical quality functions occur before a prescription drug is approved and reaches patients. CDER also monitors drugs on the market and the facilities making them to ensure continued quality.

Here are some things to know about CDER’s pharmaceutical quality functions:

• Before FDA approval, prescription drug manufacturers must prove their drugs are safe, effective, and meet quality standards. FDA’s quality standards are the same for all drug manufacturers, no matter where they are located (foreign or domestic) or whether they manufacture generic or brand-name drugs.
• CDER works to develop national and international policies that establish quality standards for drug manufacturers. For example, we publish guidance documents to help drug manufacturers understand regulatory requirements and best practices so they can produce high-quality drugs, and we work with industry organizations and international regulators to advance pharmaceutical quality policies. CDER’s research informs policy development by providing the latest scientific information related to pharmaceutical quality.
• During our review of a drug application, CDER examines how the manufacturer will ensure the identity, strength, consistency, and purity of the drug. We do this in part by evaluating the manufacturer’s facility and manufacturing process to determine whether the drug can be manufactured in compliance with U.S. law and regulations. 
• FDA performs a risk-based assessment of facilities listed in a drug application, which includes the facilities used to manufacture a drug, laboratories, and packaging facilities. FDA uses inspections as one tool to help ensure facility and process quality. During the drug approval process, CDER uses a risk-based approach to determine which drug manufacturing facilities need to be inspected prior to approving the drug (for example, an inspection is typically conducted if the drug will be the first product made at a newly built facility). A drug will not be approved if investigators discover a significant quality issue during an inspection prior to approval. Critical manufacturing problems need to be corrected before CDER can approve a drug.
• CDER maintains an inventory of all facilities engaged in commercial manufacture of US marketed drugs (which we call CDER’s Site Catalog). Most facility inspections are surveillance inspections, which assess whether the facility is operating with processes in place to assure quality and is in compliance with statutory and regulatory requirements. CDER uses a risk-based model to prioritize surveillance inspections among facilities subject to inspection. Risk factors include the compliance history of the facility, recalls or quality complaints linked to the facility, and the type of drugs manufactured at the facility such as sterile injectable drugs.
• FDA also inspects manufacturers who make non-application drugs (drugs marketed without an FDA-approved application), such as many over-the-counter drugs, to ensure the quality and safety of drugs marketed or sold in the U.S.
• CDER may request documents from a facility or request to remotely interact with a facility to evaluate compliance with required manufacturing practices. CDER also uses inspection information from regulatory partners in other countries. These alternative tools to inspection allow CDER to obtain information about manufacturing facilities without physically visiting the facility.
• We take action when there is a safety or quality concern. We may recommend a company recall its drug from the market or add a company to an “import alert” to help stop potentially unsafe products from entering the U.S. CDER may issue a “warning letter” advising a company of their manufacturing violations.
• CDER maintains an inventory of all drugs marketed in the U.S. (which we call CDER’s Product Catalog) and we sample and test drugs from this list, based on risk, to monitor for quality issues. With approximately 150,000 drugs in CDER’s Product Catalog, we select products for sampling and testing based on data received from FDA investigators, manufacturers, distributors, and wholesalers, as well as directly from consumers and patients. Decades of sampling and testing have shown that the vast majority of legally marketed drugs meet quality standards.
• Report any problems or concerns you have about the quality of a drug to FDA’s MedWatch program.