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Measles is an important childhood infection prevalent all over the world, an effective vaccination can reduce the spread of infection and controls the morbidity and mortality
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MEASLESupdate Dr.T.V.Rao MD
Early History of Measles • Reports of measles go back to at least 700, however, the first scientific description of the disease and its distinction from smallpox attributed to the Muslim physician Ibn Razi(Rhazes) 860-932 who published a book entitled "Smallpox and Measles" (in Arabic: Kitab fi al-jadari wa-al-hasbah).
Serious disease as PerWHO. • It remains a leading cause of death among young children globally, despite the availability of a safe and effective vaccine. An estimated 197 000 people died from measles in 2007, mostly children under the age of five
Measles - Parmyxoviridae • Measles is an infection of the respiratory system caused by a virus, specifically a Paramyxoviruses of the genus Morbillivirus Morbilliviruses, like other paramyxoviruses, are enveloped, single-stranded, negative-sense RNA viruses.
Measles Virus • The measles virus is a spherical, nonsegmented, single-stranded RNA virus in the Morbillivirus family, closely related to the rinderpest and canine distemper viruses. It contains six structural proteins, three that are complexed to the RNA and three that are associated with the viral membrane envelope.
Fusion Protein • The F (fusion) protein is responsible for fusion of virus and host cell membranes, viral penetration and hemolysis. The H (hemagglutinin) protein is responsible for adsorption of the virus to cells. • There is only one serotype of Measles virus and no subtypes have yet been recognized
Measles • More than 20 million people worldwide are affected by measles each year. Measles outbreaks are common in many areas, including Europe. For many U.S. travellers and expatriates, the risk for exposure to measles can be high, but the illness can be prevented by a measles-containing vaccine
Measles spread by RespiratoryRoute • Measles is spread through respiration (contact with fluids from an infected person's nose and mouth, either directly or through aerosol transmission), and is highly contagious—90% of people without immunity sharing a house with an infected person will catch it. The infection has an average incubation period of 14 days (range 6-19 days) and infectivity lasts from 2-4 days prior to 2-5 days following the onset of the rash.
Measles threat to Devloping World • In developing countries, measles affects 30 million children a year and causes 1 million deaths. Measles causes 15,000-60,000 cases of blindness per year.
Global Epidemiology • Approximately 30 million measles cases are reported annually. Most reported cases are from Africa. In 1998, the cases of measles per 100,000 total population reported to the World Health Organization was 1.6 in the Americas, 8.2 in Europe, 11.1 in the Eastern Mediterranean region, 4.2 in South East Asia, 5.0 in the Western Pacific region, and 61.7 in Africa. Only 187 confirmed cases were reported in the Western Hemisphere (mainly in Venezuela, Mexico, and the United States)
Measles a Childhood Infection • Age-specific attack rates may be highest in susceptible infants younger than 12 months, school-aged children, or young adults, depending on local immunization practices and incidence of the disease.
Prominent features and complications in Measles
Patients on Physical examination • Patients tend to appear moderately ill and uncomfortable because of their viral prodromal symptoms. • The Koplik spots are 1-2 mm, blue-gray macules on an eythematous base. • The measles rash is a Maculopapular eythematous rash that involves the palms and soles. • Lesion density is greatest above the shoulders, where macular lesions may coalesce
A rash is leading manifestations • Typically begins at the hairline and spreads caudally over the next 3 days as the prodromal symptoms resolve. • The rash lasts 4-6 days and then fades from the head downward. • Desquamation may be present but is generally not severe. • Complete recovery from the illness generally occurs within 7-10 days from the onset of the rash
Rash is a Prominent Feature
Risk factors for infection • Children with immunodeficiency due to HIV or acquired immunodeficiency syndrome (AIDS), leukemia, alkylating agents, or corticosteroid therapy, regardless of immunization status • Travel to areas where measles is endemic or contact with travellers to endemic areas • Infants who lose passive antibody prior to the age of routine immunization
Spread of Virus • The highly contagious virus is spread by coughing and sneezing, close personal contact or direct contact with infected nasal or throat secretion
Early Symptoms in Measles • The incubation period from exposure to onset of symptoms ranges from 8-12 days. The prodromal phase is marked by malaise, fever, anorexia, and conjunctivitis, cough, and coryza (the "3 Cs"). The entire course of uncomplicated measles, from late prodrome to resolution of fever and rash, is 7-10 days. Cough may be the final symptom to appear
Beginning of Illness in Measles • Approximately 10 days after the initial exposure to the virus, the classic viral prodrome occurs. • Fever • Non-productive cough • Coryza • Conjunctivitis • Additional prodromal symptoms may include malaise, myalgias, photophobia, and periorbital oedema.
Koplik Spots leading clue to Measles • With in 2-3 days, the pathognomonic Koplik spots typically arise on the buccal, gingival, and labial mucosa
Risk factors for severe measles • Malnutrition • Underlying immunodeficiency • Pregnancy • Vitamin A deficiency
Mortality Rate in Measles • The mortality rate associated with uncomplicated measles in immunocompetent, well nourished children is low but raises rapidly with malnourishment (marked in African children ), in immunocompromised, and to lesser extent with age.
Measles is highly contagiousDisease • Patients are contagious from 1-2 days before onset of symptoms. Healthy children are also contagious during the period from 3-5 days before the appearance of the rash to 4 days after the onset of rash. On the other hand, immunocompromised individuals can be contagious during the duration of the illness.
Modified Measles • Modified measles occurs in children who have received serum immunoglobulin after their exposure to measles. The measles symptom complex may still occur, but the incubation period is as long as 21 days, with the same symptoms as measles but milder.
Atypical Measles • When they are exposed to the measles virus, a mild or nonexistent prodrome of fever, headache, abdominal pain, and myalgias precedes a rash that begins on the hands and feet and spreads centrally. • The rash is most prominent in the body creases and may be macular, hemorrhagic vesicles, petechial, or urticarial. • Complications may include pneumonia, pleural effusion, hilar lymphadenopathy, Hepatosplenomegaly, hyperesthesia, or paresthesia. • Atypical measles occurs in individuals who were previously immunized with the killed measles vaccine between 1963 and 1967 and who have incomplete immunity.
Subacute sclerosing panencephalitisSSPE • SSPE is a neurodegenerative disease caused by persistent infection of the brain by an altered form of the measles virus. Neither the biology underlying the viral persistence nor the triggering mechanism for viral reactivation is well understood. In most cases, infected children remain symptom-free for 6-15 years after acute measles infection[
Subacute sclerosing panencephalitis • Subacute sclerosing panencephalitis (SSPE) is a rare chronic, progressive encephalitis that affects primarily children and young adults, caused by a persistent infection of immune resistant measles virus (which can be a result of a mutation of the virus itself). 1 in 100,000 people infected with measles develop SSPE. SSPE is 'incurable' but the condition can be managed by medication if treatment is started at an early stage. • Doctortvrao’s ‘e’ learning series
Clinical Presentation of SSPE • Characterized by a history of primary measles infection usually before the age of 2 years, followed by several asymptomatic years (6–15 on average), and then gradual, progressive psycho neurological deterioration, consisting of personality change, seizures, myoclonus, ataxia, photosensitivity, ocular abnormalities, spasticity, and coma. • Doctortvrao’s ‘e’ learning series
The Progress of SSPE • The initial symptoms of SSPE usually involve regressive changes in intellect and personality. Within several months, the psychological symptoms are compounded by neurological ones, most often consisting of myoclonic jerks. A relentless mental and motor deterioration then ensues, culminating in extreme neurologic dysfunction and death within several years of the onset of symptoms. Our patient's clinical course reflected this typical natural history. • Doctortvrao’s ‘e’ learning series
Diagnosis of Measles • Most cases of Measles are diagnosed clinically, usually in patient’s home or in General practice • Direct Virological confirmation is difficult in most of the Devloping countreis • Doctortvrao’s ‘e’ learning series
Diagnosis by Microscopy • Production of multinucleate giant cells with inclusion bodies is path gnomonic for measles. During the prodromal phase, such cells are detectable in the NPS (nasopharyngeal secretions). This is more rapid and practical than virus isolation Doctortvrao’s ‘e’ learning series
Diagnosis with Immunofluorescence Direct and indirect immunofluorescence have been used extensively to demonstrate MV antigens in cells from NPS specimens. This technique can also be applied to the urine as such cells may be present in the urine 2 to 5 days after the appearance of the rash Doctortvrao’s ‘e’ learning series
Diagnosis by Viral Isolation • Measles virus can be isolated form a variety of sources, e.g. throat or conjunctival washings, sputum, urinary sediment cells and lymphocytes. Primary human kidney (HEK) cells are the best, although primary monkey kidney can be used as well. Continuous cell lines such as Vero cells can also be used although they are not as efficient as primary cell lines • Doctortvrao’s ‘e’ learning series
Diagnosis bySerology • Diagnosis of measles infection can be made if the antibody titres rise by 4 fold between the acute and the convalescent phase or if measles-specific IgM is found. The methods that can be used include HAI, CF, neutralization and ELISA tests. Doctortvrao’s ‘e’ learning series
Diagnosis of SSPE • The presence of measles specific antibodies in the CSF is the most reliable means of laboratory diagnosis of SSPE. Demonstration of MV-specific antibodies in the CSF may be sufficient with, if necessary, demonstration of MV-specific restricted heterogeneity by isoelectric focusing • Doctortvrao’s ‘e’ learning series
Other Diseases associated with Measles • The virus has been liked with Multiple sclerosis, Paget’s disease of bone and Crohn’s disease • In all the cases tubular structures resembling measles nucelocapsids have been seen by thin section electron microscopy and immunofluorescence methods are used for demonostration of Measles antigens in Biopsy material. • Doctortvrao’s ‘e’ learning series
Epidemiological Trends • Measles epidemics occur every 2 year in developed countreis in the absence of widespread use of vaccine • Poverty and overcrowding increases epidemics
Tropics and Measles • In tropical areas particular in Africa children under 1 year of age suffer more attacks, and mortality rate increases • Malnutrition is a major contributing factor. • Doctortvrao’s ‘e’ learning series
Treatment • Severe complications from measles can be avoided though supportive care that ensures good nutrition, adequate fluid intake and treatment of dehydration with WHO-recommended oral rehydration solution (to replace fluids and other essential elements lost from diarrhoea or vomiting). Antibiotics should be prescribed to treat eye and ear infections, and pneumonia. • Doctortvrao’s ‘e’ learning series
Treatment options in Developing Countreis • All children in developing countries diagnosed with measles should receive two doses of vitamin A supplements, given 24 hours apart. This can help prevent eye damage and blindness. Vitamin A supplements have been shown to reduce the number of deaths from measles by50%.
VACCINATION • The Vaccines are Live attenuated containing Edmonston B or Schwartz strains which will give seroconversion rate of 90%. • The immunity produce may be life long. • Doctortvrao’s ‘e’ learning series
Measles Vaccine is cheap and Effective • The measles vaccine (in use for 40 years) is safe, effective and inexpensive. It costs less than one US dollar to immunize a child against measles. • Doctortvrao’s ‘e’ learning series
Measles vaccine is givenasMMR Vaccine • The measles vaccine is often incorporated with rubella and/or mumps vaccines in countries where these illnesses are problems. It is equally effective in the single or combined form • The combination proved to be effective and safe
Two doses of Measles Vaccine • Continued progress depends on ensuring that all children receive two doses of measles vaccine including one dose by their first birthday, strengthening disease surveillance systems, and providing effective treatment for measles.
Changing trends for a Booster Dose • In 2007, about 82% of the world's children received one dose of measles vaccine by their first birthday through routine health services, up from 72% in 2000. (Two doses of the vaccine are recommended to ensure immunity, as about 15% of vaccinated children fail to develop immunity from the first dose.) • Doctortvrao’s ‘e’ learning series
AutismandVaccination • In UK vaccine uptake has fallen recently due to fear over its safety, particularly as cause of Autism. • These fears have now been confirmed as Unsubstantiated.
CDC disproves Autism Theory • The official perspective of the CDC is that there is no proven connection between live-virus vaccines and autism. • Neither the CDC nor proponents of the vaccine theories think that parents should avoid vaccines. Clearly, vaccines have saved untold lives, and will continue to do so.
Strong routine immunization: for children by their first birthday. A 'second opportunity' for measles immunization through mass vaccination campaigns, to ensure that all children receive at least one dose. Effective surveillance in all countries to quickly recognize and respond to measles outbreaks. Better treatment of measles cases, to include vitamin A supplements, antibiotics if needed, and supportive care that prevents complications. Doctortvrao’s ‘e’ learning series WHOandUNICEFare collaborating
Global Initiatives • The Measles Initiative - a collaborative effort of WHO, UNICEF, the American Red Cross, the United States Centres for Disease Control and Prevention, and the United Nations Foundation - and other public and private partners play key roles in advancing the global measles strategy
Measles mortality reduction: a successful initiative • Measles deaths worldwide fell by 74% between 2000 and 2007, from an estimated 750 000 to 197 000. In addition, the Eastern Mediterranean region has cut measles deaths by a remarkable 90% — from an estimated 96 000 to 10 000 — during the same period, thus achieving the United Nations goal to reduce measles deaths by 90% by 2010, three years early. • Doctortvrao’s ‘e’ learning series
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Measles (Rubeola)
Measles is one of the most contagious diseases and can be dangerous in babies and young children. The best protection against measles is the MMR vaccine.
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Measles Virus
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Our creatively crafted Measles Virus PPT template is the best pick to demonstrate how this acute and highly contagious virus spreads from an infected person to another. Healthcare professionals and medical practitioners can use this 100% customizable set to illustrate the signs and symptoms of this disease.
The modern designs let you depict your message and thoughts clearly to the viewers. The incredible layouts and vibrant color combinations keep your audience hooked till the end of your slideshow. So, steal the show by downloading this deck now!
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Inclusions of the PPT
- An overview of the measles virus has been given comprehensively.
- A circular diagram shows the morbillivirus for easy understanding.
- A female infographic portrays the symptoms of measles precisely.
- The steps on how this virus spreads have been depicted through a hexagon.
- The treatment for measles has been represented via a listicle clearly and concisely.
- A male infographic incorporated with self-explanatory icons showcases symptoms.
Key Features
- You can change every aspect of this set without any external support or technical skills.
- The visual graphics are created after extensive and in-depth research to avoid copyright breaches.
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29 Best Measles-Themed Templates for PowerPoint & Google Slides
With over 6 million presentation templates available for you to choose from, crystalgraphics is the award-winning provider of the world’s largest collection of templates for powerpoint and google slides. so, take your time and look around. you’ll like what you see whether you want 1 great template or an ongoing subscription, we've got affordable purchasing options and 24/7 download access to fit your needs. thanks to our unbeatable combination of quality, selection and unique customization options, crystalgraphics is the company you can count on for your presentation enhancement needs. just ask any of our thousands of satisfied customers from virtually every leading company around the world. they love our products. we think you will, too" id="category_description">crystalgraphics creates templates designed to make even average presentations look incredible. below you’ll see thumbnail sized previews of the title slides of a few of our 29 best measles templates for powerpoint and google slides. the text you’ll see in in those slides is just example text. the measles-related image or video you’ll see in the background of each title slide is designed to help you set the stage for your measles-related topics and it is included with that template. in addition to the title slides, each of our templates comes with 17 additional slide layouts that you can use to create an unlimited number of presentation slides with your own added text and images. and every template is available in both widescreen and standard formats. with over 6 million presentation templates available for you to choose from, crystalgraphics is the award-winning provider of the world’s largest collection of templates for powerpoint and google slides. so, take your time and look around. you’ll like what you see whether you want 1 great template or an ongoing subscription, we've got affordable purchasing options and 24/7 download access to fit your needs. thanks to our unbeatable combination of quality, selection and unique customization options, crystalgraphics is the company you can count on for your presentation enhancement needs. just ask any of our thousands of satisfied customers from virtually every leading company around the world. they love our products. we think you will, too.
Widescreen (16:9) Presentation Templates. Change size...
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PPT theme with little sick girl is sitting near the bed
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Presentation theme featuring portrait of young boy suffering from chickenpox
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IMAGES
VIDEO
COMMENTS
Early Symptoms in Measles • The incubation period from exposure to onset of symptoms ranges from 8-12 days. The prodromal phase is marked by malaise, fever, anorexia, and conjunctivitis, cough, and coryza (the "3 Cs"). The entire course of uncomplicated measles, from late prodrome to resolution of fever and rash, is 7-10 days.
Measles virus lives in the nose and throat of an infected person. If other people breathe the contaminated air or touch a contaminated surface, then touch their eyes, nose, or mouth, they can become infected. Infected people can spread measles 4 days before they get the rash through 4 days after it appears.
Measles. An acute, febrile rash illness caused by the measles virus. Transmitted by direct contact with infectious droplets or airborne route. Measles is highly contagious. 90% of susceptible household contacts will develop illness. Ro (the number of people who are infected by a single case) is estimated to be 12-16 in an unvaccinated population.
Vaccine Associated "Measles". MMR is live vaccine Live vaccines can cause "look-alike" rashes ~5% of vaccinees will get transient measles rash ~7 to 10 days after vaccination rash similar to measles appears. Fever following MMR in 5-15% (to 103 or >) Occurs 7-12 days after vaccination Lasts 1-2 days.
Free continuing education is offered for this webinar. Instructions on how to earn continuing education will be provided at the end of the call. ... Identify the clinical presentation of measles and other causes of febrile rash illness which may mimic measles. 2. Diagnose measles infection with appropriate laboratory diagnostics.
Suspected Measles: Diagnosis, Response and Treatment. Treat children with severe measles (e.g. hospitalized) with vitamin A. Administer vitamin A immediately on diagnosis and repeat the next day. The recommended age-specific daily doses are. 50 000 IU for infants aged <6 months. 100 000 IU for infants aged 6-11 months.
Emergency Preparedness and Response | CDC
This fun and creative template will help you easily illustrate important information about measles, making it easier for medical professionals to discuss and educate patients. With fun illustrations, this medical template is perfect for healthcare presentations or lectures. You can quickly create stunning visuals to communicate measles-related ...
Measles BIO 062 Presentation Austin Cromer. The discovery of Measles can be found in the works of a Persian Physician MEASLES Katie Townes, MD UMass Medical School and HEARTT Emmanuel Okoh, MD Acting Director of Pediatrics, JFKMC and HEARTT Adapted from a lecture by Rick.
Pneumonia is an infection in the lungs. 1 out of 20 children with measles gets pneumonia. Encephalitis is the swelling of the brain. 1 out of 1,000 children with measles will develop encephalitis. Measles may cause pregnant woman to give birth prematurely, or have a low-birth-weight baby. "Measles.".
Download, print, and share free measles resources. Skip directly to site content Skip directly to search. An official website of the United States government. ... Explore, download, and print CDC's free communications and public health resources about measles and the MMR vaccine. Use the graphics on your social media channels or websites.
Nasopharynx is primary site of infection. Incubation period is 10-12 days. Prodrome is 2-4 days. 3 Cs - cough, coryza, and conjunctivitis. Stepwise increase in fever up to 103°F-105°F. Koplik spots. Rash occurs 2-4 days after prodrome, 14 days after exposure, and persists 5-6 days. Begins on face and upper neck.
Measles is spread through direct contact with or inhalation of the secretions of an infected person's nose or mouth. Signs and Symptoms Signs and symptoms of measles begin 7 to 10 days after infection has first entered the body The first symptom is a high fever along with runny rose, and irritability, drowsiness and red eyes 3 to 7 days after ...
Over 20 million cases of measles have been prevented since the start of measles vaccination in the UK. Over 4,500 lives have been saved as a result (81 lives per year) * source is UKHSA blog. MMR vaccination is free on the NHS with the first dose being offered when a child is one and the second at 3 years and 4 months old.
Download the "Measles Transmission in Children" presentation for PowerPoint or Google Slides. It's key to take care of yourself and of those around you. By learning about various illnesses and how they are spread, people can get a better understanding of them and make informed decisions about eating, exercise, and seeking medical attention ...
The measles vaccination (MMR) resulted in a 75% drop in measles deaths between 2000 and 2013 worldwide. Measles is one of the leading causes of death among young children even though a safe and cost-effective vaccine is available. During 2000-2013, measles vaccination prevented an estimated 15.6 million deaths.
Slide Formats. 16:9. 4:3. Our creatively crafted Measles Virus PPT template is the best pick to demonstrate how this acute and highly contagious virus spreads from an infected person to another. Healthcare professionals and medical practitioners can use this 100% customizable set to illustrate the signs and symptoms of this disease.
What are the "Measles"? 1. Measles is a highly contagious, acute viral illness. 2. It begins with a fever, cough, runny nose, conjunctivitis (pink eye), lasting 2-4 days prior to rash onset. 3. Affects the respiratory and immune system. 4. NO treatment. 5. Survival rate is good.
29 Best Measles-Themed Templates. CrystalGraphics creates templates designed to make even average presentations look incredible. Below you'll see thumbnail sized previews of the title slides of a few of our 29 best measles templates for PowerPoint and Google Slides. The text you'll see in in those slides is just example text.
Measles typically begins with high fever (may spike to more than 104°F), cough, runny nose (coryza) and red, watery eyes (conjunctivitis). 2 to 3 days after symptoms begin, tiny white spots (Koplik's spots) may appear inside the mouth. 3 to 5 days after symptoms begin, a rash breaks out. It usually begins as flat red spots that appear on the ...
Unlike the individual Microsoft apps that you need to buy from the Microsoft Store, this one is free to download and use. Here's how to get free PowerPoint on the Microsoft 365 (Office) app ...