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Ageing in Place

The world’s population is ageing, and with ageing comes an increased risk of disability, multimorbidity and dementia, and an increased need for support. Older people are motivated to stay in their own homes as they age as an alternative to intramural care that is cost-beneficial and often provides...

Urban Lifelines and Supply Chains: Enhancing Resilience and Sustainability with Foundational Technologies

An urban community is an intricate network connected by a myriad of functional systems and subsystems, including civil structures, underground spaces, multi-modal transportation, telecom, energy grids, retail facilities, food systems, and healthcare facilities, all operating with unique spatial and...

Photons to Fuels: Recent Progress of Photocatalytic For CO2 Reduction and H2 Production

To address the detrimental effects of climate change, innovative and timely approaches in renewable energy and environmental chemistry are essential. Photocatalytic conversion of carbon dioxide has garnered significant attention as a viable method for carbon capture and utilization, offering the...

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Chemical Society Reviews

Bridging the gap between academic research and industrial development in advanced all-solid-state lithium–sulfur batteries.

* Corresponding authors

a Chemical Sciences and Engineering Division, Argonne National Laboratory, 9700 S Cass Ave, Lemont, IL 60439, USA E-mail: [email protected] , [email protected]

b Eastern Institute for Advanced Study, Eastern Institute of Technology, Ningbo, Zhejiang, P. R. China

c Laurel Heights Secondary School, 650 Laurelwood Dr, Waterloo, ON, Canada

The energy storage and vehicle industries are heavily investing in advancing all-solid-state batteries to overcome critical limitations in existing liquid electrolyte-based lithium-ion batteries, specifically focusing on mitigating fire hazards and improving energy density. All-solid-state lithium–sulfur batteries (ASSLSBs), featuring earth-abundant sulfur cathodes, high-capacity metallic lithium anodes, and non-flammable solid electrolytes, hold significant promise. Despite these appealing advantages, persistent challenges like sluggish sulfur redox kinetics, lithium metal failure, solid electrolyte degradation, and manufacturing complexities hinder their practical use. To facilitate the transition of these technologies to an industrial scale, bridging the gap between fundamental scientific research and applied R&D activities is crucial. Our review will address the inherent challenges in cell chemistries within ASSLSBs, explore advanced characterization techniques, and delve into innovative cell structure designs. Furthermore, we will provide an overview of the recent trends in R&D and investment activities from both academia and industry. Building on the fundamental understandings and significant progress that has been made thus far, our objective is to motivate the battery community to advance ASSLSBs in a practical direction and propel the industrialized process.

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J. Lee, C. Zhao, C. Wang, A. Chen, X. Sun, K. Amine and G. Xu, Chem. Soc. Rev. , 2024, Advance Article , DOI: 10.1039/D3CS00439B

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Article Contents

National trends in prescription drug expenditures and projections for 2024.

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Eric M Tichy, James M Hoffman, Mina Tadrous, Matthew H Rim, Sandra Cuellar, John S Clark, Mary Kate Newell, Glen T Schumock, National trends in prescription drug expenditures and projections for 2024, American Journal of Health-System Pharmacy , 2024;, zxae105, https://doi.org/10.1093/ajhp/zxae105

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In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time.

To report historical patterns of pharmaceutical expenditures, to identify factors that may influence future spending, and to predict growth in drug spending in 2024 in the United States, with a focus on the nonfederal hospital and clinic sectors.

Historical patterns were assessed by examining data on drug purchases from manufacturers using the IQVIA National Sales Perspectives database. Factors that may influence drug spending in hospitals and clinics in 2024 were reviewed—including new drug approvals, patent expirations, and potential new policies or legislation. Focused analyses were conducted for biosimilars, cancer drugs, endocrine drugs, generics, and specialty drugs. For nonfederal hospitals, clinics, and overall (all sectors), estimates of growth of pharmaceutical expenditures in 2024 were based on a combination of quantitative analyses and expert opinion.

In 2023, overall pharmaceutical expenditures in the US grew 13.6% compared to 2022, for a total of $722.5 billion. Utilization (a 6.5% increase), new drugs (a 4.2% increase) and price (a 2.9% increase) drove this increase. Semaglutide was the top drug in 2023, followed by adalimumab and apixaban. Drug expenditures were $37.1 billion (a 1.1% decrease) and $135.7 billion (a 15.0% increase) in nonfederal hospitals and clinics, respectively. In clinics, increased utilization drove growth, with a small impact from price and new products. In nonfederal hospitals, a drop in utilization led the decrease in expenditures, with price and new drugs modestly contributing to growth in spending. Several new drugs that will influence spending are expected to be approved in 2024. Specialty, endocrine, and cancer drugs will continue to drive expenditures.

For 2024, we expect overall prescription drug spending to rise by 10.0% to 12.0%, whereas in clinics and hospitals we anticipate an 11.0% to 13.0% increase and a 0% to 2.0% increase, respectively, compared to 2023. These national estimates of future pharmaceutical expenditure growth may not be representative of any health system because of the myriad of local factors that influence actual spending.

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Transformations That Work

• Michael Mankins
• Patrick Litre

More than a third of large organizations have some type of transformation program underway at any given time, and many launch one major change initiative after another. Though they kick off with a lot of fanfare, most of these efforts fail to deliver. Only 12% produce lasting results, and that figure hasn’t budged in the past two decades, despite everything we’ve learned over the years about how to lead change.

Clearly, businesses need a new model for transformation. In this article the authors present one based on research with dozens of leading companies that have defied the odds, such as Ford, Dell, Amgen, T-Mobile, Adobe, and Virgin Australia. The successful programs, the authors found, employed six critical practices: treating transformation as a continuous process; building it into the company’s operating rhythm; explicitly managing organizational energy; using aspirations, not benchmarks, to set goals; driving change from the middle of the organization out; and tapping significant external capital to fund the effort from the start.

Lessons from companies that are defying the odds

Idea in Brief

The problem.

Although companies frequently engage in transformation initiatives, few are actually transformative. Research indicates that only 12% of major change programs produce lasting results.

Why It Happens

Leaders are increasingly content with incremental improvements. As a result, they experience fewer outright failures but equally fewer real transformations.

The Solution

To deliver, change programs must treat transformation as a continuous process, build it into the company’s operating rhythm, explicitly manage organizational energy, state aspirations rather than set targets, drive change from the middle out, and be funded by serious capital investments.

Nearly every major corporation has embarked on some sort of transformation in recent years. By our estimates, at any given time more than a third of large organizations have a transformation program underway. When asked, roughly 50% of CEOs we’ve interviewed report that their company has undertaken two or more major change efforts within the past five years, with nearly 20% reporting three or more.

• Michael Mankins is a leader in Bain’s Organization and Strategy practices and is a partner based in Austin, Texas. He is a coauthor of Time, Talent, Energy: Overcome Organizational Drag and Unleash Your Team’s Productive Power (Harvard Business Review Press, 2017).
• PL Patrick Litre leads Bain’s Global Transformation and Change practice and is a partner based in Atlanta.

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• 19 April 2024

Do insects have an inner life? Animal consciousness needs a rethink

• Mariana Lenharo

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Growing evidence indicates that insects such as bees show some forms of consciousness, according to a new scientific statement. Credit: Phil Savoie/Nature Picture Library

Crows , chimps and elephants : these and many other birds and mammals behave in ways that suggest they might be conscious . And the list does not end with vertebrates. Researchers are expanding their investigations of consciousness to a wider range of animals, including octopuses and even bees and flies.

Armed with such research, a coalition of scientists is calling for a rethink in the animal–human relationship . If there’s “a realistic possibility” of “conscious experience in an animal, it is irresponsible to ignore that possibility in decisions affecting that animal”, the researchers write in a document they call The New York Declaration on Animal Consciousness . Issued today during a meeting in New York City, the declaration also says that there is a “realistic possibility of conscious experience” in reptiles, fish, insects and other animals that have not always been considered to have inner lives, and “strong scientific support” for aspects of consciousness in birds and mammals.

As the evidence has accumulated, scientists are “taking the topic seriously, not dismissing it out of hand as a crazy idea in the way they might have in the past”, says Jonathan Birch, a philosopher at the London School of Economics and Political Science and one of the authors of the declaration.

The document, which had around 40 signatories early today, doesn’t state that there are definitive answers about which species are conscious. “What it says is there is sufficient evidence out there such that there’s a realistic possibility of some kinds of conscious experiences in species even quite distinct from humans,” says Anil Seth, director of the Centre for Consciousness Science at the University of Sussex near Brighton, UK, and one of the signatories. The authors hope that others will sign the declaration and that it will stimulate both more research into animal consciousness and more funding for the field.

Blurry line

The definition of consciousness is complex, but the group focuses on an aspect of consciousness called sentience, often defined as the capacity to have subjective experiences, says Birch. For an animal, such experiences would include smelling, tasting, hearing or touching the world around itself, as well as feeling fear, pleasure or pain — in essence, what it is like to be that animal. But subjective experience does not require the capacity to think about one’s experiences.

The consciousness wars: can scientists ever agree on how the mind works?

Non-human animals cannot use words to communicate their inner states. To assess consciousness in these animals, scientists often rely on indirect evidence, looking for certain behaviours that are associated with conscious experiences, Birch says.

One classic experiment is the mirror test , which investigates an animal’s ability to recognize itself in a mirror. In this experiment, scientists apply a sticker or other visual mark on an animal’s body and place the animal in front of a mirror. Some animals — including chimpanzees ( Pan troglodytes ) 1 , Asian elephants ( Elephas maximus ) 2 and cleaner fishes ( Labroides dimidiatus ) 3 — exhibit curiosity about the mark and even try to remove it. This behaviour suggests the possibility of self-awareness, which might be a sign of consciousness.

In an experiment with crows ( Corvus corone ) 4 , the birds were trained to make a specific head gesture whenever they saw a coloured square on a screen, a task they carried out with high accuracy. While the birds performed the task, scientists measured the activity in a region of their brain associated with high-level cognition. The birds’ brain activity correlated with what the birds were reporting, not with what they were actually shown. This suggests that they were aware of what they were perceiving, another potential marker of consciousness.

Invertebrate inner lives?

Another experiment showed that octopuses ( Octopus bocki ) 5 , when picking between two chambers, avoided one where they had previously received a painful stimulus in favour of one where they were given an anaesthetic. This suggests that they experience and actively avoid pain, which some researchers think indicates conscious experience.

Research shows that octopuses avoid pain, which some scientists take as a sign of consciousness. Credit: Brandon Cole/Nature Picture Library

Investigations of fruit flies ( Drosophila melanogaster ) show that they engage in both deep sleep and ‘active sleep’, in which their brain activity is the same as when they’re awake 6 . “This is perhaps similar to what we call rapid eye movement sleep in humans, which is when we have our most vivid dreams, which we interpret as conscious experiences,” says Bruno van Swinderen, a biologist at the University of Queensland in Brisbane, Australia, who studies fruit flies ’ behaviour and who also signed the declaration.

Some suggest that dreams are key components of being conscious, he notes. If flies and other invertebrates have active sleep, “then maybe this is as good a clue as any that they are perhaps conscious”.

Animal minds

Other researchers are more sceptical about the available evidence on animal consciousness. “I don’t think there is basically any decisive evidence so far,” says Hakwan Lau, a neuroscientist at the Riken Center for Brain Science in Wako, Japan.

Lau acknowledges that there is a growing body of work showing sophisticated perceptual behaviour in animals, but he contends that that’s not necessarily indicative of consciousness. In humans, for example, there is both conscious and unconscious perception. The challenge now is to develop methods that can adequately distinguish between the two in non-humans.

Seth responds that, even in the absence of definitive answers, the declaration might still have a positive influence in shaping policies relating to animal ethics and welfare.

For van Swinderen, the time is right to consider whether most animals might be conscious. “We are experiencing an artificial-intelligence revolution where similar questions are being asked about machines. So it behoves us to ask if and how this adaptive quality of the brain might have evolved in nature.”

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Torres JR , Taira BR , Bi A, et al. COVID-19 Vaccine Uptake in Undocumented Latinx Patients Presenting to the Emergency Department. JAMA Netw Open. 2024;7(4):e248578. doi:10.1001/jamanetworkopen.2024.8578

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COVID-19 Vaccine Uptake in Undocumented Latinx Patients Presenting to the Emergency Department

• 1 David Geffen School of Medicine, University of California, Los Angeles
• 2 Olive View-UCLA Medical Center, Los Angeles, California
• 3 School of Medicine, University of California, San Francisco

COVID-19 has disproportionately affected the US Latinx population, with significantly higher rates of infections, hospitalizations, and mortality. 1 , 2 Although the undocumented Latinx population in the US is growing, 3 there are limited data regarding their COVID-19 infection status, vaccination uptake, and perceptions about the COVID-19 vaccine.

We conducted this prospective, cross-sectional survey study from September 2, 2021, through March 31, 2022, at Olive View-UCLA Medical Center and San Francisco General Hospital, which serve large Latinx immigrant populations. After verbal consent, as approved by the institutional review boards of both facilities, a convenience sample of adult (aged ≥18 years) emergency department (ED) patients participated in structured interviews in English or Spanish. The study followed the STROBE reporting guideline.

We excluded patients who were critically ill, on psychiatric holds, or incarcerated or who had altered mentation. Participants were enrolled in 3 approximately equal groups based on self-reported race and ethnicity (non-Latinx [including Asian, Black, Native Hawaiian or other Pacific Islander, Middle Eastern, White, and other], legal Latinx resident or citizen, and undocumented Latinx).

Descriptive statistics were used to summarize participant responses, and comparisons were performed using bivariate hypothesis testing. Data were analyzed using Stata, version 16.1 (StataCorp LLC). Additional details on methodology and the survey instrument are provided in the eMethods in Supplement 1 .

This study included 306 participants (median [IQR] age, 51 [40-60] years; 146 female [48%], 157 male [51%], and 3 with missing sex data [1%]); 209 identified as Latinx (68%) and 34 as non-Latinx Black (11%), 43 as non-Latinx White (14%), and 20 as other race or ethnicity (7%). Among the undocumented Latinx group, 26 (25%) were uninsured, 99 (95%) reported Spanish as their primary language, and 31 (30%) used the ED as their usual source of health care ( Table 1 ).

Compared with the non-Latinx group, a prior COVID-19 infection was more likely reported by undocumented Latinx participants (odds ratio [OR], 3.42; 95% CI, 1.66-7.23) and legal Latinx residents (OR, 2.73; 95% CI, 1.32-5.83). Of all participants, 265 (87%) reported having received at least 1 COVID-19 vaccine and 41 (13%) reporting a decline in vaccination, with similar distributions for all 3 groups. The most common reason for declining vaccines was concern about potential side effects (15 participants [37%]). Compared with the undocumented Latinx group, the non-Latinx group was less likely to believe that undocumented immigrants could receive the COVID-19 vaccine in the US (OR, 0.09; 95% CI, 0.01-0.39), and 41 (13%) reported knowing undocumented people who did not obtain the vaccine because of fear of discovery and deportation ( Table 2 ). Among those who previously declined a COVID-19 vaccine, 9 (22%) expressed interest in receiving the vaccine while in the ED.

Among the population studied, a prior COVID-19 infection was most commonly reported by Latinx participants. Despite the health care access barriers undocumented Latinx individuals face, 4 we found no differences in the proportion who had received COVID-19 vaccines. Additionally, there were minimal perceptions of exclusion from eligibility for vaccination among this group. However, 13% of all participants knew people who were reluctant to get vaccinated due to concerns about their immigration status.

Limitations of our work include group differences in age, sex, and insurance status, factors that may have influenced their responses to key questions. Additionally, citizenship status and prior COVID-19 infection were self-reported, and we only sampled patients who sought care in the ED; thus, individuals who were most fearful of discovery of their immigration status may have been undercounted. Our study was also restricted to 2 EDs affiliated with teaching hospitals in California; therefore, generalizability may be limited. Overall, our findings highlight the utility of EDs for greater inclusion of the undocumented immigrant population in public health surveillance research.

Accepted for Publication: February 28, 2024.

Published: April 26, 2024. doi:10.1001/jamanetworkopen.2024.8578

Open Access: This is an open access article distributed under the terms of the CC-BY License . © 2024 Torres JR et al. JAMA Network Open .

Corresponding Author: Jesus R. Torres, MD, MPH, MSc, David Geffen School of Medicine, University of California, Los Angeles, 1100 Glendon Ave, Ste 1200, Los Angeles, CA 90024 ( [email protected] ).

Author Contributions: Drs Torres and Rodriguez had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Torres, Taira, Rodriguez.

Acquisition, analysis, or interpretation of data: Torres, Taira, Bi, Gomez, Delgado, Vera, Rodriguez.

Drafting of the manuscript: Torres, Rodriguez.

Critical review of the manuscript for important intellectual content: Torres, Taira, Bi, Gomez, Delgado, Vera, Rodriguez.

Statistical analysis: Torres.

Administrative, technical, or material support: All authors.

Supervision: Torres, Taira, Rodriguez.

Conflict of Interest Disclosures: None reported.

Data Sharing Statement: See Supplement 2 .

Additional Contributions: The authors thank Jennifer M. Diaz, BA; Aura M. Elias, BS; and Rose Diaz, MD, MPH, from the UCLA David Geffen School of Medicine for their contributions to data collection. They did not receive compensation.

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SCIENCE & ENGINEERING INDICATORS

Publications output: u.s. trends and international comparisons.

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Publication Output by Region, Country, or Economy and by Scientific Field

This section of the report outlines trends over time in publication output across regions, countries, or economies and by fields of science. This section also provides insights into the research contributions of different regions, countries, or economies and how the focus of their scientific publications has changed over time. In addition, the section highlights variations in the distribution of publications across scientific fields for different regions, countries, or economies and examines trends over time in closed-access and open-access (OA) publications. This section also summarizes federal funding acknowledgments as a source of data to shed light on published research that received federal funding. (See sidebar Using Funding Acknowledgments to Track Federally Funded Research Over Time .)

Output by Region, Country, or Economy

Total worldwide S&E publication output reached 3.3 million articles in 2022, based on entries in the Scopus database. Indicators 2018 : Bibliometric Data Filters )." data-bs-content="Publication output includes only those indexed in the Scopus database. The publication output discussion uses fractional counting, which credits coauthored publications according to the collaborating institutions or regions, countries, or economies based on the proportion of their participating authors. Country assignments refer to the institutional address of authors, with partial credit given for each international coauthorship. As part of the data analysis, filters were employed on the raw Scopus S&E publication data to remove publications with questionable quality, which appear in what are sometimes called predatory journals (NSB Indicators 2018 : Bibliometric Data Filters )." data-endnote-uuid="a5778137-c92e-4694-991d-a1545bdcca18">​ Publication output includes only those indexed in the Scopus database. The publication output discussion uses fractional counting, which credits coauthored publications according to the collaborating institutions or regions, countries, or economies based on the proportion of their participating authors. Country assignments refer to the institutional address of authors, with partial credit given for each international coauthorship. As part of the data analysis, filters were employed on the raw Scopus S&E publication data to remove publications with questionable quality, which appear in what are sometimes called predatory journals (NSB Indicators 2018 : Bibliometric Data Filters ). Approximately 86% of publications in 2022 came from regions, countries, or economies with high-income and upper-middle-income economies ( Figure PBS-1 ). The number of publications from all income-level groups grew between 2003 and 2022 ( Table SPBS-2 ). Also, the number of publications from upper-middle-income economies grew more quickly than the number from high-income economies during the more recent period between 2010 and 2022.

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S&E publications, by income group: 2003–22

Article counts refer to publications from a selection of conference proceedings and peer-reviewed journals in S&E fields from Scopus. Articles are classified by their year of publication and are assigned to a region, country, or economy on the basis of the institutional address(es) of the author(s) listed in the article. Articles are credited on a fractional count basis (i.e., for articles produced by authors from different regions, countries, or economies, each region, country, or economy receives fractional credit on the basis of the proportion of its participating authors). Data are not directly comparable with data from Science and Engineering Indicators 2022 ; see the Technical Appendix for information on data filters. Low-income regions, countries, or economies are not included in this figure because of their low publication output. Data by region, country, or economy and income group are available in Table SPBS-2 . Regions, countries, or economies are allocated to income groups based on World Bank data, using their current designation. For example, all of China’s publications from 2003 to 2022 are counted as part of the upper-middle-income category because that is China's current designation.

National Center for Science and Engineering Statistics; Science-Metrix; Elsevier, Scopus abstract and citation database, accessed April 2023; World Bank Country and Lending Groups, accessed May 2023.

Science and Engineering Indicators

In 2022, six regions, countries, or economies each produced more than 100,000 articles: China, the United States, India, Germany, the United Kingdom, and Japan. Together, these leading regions, countries, or economies accounted for over 50% of the worldwide total in 2022 ( Figure PBS-2 ; Table PBS-1 ). Figure PBS-2 and Table PBS-1 , or whole counting, as in Table SPBS-17 . There is a slight difference between the United States and China when looking at the whole-counting total production numbers. Using whole counting for 2022, the United States had 605,633 articles, whereas China had 976,141. A whole-counting measure allocates one full count to each region, country, or economy with an author contributing to the article; in fractional counting, each region, country, or economy receives a proportion of the count based on the number of authors from that region, country, or economy. For example, if an article had four authors—two from the United States, one from China, and one from Brazil—the fractional scores would be half for the United States, a quarter for China, and a quarter for Brazil. The difference between whole and fractional counting indicates that the United States has more authors working with Chinese authors than China has working with U.S. authors." data-bs-content="The proportion of output attributable to the large producers is consistent whether using fractional counting, as in Figure PBS-2 and Table PBS-1 , or whole counting, as in Table SPBS-17 . There is a slight difference between the United States and China when looking at the whole-counting total production numbers. Using whole counting for 2022, the United States had 605,633 articles, whereas China had 976,141. A whole-counting measure allocates one full count to each region, country, or economy with an author contributing to the article; in fractional counting, each region, country, or economy receives a proportion of the count based on the number of authors from that region, country, or economy. For example, if an article had four authors—two from the United States, one from China, and one from Brazil—the fractional scores would be half for the United States, a quarter for China, and a quarter for Brazil. The difference between whole and fractional counting indicates that the United States has more authors working with Chinese authors than China has working with U.S. authors." data-endnote-uuid="a3ba485a-d862-4069-8166-933aa601ea66">​ The proportion of output attributable to the large producers is consistent whether using fractional counting, as in Figure PBS-2 and Table PBS-1 , or whole counting, as in Table SPBS-17 . There is a slight difference between the United States and China when looking at the whole-counting total production numbers. Using whole counting for 2022, the United States had 605,633 articles, whereas China had 976,141. A whole-counting measure allocates one full count to each region, country, or economy with an author contributing to the article; in fractional counting, each region, country, or economy receives a proportion of the count based on the number of authors from that region, country, or economy. For example, if an article had four authors—two from the United States, one from China, and one from Brazil—the fractional scores would be half for the United States, a quarter for China, and a quarter for Brazil. The difference between whole and fractional counting indicates that the United States has more authors working with Chinese authors than China has working with U.S. authors. In absolute numbers, the growth in worldwide annual publication output (from 2.0 million in 2010 to 3.3 million in 2022) was driven in particular by two countries: China (42% of additional publications during that period) and India (11%) together accounted for more than half of that increase in publications ( Figure PBS-3 ). Russia, South Korea, Iran, and Brazil made notable contributions to the growth in the number of publications from the rest of the world from 2010 to 2022 ( Figure PBS-3 ; Table SPBS-2 ). Generally, the set of the top 15 producers of S&E articles was the same each year between 2010 and 2022, with the exception of Iran replacing Taiwan in the top 15 beginning in 2014 ( Table PBS-1 ; Table SPBS-2 ).

S&E publications for 10 leading regions, countries, or economies: 2022

Article counts refer to publications from a selection of conference proceedings and peer-reviewed journals in S&E fields from Scopus. Articles are classified by their year of publication and are assigned to a region, country, or economy on the basis of the institutional address(es) of the author(s) listed in the article. Articles are credited on a fractional count basis (i.e., for articles produced by authors from different regions, countries, or economies, each region, country, or economy receives fractional credit on the basis of the proportion of its participating authors). Data by all countries, regions, and economies are available in Table SPBS-2 .

National Center for Science and Engineering Statistics; Science-Metrix; Elsevier, Scopus abstract and citation database, accessed April 2023.

S&E publications in all fields for 15 largest producing regions, countries, or economies: 2012 and 2022

na = not applicable.

The regions, countries, or economies are ranked based on the 2022 total. Article counts refer to publications from conference proceedings and peer-reviewed journal articles in S&E and indexed in Scopus (see Technical Appendix for more details). Articles are classified by their year of publication and are assigned to a region, country, or economy on the basis of the institutional address(es) of the author(s) listed in the article. Articles are credited on a fractional count basis (i.e., for articles from multiple regions, countries, or economies, each region, country, or economy receives fractional credit on the basis of the proportion of its participating authors). Detail may not add to total because of regions, countries, or economies that are not shown. Proportions are based on the world total excluding unclassified addresses (data not presented). Details and other regions, countries, or economies are available in Table SPBS-2 .

S&E publications, by selected region, country, or economy and rest of world: 2003–22

Article counts refer to publications from a selection of conference proceedings and peer-reviewed journals in S&E fields from Scopus. Articles are classified by their year of publication and are assigned to a region, country, or economy on the basis of the institutional address(es) of the author(s) listed in the article. Articles are credited on a fractional count basis (i.e., for articles produced by authors from different countries, each country receives fractional credit on the basis of the proportion of its participating authors). Data for all regions, countries, and economies are available in Table SPBS-2 .

The U.S. trend of moderate but increasing publication output varied by state. The National Science Board’s (NSB’s) State Data Tool ( https://ncses.nsf.gov/indicators/states/ ) provides state-level data based on each state’s doctorate population and research and development (R&D) funding. Indicators include academic S&E article output per 1,000 science, engineering, and health doctorate holders in academia (NSB 2021a) and academic S&E article output per $1 million in academic S&E R&D funding (NSB 2021b).

Output by Scientific Field

The distribution of publications by field of science across region, country, or economy may indicate research priorities and capabilities. Health sciences was the field of science in which most articles were published in 2022, representing almost a quarter of all publications ( Table SPBS-2 and Table SPBS-10 ). Other fields with large numbers of publications included engineering (17% of publications in 2022), biological and biomedical sciences (13%), and social sciences (5%) ( Table SPBS-2 , Table SPBS-5 , Table SPBS-8 , and Table SPBS-16 ). In the United States, the European Union (EU-27), and Japan, health sciences publication output in 2022 far exceeded that of any other field. Table SPBS-17 through Table SPBS-31 )." data-bs-content="The use of whole counting or fractional counting to tally the publication output of nations can change the calculated publication count based on the degree to which a region, country, or economy is involved in international collaborations. Under whole counting, a nation receives credit for any publication with an author from that nation. Under fractional counting, the nation’s credit for a publication is prorated based on the share of the publication’s coauthors who are located in that nation ( Table SPBS-17 through Table SPBS-31 )." data-endnote-uuid="05c8023f-5250-4386-96cf-f321c7f293c4">​ The use of whole counting or fractional counting to tally the publication output of nations can change the calculated publication count based on the degree to which a region, country, or economy is involved in international collaborations. Under whole counting, a nation receives credit for any publication with an author from that nation. Under fractional counting, the nation’s credit for a publication is prorated based on the share of the publication’s coauthors who are located in that nation ( Table SPBS-17 through Table SPBS-31 ). Meanwhile, of the other top producers, publications from China were most highly concentrated in engineering (25%), and publications from India were published predominantly in computer and information sciences (21%) ( Figure PBS-4 ).

Distribution of national S&E research portfolios across scientific fields, by selected region, country, or economy: 2022

EU-27 = European Union.

Articles refer to publications from a selection of conference proceedings and peer-reviewed journals in S&E fields from Scopus. Articles are classified by their year of publication and are assigned to a region, country, or economy on the basis of the institutional address(es) of the author(s) listed in the article. Articles are credited on a fractional count basis (i.e., for articles from multiple countries, each country receives fractional credit on the basis of the proportion of its participating authors). See Table SPBS-1 for countries included in the EU; beginning in 2020, the United Kingdom was no longer a member of the EU. See Table SPBS-3 through Table SPBS-16 for data on all regions, countries, and economies by each S&E field.

Fields within life sciences were dominant in the United States in 2022, with more than half of all U.S. publications in health sciences (37%) or biological and biomedical sciences (14%) ( Figure PBS-5 ). There were fewer U.S. publications in engineering (11%), computer and information sciences (7%), and physics (5%). In comparison with the United States, China had a stronger focus on publications in engineering and in the physical sciences and information sciences. In 2022, 25% of China’s publications were in engineering, 11% were in computer and information sciences, and 9% were in physics ( Figure PBS-6 ). Compared with the United States, China had a lower percentage of its publications in health sciences (14%) and biological and biomedical sciences (12%). In 2022, China also had a much lower percentage of its publications in social sciences (1%) when compared with the United States (8%).

U.S. S&E publication portfolio, by field of science: 2022

Articles refer to publications from a selection of conference proceedings and peer-reviewed journals in S&E fields from Scopus. Articles are classified by their year of publication and are assigned to a region, country, or economy on the basis of the institutional address(es) of the author(s) listed in the article. Articles are credited on a fractional count basis (i.e., for articles from multiple countries, each country receives fractional credit on the basis of the proportion of its participating authors). See Table SPBS-3 through Table SPBS-16 for data on all regions, countries, and economies by each S&E field.

S&E publication portfolio from China, by field of science: 2022

Articles refer to publications from a selection of conference proceedings and peer-reviewed journals in S&E fields from Scopus. Articles are classified by their year of publication and are assigned to a region, country, or economy on the basis of the institutional address(es) of the author(s) listed in the article. Articles are credited on a fractional count basis (i.e., for articles from multiple countries, each country receives fractional credit on the basis of the proportion of its participating authors). See Table SPBS-3 through Table SPBS-16 for data on all regions, countries, and economies and by each S&E field.

All the leading regions, countries, or economies saw an increase in their output of health sciences publications between 2010 and 2022. This increase is to be expected, given the context of increasing publication rates in general over that period, with overall number of publications increasing by 71% ( Table SPBS-2 ), while publications in health sciences increased by 66% ( Table SPBS-10 ). Russia had the highest relative growth rate among the 20 leading regions, countries, or economies in health sciences, increasing its publication output by almost 450% between 2010 and 2022 ( Table SPBS-10 ). China and Iran each increased their output of health sciences publications by more than 250% over this period, while India’s health sciences publication output increased by more than 180%. The United States increased its output of health sciences publications by 32% over this period, while Germany, France, the United Kingdom, and Japan had the smallest increases, each with less than 20%.

Leading regions, countries, or economies also saw increases in engineering publications. The fastest growing between 2010 and 2022 were India (up 378%) and Russia (up 230%) ( Table SPBS-8 ). China increased its output of engineering publications by 176% from 2010 to 2022, while France, the United States, and Japan all saw declines in newly published engineering articles per year over this period (3%, 13%, and 26%, respectively).

In the United States, publication output varied from that of other regions, countries, or economies with respect to scientific fields. Of the fields not already mentioned, the fastest growing from 2010 to 2022 were psychology (up 39% from 2010 to 2022) and the social sciences (up 38%) ( Figure PBS-7 ). Meanwhile, fields with the largest decreases in U.S. publications included physics (down 31% from 2010 to 2022) and materials science (down 16%).

Index of U.S. publications, by field: 2010–22

Using funding acknowledgments to track federally funded research over time.

Federally funded research is an important component of the research ecosystem and is often envisioned as a means of supporting science performed for public benefit that may not otherwise be motivated by commercial interest (Bornmann 2013; Stephan 2012; Yin et al. 2022). Federal research funding supports applied and basic research (see Indicators 2022 report “ Research and Development: U.S. Trends and International Comparisons ”) and has long been linked to successful expansions in scientific production—through the increased productivity and impact of individual researchers and laboratories (Ebadi and Schiffauerova 2016) and the national scale (Leydesdorff and Wagner 2009). This sidebar explores funding acknowledgments, as recorded in Scopus, as an emerging source to help illustrate the extent to which published research is supported by federal agencies and the trends in federally funded research. Specifically, the share of published research acknowledging support by federal funding was highest in chemistry and smaller in other fields, such as the social sciences ( Table PBS-A ). These differences may be driven by factors such as the resource costs to conduct research and by field differences, such as the overall frequency of publication, team size, and cultural differences among the disciplines. The time period analyzed in this sidebar is 2018–22, unless otherwise indicated.

Funding acknowledgments can shed light on the ability and priorities of federal funding to support discovery as measured by peer-reviewed journal articles and conference proceedings. However, some benefits and limitations of this emerging data source are important to highlight so as to accurately interpret these trends. Each peer-reviewed journal article and conference proceeding in the Scopus database includes a field for funding acknowledgments that are extracted by algorithmic (software) means. In some cases where the acknowledgments field is incomplete, funding information from agencies is also used to identify funded publications in Scopus. Using this field, it is possible to observe the conversion of federal funds to published research outputs, but a direct linkage between funding inputs and published discoveries remains challenging. First, extraction of this information into a structured field is a relatively new effort and is most complete for the most recent 4 years. Figure SPBS-1 shows how funding acknowledgment sections have grown in coverage since 2003 and that funding information was indexed for 68% of all publications in 2022. * Many factors may have contributed to this growth in addition to improved extraction, including increasing pressure and requirements from funders to include funding acknowledgments, standardization of acknowledgment language, and incentives to demonstrate high publication output—because future funding is tied to past conversion of funds into publications—while receiving funding. † Last, this inquiry helps explore research that acknowledges any federal funding but does not only account for publications that source all their funding from a single source. In practice, a publication may be generated using funding from multiple sources within the federal government, or from additional sources in state government, local government, or the private sector.

U.S. S&E publications with and without acknowledgments of U.S. federal funding: 2003–22

Articles are classified by their year of publication and are assigned to a region, country, or economy on the basis of the institutional address(es) of the author(s) listed in the article. Whole counting is used. An article is considered to be federally funded if the funding information tied with the publication record in Scopus links it with one of the U.S. federal agencies. Not all Scopus publications have funding information available, and coverage has evolved with time. For more information, see Figure SPBS-1 . For a breakdown of federally funded papers by funding agency, see Table SPBS-90 .

National Center for Science and Engineering Statistics; Science-Metrix; Elsevier, Scopus abstract and citation database, accessed April 2023.

Figure PBS-A tracks the growth of federally funded publications relative to the total research production in the United States. Other than a small downturn from 2021 to 2022, every year has seen an increase from the previous year in the number of publications that acknowledge funding support from federal agencies. The most comprehensive data from the past 4 years show variation among subject areas in the percentage of publications that acknowledge federal support. Table PBS-A shows number and share of publications appearing between 2018 and 2022 that acknowledged funding from federal sources and those acknowledging funding from other sources. During this time, more than 50% of publications in the following subject fields acknowledged federal funding support: chemistry (55% of publications), biological and biomedical sciences (53%), astronomy and astrophysics (53%), and physics (52%). Only two subject areas have less than 30% of publications with federal funding acknowledged: agricultural sciences (28%), and social sciences (15%). Otherwise, all other fields had between 30% and 50% of their publications acknowledging federal funding.

U.S. S&E publications, by U.S. federal funding status and field: 2018–22

In conclusion, federal funding plays an important role in the current research environment in the United States. Of the 606,144 articles published in journals and conference proceedings in 2022, 35% acknowledged support from federal agencies ( Figure PBS-A ). Ultimately, acknowledgment of federal funding can help show trends in the conversion of grants into published research over time and show variation at the subject or field level.

* Missing data in funding fields in a Scopus entry may mean that the research did not receive funding, the authors did not cite any funding despite receiving it, or the algorithm was unable to extract the acknowledgment. Of the articles from 2003 that had an entry for funding acknowledgment (27% had text in the funding field in Scopus), around 76% acknowledged a federal funding source. Comparatively, of the publications in 2022 with indexed funding information (68%), 52% acknowledged a federal source. The growth of coverage of funding not being tied to federal funding acknowledgments provides evidence that the data source has become more dependable over time. Data for the percentage of publications with indexed funding sources by year and field can be found in Figure SPBS-1 .

† Table SPBS-90 displays the number of articles and conference proceedings acknowledging federal funding at the agency level and sub-agency level. These counts represent the number of supported articles as acknowledged and attributed in Scopus from 2003 to 2022.

Output and Open Access

There is growing support for the availability of S&E publications through OA sources among government and private funders, institutions, and scientists themselves. Some of these funders have imposed requirements on their grantees to publish their research results in OA journals. In the United States, the Office of Science and Technology Policy announced that all federal agencies should update their public access policies as soon as possible to ensure that results of their funded research are publicly available, with full implementation of these policies by the end of 2025 (Brainard and Kaiser 2022). Meanwhile, restricted access to scientific literature may impede researchers’ ability to stay informed (Larivière and Sugimoto 2018; Piwowar et al. 2018). As alternatives to traditional closed-access journals (where readers must subscribe to gain access or pay per article), articles may be made OA through several avenues, with different levels of availability and durability.

There are four commonly defined types of OA: Gold, Hybrid, Bronze, and Green. Gold OA denotes articles published in journals that are entirely OA as a matter of journal policy. Hybrid OA denotes articles for which the authors have elected to pay a fee for publication as OA rather than as closed access. Bronze OA denotes articles that appear as OA after an embargo period of closed access or articles that appear available as OA despite lacking license information to guarantee OA in the long term. Green OA denotes articles that are self-archived by authors in OA repositories, which are often maintained, curated, and administered by universities or other institutions. The Hybrid and Bronze categories have been combined as Other Journal-Based OA in this report because of their similar structure as journal-hosted types of OA that allow only conditional—and potentially revocable—OA.

The number of articles published annually in closed-access journals increased by 112% between 2003 and 2022 ( Figure PBS-8 ). Over the same period, annual publishing of Green OA articles increased by 228%, while Other Journal-Based OA articles (Hybrid and Bronze OA) increased by 198%. Gold OA articles (which are published in OA journals with no restrictions) had the largest percentage growth, from 19,089 articles in 2003 to 991,805 articles in 2022, an increase of over 5,000%. Hence, although the majority (77%) of S&E articles in 2003 whose access status is known were published in closed-access journals, fewer than half (49%) were in closed-access journals in 2022.

S&E publications, by publication access type: 2003–22

OA = open access.

Articles refer to publications from a selection of conference proceedings and peer-reviewed journals in S&E fields from Scopus. Articles are classified by their year of publication. OA types are mutually exclusive. For articles published under multiple OA types, the article will be counted as part of only the first type it matches in this list: Gold OA, Other Journal-Based OA, or Green OA. Summing all OA and closed-access article counts results in a smaller number of articles than for all S&E because the access status of some articles (e.g., those without digital object identifiers) cannot be reliably ascertained. Green articles are published in toll-access journals but archived in an OA archive, or "repository." These repositories may be discipline specific (like arXiv) or institutional repositories operated by universities or other institutions. Green articles may be published versions or preprints and can have any license or no license. Bronze (Other Journal-Based OA) articles are free to read on the publisher's website, without a license that grants any other rights. There may be a delay between publication and availability to read, and often articles can be removed unilaterally by the publisher. Hybrid (Other Journal-Based OA) articles are free to read at the time of publication, with an open license. These are usually published in exchange for an article processing charge. Gold articles have all the same characteristics as Hybrid articles but are published in all-OA journals, which are in turn called "Gold journals" or just "OA journals."

To conclude this section, the findings of the output analysis reveal the growth in scientific publications over time, with upper-middle-income economies exhibiting particularly large percentage increases. Meanwhile, the distribution of publications across scientific fields shows that life sciences dominated in the United States, Europe, and Japan, whereas publications in engineering and computer sciences dominated in China and India. In OA, the dramatic growth of Gold OA publications and the steady growth of publications in other OA categories show an increased shift toward open science. However, OA can impede the dissemination of some scientific research. Publishing research as OA often requires authors to pay article processing fees, which may be prohibitive for scientists in less-developed nations or whose funders do not subsidize those fees. https://www.elsevier.com/about/policies/pricing . Wiley APCs are at https://authorservices.wiley.com/author-resources/Journal-Authors/open-access/article-publication-charges.html . Springer Nature APCs are at https://www.springernature.com/gp/open-research/journals-books/journals ." data-bs-content="Many publishers make their article processing charges (APCs) known publicly. For example, a list of Elsevier APCs can be found at https://www.elsevier.com/about/policies/pricing . Wiley APCs are at https://authorservices.wiley.com/author-resources/Journal-Authors/open-access/article-publication-charges.html . Springer Nature APCs are at https://www.springernature.com/gp/open-research/journals-books/journals ." data-endnote-uuid="9a612a36-466d-4d60-af1a-57e93bd50e76">​ Many publishers make their article processing charges (APCs) known publicly. For example, a list of Elsevier APCs can be found at https://www.elsevier.com/about/policies/pricing . Wiley APCs are at https://authorservices.wiley.com/author-resources/Journal-Authors/open-access/article-publication-charges.html . Springer Nature APCs are at https://www.springernature.com/gp/open-research/journals-books/journals . The fees can be seen as shifting the costs of accessing research from readers and libraries to authors (Larivière and Sugimoto 2018).

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