research paper on organic chemistry

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Organic chemistry articles within Nature

Article | 28 March 2024

Copper-catalyzed dehydrogenation or lactonization of C(sp 3 )−H bonds

• Shupeng Zhou
• , Zi-Jun Zhang
•  &  Jin-Quan Yu

Research Briefing | 18 March 2024

‘Bandit’ algorithms help chemists to discover generally applicable conditions for reactions

In organic chemistry, finding conditions that enable a broad range of compounds to undergo a particular type of reaction is highly desirable. However, conventional methods for doing so consume a lot of time and reagents. A machine-learning method has been developed that overcomes these problems.

Article | 13 March 2024

Couple-close construction of polycyclic rings from diradicals

A couple-close approach used to build semisaturated ring systems from dual radical precursors allows sampling of regions of underexplored chemical space, leading to an annulation that can be used for late-stage functionalization of pharmaceutical scaffolds.

• , Christian J. Oswood
•  &  David W. C. MacMillan

Article | 28 February 2024

Symmetry breaking and chiral amplification in prebiotic ligation reactions

A study of a new route to proteinogenic peptides reveals how heterochiral preference can lead to homochiral peptides in a prebiotic world.

• , Jinhan Yu
•  &  Donna G. Blackmond

Article | 13 February 2024

Alkene dialkylation by triple radical sorting

We use bimolecular homolytic substitution catalysis to sort an electrophilic radical and a nucleophilic radical across an unactivated alkene, accelerating access to pharmaceutically relevant C( sp 3 )-rich molecules and defining a mechanistic approach for alkene dialkylation.

• Johnny Z. Wang
• , William L. Lyon

Article 31 January 2024 | Open Access

Stereodivergent 1,3-difunctionalization of alkenes by charge relocation

We introduce a method for the direct 1,3-difunctionalization of alkenes, based on a concept termed ‘charge relocation’, which enables stereodivergent access to 1,3-difunctionalized products of either syn - or anti -configuration from unactivated alkenes.

• Bogdan R. Brutiu
• , Giulia Iannelli
•  &  Nuno Maulide

Where I Work | 15 January 2024

Giving thanks for a glovebox: helping to make medicines from natural substances

Richmond Sarpong wishes more people had access to the nitrogen-regulated device.

• James Mitchell Crow

Nature Careers Podcast | 24 November 2023

How ChatGPT and sounds from space brought a ‘luminous jelly’ to life

Engineer-turned-artist Diana Scarborough and inorganic chemist Anna Melekhova describe how their art–science collaboration gave voice and form to a new material.

• Julie Gould

Article | 01 November 2023

Carbon-to-nitrogen single-atom transmutation of azaarenes

A new type of transformation converting a heteroaromatic carbon atom into a nitrogen atom, turning quinolines into quinazolines to enable manipulation of molecular properties, is reported.

• , Colin Stein
•  &  Mark D. Levin

News & Views | 01 November 2023

Atom-swap chemistry could aid drug discovery

An unconventional route for modifying pharmaceutically relevant molecules swaps an atom of carbon for one of nitrogen. The resulting derivatives might open up avenues of research in medicinal-chemistry campaigns.

• Filippo Ficarra
•  &  Mattia Silvi

Article | 11 October 2023

Arenium-ion-catalysed halodealkylation of fully alkylated silanes

A new method is described that uses arenium-ion-catalysed halodealkylation of silanes with four alkyl groups, typically considered synthetic dead ends, to convert Me 4 Si and related quaternary silanes into orthogonally substituted (functionalized) silanes.

• , Hendrik F. T. Klare
•  &  Martin Oestreich

Article | 03 October 2023

Complex molecule synthesis by electrocatalytic decarboxylative cross-coupling

We report a radical-based Ni/Ag-electrocatalytic cross-coupling of substituted carboxylic acids, enabling an approach to accessing complex molecular architectures, which relies on a silver additive that forms an active Ag nanoparticle-coated electrode surface along with carefully chosen ligands.

• Benxiang Zhang
• , Jiayan He
•  &  Phil S. Baran

News & Views | 27 September 2023

An all-organic laser that is electrically driven

An organic light-emitting diode has been integrated with an optically driven organic laser to produce laser light from electricity. The design bypasses many of the challenges posed by direct electrical input in such devices.

• Stéphane Kéna-Cohen

Research Briefing | 20 September 2023

The chemical synthesis and anti-cancer properties of portimines

The natural toxins portimine A and B have attracted interest for their unusual chemical architecture and potent anti-cancer activity. The first total synthesis of portimines enables the identification of portimine A’s molecular target and reveals that the toxin induces programmed cell death in human cancer cells.

Article | 20 September 2023

A crystalline doubly oxidized carbene

The synthesis and isolation of a crystalline dication derived from a bis(imino)carbene through a two-electron oxidation/oxide-ion abstraction strategy is reported that bypasses the carbene radical cation, maintaining significant electrophilicity with two accessible vacant orbitals.

• Ying Kai Loh
• , Mohand Melaimi
•  &  Guy Bertrand

Geminal-atom catalysis for cross-coupling

Heterogeneous geminal-atom catalysts, which pair single-atom sites in specific coordination and spatial proximity, offer a new avenue for the sustainable manufacture of fine chemicals.

• , Yang Zheng
•  &  Jiong Lu

Synthesis of portimines reveals the basis of their anti-cancer activity

A scalable total synthesis of portimines enables structural reassignment of portimine B and in-depth functional evaluation of portimine A, revealing that portimine A induces translation inhibition selectively in human cancer cells and is efficacious in vivo tumour-clearance models.

• Junchen Tang
• , Weichao Li

Article 06 September 2023 | Open Access

A catalytically active oscillator made from small organic molecules

We report a small-organic-molecule oscillator that catalyses an independent chemical reaction in situ without impairing its oscillating properties, allowing the construction of complex systems enhancing applications in automated synthesis and systems and polymerization chemistry.

• Matthijs ter Harmsel
• , Oliver R. Maguire
•  &  Syuzanna R. Harutyunyan

Article | 06 September 2023

Hydrogen-bond-acceptor ligands enable distal C( sp 3 )–H arylation of free alcohols

Ligands enable alcohol-directed arylation of δ-C( sp 3 )–H bonds by stabilizing hydroxyl coordination to palladium through charge balance and hydrogen bonding.

• Daniel A. Strassfeld
• , Chia-Yu Chen

Article 23 August 2023 | Open Access

Light-enabled deracemization of cyclopropanes by Al-salen photocatalysis

Irradiation of chiral Al-salen complexes with violet light demonstrates efficient deracemization of cyclopropanes, enabling reactivity and enantioselectivity to be regulated simultaneously, negating the requirement for tailored catalyst–substrate recognition motifs.

• Carina Onneken
• , Tobias Morack
•  &  Ryan Gilmour

Article | 05 July 2023

Regioselective aliphatic C–H functionalization using frustrated radical pairs

Regioselective functionalization of aliphatic carbon–hydrogen bonds is achieved using frustrated radical pairs generated from disilazide donors and an N -oxoammonium acceptor.

• , Minsoo Ju
•  &  Song Lin

Article | 26 June 2023

Functional-group translocation of cyano groups by reversible C–H sampling

Using light-based, reversible C−H sampling catalysis, a cyano functional group can be swapped with a C−H bond in a molecule, providing access to valuable structures that are difficult to obtain by other methods.

• , Qingrui Zeng
•  &  Yan Xu

News & Views | 19 June 2023

Rarely used strained molecules step up for organic synthesis

Energy released from molecules under strain can promote difficult chemical reactions. A practical method has been developed that uses an overlooked, highly strained compound to rapidly construct complex organic products.

• Fahima I. M. Idiris
•  &  Christopher R. Jones

Research Briefing | 14 June 2023

Nickel catalyses a host of chemical reactions in a general method

A minimal but general method has been developed for catalysing many different cross-coupling reactions — those in which two chemical fragments are joined. It requires only the two substrate substances, a nickel salt as a catalyst precursor, a catalyst for light-driven redox reactions and, in some cases, a nitrogen-containing base.

Article | 31 May 2023

Transannular C–H functionalization of cycloalkane carboxylic acids

Quinuclidine-pyridone and sulfonamide-pyridone ligands enable transannular γ-methylene C–H arylation of cycloalkane carboxylic acids with a range of ring sizes, bringing us closer to molecular editing of saturated carbocycles.

• Guowei Kang
• , Daniel A. Strassfeld

Article | 19 April 2023

Strain-promoted reactions of 1,2,3-cyclohexatriene and its derivatives

The strained C 6 H 6 isomer 1,2,3-cyclohexatriene and its derivatives participate in a host of reaction modes which demonstrate their potential for selective chemical transformations and provide an unconventional entryway to complex scaffolds.

• Andrew V. Kelleghan
• , Ana S. Bulger
•  &  Neil K. Garg

Research Briefing | 05 April 2023

Enzyme-inspired catalyst helps to convert methane into methanol

A catalyst with a hydrophobic cavity that contains an active iron centre has been developed to convert methane into methanol. It has a ‘catch-and-release’ mechanism whereby a hydrophobic methane molecule enters the cavity for oxidation and the resulting hydrophilic methanol molecule is released into the surrounding aqueous solution.

Article | 04 April 2023

General access to cubanes as benzene bioisosteres

The synthesis of 1,3- and 1,2-disubstituted cubanes is achieved using a cyclobutadiene precursor and a photolytic carboxylation reaction, respectively, and copper-catalysed amination, arylation, alkylation and trifluoromethylation reactions have been developed enabling the use of cubanes as bioisosteres of benzenes in drug design.

• Mario P. Wiesenfeldt
• , James A. Rossi-Ashton

Article | 30 March 2023

Copper-catalysed enantioconvergent alkylation of oxygen nucleophiles

The enantioconvergent alkylation of oxygen nucleophiles is achieved using α-haloamides and a readily available copper catalyst, and the reaction proceeds under mild conditions in the presence of a wide variety of functional groups.

• Caiyou Chen
•  &  Gregory C. Fu

Article | 20 March 2023

Enantioconvergent Cu-catalysed N -alkylation of aliphatic amines

The chemoselective and enantioconvergent N -alkylation of aliphatic amines, including ammonia, is achieved using chiral tridentate anionic ligands and a copper catalyst; the method shows excellent enantioselectivity and functional-group tolerance.

• Ji-Jun Chen
• , Jia-Heng Fang
•  &  Xin-Yuan Liu

Article 15 March 2023 | Open Access

Control of stereogenic oxygen in a helically chiral oxonium ion

The design, synthesis and characterization of a helically chiral triaryloxonium ion is reported, which is an example of a chiral non-racemic and configurationally stable molecule in which the oxygen atom is the sole stereogenic centre.

• , Mihai V. Popescu
•  &  Martin D. Smith

Article | 14 February 2023

Enantioselective transition-metal catalysis via an anion-binding approach

Chiral hydrogen-bond donors bind anions of organometallic catalysts to achieve enantiocontrol and reaction-rate enhancement through ion pairing together with other non-covalent interactions.

• John M. Ovian
• , Petra Vojáčková
•  &  Eric N. Jacobsen

News | 01 February 2023

The surprising chemicals used to embalm Egyptian mummies

Resins used to prepare bodies for the afterlife are found in vessels in an ancient workshop.

• Ewen Callaway

News & Views | 25 January 2023

Machine learning classifies catalytic-reaction mechanisms

The study of how chemical reactions work is key to the design of new reactions, but relies on hard work and expert knowledge. A machine-learning tool has been developed that could change the way this challenge is approached.

• Danilo M. Lustosa
•  &  Anat Milo

Article | 25 January 2023

Organic reaction mechanism classification using machine learning

Mechanistic elucidation through currently available kinetic analysis is limited by mathematical approximations and human interpretation, here a deep neural network model has been trained to analyse ordinary kinetic data and automatically elucidate the corresponding mechanism class.

• Jordi Burés
•  &  Igor Larrosa

Article | 05 January 2023

Electrochemical reactor dictates site selectivity in N -heteroarene carboxylations

An electrochemical strategy is described in which the direct carboxylation of pyridines and related N -heteroarenes with CO 2 shows divergent site selectivity depending on the type of reactor used.

• Guo-Quan Sun

Research Highlight | 09 December 2022

Tinkering with molecular ‘backbones’ holds promise for drug discovery

A method to edit the backbones of molecules allows chemists to modify ring-shaped chemical structures with greater ease.

Article | 06 December 2022

Electrophotocatalytic oxygenation of multiple adjacent C–H bonds

Installation of multiple C–O bonds by concurrent oxygenation of contiguous C–H bonds in a selective fashion is highly desirable, and this is achieved by repeated operation of a potent oxidative catalyst via electrophotocatalysis.

• , Yi-Lun Li
•  &  Tristan H. Lambert

Outlook | 16 November 2022

How to make plastic less of an environmental burden

Plastic has long been an ecological problem. But emerging technologies and more awareness could make the ubiquitous material part of a circular economy.

• Sarah DeWeerdt

News & Views | 10 October 2022

A leap forward in the quest for general catalysts

Truly general chemical reactions work well regardless of the structural features and functional groups in the starting molecule. A new screening protocol speeds up the identification of such reactions in the field of asymmetric catalysis.

• Manuel J. Scharf
•  &  Benjamin List

News & Views | 29 September 2022

Machine assembly of carbohydrates with more than 1,000 sugar units

Efforts to probe the biological functions of carbohydrates have long been limited by the lack of such molecules with well-defined structures. An automated carbohydrate synthesizer has been developed that could remedy this.

• Hanchao Cheng
•  &  Peng George Wang

News & Views | 16 September 2022

A stable alternative to an explosive synthetic reaction

The ozonolysis reaction is a classic of organic synthesis, but involves the formation of potentially explosive reaction intermediates. A modern, safer spin on this process makes use of previously overlooked chemistry.

• Vignesh Palani
•  &  Alison Wendlandt

Article | 15 September 2022

Synthesis of meta -substituted arene bioisosteres from [3.1.1]propellane

The potential power of the saturated carbocycle bicyclo[3.1.1]heptane as a beneficial motif for improving the pharmacokinetic and physicochemical properties of drug candidates is demonstrated.

• , Jeremy Nugent
•  &  Edward A. Anderson

Article | 01 September 2022

Screening for generality in asymmetric catalysis

 The analytical workflow outlined in this study allows multiple crude reaction mixtures to be analysed simultaneously, with substantial reductions in method development and analysis time, and maximizes the chances of finding catalytic systems with broad substrate scope.

• Corin C. Wagen
• , Spencer E. McMinn

Article | 23 August 2022

Photoexcited nitroarenes for the oxidative cleavage of alkenes

Oxidative cleavage of alkenes is achieved using nitroarenes and light irradiation as an alternative to using ozone to break the carbon–carbon bonds, avoiding the explosive intermediates formed with ozone.

• Alessandro Ruffoni
• , Charlotte Hampton
•  &  Daniele Leonori

Article | 09 August 2022

Molecular editing of aza-arene C–H bonds by distance, geometry and chirality

A unified catalytic remote-directing template strategy enabled precise differentiation of remote and adjacent C6–H and C7–H bonds, and similar C3–H and C7–H bonds of a pharmaceutically relevant bicyclic aza-arene scaffold.

• Zhoulong Fan
• , Xiangyang Chen

Article | 06 July 2022

RETRACTED ARTICLE: Intrinsically unidirectional chemically fuelled rotary molecular motors

A homochiral rotary molecular motor shows autonomous unidirectional rotation around a single bond driven by a chemical fuel.

•  &  Depeng Zhao

News & Views | 27 June 2022

Synthesis reveals unexpected biological targets of a traditional medicine

A compound made by plants used in traditional medicine has been prepared by chemical synthesis, providing enough for biological testing. The unexpected finding that it acts at opioid receptors raises prospects for drug discovery.

• Nicholas P. R. Onuska
•  &  Joshua G. Pierce

Obituary | 23 June 2022

David A. Evans (1941–2022)

Chemist who developed ways to synthesize and depict bioactive products.

• Mark Lautens

Article | 16 June 2022

Site-selective, stereocontrolled glycosylation of minimally protected sugars

A simplified synthesis strategy for stereo- and site-selective glycosylations, using minimally protected mono- and disaccharides and thiourea small-molecule catalysts, enables highly selective functionalization of carbohydrates.

• , Samuel M. Levi

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Organic & Biomolecular Chemistry  ( OBC ) publishes original and high impact research and reviews in organic chemistry.

We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products.

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Organic synthesis

We welcome important research in all areas of organic synthesis, including studies on small organic molecules and biomolecules, and studies that report purely synthetic work without biological data. Total or multistep syntheses should report new or improved strategies or methods, or a more efficient route to the target compound.

Methodology studies should show a significant improvement on known methods. Research that extends the known methodology to a different class of compounds is generally not suitable unless that class is significantly different in scope to previously reported methodology. Where methods are directed towards a narrow range of structures, the importance of these targets must be clearly justified.

Physical and theoretical organic chemistry

We welcome studies that report new models of reactivity, selectivity, bonding or structure, or new computational methods and have relevance for the design of subsequent experiments. That relevance should be clearly justified in the paper. Relevance is perhaps most clearly demonstrated by the description of testable predictions derived from the results of the reported theoretical work; the tests of these predictions could be contained in the same paper in which the predictions are described. Computational research that merely reproduces experimental data is not suitable for  OBC.

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We welcome articles that report new or improved methodologies in the chemical aspects of chemical biology, including design, development and use of chemical tools, chemical studies of biomolecules such as carbohydrates, proteins and nucleic acids or biological processes such as protein-protein interactions and epigenetics, and chemical methods such as imaging and labelling techniques.

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Theoretical studies that provide significant new mechanistic insights into synthetic or biological catalysts are welcome. Routine biochemistry studies of catalytic mechanisms, for instance, routine studies using tools such as site-directed mutagenesis, are not typically suitable.

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We welcome studies that report important new work in the molecular design of supramolecular or macromolecular compounds or organic materials either with a strong component in organic synthesis or with novel organic structural features. You may wish to consider our materials journals for articles outside this scope.

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We welcome studies that report significant synthetic or bioorganic research that is directed towards medicinal chemistry applications. Studies that show routine syntheses accompanied by biological testing are generally not suitable for  OBC . Our companion journal,  RSC Medicinal Chemistry , is more suitable for articles that report significant research in core medicinal chemistry disciplines.

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Find out who is on the editorial and advisory boards for the  Organic & Biomolecular Chemistry  journal.

Anthony Davis , University of Bristol, UK

Associate editors

Jeroen Dickschat , University of Bonn, Germany

Katrina Jolliffe , University of Sydney, Australia

Motomu Kanai , University of Tokyo, Japan

Xiaohua Liu , Sichuan University, China

Santanu Mukherjee , Indian Institute of Science, Bangalore, India

Scott Silverman , University of Illinois at Urbana-Champaign, USA

Cristina Trujillo , The University of Manchester, UK

Huan Wang , Nanjing University, China

Editorial board members

S.S.V Ramasastry , Indian Institute of Science Education and Research Mohali, India

Corinna Schindler , University of Michigan, USA

Judy I-Chia Wu , University of Houston, USA

Igor Alabugin , Florida State University, USA

Gonçalo Bernardes , University of Cambridge, UK

Shunsuke Chiba , Nanyang Technological University, Singapore

Andre Cobb , Kings College London, UK

Steven Cobb , Durham University, UK

Ratmir Derda , University of Alberta, Canada

Antonio Echavarren , Autonomous University of Madrid, Spain

Ben Feringa , University of Groningen, Netherlands

Amar Flood , Indiana University Bloomington, USA

Carmen Galan , University of Bristol, UK

Christian Hackenberger , Leibniz-Institut für Molekulare Pharmakologie and Humboldt Universität zu Berlin, Germany

Jason Harper , University of New South Wales, Australia

Ivan Huc , Ludwig-Maximilian University of Munich, Germany

Elizabeth Krenske , University of Queensland, Australia

Mahesh Lakshman , The City College of New York, USA

Lei Liu , Tsinghua University, China

Shih-Yuan Liu , Boston College, USA

Geraldine Masson , Institut de Chimie des Substances Naturelles (CNRS), France

Elizabeth New , University of Sydney, Australia

Dhevalapally Ramachary , University of Hyderabad, India

Paolo Scrimin , University of Padova, Italy

Oliver Seitz , Humboldt University of Berlin, Germany

Jay Siegel , University of Zürich, Switzerland

Corey Stephenson , University of Michigan, USA

Dean Tantillo , University of California Davis, USA

Mark Taylor , University of Toronto, Canada

Georgios Vassilikogiannakis , University of Crete, Greece

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Shuli You , Shanghai Institute of Organic Chemistry, China

Jian Zhou , East China Normal University, China

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Urgent accounts of highly-important new research. No strict page limit but generally up to five journal pages in length. Research findings should be presented in a succinct and informative way, emphasising the importance and potential impact of the research. Authors are particularly encouraged to prepare a title and abstract which concisely summarise the key findings of their research and their importance, avoiding the use of non-standard abbreviations, acronyms and symbols, as this will enable potential readers to quickly understand the significance of the research. Authors should also consider using recognisable, searchable terms, as around 70% of our readers come directly via search engines. The table of contents graphic should give the reader a clear indication of the topic of the study, eg by showing key compounds.

Full accounts of important original research. Full papers may be an expansion of work previously published in a Communication; however, the new work reported must represent a significant extension on what was previously published.

The importance and potential impact of the research should be emphasised. Authors are particularly encouraged to prepare a title and abstract which concisely summarise the key findings of their research and their importance, avoiding the use of non-standard abbreviations, acronyms and symbols, as this will enable potential readers to quickly understand the significance of the research. Authors should also consider using recognisable, searchable terms, as around 70% of our readers come directly via search engines. The table of contents graphic should give the reader a clear indication of the topic of the study, eg by showing key compounds.

Concise and critical reviews of important or emerging topics in organic chemistry. Easy to read and covering current areas of interest, rather than comprehensive reviews of the literature. Download our  author guidelines for Organic and Biomolecular Chemistry Reviews  (PDF).

Comments and Replies are a medium for the discussion and exchange of scientific opinions between authors and readers concerning material published in Organic & Biomolecular Chemistry .

For publication, a Comment should present an alternative analysis of and/or new insight into the previously published material. Any Reply should further the discussion presented in the original article and the Comment. Comments and Replies that contain any form of personal attack are not suitable for publication. 

Comments that are acceptable for publication will be forwarded to the authors of the work being discussed, and these authors will be given the opportunity to submit a Reply. The Comment and Reply will both be subject to rigorous peer review in consultation with the journal’s Editorial Board where appropriate. The Comment and Reply will be published together.

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As part of our commitment to transparency and open science,  Organic & Biomolecular Chemistry  is now offering authors the option of transparent peer review, where the editor’s decision letter, reviewers’ comments and authors’ response for all versions of the manuscript will be published alongside the article under an  Open Access Creative Commons licence (CC-BY) .

Reviewers will remain anonymous unless they choose to sign their report.

Find out more about our transparent peer review policy

Journal specific guidelines

Data and supporting information, characterisation of compounds.

OBC has minimum characterisation data requirements for i) new compounds, and ii) known compounds that have been synthesised by a new method. These requirements are described below.

There is no requirement to provide characterisation data for the synthesis of a known compound by a literature method; in these cases authors should provide a literature reference to previously-published characterisation data for that compound. However, authors are welcome to provide details of improved experimental protocols, more detailed characterisation data, or selected data from known compounds.

Organic compounds

Data required for both new compounds and known compounds synthesised by a new method Copies of 1 H NMR spectra (which contain no more than trace peaks that are not assigned to the structure in question) should be supplied as supplementary material. Spectra should be of high resolution and displayed in landscape, ideally with one spectrum per page.

Data required for new compounds only (in addition to the data specified above) It is the responsibility of authors to provide fully convincing evidence for the homogeneity, purity and identity of all compounds they claim as new. This evidence is required to establish that the properties and constants reported are those of the compound with the new structure claimed. Referees will assess, as a whole, the evidence presented in support of the claims made by the authors.

The following are required in all cases:

• Complete numerical listings of 1 H, 13 C NMR peaks in support of the assigned structure
• Copies of 13 C NMR spectra (containing no more than trace peaks that are not assigned to the structure in question) as supplementary material. Spectra should be of high resolution and displayed in landscape, ideally with one spectrum per page
• High-resolution mass spectrometry (HRMS), with a found value within 0.003m/z unit of the calculated value of a parent-derived ion. Elemental analysis data may be provided if HRMS is not available.

The following are required in specific cases:

• Infrared spectra should be supplied to support functional group transformations when such data are chemically necessary to establish the transformations
• Specific rotation should be supplied for chiral non-racemic compounds, when such data are chemically necessary or of intrinsically high importance for future researchers. Such data are expected when stereocenters are created or defined during asymmetric synthesis or catalysis
• The determination of enantiomeric excess of nonracemic, chiral substances should be supported with either GC/HPLC traces with retention times for both enantiomers and separation conditions (that is, chiral support, solvent and flow rate) or copies of the spectra for Mosher Ester/Chiral Shift Reagent analysis
• Copies of 2D NMR and related experiments (that is, NOE, etc) should be supplied as supplementary material in cases where these data are used to assign the structure
• Proof of absolute configuration should be supplied for chiral compounds. In cases where this is not available, a statement as to why this cannot be supplied should be included in the manuscript. For closely related structures assignment by analogy is acceptable if the configuration of one compound in the series is unambiguously assigned

In a small number of cases, some of the characterisation techniques which are normally required for new organic compounds may not be applicable or possible to obtain (for example, for some supramolecular systems). In these circumstances, the evidence for identity and purity will be judged on a case-by-case basis by the editor and referees.

Biomolecules (such as enzymes, peptides, proteins, DNA/RNA, oligosaccharides, oligonucleotides)

It is not possible to give hard and fast requirements for the characterisation of biomolecules as the applicability and availability of different techniques often depend on molecule type or size. In all cases, LC-MS or equivalent data (for example, HPLC data plus MS data on collected peaks) should be supplied for key synthetic intermediates, and as evidence of the purity and identity of the final compound.

Additional data, such as high field 1 H, 13 C NMR, X-ray crystallography or sequencing data (for proteins and oligonucleotides) may be provided if available. In some cases, authors may be required to provide some of this additional data if it is thought necessary by the referees.

For new derivatives comprising modified monomers, the usual organic chemistry analytical requirements for the novel monomer must be provided (see Organic compounds). It is not however necessary to provide this level of characterisation for the oligomer into which the novel monomer is incorporated.

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We ask that the following information be provided where possible:

• As a minimum, papers reporting QM work should include the atomic coordinates, energies, and number of imaginary frequencies for all computed stationary points.
• The level of theory used for computations should be mentioned in the text, and/or in the caption of the first figure that reports the results of those computations.
• Computational methodology should be described in sufficient detail to allow calculations to be reproduced by other researchers.
• Where calculations are performed with density functional theory, the integration grid used for the calculations should be specified.
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• For transition states (TSs), the magnitude of the frequency of the imaginary vibrational mode may also be reported.
• For intrinsic reaction coordinate (IRC) calculations, any shoulders in the IRC plots should be noted. If IRC calculations reveal that a TS corresponded to a reaction pathway different from that suggested by simple animation of its imaginary mode, then the IRC results (plots and details of reactants/products) should be included in the ESI. 
• Where computational work is included as part of a synthetic study, full details of any theoretical characterization (for example, computational NMR or VCD) of products and/or important synthetic intermediates should be documented.
• In the spirit of FAIR data, mol2 or pdb files for coordinates would also be welcomed.

Guidelines on writing titles, abstracts & table of contents entry

The title, abstract and graphical abstract are the first parts of your manuscript that editors, referees and potential readers will see, and once published they play a major part in a researcher’s decision to read your article. Therefore it’s important that these clearly and concisely show the main findings of your research and why they are important.

Title The title should be short and straightforward to appeal to a general reader, but detailed enough to properly reflect the contents of the article.

• Keep it relatively short – between 8 and 15 words is ideal
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Abstract The abstract is a single paragraph which summarises the findings of your research. It will help readers to decide whether your article is of interest to them.

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• Like your title, make sure you use familiar, searchable terms and keywords

Table of contents entry A table of contents entry (graphical abstract) is required, which should be submitted at the revision stage. This should include an eye-catching graphic and 1-2 sentence(s) of text to summarise the key findings of the article to the reader. It will appear in the table of contents and feeds – for example, RSS feeds.

The graphic should:

• Be simple, but informative.
• Capture the reader’s attention (the use of colour is encouraged) – for example, for synthetic articles a target compound or key reaction scheme work well.
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The text should:

• Be concise and focus only on the key findings of the manuscript and their importance, not the processes used; think about what would grab the attention of the potential reader and would encourage them to read the full article.
• Avoid repeating or paraphrasing the title or abstract.
• Use easily recognisable words and phrases that can be read quickly.

Table of Contents specifications:

• The figure should be a maximum size of 8 cm wide x 4 cm high.
• Figures should be supplied as TIFF files, with a resolution of 600 dpi or greater.
• The text supplied should be 1-2 sentences long, using a maximum of 250 characters.

Iron-catalyzed arylation of α-aryl-α-diazoesters From DOI:  10.1039/C5OB02418H

Copper-catalyzed electrophilic amination using N-methoxyamines From DOI: 10.1039/C5OB02167G

Anti-Selective aminofluorination of alkenes with amidines mediated by hypervalent iodine(III) reagents From DOI: 10.1039/C5OB01854D

Lewis acid-promoted [2 + 2] cycloadditions of alkenes with aryl ketenes From DOI: 10.1039/C5OB01837D

A versatile synthesis of chiral β-aminophosphines From DOI: 10.1039/C5OB02439K

Ruthenium photoredox-triggered phospholipid membrane formation From DOI: 10.1039/C6OB00290K

An alternative, unsuitable way of writing the final example above would be:

Ru(bpy 3 ) 2+ 11-watt CFL-triggered tool reduces Cu(II) and initiates CuAAC reaction leading to phospholipid synthesis and in situ membrane formation

This title is too detailed and includes terms and compound names which are too specific (e.g.Ru(bpy 3 ) 2+ , CuAAC)

A method for the preparation of chiral β-aminophosphines having substituted P-aryl groups is described. Ring-opening of cyclic sulfamidates with metal diarylphosphinites yields β-aminophosphine oxides, which are then reduced to the corresponding phosphines. Effects of the diarylphosphinite countercation on the regioselectivity of the ring-opening reaction (P- versus O-alkylation) are discussed. This method enables the introduction of electron-deficient, electron-rich and sterically hindered diarylphosphino groups, as demonstrated by the synthesis of a series of novel, P-aryl-substituted β-aminophosphines derived from tert-leucinol, valinol and phenylglycinol. Access to these derivatives will create new opportunities for steric and electronic tuning of β-aminophosphine-derived chiral ligands and organocatalysts.

From DOI: 10.1039/C5OB02439K

Copper-catalysed electrophilic amination of a triarylboroxin using an N-methoxyamine to give quick access to a variety of anilines was reported. The reaction was especially useful for syntheses of functionalised anilines when combined with our previously reported nucleophilic addition to N-methoxyamides.

From DOI: 10.1039/C5OB02167G

Advanced glycation end products (AGEs) are associated with various diseases, especially during aging and the development of diabetes and uremia. To better understand these biological processes, investigation of the in vivo kinetics of AGEs, i.e., analysis of trafficking and clearance properties, was carried out by molecular imaging. Following the preparation of Cy7.5-labeled AGE-albumin and intravenous injection in BALB/cA-nu/nu mice, noninvasive fluorescence kinetics analysis was performed. In vivo imaging and fluorescence microscopy analysis revealed that non-enzymatic AGEs were smoothly captured by scavenger cells in the liver, i.e., Kupffer and other sinusoidal cells, but were unable to be properly cleared from the body. Overall, these results highlight an important link between AGEs and various disorders

From DOI: 10.1039/C6OB00098C

Table of contents

A new route to a tetracyclic lactam was developed and the product, called VG1, was found to inhibit nonsense-mediated mRNA decay at μM concentrations. From DOI:  10.1039/c5ob02482j

Benzoyl-Oxyma is a highly crystalline, readily prepared, safer alternative to benzoyloxybenzotriazole, useful in the selective benzoylation of carbohydrate polyols. From DOI:  10.1039/C5OB02092A

A platinum complex/peptide chimera shows specific DNA binding and covalent platination with potential as a novel chemotherapeutic. From DOI:  10.1039/C5OB01885D

Information about drawing structures or schemes

When drawing structures or schemes, authors should use the correct sizes and settings in order to maintain consistency. These graphics should ideally be created in ChemDraw and they should be supplied at the size you wish them to appear in print, using the same drawing settings for all structures.

Templates are available on our  Author templates & services  page to help you produce clear chemical structures from several drawing programs (for example, ChemDraw) and you may also use the article templates to see how figures will look in the final manuscript. Full guidance on presentation of structures and other graphics is available on our  Author guidelines  page.

When submitting an article which contains structures or schemes to  OBC , authors should pay particular attention to the following key points:

• Graphic widths should be up to 8.3 cm (one-column) or 17.1 cm (two-column)
• Graphics should ideally be created to fit these widths to avoid articles containing large amounts of white space
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• Use solid or hatched wedges to depict stereochemistry
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• Recommended text size is Arial 7pt and bond lengths 0.43 cm

Submitting incorrectly-formatted files will result in a request from the handling editor to provide revised versions.

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On submission authors are asked to supply details of the two previously published articles most related to the submission-one from the author’s own group and one from the wider community. Authors are also asked to supply a very brief statement about the novelty and importance of the research. These pieces of information will assist editors and referees in the peer review process.

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Organic & Biomolecular Chemistry  is a hybrid (transformative) journal and gives authors the choice of publishing their research either via the traditional subscription-based model or instead by choosing our gold open access option.  Find out more about our Transformative Journals. which are Plan S compliant .

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For authors who want to publish their article gold open access , Organic & Biomolecular Chemistry  charges an article processing charge (APC) of £2,750 (+ any applicable tax). Our APC is all-inclusive and makes your article freely available online immediately, permanently, and includes your choice of Creative Commons licence (CC BY or CC BY-NC) at no extra cost. It is not a submission charge, so you only pay if your article is accepted for publication.

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*2022 Journal Citation Reports (Clarivate Analytics, 2023)

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Themed collection Top 50 Articles of 2016: Organic Chemistry

Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides

Glycosylation of peptides is a promising strategy for modulating the physicochemical properties of peptide drugs and for improving their absorption through biological membranes.

Pot economy and one-pot synthesis

This review describes the importance and usefulness of pot-economy and one-pot reactions in current synthetic organic chemistry.

Peptide-based synthetic vaccines

This review summarise the current stand and future perspective on synthetic peptide-based vaccines.

Efficient metal-free photochemical borylation of aryl halides under batch and continuous-flow conditions

A metal-free C–B bond forming reaction of aryl halides under batch and continuous-flow conditions is described.

The total synthesis of K-252c (staurosporinone) via a sequential C–H functionalisation strategy

A synthesis of the bioactive indolocarbazole alkaloid K-252c (staurosporinone) via a sequential C–H functionalisation strategy is reported.

A visible-light-promoted radical reaction system for azidation and halogenation of tertiary aliphatic C–H bonds

A highly tunable visible-light-promoted reaction system for the radical-mediated functionalization of tertiary aliphatic C–H bonds of complex substrates has been developed.

Aminofluorination: transition-metal-free N–F bond insertion into diazocarbonyl compounds

Gem-aminofluorination of diazocarbonyl compounds has been achieved for the first time.

Rh( III )-catalyzed diastereoselective C–H bond addition/cyclization cascade of enone tethered aldehydes

Rh( III )-catalyzed cascade addition of C–H bonds across alkene and carbonyl π-bonds to form two new σ C–C bonds is accomplished.

Visible light-mediated gold-catalysed carbon(sp 2 )–carbon(sp) cross-coupling

A new method for the alkynylation of aryldiazonium salts with TMS-alkynes via dual gold and photoredox catalysis is described.

Dual gold/photoredox-catalyzed C(sp)–H arylation of terminal alkynes with diazonium salts

The arylation of alkyl and aromatic terminal alkynes by a dual gold/photoredox catalytic system is described.

Access to a new class of synthetic building blocks via trifluoromethoxylation of pyridines and pyrimidines

One-pot trifluoromethoxylation of functionalized pyridines and pyrimidines via OCF 3 -migraion.

Profiling the reactivity of cyclic C-nucleophiles towards electrophilic sulfur in cysteine sulfenic acid

Oxidation of a protein cysteine thiol to sulfenic acid, termed S -sulfenylation, is a reversible post-translational modification that plays a crucial role in regulating protein function and is correlated with disease states.

About this collection

We are delighted to present a collection showcasing the 50 most downloaded Chemical Science articles of 2016. This is only available for a limited time and provides an easy way to quickly access the most important papers published in Chemical Science in the past year. These articles highlight exciting and impactful research across a broad range of subject areas, analytical chemistry, chemical biology, catalysis, energy, inorganic chemistry, materials science, nanoscience, organic chemistry and physical chemistry. We hope you enjoy reading this collection!

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Organic Chemistry Research Paper Topics

• Carbon family
• Fermentation
• Hydrologic cycle
• Natural gas
• Nitrogen cycle
• Nitrogen family
• Oxygen family

In 1828, German chemist Friedrich Wöhler (1800–1882) proved that this theory of vitalism was untrue. He found a very simple way to convert chemical compounds from living organisms into comparable compounds from nonliving entities.

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As a result of Wöhler’s research, the definition of organic chemistry changed. The new definition was based on the observation that every compound discovered in living organisms had one property in common: they all contained the element carbon. As a result, the modern definition of organic chemistry—as the study of carbon compounds—was adopted.

Organic and Inorganic Chemistry

One important point that Wöhler’s research showed was that the principles and techniques of chemistry apply equally well to compounds found in living organisms and in nonliving things. Nonetheless, some important differences between organic and inorganic (not organic) compounds exist. These include the following:

• The number of organic compounds vastly exceeds the number of inorganic compounds. The ratio of carbon-based compounds to noncarbon- based compounds is at least ten to one, with close to 10 million organic compounds known today. The reason for this dramatic difference is a special property of the carbon atom: its ability to join with other carbon atoms in very long chains, in rings, and in other kinds of geometric arrangements. It is not at all unusual for dozens, hundreds, or thousands of carbon atoms to bond to each other within a single compound—a property that no other element exhibits.
• In general, organic compounds tend to have much lower melting and boiling points than do inorganic compounds.
• In general, organic compounds are less likely to dissolve in water than are inorganic compounds.
• Organic compounds are likely to be more flammable but poorer conductors of heat and electricity than are inorganic compounds.
• Organic reactions tend to take place more slowly and to produce a much more complex set of products than do inorganic reactions.

Functional Groups and Organic Families

The huge number of organic compounds requires that some system be developed for organizing them. The criterion on which those compounds are organized is the presence of various functional groups. A functional group is an arrangement of atoms that is responsible for certain characteristic physical and chemical properties in a compound. For example, one such functional group is the hydroxyl group, consisting of an oxygen atom and hydrogen atom joined to each other. It is represented by the formula -OH.

All organic compounds with the same functional group are said to belong to the same organic family. Any organic compound that contains a hydroxyl group, for instance, is called an alcohol. All alcohols are similar to each other in that: (1) they contain one or more hydroxyl groups, and (2) because of those groups, they have similar physical and chemical properties. For example, alcohols tend to be more soluble in water than other organic compounds because the hydroxyl groups in the alcohol form bonds with water molecules.

The simplest organic compounds are the hydrocarbons, compounds that contain only two elements: carbon and hydrogen. The class of hydrocarbons can be divided into subgroups depending on the way in which carbon and hydrogen atoms are joined to each other. In some hydrocarbons, for example, carbon and hydrogen atoms are joined to each other only by single bonds. A single bond is a chemical bond that consists of a pair of electrons. Such hydrocarbons are known as saturated hydrocarbons.

In other hydrocarbons, carbon and hydrogen atoms are joined to each other by double or triple bonds. A double bond consists of two pairs of electrons, and a triple bond consists of three pairs of electrons. Hydrocarbons containing double and triple bonds are said to be unsaturated.

Hydrocarbons can also be open-chain or ring compounds. In an open-chain hydrocarbon, the carbon atoms are all arranged in a straight line, like a strand of spaghetti. In a ring hydrocarbon, the carbons are arranged in a continuous loop, such as a square, a pentagon, or a triangle.

Back to Science Research Paper Topics .

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Halide Exchange and Transport in Halide Perovskite Lattices , Temban Acha Billy

Synthesis and Study of High-Spin Stable Organic Radicals for Electrical Conductors and Mannosamine Nitroxide for MRI Contrast Agents , Shuyang Zhang

Designing Experiments: The Impact of Peer Review Structure on Organic Chemistry Students' Experimental Designs , Katie Patterson

Study of halide gradient formation via solution-solid halide exchange in crystalline CH 3 NH 3 PbBr 3 thin films , Behnaz Akbari

Oxygen Binding Thermodynamics of Human Hemoglobin in the Red Blood Cell , Kyle K. Hill

Developing Techniques for the Identification of Non-Canonical RNA Pairing and Analysis of LC-MS Datasets , Christopher Jurich

Surface Functionalization of Elastomers for Tunable Crystal Growth and Smart Adhesives , John Kapitan

Issue of False Amphetamine Field Test Positives Caused By Sugar. Use of Baeyer Test as a Secondary Test Solution. , Reed A. Knutson, Jennah Duncan, Kara Peightal, and Samuel Thomas

Harnessing Surface Chemistry and Instabilities in Silicone Elastomers to Synthesize Adaptive Systems with Mechanically Tunable Surface Properties and Functionality , Ali Jamal Mazaltarim

How Oxygen-Binding Affects Structural Evolution of Even-Sized Gold Anion Clusters. (Size Range 20 to 34) , David Brunken-Deibert

Analysis of Hydroxychloroquine Interaction with Serum Proteins by High Performance Affinity Chromatography , Kyungah Suh, Sadia Sharmeen, and David S. Hage

The Application and Development of Metabolomics Methodologies for the Profiling of Food and Cellular Toxicity , Jade Woods

Evaluation of the Overall Binding of Acetohexamide and Tolbutamide with Methyl Glyoxal-Modified HSA by High-Performance Affinity Chromatography , Ashley G. Woolfork and David S. Hage

C(sp2)-C(sp3) Cross-Coupling of Aryl Halides and Active C(sp3)-H Bonds via Dual Catalysis: Organic Photocatalysis/Nickel Redox Catalysis , Nicholas Armada

Phosphonate-Directed Catalytic Asymmetric Hydroboration: Synthesis of Functionalized Chiral Secondary and Tertiary Boronic Esters and Mechanistic Insights , Suman Chakrabarty

COMPUTATIONAL STUDIES OF THERMAL PROPERTIES AND DESALINATION PERFORMANCE OF LOW-DIMENSIONAL MATERIALS , Yang Hong

QUANTUM CHEMICAL CALCULATIONS APPLIED TO SOMO-HOMO CONVERSION AND VIBRATIONALLY AVERAGED NMR SHIELDING PARAMETERS , Erik Johnson

Design and Synthesis of Stable Aminyl and Nitroxide Radical Precursors , Joshua Bryan Lovell

Development of Nanomaterial Supports for the Study of Affinity-Based Analytes Using Ultra-Thin Layer Chromatography , Allegra Pekarek

ANALYSIS OF DRUG-PROTEIN INTERACTIONS DURING DIABETES BY HIGH-PERFORMANCE AFFINITY CHROMATOGRAPHY , Pingyang Tao

Electropolymerization and Characterization of Thin Film Dielectrics , Christopher White II

Synthesis, Characterization, and Catalytic Activity of Copper Palladium Oxide Solid Solutions. , Gregory L. Christensen

GLOBAL MINIMUM SEARCH AND CARBON MONOXIDE BINDING STUDIES OF NOVEL GOLD NANOCLUSTERS , Navneet S. Khetrapal

Mass Spectrometry and Nuclear Magnetic Resonance in the Chemometric Analysis of Cellular Metabolism , Eli Riekeberg

Ultrafast Affinity Extraction and High-Performance Affinity Chromatography Applications for Measuring Free Drug Fractions: Interactions of Sulfonylurea Drugs with Normal and Glycated Human Serum Albumin , Bao Yang

DEVELOPMENT OF ENTRAPMENT COLUMNS FOR THE STUDY OF AFFINITY BASED ANALYSIS OF DRUG-PROTEIN INTERACTIONS , Shiden T. Azaria

Chemical Vapor Deposition of Two-Dimensional Materials and Heterostructures , Alex J. Boson

Bioinformatic and Biophysical Analyses of Proteins , Jonathan Catazaro

Developing Functionalized Peroxide Precursors for the Synthesis of Cyclic and Spirocyclic Ethers , Anna J. Diepenbrock

Decarboxylative Elimination for the Systhesis of Olefins Via Photoredox/Cobalt Dual Catalysis , Renjie Gui

Enantioselective γ- and δ -Borylation of Unsaturated Carbonyl Derivatives: Synthesis, Mechanistic Insights, and Applications. , Gia L. Hoang

Entrapment of proteins in high-performance affinity columns for chromatographic studies of drug-protein interactions , Saumen Poddar, Elliott Rodriguez, Shiden Azaria, and David S. Hage

Genetic Code Expansion in Biochemical Investigations and Biomedical Applications , Nanxi Wang

Applying the Diffusion of Innovation Theory to Characterize STEM Faculty Attending Professional Development Programs , Dihua Xue

Who is attending pedagogical workshops? Applying the Innovation Diffusion to Characterize Faculty Attendees , Victoria Dihua Xue, Trisha Vickrey, and Marilyne Stains

Genetically Encoded Fluorescent Protein Biosensor for Nitric Oxide , Wenjia Zhai

STUDIES IN DIRECTED CATALYTIC ASYMMETRIC HYDROBORATION OF 1,2-DISUBSTITUTED UNSATURATED AMIDE , Shuyang Zhang

Synthesis and Applications of Cyclobutenes , Benjamin Enns

Binding of Oxygen to Human Hemoglobin Within the Erythrocyte Using ICAM Spectrophotometry , Kyle K. Hill

Design and Synthesis of Novel Octacarboxy Porphyrinic Metal-Organic Frameworks , Jacob A. Johnson

Development of a Direct Activity Probe for Rho-Associated Protein Kinase , Maia Kelly

Thermolysis of Hypervalent Iodine Complexes: Synthesis of Fluorinated Radiotracers for Positron Emission Tomography and Synthesis of Quaternary α-Alkyl α-Aryl Amino Acids , Jayson J. Kempinger

Synthesis and Applications of Lanthanide Sulfides and Oxides , Christopher Marin

SELECTIVE IODINATION USING DIARYLIODONIUM SALTS , William H. Miller IV

MOLECULAR MECHANISM FOR THE BIOSYNTHESIS AND REGULATION OF SECONDARY METABOLITES IN LYSOBACTER , Simon Tesfamichael Tombosa

STUDIES IN ASYMMETRIC CATALYSIS: SUPRAMOLECULAR CATALYSIS AND BORANE-ASSISTED HYDROGENATION , Kazuya Toyama

Molecular Mechanism for the Biosynthesis of Antifungal HSAF and Antibacterial WAP-8294A2 , Haotong Chen

Toward the Probing of DHQS Activity by Protein Engineering through the Introduction of Unnatural Amino Acids and the Selection of tRNA/tRNA Synthetase Pairs , Shaina E. Ives

Toward an Expanded Role for Collision-Induced Dissociation in Glycoproteomic Analysis , Venkata Kolli

New Methods for Synthesis of Organic Peroxides and Application of Peroxide Electrophiles to Synthesis of Functionalized Ethers , Shiva Kumar Kyasa

Chromatographic Analysis of Drug-Protein Interactions During Diabetes and Characterization of Human Serum Albumin Through Multidimensional Mass Spectrometry , Ryan E. Matsuda

THREE-DIMENSIONAL SCAFFOLDS OF GRAPHENE, CARBON NANOTUBES AND TRANSITION-METAL OXIDES FOR APPLICATIONS IN ELECTRONICS, SENSORS AND ENERGY STORAGE , Gilbert N. Mbah

TOWARD THE MEASUREMENT OF BIODISTRIBUTION OF 18 F-LABELED INDUSTRIAL CHEMICALS WITH POSITRON EMISSION TOMOGRAPHY (PET) , Katelyenn S. McCauley

Investigations into the Molecular Mechanisms of Bacterial Pathogen-Host Interactions: Construction of a Dual Plasmid System for Incorporation of Unnatural Amino Acids into Pseudomonas syringae pv. tomato DC3000 , Scotty D. Raber

Applications of High Performance Affinity Chromatography with High Capacity Stationary Phases Made by Entrapment , John A. Vargas Badilla

Uses of Diaryliodonium Salts and Methods for their Synthesis , Jordan M. Veness

The intersection of nuclear magnetic resonance and quantum chemistry , Yali Wang

Chemometric and Bioinformatic Analyses of Cellular Biochemistry , Bradley Worley

Analysis of Free Solute Fractions and Solute-Protein Interactions Using Ultrafast Affinity Extraction and Affinity Microcolumns , Xiwei Zheng

The 8-Silyloxyquinoline Scaffold as a Versatile Platform for the Sensitive Detection of Aqueous Fluoride , Xinqi Zhou

Nanostructured Cerium Oxide Based Catalysts: Synthesis, Physical Properties, and Catalytic Performance , Yunyun Zhou

Hydrolytically Stable Analogues of Sugar Phosphates and a Miniaturized in Situ Enzymatic Screen , Xiang Fei

Development and Application of Combined Quantum Mechanical and Molecular Mechanical Methods , Rui Lai

Syntheses of Aminyl Diradicals and Nitroxide Tetra- and Octaradicals , Arnon Olankitwanit

Analysis of Drug Interactions with Lipoproteins by High Performance Affinity Chromatography , Matthew R. Sobansky

Studies in Asymmetric Synthesis: Supramolecular Catalysis, C-H Activation, and D-Cycloserine Synthesis , Nathan C. Thacker

Application of Nuclear Magnetic Resonance Based Metabolomics to Study the Central Metabolism of Staphylococci , Bo Zhang

IMPLEMENTATION AND APPLICATION OF THE MMFF94 FORCE FIELD , Hongbo Zhu

The Electrochemical Analysis of Bovine Bone Derived Supercapacitors, Organic Peroxide Explosives, and Conducting Polymer Nanojunctions , Paul Goodman

The Development and Applications of NMR Metabolomics Analysis of Bacterial Metabolomes , Steven M. Halouska

Utilizing NMR Spectroscopy and Molecular Docking as Tools for the Structural Determination and Functional Annotation of Proteins , Jaime Stark

A. Catalysis of CO-PROX by Water-Soluble Rhodium Fluorinated Porphyrins B. Studies toward Fluorination of Electron Rich Aromatics by Nucleophilic Fluoride , Shri Harsha Uppaluri

Regulation of Secondary Metabolism in Lysobacter enzymogenes : Studies of Intercellular and Intracellular Signaling , Stephen J. Wright

DIRECTED CATALYTIC ASYMMETRIC HYDROBORATION OF 1,1-DISUBSTITUTED ALKENES , Mohammad Odeh Bani Khaled

I. Synthesis of β-Sitosterol and Phytosterol Esters; II. New Methodology for Singlet Oxygen Generation from 1,1-Dihydroperoxides , Jiliang Hang

Experimental and Theoretical Studies in Solid-state Nuclear Magnetic Resonance , Monica N. Kinde

Experimental and Theoretical Studies in Nuclear Magnetic Resonance , John D. Persons

RHODIUM-CATALYZED HYDROBORATION OF 1,1-DISUBSTITUTED ALKENES , Scott A. Pettibone

INVESTIGATIONS OF INTER- AND INTRAMOLECULAR C-O BOND FORMING REACTIONS OF PEROXIDE ELECTROPHILES , Benjamin W. Puffer

The Use of Rhenium (VII) Oxide as a Catalyst for the Substution of Hemiacetals , Michael W. Richardson

Characterization of Novel Macrocyclic Polyether Modified Pseudostationary Phases for use in Micellar Electrokinetic Chromatography and Development of a Chemiluminescence Presumptive Assay for Peroxide-based Explosives , Raychelle Burks

Preparation and Characterization of Biomimetic Hydroxyapatite-Resorbable Polymer Composites for Hard Tissue Repair , Kristopher R. Hiebner

High Yield Synthesis of Positron Emission Tomography Ligands for Metabotropic Glutamate Receptor Imaging , Saraanne E. Hitchcock

Optimization and Implementation of Entrapment: A Novel Immobilization Technique for High-performance Affinity Chromatography , Abby J. Jackson

Fabrication and Catalytic Property of Cerium Oxide Nanomaterials , Keren Jiang

Affinity Chromatography in Environmental Analysis and Drug-Protein Interaction Studies , Efthimia Papastavros

Development and Optimization of Organic Based Monoliths for Use in Affinity Chromatography , Erika L. Pfaunmiller

I. An Improved Procedure for Alkene Ozonolysis. II. Exploring a New Structural Paradigm for Peroxide Antimalarials. , Charles Edward Schiaffo

QUANTUM MECHANICAL AND MOLECULAR MECHANICAL STUDY OF SOLVENT EFFECTS , Dejun Si

Resorbable Polymer-Hydroxyapatite Composites for Bone Trauma Treatment: Synthesis and Properties , Troy E. Wiegand

PURIFICATION OF LYSINE DECARBOXYLASE: A MODEL SYSTEM FOR PLP ENZYME INHIBITOR DEVELOPMENT AND STUDY , Leah C. Zohner

Characterization of Glycation Sites on Human Serum Albumin using Mass Spectrometry , Omar S. Barnaby

HIGH TEMPERATURE RARE EARTH COMPOUNDS: SYNTHESIS, CHARACTERIZATION AND APPLICATIONS IN DEVICE FABRICATION , Joseph R. Brewer

Classification, Synthesis and Characterization of Pyridyl Porphyrin Frameworks , Lucas D. DeVries

Ultrasonic Activation of Triacetone Triperoxide , LaTravia R. Dobson

Characteristics and Stability of Oxide Films on Plutonium Surfaces , Harry Guillermo García Flores

Controlling Reductive Elimination From Novel I(III) Salts Using a SECURE Method , Joseph W. Graskemper

I. A NEW SYNTHETIC APPROACH TO THE SYNTHESIS OF N-(PHOSPHONOACETYL)-L-ORNITHINE, II. THE INFLUENCE OF PYRIDINE ON THE OZONOLYSIS OF ALKENES , Bradley M. Johnson

Chromatographic Studies of Drug-Protein Binding in Diabetes , Kathryn (Krina) S. Joseph

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