2024 ACTS Distinguished Investigator Translation from Proof of Concept: Shivan Mehta, MD, MBA, MSHP
What Is the “Normal” Sarcoma Immune Microenvironment?
TROP2-Targeting ADCs as New Tools in the TNBC and HR+/HER2- Breast Cancer Treatment Arsenal
Spatial AI Biomarkers: Expending The Eligible Patient Pool with Novel Histopathology Signatures
TAR200 for non-muscle invasive bladder cancer, a novel approach
COMMENTS
What are the T0 to T4 Research Classifications?
The T0 to T4 classification system replaced the Type 1 Translational Research (T1TR) and Type 2 Translational Research (T2TR) categories to allow more precise identification of supported research and development of a diverse, balanced research portfolio. In June 2013, the Institute of Medicine (IOM) released an independent appraisal of the ...
What Constitutes Translational Research? Implications for the Scope of
Importance of Translational Research. In one study of 101 very promising claims of scientific discoveries with unambiguous clinical potential published in major science journals between 1979 and 1983, only five resulted in interventions with licensed clinical use by 2003. 8 Estimates of the median time required for new scientific discoveries to result in successfully completed clinical trials ...
Mapping the evolving definitions of translational research
Translational research as a concept has been widely used and applied in scientific literature for more than a decade. It is most broadly and simply defined as research steps to take discoveries "from the bench to the beside and back again." ... Tuttle KR, et al. Type 2 translational research for CKD. Clinical Journal of the American Society ...
Translational research is all-encompassing and lets everyone be a
Instead, all articles published in Pediatric Research represent translational research and categorized based on methodology: basic translational research, clinical translational research, or ...
Addressing core challenges for the next generation of type 2
Society for Prevention Research Type 2 Translational Task Force Members and Contributing Authors ... indicates much progress is needed to achieve population-level impact. In part, progress requires Type 2 translation research that investigates the complex processes and systems through which evidence-based interventions are adopted, implemented ...
PDF Type 2 Translational Research: Advances, Challenges, Illustrative
Part 3. Translation Research Review Core Challenge #2: Needed Scientific Advances-Key Research Questions for Each Translation Phase *Source: Spoth, Rohrbach, Greenberg, et al. (2013). Addressing core challenges for the next generation of Type 2 translation research and systems: The Translation Science to Population Impact (TSci Impact) framework.
Addressing Core Challenges for the Next Generation of Type 2
The SPR Board of Directors appointed the Mapping Advances in Prevention Science Type 2 Translational Research Task Force (Spoth and Rohrbach, Co-Chairs) to develop the Type 2 translation research population impact framework outlined in this paper. The intent of this work is to enhance the next generation of T2 translation science to have ...
Everyday characterizations of translational research: researchers' own
The term "translational research" was first used in a US national cancer program in the 90's and has since appeared in research programs, research strategies, academic articles and journals ...
Introduction: What Is Translational Research
Dische and Saunders [ 15] mention the definition given by Julie Denekamp: Translational Research is the application of scientific method to address a health need. Barry S. Coller has very simply defined [ 16] it as: Successful implementation of a laboratory concept into a clinical protocol.
PDF Addressing Core Challenges for the Next Generation of Type 2
Research Type 2 Translational Task Force Members and Contributing Authors Published online: 21 February 2013 # The Author(s) 2013. This article is published with open access at Springerlink.com Abstract Evidence-based preventive interventions devel-oped over the past two decades represent great potential for enhancing public health and well-being.
Translational research: Essential contributions from interpretive
definition of Type 2 translational research. Models other than the NIH 2-phase model exist for classifying types of translational research (Sussman et al., 2006). In most of them, each type of research is conceptualized as a phase in a linear process of knowledge development that leads from basic or bench research directly or indirectly
What is Translational Research?
In clinical and translational research, scientific discoveries are moved along a virtual path from the laboratory into real-world practice, leading to improved human health. Translational research definitions courtesy of Harvard Catalyst and the Harvard Clinical and Translational Science Center, a Clinical and Translational Science Award (CTSA ...
Type 2 translational research for CKD
This review identifies key elements of type 2 translational research and highlights the current scope of this type of research for CKD. For type 2 translation to achieve the goals of providing high-quality care and better health outcomes, key facilitators (e.g., theory-based frameworks, adaptable interventions, and inclusion of sustainability ...
Introduction to 'type 2' translational research
Introduction to 'type 2' translational research. Introduction to 'type 2' translational research WMJ. 2009 Aug;108(5):282-3. Author Maureen A Smith 1 Affiliation 1 Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wis, USA. PMID: 19743771 No abstract available ...
Type 2 translational research for CKD
This review identifies key elements of type 2 translational research and highlights the current scope of this type of research for CKD. For type 2 translation to achieve the goals of providing high-quality care and better health outcomes, key facilitators (e.g., theory-based frameworks, adaptable interventions, and inclusion of sustainability ...
Translational research
Translational research (also called translation research, translational science, or, when the context is clear, simply translation) [1] [2] is research aimed at translating (converting) results in basic research into results that directly benefit humans. The term is used in science and technology, especially in biology and medical science.
Translational research in type 2 diabetes
In 2011, a study population of 250,000 people was identified from 25 communities across China, aims to research the interaction between type 2 diabetes and cancer, as phase I of a prospective study. Our study showed that the detection rate of urinary BPA was 87.7%, with a median value of 0.81 ng/mL. Higher levels of urinary BPA associated with ...
A framework for clinical and translational research in the era of rigor
Introduction. Clinical and translational research (CTR) has been experiencing a resurgence since the mid-2000s along with an embracing of team science within the CTR community [1-4].Around this same time, articles questioning or discussing the validity of published research results began to emerge in academic as well as nonacademic publications [5-7].
Results of a Type 2 Translational Research Trial to Prevent Adolescent
This type-2 translational research study indicates that public health can be promoted and health-risking behaviors in early adolescence can be prevented by coalitions of community stakeholders trained to use the CTC system for translating the advances of prevention science into well-chosen and well-implemented prevention practices in ...
Addressing Core Challenges for the Next Generation of Type 2 ...
Evidence-based preventive interventions developed over the past two decades represent great potential for enhancing public health and well-being. Research confirming the limited extent to which these interventions have been broadly and effectively implemented, however, indicates much progress is needed to achieve population-level impact. In part, progress requires Type 2 translation research ...
Results of a type 2 translational research trial to prevent adolescent
Results of a type 2 translational research trial to prevent adolescent drug use and delinquency: A test of communities that care. / Hawkins, J. David; Oesterle, Sabrina; Brown, Eric C. et al. In: Archives of Pediatrics and Adolescent Medicine, Vol. 163, No. 9, 09.2009, p. 789-798. Research output: Contribution to journal › Article › peer-review
Advancing Infection Research through Translational Models
Infection research stands at the forefront of global health initiatives, particularly considering emerging pathogens and antimicrobial resistance. The quest for effective interventions necessitates bridging the gap between basic research findings and clinical applications. Translational models serve as indispensable tools in this effort, facilitating the translation of fundamental discoveries ...
The translational gap for gene therapies in low- and middle-income
Gene therapy aims to modify or manipulate gene expression or to alter the biological properties of living cells for therapeutic use, an innovative medical approach that currently sits at an inflection point (1, 2).After the first gene therapies developed in the 1990s, research and development (R&D) remained stagnant until the mid-2010s when the convergence of next-generation technologies ...
Defining Translational Research: Implications for Training
Some basic research and population-based research is translational, but neither type of research is by definition translational. In contrast, patient-oriented research fundamentally addresses issues that have the potential to translate to clinical practice and therefore affect health. For these reasons, the model includes only part of basic ...
Chronic atrophic gastritis and risk of incident upper gastrointestinal
Moreover, CAG was correlated with a 2.77-fold heightened risk of oesophagogastric junction cancer (OR = 2.77, 95%CI 2.21-3.46). Notably, for the same type of upper gastrointestinal cancer, it was observed that diagnosing CAG through histological methods was linked to a 33-77% higher risk of developing cancer compared to diagnosing CAG ...
Global Rare Disease Diagnostics Market Insights 2024-2030: Rising Use
Global Rare Disease Diagnostics Market Insights 2024-2030: Rising Use in Translational & Genomic Research Driving the Industry to $8.23 Billion by 2030 Research and Markets Wed, May 8, 2024, 5:07 ...
Osteoarthritis and risk of type 2 diabetes: A two-sample ...
Methods: We performed two-sample Mendelian randomization (MR) analyses to obtain nonconfounding estimates of the effect of OA on T2D risk. Single nucleotide polymorphisms (SNPs) from genome-wide association studies were selected as genetic instruments for radiographic knee and hip OA (ie, Kellgren-Lawrence grade ≥2).
Translational research in type 2 diabetes
In 2011, a study population of 250,000 people was identified from 25 communities across China, aims to research the interaction between type 2 diabetes and cancer, as phase I of a prospective study. Our study showed that the detection rate of urinary BPA was 87.7%, with a median value of 0.81 ng/mL. Higher levels of urinary BPA associated with ...
IMAGES
VIDEO
COMMENTS
The T0 to T4 classification system replaced the Type 1 Translational Research (T1TR) and Type 2 Translational Research (T2TR) categories to allow more precise identification of supported research and development of a diverse, balanced research portfolio. In June 2013, the Institute of Medicine (IOM) released an independent appraisal of the ...
Importance of Translational Research. In one study of 101 very promising claims of scientific discoveries with unambiguous clinical potential published in major science journals between 1979 and 1983, only five resulted in interventions with licensed clinical use by 2003. 8 Estimates of the median time required for new scientific discoveries to result in successfully completed clinical trials ...
Translational research as a concept has been widely used and applied in scientific literature for more than a decade. It is most broadly and simply defined as research steps to take discoveries "from the bench to the beside and back again." ... Tuttle KR, et al. Type 2 translational research for CKD. Clinical Journal of the American Society ...
Instead, all articles published in Pediatric Research represent translational research and categorized based on methodology: basic translational research, clinical translational research, or ...
Society for Prevention Research Type 2 Translational Task Force Members and Contributing Authors ... indicates much progress is needed to achieve population-level impact. In part, progress requires Type 2 translation research that investigates the complex processes and systems through which evidence-based interventions are adopted, implemented ...
Part 3. Translation Research Review Core Challenge #2: Needed Scientific Advances-Key Research Questions for Each Translation Phase *Source: Spoth, Rohrbach, Greenberg, et al. (2013). Addressing core challenges for the next generation of Type 2 translation research and systems: The Translation Science to Population Impact (TSci Impact) framework.
The SPR Board of Directors appointed the Mapping Advances in Prevention Science Type 2 Translational Research Task Force (Spoth and Rohrbach, Co-Chairs) to develop the Type 2 translation research population impact framework outlined in this paper. The intent of this work is to enhance the next generation of T2 translation science to have ...
The term "translational research" was first used in a US national cancer program in the 90's and has since appeared in research programs, research strategies, academic articles and journals ...
Dische and Saunders [ 15] mention the definition given by Julie Denekamp: Translational Research is the application of scientific method to address a health need. Barry S. Coller has very simply defined [ 16] it as: Successful implementation of a laboratory concept into a clinical protocol.
Research Type 2 Translational Task Force Members and Contributing Authors Published online: 21 February 2013 # The Author(s) 2013. This article is published with open access at Springerlink.com Abstract Evidence-based preventive interventions devel-oped over the past two decades represent great potential for enhancing public health and well-being.
definition of Type 2 translational research. Models other than the NIH 2-phase model exist for classifying types of translational research (Sussman et al., 2006). In most of them, each type of research is conceptualized as a phase in a linear process of knowledge development that leads from basic or bench research directly or indirectly
In clinical and translational research, scientific discoveries are moved along a virtual path from the laboratory into real-world practice, leading to improved human health. Translational research definitions courtesy of Harvard Catalyst and the Harvard Clinical and Translational Science Center, a Clinical and Translational Science Award (CTSA ...
This review identifies key elements of type 2 translational research and highlights the current scope of this type of research for CKD. For type 2 translation to achieve the goals of providing high-quality care and better health outcomes, key facilitators (e.g., theory-based frameworks, adaptable interventions, and inclusion of sustainability ...
Introduction to 'type 2' translational research. Introduction to 'type 2' translational research WMJ. 2009 Aug;108(5):282-3. Author Maureen A Smith 1 Affiliation 1 Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wis, USA. PMID: 19743771 No abstract available ...
This review identifies key elements of type 2 translational research and highlights the current scope of this type of research for CKD. For type 2 translation to achieve the goals of providing high-quality care and better health outcomes, key facilitators (e.g., theory-based frameworks, adaptable interventions, and inclusion of sustainability ...
Translational research (also called translation research, translational science, or, when the context is clear, simply translation) [1] [2] is research aimed at translating (converting) results in basic research into results that directly benefit humans. The term is used in science and technology, especially in biology and medical science.
In 2011, a study population of 250,000 people was identified from 25 communities across China, aims to research the interaction between type 2 diabetes and cancer, as phase I of a prospective study. Our study showed that the detection rate of urinary BPA was 87.7%, with a median value of 0.81 ng/mL. Higher levels of urinary BPA associated with ...
Introduction. Clinical and translational research (CTR) has been experiencing a resurgence since the mid-2000s along with an embracing of team science within the CTR community [1-4].Around this same time, articles questioning or discussing the validity of published research results began to emerge in academic as well as nonacademic publications [5-7].
This type-2 translational research study indicates that public health can be promoted and health-risking behaviors in early adolescence can be prevented by coalitions of community stakeholders trained to use the CTC system for translating the advances of prevention science into well-chosen and well-implemented prevention practices in ...
Evidence-based preventive interventions developed over the past two decades represent great potential for enhancing public health and well-being. Research confirming the limited extent to which these interventions have been broadly and effectively implemented, however, indicates much progress is needed to achieve population-level impact. In part, progress requires Type 2 translation research ...
Results of a type 2 translational research trial to prevent adolescent drug use and delinquency: A test of communities that care. / Hawkins, J. David; Oesterle, Sabrina; Brown, Eric C. et al. In: Archives of Pediatrics and Adolescent Medicine, Vol. 163, No. 9, 09.2009, p. 789-798. Research output: Contribution to journal › Article › peer-review
Infection research stands at the forefront of global health initiatives, particularly considering emerging pathogens and antimicrobial resistance. The quest for effective interventions necessitates bridging the gap between basic research findings and clinical applications. Translational models serve as indispensable tools in this effort, facilitating the translation of fundamental discoveries ...
Gene therapy aims to modify or manipulate gene expression or to alter the biological properties of living cells for therapeutic use, an innovative medical approach that currently sits at an inflection point (1, 2).After the first gene therapies developed in the 1990s, research and development (R&D) remained stagnant until the mid-2010s when the convergence of next-generation technologies ...
Some basic research and population-based research is translational, but neither type of research is by definition translational. In contrast, patient-oriented research fundamentally addresses issues that have the potential to translate to clinical practice and therefore affect health. For these reasons, the model includes only part of basic ...
Moreover, CAG was correlated with a 2.77-fold heightened risk of oesophagogastric junction cancer (OR = 2.77, 95%CI 2.21-3.46). Notably, for the same type of upper gastrointestinal cancer, it was observed that diagnosing CAG through histological methods was linked to a 33-77% higher risk of developing cancer compared to diagnosing CAG ...
Global Rare Disease Diagnostics Market Insights 2024-2030: Rising Use in Translational & Genomic Research Driving the Industry to $8.23 Billion by 2030 Research and Markets Wed, May 8, 2024, 5:07 ...
Methods: We performed two-sample Mendelian randomization (MR) analyses to obtain nonconfounding estimates of the effect of OA on T2D risk. Single nucleotide polymorphisms (SNPs) from genome-wide association studies were selected as genetic instruments for radiographic knee and hip OA (ie, Kellgren-Lawrence grade ≥2).
In 2011, a study population of 250,000 people was identified from 25 communities across China, aims to research the interaction between type 2 diabetes and cancer, as phase I of a prospective study. Our study showed that the detection rate of urinary BPA was 87.7%, with a median value of 0.81 ng/mL. Higher levels of urinary BPA associated with ...